Automated driving (AD) has substantially improved vehicle safety and driving comfort, but their impact on passenger well-being, particularly infant sleep, is not sufficiently studied. Sudden acceleration, abrupt braking, and sharp maneuvers can disrupt infant sleep, compromising both passenger comfort and parental convenience. To solve this problem, this paper explores the integration of reinforcement learning (RL) within AD to personalize driving behavior and optimally balance occupant comfort and travel efficiency. In particular, we propose an intelligent cruise control framework that adapts to varying driving conditions to enhance infant sleep quality by effectively synergizing wearable sensing and vehicle data. Long short-term memory (LSTM) and transformer-based neural networks are integrated with RL to model the relationship between driving behavior and infant sleep quality under diverse traffic and road conditions. Based on the sleep quality indicators from the wearable sensors, driving action data from vehicle controllers, and map data from map applications, the model dynamically computes the optimal driving aggressiveness level, which is subsequently translated into specific AD control strategies, e.g., the magnitude and frequency of acceleration, lane change, and overtaking. Simulation results demonstrate that the proposed solution significantly improves infant sleep quality compared to baseline methods, while preserving desirable travel efficiency.
Due to time constraints, mental health professionals in China are unable to offer patients prolonged talk therapy, leaving a gap in care for patients with psychological disorders, including aberrant sleep and eating patterns, maladaptive explanatory styles, and gastrointestinal dysfunction. To bridge this gap in care and address these problems in a large-scale manner, we built NeuroPal, a large language model (LLM)-assistant that provides scalable, evidence-based interventions with three clinically validated modules: (1) a sleep chronotherapy planner to output personalized circadian rhythm correction protocols, (2) a cognitive-behavioral reframing engine grounded in CBT and humanistic principles to shift negative attributional biases, and (3) a biochemical regulation advisor to output phytotherapy formulations to regulate sleep-metabolism-gut-axis imbalances. In collaboration with Peking Union Medical College Hospital and Xiangya Hospital Central South University, we ran an RCT protocol with 513 participants with mood/anxiety disorders and showed statistically significant improvements towards primary endpoints (> p<.01). Experiment shows 37.2% drop in the Pittsburgh Sleep Quality Index (PSQI), 28.6% rise in positive affective word usages (LIWC analysis), and 23.4% improvement in patient-reported digestive comfort. The assistant also reached 89.1% adherence rates, significantly higher than the human-guided therapy intervention (72.3%) in matched controls. Our results indicate that an LLM-driven multimodal intervention is able to successfully bridge time-constrained clinical practice while preserving therapeutic effectiveness. For next steps, we plan to explore longitudinal outcome tracking and FDA/CFDA certification routes.
Bed-based pressure-sensitive mats (PSMs) offer a non-intrusive way of monitoring patients during sleep. We focus on four-way sleep position classification using data collected from a PSM placed under a mattress in a sleep clinic. Sleep positions can affect sleep quality and the prevalence of sleep disorders, such as apnea. Measurements were performed on patients with suspected sleep disorders referred for assessments at a sleep clinic. Training deep learning models can be challenging in clinical settings due to the need for large amounts of labeled data. To overcome the shortage of labeled training data, we utilize transfer learning to adapt pre-trained deep learning models to accurately estimate sleep positions from a low-resolution PSM dataset collected in a polysomnography sleep lab. Our approach leverages Vision Transformer models pre-trained on ImageNet using masked autoencoding (ViTMAE) and a pre-trained model for human pose estimation (ViTPose). These approaches outperform previous work from PSM-based sleep pose classification using deep learning (TCN) as well as traditional machine learning models (SVM, XGBoost, Random Forest) that use engineered features. We evaluate the performance of sleep position classification from 112 nights of patient recordings and validate it on a higher resolution 13-patient dataset. Despite the challenges of differentiating between sleep positions from low-resolution PSM data, our approach shows promise for real-world deployment in clinical settings
Sleep is an essential component of human physiology, contributing significantly to overall health and quality of life. Accurate sleep staging and disorder detection are crucial for assessing sleep quality. Studies in the literature have proposed PSG-based approaches and machine-learning methods utilizing single-modality signals. However, existing methods often lack multimodal, multilabel frameworks and address sleep stages and disorders classification separately. In this paper, we propose a 1D-Vision Transformer for simultaneous classification of sleep stages and sleep disorders. Our method exploits the sleep disorders' correlation with specific sleep stage patterns and performs a simultaneous identification of a sleep stage and sleep disorder. The model is trained and tested using multimodal-multilabel sensory data (including photoplethysmogram, respiratory flow, and respiratory effort signals). The proposed method shows an overall accuracy (cohen's Kappa) of 78% (0.66) for five-stage sleep classification and 74% (0.58) for sleep apnea classification. Moreover, we analyzed the encoder attention weights to clarify our models' predictions and investigate the influence different features have on the models' outputs. The result shows that identified patterns, such as respiratory troughs and peaks, make a higher contribution to the final classification process.
