Deep Learning (DL) systems are increasingly deployed in safety-critical applications, yet they remain vulnerable to robustness issues that can lead to significant failures. While numerous Test Input Generators (TIGs) have been developed to evaluate DL robustness, a comprehensive assessment of their effectiveness across different dimensions is still lacking. This paper presents a comprehensive assessment of four state-of-the-art TIGs--DeepHunter, DeepFault, AdvGAN, and SinVAD--across multiple critical aspects: fault-revealing capability, naturalness, diversity, and efficiency. Our empirical study leverages three pre-trained models (LeNet-5, VGG16, and EfficientNetB3) on datasets of varying complexity (MNIST, CIFAR-10, and ImageNet-1K) to evaluate TIG performance. Our findings reveal important trade-offs in robustness revealing capability, variation in test case generation, and computational efficiency across TIGs. The results also show that TIG performance varies significantly with dataset complexity, as tools that perform well on simpler datasets may struggle with more complex ones. In contrast, others maintain steadier performance or better scalability. This paper offers practical guidance for selecting appropriate TIGs aligned with specific objectives and dataset characteristics. Nonetheless, more work is needed to address TIG limitations and advance TIGs for real-world, safety-critical systems.
The recent advancements in Deep Learning models and techniques have led to significant strides in performance across diverse tasks and modalities. However, while the overall capabilities of models show promising growth, our understanding of their internal reasoning processes remains limited, particularly concerning systematic inconsistencies or errors patterns of logical or inferential flaws. These inconsistencies may manifest as contradictory outputs, failure to generalize across similar tasks, or erroneous conclusions in specific contexts. Even detecting and measuring such reasoning discrepancies is challenging, as they may arise from opaque internal procedures, biases and imbalances in training data, or the inherent complexity of the task. Without effective methods to detect, measure, and mitigate these errors, there is a risk of deploying models that are biased, exploitable, or logically unreliable. This thesis aims to address these issues by producing novel methods for deep learning models that reason over knowledge graphs, natural language, and images. The thesis contributes two techniques for detecting and quantifying predictive inconsistencies originating from opaque internal procedures in natural language and image processing models. To mitigate inconsistencies from biases in training data, this thesis presents a data efficient sampling method to improve fairness and performance and a synthetic dataset generation approach in low resource scenarios. Finally, the thesis offers two techniques to optimize the models for complex reasoning tasks. These methods enhance model performance while allowing for more faithful and interpretable exploration and exploitation during inference. Critically, this thesis provides a comprehensive framework to improve the robustness, fairness, and interpretability of deep learning models across diverse tasks and modalities.
In this paper, we explore the feasibility of using communication signals for extended target (ET) tracking in an integrated sensing and communication (ISAC) system. The ET is characterized by its center range, azimuth, orientation, and contour shape, for which conventional scatterer-based tracking algorithms are hardly feasible due to the limited scatterer resolution in ISAC. To address this challenge, we propose ISACTrackNet, a deep learning-based tracking model that directly estimates ET kinematic and contour parameters from noisy received echoes. The model consists of three modules: Denoising module for clutter and self-interference suppression, Encoder module for instantaneous state estimation, and KalmanNet module for prediction refinement within a constant-velocity state-space model. Simulation results show that ISACTrackNet achieves near-optimal accuracy in position and angle estimation compared to radar-based tracking methods, even under limited measurement resolution and partial occlusions, but orientation and contour shape estimation remains slightly suboptimal. These results clearly demonstrate the feasibility of using communication-only signals for reliable ET tracking.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with most cases diagnosed at stage IV and a five-year overall survival rate below 5%. Early detection and prognosis modeling are crucial for improving patient outcomes and guiding early intervention strategies. In this study, we developed and evaluated a deep learning fusion model that integrates radiology reports and CT imaging to predict PDAC risk. The model achieved a concordance index (C-index) of 0.6750 (95% CI: 0.6429, 0.7121) and 0.6435 (95% CI: 0.6055, 0.6789) on the internal and external dataset, respectively, for 5-year survival risk estimation. Kaplan-Meier analysis demonstrated significant separation (p<0.0001) between the low and high risk groups predicted by the fusion model. These findings highlight the potential of deep learning-based survival models in leveraging clinical and imaging data for pancreatic cancer.
