Data augmentation is a promising tool for enhancing out-of-distribution generalization, where the key is to produce diverse, challenging variations of the source domain via costly targeted augmentations that maximize its generalization effect. Conversely, random augmentation is inexpensive but is deemed suboptimal due to its limited effect. In this paper, we revisit random augmentation and explore methods to address its shortcomings. We show that the stochastic nature of random augmentation can produce a set of colliding augmentations that distorts the learned features, similar to catastrophic forgetting. We propose a simple solution that improves the generalization effect of random augmentation by addressing forgetting, which displays strong generalization performance across various single source domain generalization (sDG) benchmarks.
Deep learning models often struggle to maintain performance when deployed on data distributions different from their training data, particularly in real-world applications where environmental conditions frequently change. While Multi-source Domain Generalization (MDG) has shown promise in addressing this challenge by leveraging multiple source domains during training, its practical application is limited by the significant costs and difficulties associated with creating multi-domain datasets. To address this limitation, we propose Pseudo Multi-source Domain Generalization (PMDG), a novel framework that enables the application of sophisticated MDG algorithms in more practical Single-source Domain Generalization (SDG) settings. PMDG generates multiple pseudo-domains from a single source domain through style transfer and data augmentation techniques, creating a synthetic multi-domain dataset that can be used with existing MDG algorithms. Through extensive experiments with PseudoDomainBed, our modified version of the DomainBed benchmark, we analyze the effectiveness of PMDG across multiple datasets and architectures. Our analysis reveals several key findings, including a positive correlation between MDG and PMDG performance and the potential of pseudo-domains to match or exceed actual multi-domain performance with sufficient data. These comprehensive empirical results provide valuable insights for future research in domain generalization. Our code is available at https://github.com/s-enmt/PseudoDomainBed.
Data augmentation is a popular tool for single source domain generalization, which expands the source domain by generating simulated ones, improving generalization on unseen target domains. In this work, we show that the performance of such augmentation-based methods in the target domains universally fluctuates during training, posing challenges in model selection under realistic scenarios. We argue that the fluctuation stems from the inability of the model to accumulate the knowledge learned from diverse augmentations, exacerbating feature distortion during training. Based on this observation, we propose a novel generalization method, coined Parameter-Space Ensemble with Entropy Regularization (PEER), that uses a proxy model to learn the augmented data on behalf of the main model. The main model is updated by averaging its parameters with the proxy model, progressively accumulating knowledge over the training steps. Maximizing the mutual information between the output representations of the two models guides the learning process of the proxy model, mitigating feature distortion during training. Experimental results demonstrate the effectiveness of PEER in reducing the OOD performance fluctuation and enhancing generalization across various datasets, including PACS, Digits, Office-Home, and VLCS. Notably, our method with simple random augmentation achieves state-of-the-art performance, surpassing prior approaches on sDG that utilize complex data augmentation strategies.
Despite domain generalization (DG) has significantly addressed the performance degradation of pre-trained models caused by domain shifts, it often falls short in real-world deployment. Test-time adaptation (TTA), which adjusts a learned model using unlabeled test data, presents a promising solution. However, most existing TTA methods struggle to deliver strong performance in medical image segmentation, primarily because they overlook the crucial prior knowledge inherent to medical images. To address this challenge, we incorporate morphological information and propose a framework based on multi-graph matching. Specifically, we introduce learnable universe embeddings that integrate morphological priors during multi-source training, along with novel unsupervised test-time paradigms for domain adaptation. This approach guarantees cycle-consistency in multi-matching while enabling the model to more effectively capture the invariant priors of unseen data, significantly mitigating the effects of domain shifts. Extensive experiments demonstrate that our method outperforms other state-of-the-art approaches on two medical image segmentation benchmarks for both multi-source and single-source domain generalization tasks. The source code is available at https://github.com/Yore0/TTDG-MGM.