The analysis of lifelogs can yield valuable insights into an individual's daily life, particularly with regard to their health and well-being. The accurate assessment of quality of life is necessitated by the use of diverse sensors and precise synchronization. To rectify this issue, this study proposes the image-based sleep quality and stress level estimation flow (PixleepFlow). PixleepFlow employs a conversion methodology into composite image data to examine sleep patterns and their impact on overall health. Experiments were conducted using lifelog datasets to ascertain the optimal combination of data formats. In addition, we identified which sensor information has the greatest influence on the quality of life through Explainable Artificial Intelligence(XAI). As a result, PixleepFlow produced more significant results than various data formats. This study was part of a written-based competition, and the additional findings from the lifelog dataset are detailed in Section Section IV. More information about PixleepFlow can be found at https://github.com/seongjiko/Pixleep.
Sleep is essential for maintaining human health and quality of life. Analyzing physiological signals during sleep is critical in assessing sleep quality and diagnosing sleep disorders. However, manual diagnoses by clinicians are time-intensive and subjective. Despite advances in deep learning that have enhanced automation, these approaches remain heavily dependent on large-scale labeled datasets. This study introduces SynthSleepNet, a multimodal hybrid self-supervised learning framework designed for analyzing polysomnography (PSG) data. SynthSleepNet effectively integrates masked prediction and contrastive learning to leverage complementary features across multiple modalities, including electroencephalogram (EEG), electrooculography (EOG), electromyography (EMG), and electrocardiogram (ECG). This approach enables the model to learn highly expressive representations of PSG data. Furthermore, a temporal context module based on Mamba was developed to efficiently capture contextual information across signals. SynthSleepNet achieved superior performance compared to state-of-the-art methods across three downstream tasks: sleep-stage classification, apnea detection, and hypopnea detection, with accuracies of 89.89%, 99.75%, and 89.60%, respectively. The model demonstrated robust performance in a semi-supervised learning environment with limited labels, achieving accuracies of 87.98%, 99.37%, and 77.52% in the same tasks. These results underscore the potential of the model as a foundational tool for the comprehensive analysis of PSG data. SynthSleepNet demonstrates comprehensively superior performance across multiple downstream tasks compared to other methodologies, making it expected to set a new standard for sleep disorder monitoring and diagnostic systems.
Sleep staging is a key method for assessing sleep quality and diagnosing sleep disorders. However, current deep learning methods face challenges: 1) postfusion techniques ignore the varying contributions of different modalities; 2) unprocessed sleep data can interfere with frequency-domain information. To tackle these issues, this paper proposes a gated multimodal temporal neural network for multidomain sleep data, including heart rate, motion, steps, EEG (Fpz-Cz, Pz-Oz), and EOG from WristHR-Motion-Sleep and SleepEDF-78. The model integrates: 1) a pre-processing module for feature alignment, missing value handling, and EEG de-trending; 2) a feature extraction module for complex sleep features in the time dimension; and 3) a dynamic fusion module for real-time modality weighting.Experiments show classification accuracies of 85.03% on SleepEDF-78 and 94.54% on WristHR-Motion-Sleep datasets. The model handles heterogeneous datasets and outperforms state-of-the-art models by 1.00%-4.00%.
Chronic itch affects 13% of the US population, is highly debilitating, and underlies many medical conditions. A major challenge in clinical care and new therapeutics development is the lack of an objective measure for quantifying itch, leading to reliance on subjective measures like patients' self-assessment of itch severity. In this paper, we show that a home radio device paired with artificial intelligence (AI) can concurrently capture scratching and evaluate its impact on sleep quality by analyzing radio signals bouncing in the environment. The device eliminates the need for wearable sensors or skin contact, enabling monitoring of chronic itch over extended periods at home without burdening patients or interfering with their skin condition. To validate the technology, we conducted an observational clinical study of chronic pruritus patients, monitored at home for one month using both the radio device and an infrared camera. Comparing the output of the device to ground truth data from the camera demonstrates its feasibility and accuracy (ROC AUC = 0.997, sensitivity = 0.825, specificity = 0.997). The results reveal a significant correlation between scratching and low sleep quality, manifested as a reduction in sleep efficiency (R = 0.6, p < 0.001) and an increase in sleep latency (R = 0.68, p < 0.001). Our study underscores the potential of passive, long-term, at-home monitoring of chronic scratching and its sleep implications, offering a valuable tool for both clinical care of chronic itch patients and pharmaceutical clinical trials.