Microfluidic Live-Cell Imaging yields data on microbial cell factories. However, continuous acquisition is challenging as high-throughput experiments often lack realtime insights, delaying responses to stochastic events. We introduce three components in the Experiment Automation Pipeline for Event-Driven Microscopy to Smart Microfluidic Single-Cell Analysis: a fast, accurate Deep Learning autofocusing method predicting the focus offset, an evaluation of real-time segmentation methods and a realtime data analysis dashboard. Our autofocusing achieves a Mean Absolute Error of 0.0226\textmu m with inference times below 50~ms. Among eleven Deep Learning segmentation methods, Cellpose~3 reached a Panoptic Quality of 93.58\%, while a distance-based method is fastest (121~ms, Panoptic Quality 93.02\%). All six Deep Learning Foundation Models were unsuitable for real-time segmentation.
Type 1 diabetes (T1D) management can be significantly enhanced through the use of predictive machine learning (ML) algorithms, which can mitigate the risk of adverse events like hypoglycemia. Hypoglycemia, characterized by blood glucose levels below 70 mg/dL, is a life-threatening condition typically caused by excessive insulin administration, missed meals, or physical activity. Its asymptomatic nature impedes timely intervention, making ML models crucial for early detection. This study integrates short- (up to 2h) and long-term (up to 24h) prediction horizons (PHs) within a single classification model to enhance decision support. The predicted times are 5-15 min, 15-30 min, 30 min-1h, 1-2h, 2-4h, 4-8h, 8-12h, and 12-24h before hypoglycemia. In addition, a simplified model classifying up to 4h before hypoglycemia is compared. We trained ResNet and LSTM models on glucose levels, insulin doses, and acceleration data. The results demonstrate the superiority of the LSTM models when classifying nine classes. In particular, subject-specific models yielded better performance but achieved high recall only for classes 0, 1, and 2 with 98%, 72%, and 50%, respectively. A population-based six-class model improved the results with at least 60% of events detected. In contrast, longer PHs remain challenging with the current approach and may be considered with different models.
Cooper is an open-source package for solving constrained optimization problems involving deep learning models. Cooper implements several Lagrangian-based first-order update schemes, making it easy to combine constrained optimization algorithms with high-level features of PyTorch such as automatic differentiation, and specialized deep learning architectures and optimizers. Although Cooper is specifically designed for deep learning applications where gradients are estimated based on mini-batches, it is suitable for general non-convex continuous constrained optimization. Cooper's source code is available at https://github.com/cooper-org/cooper.
Edge detection remains a fundamental yet challenging task in computer vision, especially under varying illumination, noise, and complex scene conditions. This paper introduces a Hybrid Multi-Stage Learning Framework that integrates Convolutional Neural Network (CNN) feature extraction with a Support Vector Machine (SVM) classifier to improve edge localization and structural accuracy. Unlike conventional end-to-end deep learning models, our approach decouples feature representation and classification stages, enhancing robustness and interpretability. Extensive experiments conducted on benchmark datasets such as BSDS500 and NYUDv2 demonstrate that the proposed framework outperforms traditional edge detectors and even recent learning-based methods in terms of Optimal Dataset Scale (ODS) and Optimal Image Scale (OIS), while maintaining competitive Average Precision (AP). Both qualitative and quantitative results highlight enhanced performance on edge continuity, noise suppression, and perceptual clarity achieved by our method. This work not only bridges classical and deep learning paradigms but also sets a new direction for scalable, interpretable, and high-quality edge detection solutions.