Automated knee cartilage segmentation using point-of-care ultrasound devices and deep-learning networks has the potential to enhance the management of knee osteoarthritis. However, segmentation algorithms often struggle with domain shifts caused by variations in ultrasound devices and acquisition parameters, limiting their generalizability. In this paper, we propose Mono2D, a monogenic layer that extracts multi-scale, contrast- and intensity-invariant local phase features using trainable bandpass quadrature filters. This layer mitigates domain shifts, improving generalization to out-of-distribution domains. Mono2D is integrated before the first layer of a segmentation network, and its parameters jointly trained alongside the network's parameters. We evaluated Mono2D on a multi-domain 2D ultrasound knee cartilage dataset for single-source domain generalization (SSDG). Our results demonstrate that Mono2D outperforms other SSDG methods in terms of Dice score and mean average surface distance. To further assess its generalizability, we evaluate Mono2D on a multi-site prostate MRI dataset, where it continues to outperform other SSDG methods, highlighting its potential to improve domain generalization in medical imaging. Nevertheless, further evaluation on diverse datasets is still necessary to assess its clinical utility.
Single-source domain generalization (SDG) in medical image segmentation remains a significant challenge, particularly for images with varying color distributions and qualities. Previous approaches often struggle when models trained on high-quality images fail to generalize to low-quality test images due to these color and quality shifts. In this work, we propose two novel techniques to enhance generalization: dynamic color image normalization (DCIN) module and color-quality generalization (CQG) loss. The DCIN dynamically normalizes the color of test images using two reference image selection strategies. Specifically, the DCIN utilizes a global reference image selection (GRIS), which finds a universal reference image, and a local reference image selection (LRIS), which selects a semantically similar reference image per test sample. Additionally, CQG loss enforces invariance to color and quality variations by ensuring consistent segmentation predictions across transformed image pairs. Experimental results show that our proposals significantly improve segmentation performance over the baseline on two target domain datasets, despite being trained solely on a single source domain. Notably, our model achieved up to a 32.3-point increase in Dice score compared to the baseline, consistently producing robust and usable results even under substantial domain shifts. Our work contributes to the development of more robust medical image segmentation models that generalize across unseen domains. The implementation code is available at https://github.com/RaviShah1/DCIN-CQG.
By extracting radio frequency (RF) fingerprints from received signals, specific emitter identification (SEI) becomes a promising technique for physical layer identification of wireless devices. Recently, channel-robust SEI has attracted increasing attention due to the weak robustness exhibited by deep learning (DL)-based SEI methods in cross-channel conditions. To address these limitations, we propose a novel channel-robust SEI framework based on single-source domain generalization (SDG). Initially, we analyze the weak robustness of existing SEI methods from the perspective of the “shortcut learning” phenomenon in DL. Shortcut learning may lead traditional SEI methods to prioritize easily-mined, yet transient, channel characteristics in signal samples, rather than focusing on the more stable RF fingerprints derived from hardware differences. Next, from the perspective of SDG, we outline the optimization goal to rectify the shortcut learning in SEI. Inspired by this optimization goal, we then propose a channel-robust SEI method. This method consists of feature embedding through a multi-scale convolutional attention network (MSCAN), domain expansion using random overlay augmentation (ROA) to generate multiple virtual domains, and dual alignment strategy based on contrastive learning. Specifically, supervised contrastive learning is implemented for category-wise alignment, while supervised contrastive adversarial learning is utilized for domain-wise alignment. This dual alignment strategy can optimize the MSCAN to learn discriminative and domain-invariant feature representations, thereby enhancing the robustness of SEI. Simulation experiments on the ORACLE dataset and the WiSig dataset have demonstrated the superiority of our method compared to state-of-the-art techniques. The codes can be downloaded from GitHub1.
Domain shifts in medical image segmentation, particularly when data comes from different centers, pose significant challenges. Intra-center variability, such as differences in scanner models or imaging protocols, can cause domain shifts as large as, or even larger than, those between centers. To address this, we propose the "one image as one domain" (OIOD) hypothesis, which treats each image as a unique domain, enabling flexible and robust domain generalization. Based on this hypothesis, we develop a unified disentanglement-based domain generalization (UniDDG) framework, which simultaneously handles both multi-source and single-source domain generalization without requiring explicit domain labels. This approach simplifies training with a fixed architecture, independent of the number of source domains, reducing complexity and enhancing scalability. We decouple each input image into content representation and style code, then exchange and combine these within the batch for segmentation, reconstruction, and further disentanglement. By maintaining distinct style codes for each image, our model ensures thorough decoupling of content representations and style codes, improving domain invariance of the content representations. Additionally, we enhance generalization with expansion mask attention (EMA) for boundary preservation and style augmentation (SA) to simulate diverse image styles, improving robustness to domain shifts. Extensive experiments show that our method achieves Dice scores of 84.43% and 88.91% for multi-source to single-center and single-center generalization in optic disc and optic cup segmentation, respectively, and 86.96% and 88.56% for prostate segmentation, outperforming current state-of-the-art domain generalization methods, offering superior performance and adaptability across clinical settings.