People exhibit unique emotional responses. In the same scenario, the emotional reactions of two individuals can be either similar or vastly different. For instance, consider one person's reaction to an invitation to smoke versus another person's response to a query about their sleep quality. The identification of these individual traits through the observation of common physical parameters opens the door to a wide range of applications, including psychological analysis, criminology, disease prediction, addiction control, and more. While there has been previous research in the fields of psychometrics, inertial sensors, computer vision, and audio analysis, this paper introduces a novel technique for identifying human traits in real time using brainwave data. To achieve this, we begin with an extensive study of brainwave data collected from 80 participants using a portable EEG headset. We also conduct a statistical analysis of the collected data utilizing box plots. Our analysis uncovers several new insights, leading us to a groundbreaking unified approach for identifying diverse human traits by leveraging machine learning techniques on EEG data. Our analysis demonstrates that this proposed solution achieves high accuracy. Moreover, we explore two deep-learning models to compare the performance of our solution. Consequently, we have developed an integrated, real-time trait identification solution using EEG data, based on the insights from our analysis. To validate our approach, we conducted a rigorous user evaluation with an additional 20 participants. The outcomes of this evaluation illustrate both high accuracy and favorable user ratings, emphasizing the robust potential of our proposed method to serve as a versatile solution for human trait identification.
Longitudinal monitoring of heart rate (HR) and heart rate variability (HRV) can aid in tracking cardiovascular diseases (CVDs), sleep quality, sleep disorders, and reflect autonomic nervous system activity, stress levels, and overall well-being. These metrics are valuable in both clinical and everyday settings. In this paper, we present a transformer network aimed primarily at detecting the precise timing of heart beats from predicted electrocardiogram (ECG), derived from input Ballistocardiogram (BCG). We compared the performance of segment and subject models across three datasets: a lab dataset with 46 young subjects, an elder dataset with 28 elderly adults, and a combined dataset. The segment model demonstrated superior performance, with correlation coefficients of 0.97 for HR and mean heart beat interval (MHBI) when compared to ground truth. This non-invasive method offers significant potential for long-term, in-home HR and HRV monitoring, aiding in the early indication and prevention of cardiovascular issues.
This systematic review examines the synergistic and individual influences of resistance exercise, dietary protein supplementation, and sleep/recovery on muscle protein synthesis (MPS). Electronic databases such as Scopus, Google Scholar, and Web of Science were extensively used. Studies were selected based on relevance to the criteria and were ensured to be directly applicable to the objectives. Research indicates that a protein dose of 20 to 25 grams maximally stimulates MPS post-resistance training. It is observed that physically frail individuals aged 76 to 92 and middle-aged adults aged 62 to 74 have lower mixed muscle protein synthetic rates than individuals aged 20 to 32. High-whey protein and leucine-enriched supplements enhance MPS more efficiently than standard dairy products in older adults engaged in resistance programs. Similarly, protein intake before sleep boosts overnight MPS rates, which helps prevent muscle loss associated with sleep debt, exercise-induced damage, and muscle-wasting conditions like sarcopenia and cachexia. Resistance exercise is a functional intervention to achieve muscular adaptation and improve function. Future research should focus on variables such as fluctuating fitness levels, age groups, genetics, and lifestyle factors to generate more accurate and beneficial results.
Accurate sleep stage classification is crucial for diagnosing sleep disorders and evaluating sleep quality. While polysomnography (PSG) remains the gold standard, photoplethysmography (PPG) is more practical due to its affordability and widespread use in wearable devices. However, state-of-the-art sleep staging methods often require prolonged continuous signal acquisition, making them impractical for wearable devices due to high energy consumption. Shorter signal acquisitions are more feasible but less accurate. Our work proposes an adapted sleep staging model based on top-performing state-of-the-art methods and evaluates its performance with different PPG segment sizes. We concatenate 30-second PPG segments over 15-minute intervals to leverage longer segment contexts. This approach achieved an accuracy of 0.75, a Cohen's Kappa of 0.60, an F1-Weighted score of 0.74, and an F1-Macro score of 0.60. Although reducing segment size decreased sensitivity for deep and REM stages, our strategy outperformed single 30-second window methods, particularly for these stages.
