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arXiv:2507.02288

Prompt Disentanglement via Language Guidance and Representation Alignment for Domain Generalization

Domain Generalization (DG) seeks to develop a versatile model capable of performing effectively on unseen target domains. Notably, recent advances in pre-trained Visual Foundation Models (VFMs), such as CLIP, have demonstrated considerable potential in enhancing the generalization capabilities of deep learning models. Despite the increasing attention toward VFM-based domain prompt tuning within DG, the effective design of prompts capable of disentangling invariant features across diverse domains remains a critical challenge. In this paper, we propose addressing this challenge by leveraging the controllable and flexible language prompt of the VFM. Noting that the text modality of VFMs is naturally easier to disentangle, we introduce a novel framework for text feature-guided visual prompt tuning. This framework first automatically disentangles the text prompt using a large language model (LLM) and then learns domain-invariant visual representation guided by the disentangled text feature. However, relying solely on language to guide visual feature disentanglement has limitations, as visual features can sometimes be too complex or nuanced to be fully captured by descriptive text. To address this, we introduce Worst Explicit Representation Alignment (WERA), which extends text-guided visual prompts by incorporating an additional set of abstract prompts. These prompts enhance source domain diversity through stylized image augmentations, while alignment constraints ensure that visual representations remain consistent across both the original and augmented distributions. Experiments conducted on major DG datasets, including PACS, VLCS, OfficeHome, DomainNet, and TerraInc, demonstrate that our proposed method outperforms state-of-the-art DG methods.

arXiv:2506.22908공식 코드 · Papers with Code

Attention to Burstiness: Low-Rank Bilinear Prompt Tuning

Visual Prompt Tuning (VPT) is a parameter-efficient fune-tuning technique that adapts a pre-trained vision Transformer (ViT) by learning a small set of parameters in the input space, known as prompts. In VPT, we uncover ``burstiness'' in the values arising from the interaction of image patch embeddings, and the key and query projectors within Transformer's self-attention module. Furthermore, the values of patch embeddings and the key and query projectors exhibit Laplacian and hyper-Laplacian distribution, respectively. Intuitively, these non-Gaussian distributions pose challenges for learning prompts. To address this, we propose whitening these data, de-correlating them and equalizing their variance towards more Gaussian before learning prompts. We derive the whitening matrix over random image patch embeddings and ViT's key and query projectors, and multiply it with the prompt to be learned in a bilinear manner. Surprisingly, this method significantly accelerates prompt tuning and boosts accuracy, e.g., $>$25 accuracy points on the CUB dataset; interestingly, it learns ``bursty prompts''. Extending the bilinear model which is known to introduce burstiness, we present a compact, low-rank version by learning two smaller matrices whose multiplication yields the final prompts. We call the proposed methods Bilinear Prompt Tuning (BPT). Extensive experiments across multiple benchmark datasets demonstrate that BPT methods not only outperform various VPT methods but also reduce parameter count and computation overhead.

arXiv:2505.23694공식 코드 · Papers with Code

DA-VPT: Semantic-Guided Visual Prompt Tuning for Vision Transformers

Visual Prompt Tuning (VPT) has become a promising solution for Parameter-Efficient Fine-Tuning (PEFT) approach for Vision Transformer (ViT) models by partially fine-tuning learnable tokens while keeping most model parameters frozen. Recent research has explored modifying the connection structures of the prompts. However, the fundamental correlation and distribution between the prompts and image tokens remain unexplored. In this paper, we leverage metric learning techniques to investigate how the distribution of prompts affects fine-tuning performance. Specifically, we propose a novel framework, Distribution Aware Visual Prompt Tuning (DA-VPT), to guide the distributions of the prompts by learning the distance metric from their class-related semantic data. Our method demonstrates that the prompts can serve as an effective bridge to share semantic information between image patches and the class token. We extensively evaluated our approach on popular benchmarks in both recognition and segmentation tasks. The results demonstrate that our approach enables more effective and efficient fine-tuning of ViT models by leveraging semantic information to guide the learning of the prompts, leading to improved performance on various downstream vision tasks.

arXiv:2504.01655공식 코드 · Papers with Code

Q-Adapt: Adapting LMM for Visual Quality Assessment with Progressive Instruction Tuning