Objective: Neonates are highly susceptible to seizures, which can have severe long-term consequences if undetected and left untreated. Early detection is crucial and typically requires continuous electroencephalography (EEG) monitoring in a hospital setting, which is costly, inconvenient, and requires specialized experts for diagnosis. In this work, we propose a new low-cost active dry-contact electrode-based adjustable EEG headset, a new explainable deep learning model to detect neonatal seizures, and an advanced signal processing algorithm to remove artifacts to address the key aspects that lead to the underdiagnosis of neonatal seizures. Methods: EEG signals are acquired through active electrodes and processed using a custom-designed analog front end (AFE) that filters and digitizes the captured EEG signals. The adjustable headset is designed using three-dimensional (3D) printing and laser cutting to fit a wide range of head sizes. A deep learning model is developed to classify seizure and non-seizure epochs in real-time. Furthermore, a separate multimodal deep learning model is designed to remove noise artifacts. The device is tested on a pediatric patient with absence seizures in a hospital setting. Simultaneous recordings are captured using both the custom device and the commercial wet electrode device available in the hospital for comparison. Results: The signals obtained using our custom design and a commercial device show a high correlation (>0.8). Further analysis using signal-to-noise ratio values shows that our device can mitigate noise similar to the commercial device. The proposed deep learning model has improvements in accuracy and recall by 2.76% and 16.33%, respectively, compared to the state-of-the-art. Furthermore, the developed artifact removal algorithm can identify and remove artifacts while keeping seizure patterns intact.
Deep learning has become a cornerstone of modern artificial intelligence, enabling transformative applications across a wide range of domains. As the core element of deep learning, the quality and security of training data critically influence model performance and reliability. However, during the training process, deep learning models face the significant threat of data poisoning, where attackers introduce maliciously manipulated training data to degrade model accuracy or lead to anomalous behavior. While existing surveys provide valuable insights into data poisoning, they generally adopt a broad perspective, encompassing both attacks and defenses, but lack a dedicated, in-depth analysis of poisoning attacks specifically in deep learning. In this survey, we bridge this gap by presenting a comprehensive and targeted review of data poisoning in deep learning. First, this survey categorizes data poisoning attacks across multiple perspectives, providing an in-depth analysis of their characteristics and underlying design princinples. Second, the discussion is extended to the emerging area of data poisoning in large language models(LLMs). Finally, we explore critical open challenges in the field and propose potential research directions to advance the field further. To support further exploration, an up-to-date repository of resources on data poisoning in deep learning is available at https://github.com/Pinlong-Zhao/Data-Poisoning.
The integration of heterogeneous multi-omics datasets at a systems level remains a central challenge for developing analytical and computational models in precision cancer diagnostics. This paper introduces Multi-Omics Graph Kolmogorov-Arnold Network (MOGKAN), a deep learning framework that utilizes messenger-RNA, micro-RNA sequences, and DNA methylation samples together with Protein-Protein Interaction (PPI) networks for cancer classification across 31 different cancer types. The proposed approach combines differential gene expression with DESeq2, Linear Models for Microarray (LIMMA), and Least Absolute Shrinkage and Selection Operator (LASSO) regression to reduce multi-omics data dimensionality while preserving relevant biological features. The model architecture is based on the Kolmogorov-Arnold theorem principle and uses trainable univariate functions to enhance interpretability and feature analysis. MOGKAN achieves classification accuracy of 96.28 percent and exhibits low experimental variability in comparison to related deep learning-based models. The biomarkers identified by MOGKAN were validated as cancer-related markers through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. By integrating multi-omics data with graph-based deep learning, our proposed approach demonstrates robust predictive performance and interpretability with potential to enhance the translation of complex multi-omics data into clinically actionable cancer diagnostics.
In this paper, we adopt a probability distribution estimation perspective to explore the optimization mechanisms of supervised classification using deep neural networks. We demonstrate that, when employing the Fenchel-Young loss, despite the non-convex nature of the fitting error with respect to the model's parameters, global optimal solutions can be approximated by simultaneously minimizing both the gradient norm and the structural error. The former can be controlled through gradient descent algorithms. For the latter, we prove that it can be managed by increasing the number of parameters and ensuring parameter independence, thereby providing theoretical insights into mechanisms such as over-parameterization and random initialization. Ultimately, the paper validates the key conclusions of the proposed method through empirical results, illustrating its practical effectiveness.
