Brain Segmentation

The RSNA-ASNR-MICCAI BraTS 2021 challenge utilizes multi-institutional pre-operative baseline multi-parametric magnetic resonance imaging (mpMRI) scans, and focuses on the evaluation of state-of-the-art methods for (Task 1) the segmentation of intrinsically heterogeneous brain glioblastoma sub-regions in mpMRI scans. Furthemore, this BraTS 2021 challenge also focuses on the evaluation of (Task 2) classification methods to predict the MGMT promoter methylation status.

**CrossMoDA is a large and multi-class benchmark for unsupervised cross-modality Domain Adaptation. The goal of the challenge is to segment two key brain structures involved in the follow-up and treatment planning of vestibular schwannoma (VS): the VS and the cochleas. Currently, the diagnosis and surveillance in patients with VS are commonly performed using contrast-enhanced T1 (ceT1) MR imaging.

DOI This mouse cerebellar atlas can be used for mouse cerebellar morphometry. We recommend to use Multi Atlas Segmentation and Morphometric analysis toolkit (MASMAT) for mouse brain MRI along with other mouse brain atlases in this repo. ## Reference/citation: - If you're using the this mouse MRI cerebellar atlas in your paper, we ask you to please kindly cite the following papers: - Ma, D., Cardoso, M. J., Zuluaga, M. A., Modat, M., Powell, N. M., Wiseman, F. K., Cleary, J. O., Sinclair, B., Harrison, I. F., Siow, B., Popuri, K., Lee, S., Matsubara, J. A., Sarunic, M. V, Beg, M. F., Tybulewicz, V. L. J., Fisher, E. M. C., Lythgoe, M. F., & Ourselin, S. (2020). Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellum of the Tc1 mouse model of Down Syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI. NeuroImage, 117271. https://doi.org/https://doi.org/10.1016/j.neuroimage.2020.117271 - Ma, D., Cardoso, M. J., Zuluaga, M. A., Modat, M., Powell, N., Wiseman, F., Tybulewicz, V., Fisher, E., Lythgoe, M. F., & Ourselin, S. (2015). Grey Matter Sublayer Thickness Estimation in the Mouse Cerebellum. In Medical Image Computing and Computer Assisted Intervention 2015 (pp. 644–651). https://doi.org/10.1007/978-3-319-24574-4_77

This is the dataset released along with the publication: CUTS: A Deep Learning and Topological Framework for Multigranular Unsupervised Medical Image Segmentation [ArXiv] [MICCAI] [GitHub]