The rapid advancement of Large Multi-modal Foundation Models (LMM) has paved the way for the possible Explainable Image Quality Assessment (EIQA) with instruction tuning from two perspectives: overall quality explanation, and attribute-wise perception answering. However, existing works usually overlooked the conflicts between these two types of perception explanations during joint instruction tuning, leading to insufficient perception understanding. To mitigate this, we propose a new paradigm for perception-oriented instruction tuning, i.e., Q-Adapt, which aims to eliminate the conflicts and achieve the synergy between these two EIQA tasks when adapting LMM, resulting in enhanced multi-faceted explanations of IQA. Particularly, we propose a progressive instruction tuning strategy by dividing the adaption process of LMM for EIQA into two stages, where the first stage empowers the LMM with universal perception knowledge tailored for two tasks using an efficient transfer learning strategy, i.e., LoRA, and the second stage introduces the instruction-adaptive visual prompt tuning to dynamically adapt visual features for the different instructions from two tasks. In this way, our proposed Q-Adapt can achieve a lightweight visual quality evaluator, demonstrating comparable performance and, in some instances, superior results across perceptual-related benchmarks and commonly-used IQA databases. The source code is publicly available at https://github.com/yeppp27/Q-Adapt.

arXiv:2503.17650

Visual Variational Autoencoder Prompt Tuning

Parameter-efficient fine-tuning (PEFT) has emerged as a crucial approach for adapting large vision transformers to downstream tasks without the prohibitive computational costs of full fine-tuning. While existing visual prompt tuning (VPT) methods have made significant strides, they predominantly rely on static, domain-specific prompts that fail to capture the rich visual diversity within individual instances. This paper introduces V$^2$APT (Visual Variational Autoencoder Prompt Tuning), a novel framework that generates dynamic, input-dependent prompts using a variational autoencoder architecture. By learning a latent representation of image-specific features and decoding them into customized prompts, V$^2$APT adapts to the unique visual characteristics of each input. Extensive experiments on FGVC, HTA, and VTAB-1k benchmarks demonstrate that our approach consistently outperforms state-of-the-art PEFT methods. Notably, V$^2$APT achieves +3.2\% improvement over VPT-Deep on HTA, with an average performance gain of +2.0\% across all three datasets.

arXiv:2503.06084

Exploring Interpretability for Visual Prompt Tuning with Hierarchical Concepts

Visual prompt tuning offers significant advantages for adapting pre-trained visual foundation models to specific tasks. However, current research provides limited insight into the interpretability of this approach, which is essential for enhancing AI reliability and enabling AI-driven knowledge discovery. In this paper, rather than learning abstract prompt embeddings, we propose the first framework, named Interpretable Visual Prompt Tuning (IVPT), to explore interpretability for visual prompts, by introducing hierarchical concept prototypes. Specifically, visual prompts are linked to human-understandable semantic concepts, represented as a set of category-agnostic prototypes, each corresponding to a specific region of the image. Then, IVPT aggregates features from these regions to generate interpretable prompts, which are structured hierarchically to explain visual prompts at different granularities. Comprehensive qualitative and quantitative evaluations on fine-grained classification benchmarks show its superior interpretability and performance over conventional visual prompt tuning methods and existing interpretable methods.

arXiv:2503.06901공식 코드 · Papers with Code

Iterative Prompt Relocation for Distribution-Adaptive Visual Prompt Tuning

Visual prompt tuning (VPT) provides an efficient and effective solution for adapting pre-trained models to various downstream tasks by incorporating learnable prompts. However, most prior art indiscriminately applies a fixed prompt distribution across different tasks, neglecting the importance of each block differing depending on the task. In this paper, we investigate adaptive distribution optimization (ADO) by addressing two key questions: (1) How to appropriately and formally define ADO, and (2) How to design an adaptive distribution strategy guided by this definition? Through in-depth analysis, we provide an affirmative answer that properly adjusting the distribution significantly improves VPT performance, and further uncover a key insight that a nested relationship exists between ADO and VPT. Based on these findings, we propose a new VPT framework, termed PRO-VPT (iterative Prompt RelOcation-based VPT), which adaptively adjusts the distribution building upon a nested optimization formulation. Specifically, we develop a prompt relocation strategy for ADO derived from this formulation, comprising two optimization steps: identifying and pruning idle prompts, followed by determining the optimal blocks for their relocation. By iteratively performing prompt relocation and VPT, our proposal adaptively learns the optimal prompt distribution, thereby unlocking the full potential of VPT. Extensive experiments demonstrate that our proposal significantly outperforms state-of-the-art VPT methods, e.g., PRO-VPT surpasses VPT by 1.6% average accuracy, leading prompt-based methods to state-of-the-art performance on the VTAB-1k benchmark. The code is available at https://github.com/ckshang/PRO-VPT.