Differentially Private Stochastic Gradient Descent (DP-SGD) is a widely adopted technique for privacy-preserving deep learning. A critical challenge in DP-SGD is selecting the optimal clipping threshold C, which involves balancing the trade-off between clipping bias and noise magnitude, incurring substantial privacy and computing overhead during hyperparameter tuning. In this paper, we propose Dynamic Clipping DP-SGD (DC-SGD), a framework that leverages differentially private histograms to estimate gradient norm distributions and dynamically adjust the clipping threshold C. Our framework includes two novel mechanisms: DC-SGD-P and DC-SGD-E. DC-SGD-P adjusts the clipping threshold based on a percentile of gradient norms, while DC-SGD-E minimizes the expected squared error of gradients to optimize C. These dynamic adjustments significantly reduce the burden of hyperparameter tuning C. The extensive experiments on various deep learning tasks, including image classification and natural language processing, show that our proposed dynamic algorithms achieve up to 9 times acceleration on hyperparameter tuning than DP-SGD. And DC-SGD-E can achieve an accuracy improvement of 10.62% on CIFAR10 than DP-SGD under the same privacy budget of hyperparameter tuning. We conduct rigorous theoretical privacy and convergence analyses, showing that our methods seamlessly integrate with the Adam optimizer. Our results highlight the robust performance and efficiency of DC-SGD, offering a practical solution for differentially private deep learning with reduced computational overhead and enhanced privacy guarantees.
The extraction of geoelectric structural information from airborne transient electromagnetic(ATEM)data primarily involves data processing and inversion. Conventional methods rely on empirical parameter selection, making it difficult to process complex field data with high noise levels. Additionally, inversion computations are time consuming and often suffer from multiple local minima. Existing deep learning-based approaches separate the data processing steps, where independently trained denoising networks struggle to ensure the reliability of subsequent inversions. Moreover, end to end networks lack interpretability. To address these issues, we propose a unified and interpretable deep learning inversion paradigm based on disentangled representation learning. The network explicitly decomposes noisy data into noise and signal factors, completing the entire data processing workflow based on the signal factors while incorporating physical information for guidance. This approach enhances the network's reliability and interpretability. The inversion results on field data demonstrate that our method can directly use noisy data to accurately reconstruct the subsurface electrical structure. Furthermore, it effectively processes data severely affected by environmental noise, which traditional methods struggle with, yielding improved lateral structural resolution.
As a fundamental task in computer vision, semantic segmentation is widely applied in fields such as autonomous driving, remote sensing image analysis, and medical image processing. In recent years, Transformer-based segmentation methods have demonstrated strong performance in global feature modeling. However, they still struggle with blurred target boundaries and insufficient recognition of small targets. To address these issues, this study proposes a Mask2Former-based semantic segmentation algorithm incorporating a boundary enhancement feature bridging module (BEFBM). The goal is to improve target boundary accuracy and segmentation consistency. Built upon the Mask2Former framework, this method constructs a boundary-aware feature map and introduces a feature bridging mechanism. This enables effective cross-scale feature fusion, enhancing the model's ability to focus on target boundaries. Experiments on the Cityscapes dataset demonstrate that, compared to mainstream segmentation methods, the proposed approach achieves significant improvements in metrics such as mIOU, mDICE, and mRecall. It also exhibits superior boundary retention in complex scenes. Visual analysis further confirms the model's advantages in fine-grained regions. Future research will focus on optimizing computational efficiency and exploring its potential in other high-precision segmentation tasks.