DOI Mouse Brain MRI atlas (both in-vivo and ex-vivo) (repository relocated from the original webpage) ## List of atlases - FVB_NCrl: Brain MRI atlas of the wild-type FVB_NCrl mouse strain (used as the background strain for the rTg4510 which is a tauopathy model mice express a repressible form of human tau containing the P301L mutation that has been linked with familial frontotemporal dementia.) - NeAt: Brain MRI atlas of the whld-type C57BL/6J mouse strain. Atlas was created based on the original MRM NeAt mouse brain atlas (template images reoriented and bias-corrected, left/right structure label seperated, and 4th ventricle manual segmentation added). - Tc1 Cerebellum: TC1 mouse cerebellar cortical sublayer lobules.This mouse cerebellar atlas can be used for mouse cerebellar morphometry. ## Citation - If you use the segmented brain structure, or use the atlas along with the automatic mouse brain MRI segmentation tools, we ask you to kindly cite the following papers: - Ma D, Cardoso MJ, Modat M, Powell N, Wells J, Holmes H, Wiseman F, Tybulewicz V, Fisher E, Lythgoe MF, Ourselin S. Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion. PloS one. 2014 Jan 27;9(1):e86576. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086576 - Ma D, Holmes HE, Cardoso MJ, Modat M, Harrison IF, Powell NM, O'Callaghan J, Ismail O, Johnson RA, O’Neill MJ, Collins EC, Mirza F. Beg, Karteek Popuri, Mark F. Lythgoe, and Sebastien Ourselin Study the longitudinal in vivo and cross-sectional ex vivo brain volume difference for disease progression and treatment effect on mouse model of tauopathy using automated MRI structural parcellation. Frontiers in Neuroscience. 2019;13:11. https://www.frontiersin.org/articles/10.3389/fnins.2019.00011 - If you use the brain MR images of the FVB_NCrl mouse strain (the wildtype background of rTg4510), we ask you to kindly cite the following papers: - Wells JA, O'Callaghan JM, Holmes HE, Powell NM, Johnson RA, Siow B, Torrealdea F, Ismail O, Walker-Samuel S, Golay X, Rega M. In vivo imaging of tau pathology using multi-parametric quantitative MRI. Neuroimage. 2015 May 1;111:369-78. https://www.sciencedirect.com/science/article/pii/S105381191500124X - Holmes HE, Colgan N, Ismail O, Ma D, Powell NM, O'Callaghan JM, Harrison IF, Johnson RA, Murray TK, Ahmed Z, Heggenes M. Imaging the accumulation and suppression of tau pathology using multiparametric MRI. Neurobiology of aging. 2016 Mar 1;39:184-94. https://www.sciencedirect.com/science/article/pii/S0197458015006053 - Holmes HE, Powell NM, Ma D, Ismail O, Harrison IF, Wells JA, Colgan N, O'Callaghan JM, Johnson RA, Murray TK, Ahmed Z. Comparison of in vivo and ex vivo MRI for the detection of structural abnormalities in a mouse model of tauopathy. Frontiers in neuroinformatics. 2017 Mar 31;11:20. https://www.frontiersin.org/articles/10.3389/fninf.2017.00020/full - If you're using the mouse MRI T2* Active Starining Cerebellar atlas, we ask you to please kindly cite the following papers: - Ma, D., Cardoso, M. J., Zuluaga, M. A., Modat, M., Powell, N. M., Wiseman, F. K., Cleary, J. O., Sinclair, B., Harrison, I. F., Siow, B., Popuri, K., Lee, S., Matsubara, J. A., Sarunic, M. V, Beg, M. F., Tybulewicz, V. L. J., Fisher, E. M. C., Lythgoe, M. F., & Ourselin, S. (2020). Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellum of the Tc1 mouse model of Down Syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI. NeuroImage, 117271. https://doi.org/https://doi.org/10.1016/j.neuroimage.2020.117271 - Ma, D., Cardoso, M. J., Zuluaga, M. A., Modat, M., Powell, N., Wiseman, F., Tybulewicz, V., Fisher, E., Lythgoe, M. F., & Ourselin, S. (2015). Grey Matter Sublayer Thickness Estimation in the Mouse Cerebellum. In Medical Image Computing and Computer Assisted Intervention 2015 (pp. 644–651). https://doi.org/10.1007/978-3-319-24574-4_77 ## Reference - For the original information of the NeAt atlas, please please refer to the website: http://brainatlas.mbi.ufl.edu/, and the following two reference papers: - Ma Yu, Smith David, Hof Patrick R, Foerster Bernd, Hamilton Scott, Blackband Stephen J, Yu Mei, Benveniste Helene In Vivo 3D Digital Atlas Database of the Adult C57BL/6J Mouse Brain by Magnetic Resonance Microscopy. Front. Neuroanat. 2, 1 (2008). - Ma Yu, Hof P R, Grant S C, Blackband S J, Bennett R, Slatest L, McGuigan M D, Benveniste H A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience 135, 1203–15 (2005). ## Funding The works in this repositories received multiple funding from EPSRC, UCL Leonard Wolfson Experimental Neurology center, Medical Research Council (MRC), the NIHR Biomedical Research Unit (Dementia) at UCL and the National Institute for Health Research University College London Hospitals Biomedical Research center, the UK Regenerative Medicine Platform Safety Hub, and the Kings College London and UCL Comprehensive Cancer Imaging center CRUK & EPSRC in association with the MRC and DoH (England), UCL Faculty of Engineering funding scheme, Alzheimer Society Reseasrch Program from Alzheimer Society Canada, NSERC, CIHR, MSFHR Canada， Eli Lilly and Company, Wellcome Trust, the Francis Crick Institute, Cancer Research UK, and University of Melbourne McKenzie Fellowship.