arXiv:2501.18936

Adaptive Prompt: Unlocking the Power of Visual Prompt Tuning

Visual Prompt Tuning (VPT) has recently emerged as a powerful method for adapting pre-trained vision models to downstream tasks. By introducing learnable prompt tokens as task-specific instructions, VPT effectively guides pre-trained transformer models with minimal overhead. Despite its empirical success, a comprehensive theoretical understanding of VPT remains an active area of research. Building on recent insights into the connection between mixture of experts and prompt-based approaches, we identify a key limitation in VPT: the restricted functional expressiveness in prompt formulation. To address this limitation, we propose Visual Adaptive Prompt Tuning (VAPT), a new generation of prompts that redefines prompts as adaptive functions of the input. Our theoretical analysis shows that this simple yet intuitive approach achieves optimal sample efficiency. Empirical results on VTAB-1K and FGVC further demonstrate VAPT's effectiveness, with performance gains of 7.34% and 1.04% over fully fine-tuning baselines, respectively. Notably, VAPT also surpasses VPT by a substantial margin while using fewer parameters. These results highlight both the effectiveness and efficiency of our method and pave the way for future research to explore the potential of adaptive prompts.

arXiv:2501.09333

Prompt-CAM: A Simpler Interpretable Transformer for Fine-Grained Analysis

We present a simple usage of pre-trained Vision Transformers (ViTs) for fine-grained analysis, aiming to identify and localize the traits that distinguish visually similar categories, such as different bird species or dog breeds. Pre-trained ViTs such as DINO have shown remarkable capabilities to extract localized, informative features. However, using saliency maps like Grad-CAM can hardly point out the traits: they often locate the whole object by a blurred, coarse heatmap, not traits. We propose a novel approach Prompt Class Attention Map (Prompt-CAM) to the rescue. Prompt-CAM learns class-specific prompts to a pre-trained ViT and uses the corresponding outputs for classification. To classify an image correctly, the true-class prompt must attend to the unique image patches not seen in other classes' images, i.e., traits. As such, the true class's multi-head attention maps reveal traits and their locations. Implementation-wise, Prompt-CAM is almost a free lunch by simply modifying the prediction head of Visual Prompt Tuning (VPT). This makes Prompt-CAM fairly easy to train and apply, sharply contrasting other interpretable methods that design specific models and training processes. It is even simpler than the recently published INterpretable TRansformer (INTR), whose encoder-decoder architecture prevents it from leveraging pre-trained ViTs. Extensive empirical studies on a dozen datasets from various domains (e.g., birds, fishes, insects, fungi, flowers, food, and cars) validate Prompt-CAM superior interpretation capability.

arXiv:2501.05228

Harnessing Large Language and Vision-Language Models for Robust Out-of-Distribution Detection

Out-of-distribution (OOD) detection has seen significant advancements with zero-shot approaches by leveraging the powerful Vision-Language Models (VLMs) such as CLIP. However, prior research works have predominantly focused on enhancing Far-OOD performance, while potentially compromising Near-OOD efficacy, as observed from our pilot study. To address this issue, we propose a novel strategy to enhance zero-shot OOD detection performances for both Far-OOD and Near-OOD scenarios by innovatively harnessing Large Language Models (LLMs) and VLMs. Our approach first exploit an LLM to generate superclasses of the ID labels and their corresponding background descriptions followed by feature extraction using CLIP. We then isolate the core semantic features for ID data by subtracting background features from the superclass features. The refined representation facilitates the selection of more appropriate negative labels for OOD data from a comprehensive candidate label set of WordNet, thereby enhancing the performance of zero-shot OOD detection in both scenarios. Furthermore, we introduce novel few-shot prompt tuning and visual prompt tuning to adapt the proposed framework to better align with the target distribution. Experimental results demonstrate that the proposed approach consistently outperforms current state-of-the-art methods across multiple benchmarks, with an improvement of up to 2.9% in AUROC and a reduction of up to 12.6% in FPR95. Additionally, our method exhibits superior robustness against covariate shift across different domains, further highlighting its effectiveness in real-world scenarios.

arXiv:2501.03839

MedFocusCLIP : Improving few shot classification in medical datasets using pixel wise attention

