Antibody-antigen binding prediction

Antibody-antigen binding prediction involves using computational or experimental methods to assess how well an antibody interacts with its target antigen. This can be done by analyzing features such as sequence, structure, and physicochemical properties. These predictions aid in designing therapeutic antibodies, vaccines, and diagnostic tests. Validation through experimental assays ensures the accuracy of the predictions and their applicability in biomedical research and development.

The binding site prediction task is used to predict which antibody residues interact with an antigen. A residue is considered part of the paratope’s binding site if any of its heavy atoms (non-hydrogen atoms) is located within 4.5˚A of any antigen-heavy atom.