Recent years have witnessed the rapid progression of deep learning, pushing us closer to the realization of AGI (Artificial General Intelligence). Probabilistic modeling is critical to many of these advancements, which provides a foundational framework for capturing data distributions. However, as the scale and complexity of AI applications grow, traditional probabilistic modeling faces escalating challenges, such as high-dimensional parameter spaces, heterogeneous data sources, and evolving real-world requirements often render classical approaches insufficiently flexible. This paper proposes a novel concept, Probability Engineering, which treats the already-learned probability distributions within deep learning as engineering artifacts. Rather than merely fitting or inferring distributions, we actively modify and reinforce them to better address the diverse and evolving demands of modern AI. Specifically, Probability Engineering introduces novel techniques and constraints to refine existing probability distributions, improving their robustness, efficiency, adaptability, or trustworthiness. We showcase this paradigm through a series of applications spanning Bayesian deep learning, Edge AI (including federated learning and knowledge distillation), and Generative AI (such as text-to-image generation with diffusion models and high-quality text generation with large language models). These case studies demonstrate how probability distributions once treated as static objects can be engineered to meet the diverse and evolving requirements of large-scale, data-intensive, and trustworthy AI systems. By systematically expanding and strengthening the role of probabilistic modeling, Probability Engineering paves the way for more robust, adaptive, efficient, and trustworthy deep learning solutions in today's fast-growing AI era.
We used contrastive neural networks to learn useful similarity scores between the 144 cartridge casings in the NBIDE dataset, under the common-but-unknown source paradigm. The common-but-unknown source problem is a problem archetype in forensics where the question is whether two objects share a common source (e.g. were two cartridge casings fired from the same firearm). Similarity scores are often used to interpret evidence under this paradigm. We directly compared our results to a state-of-the-art algorithm, Congruent Matching Cells (CMC). When trained on the E3 dataset of 2967 cartridge casings, contrastive learning achieved an ROC AUC of 0.892. The CMC algorithm achieved 0.867. We also conducted an ablation study where we varied the neural network architecture; specifically, the network's width or depth. The ablation study showed that contrastive network performance results are somewhat robust to the network architecture. This work was in part motivated by the use of similarity scores attained via contrastive learning for standard evidence interpretation methods such as score-based likelihood ratios.
The relationship between RNA structure and function has recently attracted interest within the deep learning community, a trend expected to intensify as nucleic acid structure models advance. Despite this momentum, a lack of standardized, accessible benchmarks for applying deep learning to RNA 3D structures hinders progress. To this end, we introduce a collection of seven benchmarking datasets specifically designed to support RNA structure-function prediction. Built on top of the established Python package rnaglib, our library streamlines data distribution and encoding, provides tools for dataset splitting and evaluation, and offers a comprehensive, user-friendly environment for model comparison. The modular and reproducible design of our datasets encourages community contributions and enables rapid customization. To demonstrate the utility of our benchmarks, we report baseline results for all tasks using a relational graph neural network.
Quantitative investment (quant) is an emerging, technology-driven approach in asset management, increasingy shaped by advancements in artificial intelligence. Recent advances in deep learning and large language models (LLMs) for quant finance have improved predictive modeling and enabled agent-based automation, suggesting a potential paradigm shift in this field. In this survey, taking alpha strategy as a representative example, we explore how AI contributes to the quantitative investment pipeline. We first examine the early stage of quant research, centered on human-crafted features and traditional statistical models with an established alpha pipeline. We then discuss the rise of deep learning, which enabled scalable modeling across the entire pipeline from data processing to order execution. Building on this, we highlight the emerging role of LLMs in extending AI beyond prediction, empowering autonomous agents to process unstructured data, generate alphas, and support self-iterative workflows.
Orange grading is a crucial step in the fruit industry, as it helps to sort oranges according to different criteria such as size, quality, ripeness, and health condition, ensuring safety for human consumption and better price allocation and client satisfaction. Automated grading enables faster processing, precision, and reduced human labor. In this paper, we implement a deep learning-based solution for orange grading via machine vision. Unlike typical grading systems that analyze fruits from a single view, we capture multiview images of each single orange in order to enable a richer representation. Afterwards, we compose the acquired images into one collage. This enables the analysis of the whole orange skin. We train a convolutional neural network (CNN) on the composed images to grade the oranges into three classes, namely good, bad, and undefined. We also evaluate the performance with two different CNNs (ResNet-18 and SqueezeNet). We show experimentally that multi-view grading is superior to single view grading.