Cross-scene image classification aims to transfer prior knowledge of ground materials to annotate regions with different distributions and reduce hand-crafted cost in the field of remote sensing. However, existing approaches focus on single-source domain generalization to unseen target domains, and are easily confused by large real-world domain shifts due to the limited training information and insufficient diversity modeling capacity. To address this gap, we propose a novel multi-source collaborative domain generalization framework (MS-CDG) based on homogeneity and heterogeneity characteristics of multi-source remote sensing data, which considers data-aware adversarial augmentation and model-aware multi-level diversification simultaneously to enhance cross-scene generalization performance. The data-aware adversarial augmentation adopts an adversary neural network with semantic guide to generate MS samples by adaptively learning realistic channel and distribution changes across domains. In views of cross-domain and intra-domain modeling, the model-aware diversification transforms the shared spatial-channel features of MS data into the class-wise prototype and kernel mixture module, to address domain discrepancies and cluster different classes effectively. Finally, the joint classification of original and augmented MS samples is employed by introducing a distribution consistency alignment to increase model diversity and ensure better domain-invariant representation learning. Extensive experiments on three public MS remote sensing datasets demonstrate the superior performance of the proposed method when benchmarked with the state-of-the-art methods.
We consider the problem of single-source domain generalization. Existing methods typically rely on extensive augmentations to synthetically cover diverse domains during training. However, they struggle with semantic shifts (e.g., background and viewpoint changes), as they often learn global features instead of local concepts that tend to be domain invariant. To address this gap, we propose an approach that compels models to leverage such local concepts during prediction. Given no suitable dataset with per-class concepts and localization maps exists, we first develop a novel pipeline to generate annotations by exploiting the rich features of diffusion and large-language models. Our next innovation is TIDE, a novel training scheme with a concept saliency alignment loss that ensures model focus on the right per-concept regions and a local concept contrastive loss that promotes learning domain-invariant concept representations. This not only gives a robust model but also can be visually interpreted using the predicted concept saliency maps. Given these maps at test time, our final contribution is a new correction algorithm that uses the corresponding local concept representations to iteratively refine the prediction until it aligns with prototypical concept representations that we store at the end of model training. We evaluate our approach extensively on four standard DG benchmark datasets and substantially outperform the current state-ofthe-art (12% improvement on average) while also demonstrating that our predictions can be visually interpreted
Fetal brain tissue segmentation in magnetic resonance imaging (MRI) is a crucial tool that supports understanding of neurodevelopment, yet it faces challenges due to the heterogeneity of data coming from different scanners and settings, as well as data scarcity. Recent approaches based on domain randomization, like SynthSeg, have shown great potential for single-source domain generalization by simulating images with randomized contrast and image resolution from the label maps. In this work, we investigate how to maximize the out-of-domain (OOD) generalization potential of SynthSegbased methods in fetal brain MRI. Specifically, we demonstrate that the simple Gaussian mixture models employed in FetalSynthSeg outperform physics-informed generation methods in terms of OOD generalization. We further show that incorporating intensity clustering significantly enhances generalization in settings with limited label classes by producing more realistic synthetic data. By combining synthetic pretraining with fine-tuning on real images and applying weight-space interpolation between the two models, we propose DRIFTS as an effective and practical solution for single-source domain generalization. DRIFTS consistently outperforms current state-of-the-art models across multiple benchmarks and is, to our knowledge, the first method to achieve accurate brain tissue segmentation on fetal T1-weighted images. We validate our approach on 308 subjects from four datasets acquired at three different sites, covering a range of scanner field strengths (0.55T to 3T) and both T1w and T2w modalities. We conclude with five practical recommendations to guide the development of SynthSeg-based methods for other organs and imaging modalities.