Sleep staging is critical to assess sleep quality and diagnose disorders. Despite advancements in artificial intelligence enabling automated sleep staging, significant challenges remain: (1) Simultaneously extracting prominent temporal and spatial sleep features from multi-channel raw signals, including characteristic sleep waveforms and salient spatial brain networks. (2) Capturing the spatial-temporal coupling patterns essential for accurate sleep staging. To address these challenges, we propose a novel framework named ST-USleepNet, comprising a spatial-temporal graph construction module (ST) and a U-shaped sleep network (USleepNet). The ST module converts raw signals into a spatial-temporal graph based on signal similarity, temporal, and spatial relationships to model spatial-temporal coupling patterns. The USleepNet employs a U-shaped structure for both the temporal and spatial streams, mirroring its original use in image segmentation to isolate significant targets. Applied to raw sleep signals and graph data from the ST module, USleepNet effectively segments these inputs, simultaneously extracting prominent temporal and spatial sleep features. Testing on three datasets demonstrates that ST-USleepNet outperforms existing baselines, and model visualizations confirm its efficacy in extracting prominent sleep features and temporal-spatial coupling patterns across various sleep stages. The code is available at https://github.com/Majy-Yuji/ST-USleepNet.
We explore the application of large language models (LLMs), pre-trained models with massive textual data for detecting and improving these altered states. We investigate the use of LLMs to estimate attention states, sleep stages, and sleep quality and generate sleep improvement suggestions and adaptive guided imagery scripts based on electroencephalogram (EEG) and physical activity data (e.g. waveforms, power spectrogram images, numerical features). Our results show that LLMs can estimate sleep quality based on human textual behavioral features and provide personalized sleep improvement suggestions and guided imagery scripts; however detecting attention, sleep stages, and sleep quality based on EEG and activity data requires further training data and domain-specific knowledge.
Sleep plays a crucial role in neonatal development. Monitoring the sleep patterns in neonates in a Neonatal Intensive Care Unit (NICU) is imperative for understanding the maturation process. While polysomnography (PSG) is considered the best practice for sleep classification, its expense and reliance on human annotation pose challenges. Existing research often relies on multichannel EEG signals; however, concerns arise regarding the vulnerability of neonates and the potential impact on their sleep quality. This paper introduces a novel approach to neonatal sleep stage classification using a single-channel gradient boosting algorithm with Hjorth features. The gradient boosting parameters are fine-tuned using random search cross-validation (randomsearchCV), achieving an accuracy of 82.35% for neonatal sleep-wake classification. Validation is conducted through 5-fold cross-validation. The proposed algorithm not only enhances existing neonatal sleep algorithms but also opens avenues for broader applications.
In wearable smart systems, continuous monitoring and accurate classification of different sleep-related conditions are critical for enhancing sleep quality and preventing sleep-related chronic conditions. However, the requirements for device-skin coupling quality in electrophysiological sleep monitoring systems hinder the comfort and reliability of night wearing. Here, we report a washable, skin-compatible smart garment sleep monitoring system that captures local skin strain signals under weak device-skin coupling conditions without positioning or skin preparation requirements. A printed textile-based strain sensor array responds to strain from 0.1% to 10% with a gauge factor as high as 100 and shows independence to extrinsic motion artefacts via strain-isolating printed pattern design. Through reversible starching treatment, ink penetration depth during direct printing on garments is controlled to achieve batch-to-batch performance variation < 10%. Coupled with deep learning, explainable artificial intelligence (XAI), and transfer learning data processing, the smart garment is capable of classifying six sleep states with an accuracy of 98.6%, maintaining excellent explainability (classification with low bias) and generalization (95% accuracy on new users with few-shot learning less than 15 samples per class) in practical applications, paving the way for next-generation daily sleep healthcare management.
Traditional sleep staging categorizes sleep and wakefulness into five coarse-grained classes, overlooking subtle variations within each stage. It provides limited information about the duration of arousal and may hinder research on sleep fragmentation and relevant sleep disorders. To address this issue, we propose a deep learning method for automatic and scalable annotation of continuous sleep depth index (SDI) using existing discrete sleep staging labels. Our approach was validated using polysomnography from over 10,000 recordings across four large-scale cohorts. The results showcased a strong correlation between the decrease in sleep depth index and the increase in duration of arousal. Specific case studies indicated that the sleep depth index captured more nuanced sleep structures than conventional sleep staging. Gaussian mixture models based on the digital biomarkers extracted from the sleep depth index identified two subtypes of sleep, where participants in the disturbed sleep group had a higher prevalence of sleep apnea, insomnia, poor subjective sleep quality, hypertension, and cardiovascular disease. The disturbed subtype was associated with a 42% (hazard ratio 1.42, 95% CI 1.24-1.62) increased risk of mortality and a 29% (hazard ratio 1.29, 95% CI 1.00-1.67) increased risk of fatal cardiovascular disease. Our study underscores the utility of the proposed method for continuous sleep depth annotation, which could reveal more detailed information about the sleep structure and yield novel digital biomarkers for routine clinical use in sleep medicine.