With the popularity of foundational models, parameter efficient fine tuning has become the defacto approach to leverage pretrained models to perform downstream tasks. Taking inspiration from recent advances in large language models, Visual Prompt Tuning, and similar techniques, learn an additional prompt to efficiently finetune a pretrained vision foundational model. However, we observe that such prompting is insufficient for fine-grained visual classification tasks such as medical image classification, where there is large inter-class variance, and small intra-class variance. Hence, in this paper we propose to leverage advanced segmentation capabilities of Segment Anything Model 2 (SAM2) as a visual prompting cue to help visual encoder in the CLIP (Contrastive Language-Image Pretraining) by guiding the attention in CLIP visual encoder to relevant regions in the image. This helps the model to focus on highly discriminative regions, without getting distracted from visually similar background features, an essential requirement in a fewshot, finegrained classification setting. We evaluate our method on diverse medical datasets including X-rays, CT scans, and MRI images, and report an accuracy of (71%, 81%, 86%, 58%) from the proposed approach on (COVID, lung-disease, brain-tumor, breast-cancer) datasets against (66%, 70%, 68%, 29%) from a pretrained CLIP model after fewshot training. The proposed approach also allows to obtain interpretable explanation for the classification performance through the localization obtained using segmentation.

arXiv:2412.20392

Defending Multimodal Backdoored Models by Repulsive Visual Prompt Tuning

Multimodal contrastive learning models (e.g., CLIP) can learn high-quality representations from large-scale image-text datasets, yet they exhibit significant vulnerabilities to backdoor attacks, raising serious safety concerns. In this paper, we disclose that CLIP's vulnerabilities primarily stem from its excessive encoding of class-irrelevant features, which can compromise the model's visual feature resistivity to input perturbations, making it more susceptible to capturing the trigger patterns inserted by backdoor attacks. Inspired by this finding, we propose Repulsive Visual Prompt Tuning (RVPT), a novel defense approach that employs specially designed deep visual prompt tuning and feature-repelling loss to eliminate excessive class-irrelevant features while simultaneously optimizing cross-entropy loss to maintain clean accuracy. Unlike existing multimodal backdoor defense methods that typically require the availability of poisoned data or involve fine-tuning the entire model, RVPT leverages few-shot downstream clean samples and only tunes a small number of parameters. Empirical results demonstrate that RVPT tunes only 0.27\% of the parameters relative to CLIP, yet it significantly outperforms state-of-the-art baselines, reducing the attack success rate from 67.53\% to 2.76\% against SoTA attacks and effectively generalizing its defensive capabilities across multiple datasets.

arXiv:2412.16956공식 코드 · Papers with Code

Semantic Hierarchical Prompt Tuning for Parameter-Efficient Fine-Tuning

As the scale of vision models continues to grow, Visual Prompt Tuning (VPT) has emerged as a parameter-efficient transfer learning technique, noted for its superior performance compared to full fine-tuning. However, indiscriminately applying prompts to every layer without considering their inherent correlations, can cause significant disturbances, leading to suboptimal transferability. Additionally, VPT disrupts the original self-attention structure, affecting the aggregation of visual features, and lacks a mechanism for explicitly mining discriminative visual features, which are crucial for classification. To address these issues, we propose a Semantic Hierarchical Prompt (SHIP) fine-tuning strategy. We adaptively construct semantic hierarchies and use semantic-independent and semantic-shared prompts to learn hierarchical representations. We also integrate attribute prompts and a prompt matching loss to enhance feature discrimination and employ decoupled attention for robustness and reduced inference costs. SHIP significantly improves performance, achieving a 4.9% gain in accuracy over VPT with a ViT-B/16 backbone on VTAB-1k tasks. Our code is available at https://github.com/haoweiz23/SHIP.

arXiv:2412.14640

Adaptive Prompt Tuning: Vision Guided Prompt Tuning with Cross-Attention for Fine-Grained Few-Shot Learning

Few-shot, fine-grained classification in computer vision poses significant challenges due to the need to differentiate subtle class distinctions with limited data. This paper presents a novel method that enhances the Contrastive Language-Image Pre-Training (CLIP) model through adaptive prompt tuning, guided by real-time visual inputs. Unlike existing techniques such as Context Optimization (CoOp) and Visual Prompt Tuning (VPT), which are constrained by static prompts or visual token reliance, the proposed approach leverages a cross-attention mechanism to dynamically refine text prompts for the image at hand. This enables an image-specific alignment of textual features with image patches extracted from the Vision Transformer, making the model more effective for datasets with high intra-class variance and low inter-class differences. The method is evaluated on several datasets, including CUBirds, Oxford Flowers, and FGVC Aircraft, showing significant performance gains over static prompt tuning approaches. To ensure these performance gains translate into trustworthy predictions, we integrate Monte-Carlo Dropout in our approach to improve the reliability of the model predictions and uncertainty estimates. This integration provides valuable insights into the model's predictive confidence, helping to identify when predictions can be trusted and when additional verification is necessary. This dynamic approach offers a robust solution, advancing the state-of-the-art for few-shot fine-grained classification.

arXiv:2411.16123공식 코드 · Papers with Code

Med-PerSAM: One-Shot Visual Prompt Tuning for Personalized Segment Anything Model in Medical Domain

Leveraging pre-trained models with tailored prompts for in-context learning has proven highly effective in NLP tasks. Building on this success, recent studies have applied a similar approach to the Segment Anything Model (SAM) within a ``one-shot" framework, where only a single reference image and its label are employed. However, these methods face limitations in the medical domain, primarily due to SAM's essential requirement for visual prompts and the over-reliance on pixel similarity for generating them. This dependency may lead to (1) inaccurate prompt generation and (2) clustering of point prompts, resulting in suboptimal outcomes. To address these challenges, we introduce \textbf{Med-PerSAM}, a novel and straightforward one-shot framework designed for the medical domain. Med-PerSAM uses only visual prompt engineering and eliminates the need for additional training of the pretrained SAM or human intervention, owing to our novel automated prompt generation process. By integrating our lightweight warping-based prompt tuning model with SAM, we enable the extraction and iterative refinement of visual prompts, enhancing the performance of the pre-trained SAM. This advancement is particularly meaningful in the medical domain, where creating visual prompts poses notable challenges for individuals lacking medical expertise. Our model outperforms various foundational models and previous SAM-based approaches across diverse 2D medical imaging datasets.

arXiv:2411.01327공식 코드 · Papers with Code

Visual Fourier Prompt Tuning

With the scale of vision Transformer-based models continuing to grow, finetuning these large-scale pretrained models for new tasks has become increasingly parameter-intensive. Visual prompt tuning is introduced as a parameter-efficient finetuning (PEFT) method to this trend. Despite its successes, a notable research challenge persists within almost all PEFT approaches: significant performance degradation is observed when there is a substantial disparity between the datasets applied in pretraining and finetuning phases. To address this challenge, we draw inspiration from human visual cognition, and propose the Visual Fourier Prompt Tuning (VFPT) method as a general and effective solution for adapting large-scale transformer-based models. Our approach innovatively incorporates the Fast Fourier Transform into prompt embeddings and harmoniously considers both spatial and frequency domain information. Apart from its inherent simplicity and intuitiveness, VFPT exhibits superior performance across all datasets, offering a general solution to dataset challenges, irrespective of data disparities. Empirical results demonstrate that our approach outperforms current state-of-the-art baselines on two benchmarks, with low parameter usage (e.g., 0.57% of model parameters on VTAB-1k) and notable performance enhancements (e.g., 73.20% of mean accuracy on VTAB-1k). Our code is avaliable at https://github.com/runtsang/VFPT.

arXiv:2410.21042공식 코드 · Papers with Code

Improving Visual Prompt Tuning by Gaussian Neighborhood Minimization for Long-Tailed Visual Recognition

Long-tail learning has garnered widespread attention and achieved significant progress in recent times. However, even with pre-trained prior knowledge, models still exhibit weaker generalization performance on tail classes. The promising Sharpness-Aware Minimization (SAM) can effectively improve the generalization capability of models by seeking out flat minima in the loss landscape, which, however, comes at the cost of doubling the computational time. Since the update rule of SAM necessitates two consecutive (non-parallelizable) forward and backpropagation at each step. To address this issue, we propose a novel method called Random SAM prompt tuning (RSAM-PT) to improve the model generalization, requiring only one-step gradient computation at each step. Specifically, we search for the gradient descent direction within a random neighborhood of the parameters during each gradient update. To amplify the impact of tail-class samples and avoid overfitting, we employ the deferred re-weight scheme to increase the significance of tail-class samples. The classification accuracy of long-tailed data can be significantly improved by the proposed RSAM-PT, particularly for tail classes. RSAM-PT achieves the state-of-the-art performance of 90.3\%, 76.5\%, and 50.1\% on benchmark datasets CIFAR100-LT (IF 100), iNaturalist 2018, and Places-LT, respectively. The source code is temporarily available at https://github.com/Keke921/GNM-PT.