Sleep quality directly impacts human health and quality of life, so accurate sleep staging is essential for assessing sleep quality. However, most traditional methods are inefficient and time-consuming due to segmenting different sleep cycles by manual labeling. In contrast, automated sleep staging technology not only directly assesses sleep quality but also helps sleep specialists analyze sleep status, significantly improving efficiency and reducing the cost of sleep monitoring, especially for continuous sleep monitoring. Most of the existing models, however, are deficient in computational efficiency, lightweight design, and model interpretability. In this paper, we propose a neural network architecture based on the prior knowledge of sleep experts. Specifically, 1) Propose an end-to-end model named DetectsleepNet that uses single-channel EEG signals without additional data processing, which has achieved an impressive 80.9% accuracy on the SHHS dataset and an outstanding 88.0% accuracy on the Physio2018 dataset. 2) Constructure an efficient lightweight sleep staging model named DetectsleepNet-tiny based on DetectsleepNet, which has just 6% of the parameter numbers of existing models, but its accuracy exceeds 99% of state-of-the-art models, 3) Introducing a specific inference header to assess the attention given to a specific EEG segment in each sleep frame, enhancing the transparency in the decisions of models. Our model comprises fewer parameters compared to existing ones and ulteriorly explores the interpretability of the model to facilitate its application in healthcare. The code is available at https://github.com/komdec/DetectSleepNet.git.
In health, most large language model (LLM) research has focused on clinical tasks. However, mobile and wearable devices, which are rarely integrated into such tasks, provide rich, longitudinal data for personal health monitoring. Here we present Personal Health Large Language Model (PH-LLM), fine-tuned from Gemini for understanding and reasoning over numerical time-series personal health data. We created and curated three datasets that test 1) production of personalized insights and recommendations from sleep patterns, physical activity, and physiological responses, 2) expert domain knowledge, and 3) prediction of self-reported sleep outcomes. For the first task we designed 857 case studies in collaboration with domain experts to assess real-world scenarios in sleep and fitness. Through comprehensive evaluation of domain-specific rubrics, we observed that Gemini Ultra 1.0 and PH-LLM are not statistically different from expert performance in fitness and, while experts remain superior for sleep, fine-tuning PH-LLM provided significant improvements in using relevant domain knowledge and personalizing information for sleep insights. We evaluated PH-LLM domain knowledge using multiple choice sleep medicine and fitness examinations. PH-LLM achieved 79% on sleep and 88% on fitness, exceeding average scores from a sample of human experts. Finally, we trained PH-LLM to predict self-reported sleep quality outcomes from textual and multimodal encoding representations of wearable data, and demonstrate that multimodal encoding is required to match performance of specialized discriminative models. Although further development and evaluation are necessary in the safety-critical personal health domain, these results demonstrate both the broad knowledge and capabilities of Gemini models and the benefit of contextualizing physiological data for personal health applications as done with PH-LLM.
Objective. Sleep is a critical physiological process that plays a vital role in maintaining physical and mental health. Accurate detection of arousals and sleep stages is essential for the diagnosis of sleep disorders, as frequent and excessive occurrences of arousals disrupt sleep stage patterns and lead to poor sleep quality, negatively impacting physical and mental health. Polysomnography is a traditional method for arousal and sleep stage detection that is time-consuming and prone to high variability among experts. Approach. In this paper, we propose a novel multi-task learning approach for arousal and sleep stage detection using fully convolutional neural networks. Our model, FullSleepNet, accepts a full-night single-channel EEG signal as input and produces segmentation masks for arousal and sleep stage labels. FullSleepNet comprises four modules: a convolutional module to extract local features, a recurrent module to capture long-range dependencies, an attention mechanism to focus on relevant parts of the input, and a segmentation module to output final predictions. Main results. By unifying the two interrelated tasks as segmentation problems and employing a multi-task learning approach, FullSleepNet achieves state-of-the-art performance for arousal detection with an area under the precision-recall curve of 0.70 on Sleep Heart Health Study and Multi-Ethnic Study of Atherosclerosis datasets. For sleep stage classification, FullSleepNet obtains comparable performance on both datasets, achieving an accuracy of 0.88 on the former and an accuracy of 0.83 on the latter. Significance. Our results demonstrate that FullSleepNet offers improved practicality, efficiency, and accuracy for the detection of arousal and classification of sleep stages using raw EEG signals as input.