arXiv:2410.05239공식 코드 · Papers with Code

TuneVLSeg: Prompt Tuning Benchmark for Vision-Language Segmentation Models

Vision-Language Models (VLMs) have shown impressive performance in vision tasks, but adapting them to new domains often requires expensive fine-tuning. Prompt tuning techniques, including textual, visual, and multimodal prompting, offer efficient alternatives by leveraging learnable prompts. However, their application to Vision-Language Segmentation Models (VLSMs) and evaluation under significant domain shifts remain unexplored. This work presents an open-source benchmarking framework, TuneVLSeg, to integrate various unimodal and multimodal prompt tuning techniques into VLSMs, making prompt tuning usable for downstream segmentation datasets with any number of classes. TuneVLSeg includes $6$ prompt tuning strategies on various prompt depths used in $2$ VLSMs totaling of $8$ different combinations. We test various prompt tuning on $8$ diverse medical datasets, including $3$ radiology datasets (breast tumor, echocardiograph, chest X-ray pathologies) and $5$ non-radiology datasets (polyp, ulcer, skin cancer), and two natural domain segmentation datasets. Our study found that textual prompt tuning struggles under significant domain shifts, from natural-domain images to medical data. Furthermore, visual prompt tuning, with fewer hyperparameters than multimodal prompt tuning, often achieves performance competitive to multimodal approaches, making it a valuable first attempt. Our work advances the understanding and applicability of different prompt-tuning techniques for robust domain-specific segmentation. The source code is available at https://github.com/naamiinepal/tunevlseg.

arXiv:2409.03804

End-to-end Multi-source Visual Prompt Tuning for Survival Analysis in Whole Slide Images

Survival analysis using pathology images poses a considerable challenge, as it requires the localization of relevant information from the multitude of tiles within whole slide images (WSIs). Current methods typically resort to a two-stage approach, where a pre-trained network extracts features from tiles, which are then used by survival models. This process, however, does not optimize the survival models in an end-to-end manner, and the pre-extracted features may not be ideally suited for survival prediction. To address this limitation, we present a novel end-to-end Visual Prompt Tuning framework for survival analysis, named VPTSurv. VPTSurv refines feature embeddings through an efficient encoder-decoder framework. The encoder remains fixed while the framework introduces tunable visual prompts and adaptors, thus permitting end-to-end training specifically for survival prediction by optimizing only the lightweight adaptors and the decoder. Moreover, the versatile VPTSurv framework accommodates multi-source information as prompts, thereby enriching the survival model. VPTSurv achieves substantial increases of 8.7% and 12.5% in the C-index on two immunohistochemical pathology image datasets. These significant improvements highlight the transformative potential of the end-to-end VPT framework over traditional two-stage methods.

arXiv:2409.06706공식 코드 · Papers with Code

SAN: Hypothesizing Long-Term Synaptic Development and Neural Engram Mechanism in Scalable Model's Parameter-Efficient Fine-Tuning

Advances in Parameter-Efficient Fine-Tuning (PEFT) bridged the performance gap with Full Fine-Tuning (FFT) through sophisticated analysis of pre-trained parameter spaces. Starting from drawing insights from Neural Engrams (NE) in Biological Neural Networks (BNNs), we establish a connection between the low-rank property observed during PEFT's parameter space shifting and neurobiological mechanisms. This observation leads to our proposed method, Synapse and Neuron (SAN), which decomposes and propagates scaling components from anterior feature adjusting vectors towards posterior weight matrices. Our approach is theoretically grounded in Long-Term Potentiation/Depression (LTP/D) phenomena, which govern synapse development through neurotransmitter release modulation. Extensive experiments demonstrate its effectiveness: on \textbf{vision tasks} across VTAB, FGVC, and GIC (25 datasets) using ViT, SwinT and ConvNeXt, SAN outperforms FFT up to 8.7% and LoRA by 3.2%; on language tasks using Commonsense Reasoning (8 datasets) with LLaMA models (all generations), surpassing ChatGPT up to 8.5% and LoRA by 4.7%; on visual-language tasks using Mixed Visual Instruction (7 datasets) with LLaVA models, it exceeds FFT up to 2.4% and LoRA by 1.9%. Our code and W&B log will be released.