Deploying deep segmentation models in new medical centers poses a significant challenge due to statistical disparities between source and unknown domains. Recent advancements in domain generalization (DG) have shown improved generalization performance by leveraging disentanglement techniques on domain-specific and domain-invariant features. However, existing DG methods face challenges in achieving optimal feature segregation. To address this, we introduce a pixel-level contrastive single domain generalization (PCSDG) framework and a structure-aware brightness augmentation (SABA) technique for joint optic disc and cup segmentation. First, a disentanglement module captures content and style-related maps, pixel-wise multiplied with the original image to generate saliency-based attention maps, resulting in distinct structure and style representations. Second, Using a contrastive loss in the latent space enhances segregation. Finally, SABA introduces random brightness variations, preserving anatomical information and diversifying sample styles. Experimental validation on two public fundus image datasets with two source domains and five target domains demonstrates the superior performance of PCSDG and SABA across diverse domains when compared to state-of-the-art methods. Our code and models are made public at: https://github.com/HopkinsKwong/PCSDG
Single-source domain generalization (SDG) aims to learn a model from a single source domain that can generalize well on unseen target domains. This is an important task in computer vision, particularly relevant to medical imaging where domain shifts are common. In this work, we consider a challenging yet practical setting: SDG for cross-modality medical image segmentation. We combine causality-inspired theoretical insights on learning domain-invariant representations with recent advancements in diffusion-based augmentation to improve generalization across diverse imaging modalities. Guided by the ``intervention-augmentation equivariant'' principle, we use controlled diffusion models (DMs) to simulate diverse imaging styles while preserving the content, leveraging rich generative priors in large-scale pretrained DMs to comprehensively perturb the multidimensional style variable. Extensive experiments on challenging cross-modality segmentation tasks demonstrate that our approach consistently outperforms state-of-the-art SDG methods across three distinct anatomies and imaging modalities. The source code is available at \href{https://github.com/ratschlab/ICMSeg}{https://github.com/ratschlab/ICMSeg}.
Open-set single-source domain generalization aims to use a single-source domain to learn a robust model that can be generalized to unknown target domains with both domain shifts and label shifts. The scarcity of the source domain and the unknown data distribution of the target domain pose a great challenge for domain-invariant feature learning and unknown class recognition. In this paper, we propose a novel learning approach based on domain expansion and boundary growth to expand the scarce source samples and enlarge the boundaries across the known classes that indirectly broaden the boundary between the known and unknown classes. Specifically, we achieve domain expansion by employing both background suppression and style augmentation on the source data to synthesize new samples. Then we force the model to distill consistent knowledge from the synthesized samples so that the model can learn domain-invariant information. Furthermore, we realize boundary growth across classes by using edge maps as an additional modality of samples when training multi-binary classifiers. In this way, it enlarges the boundary between the inliers and outliers, and consequently improves the unknown class recognition during open-set generalization. Extensive experiments show that our approach can achieve significant improvements and reach state-of-the-art performance on several cross-domain image classification datasets.
Person Re-identification (Person ReID) has advanced significantly in fully supervised and domain generalized Person R e ID. However, methods developed for one task domain transfer poorly to the other. An ideal Person ReID method should be effective regardless of the number of domains involved in training or testing. Furthermore, given training data from the target domain, it should perform at least as well as state-of-the-art (SOTA) fully supervised Person ReID methods. We call this paradigm Omni-Domain Generalization Person ReID, referred to as ODG-ReID, and propose a way to achieve this by expanding compatible backbone architectures into multiple diverse pathways. Our method, Aligned Divergent Pathways (ADP), first converts a base architecture into a multi-branch structure by copying the tail of the original backbone. We design our module Dynamic Max-Deviance Adaptive Instance Normalization (DyMAIN) that encourages learning of generalized features that are robust to omni-domain directions and apply DyMAIN to the branches of ADP. Our proposed Phased Mixture-of-Cosines (PMoC) coordinates a mix of stable and turbulent learning rate schedules among branches for further diversified learning. Finally, we realign the feature space between branches with our proposed Dimensional Consistency Metric Loss (DCML). ADP outperforms the state-of-the-art (SOTA) results for multi-source domain generalization and supervised ReID within the same domain. Furthermore, our method demonstrates improvement on a wide range of single-source domain generalization benchmarks, achieving Omni-Domain Generalization over Person ReID tasks.
Single-source domain generalization attempts to learn a model on a source domain and deploy it to unseen target domains. Limiting access only to source domain data imposes two key challenges - how to train a model that can generalize and how to verify that it does. The standard practice of validation on the training distribution does not accurately reflect the model's generalization ability, while validation on the test distribution is a malpractice to avoid. In this work, we construct an independent validation set by transforming source domain images with a comprehensive list of augmentations, covering a broad spectrum of potential distribution shifts in target domains. We demonstrate a high correlation between validation and test performance for multiple methods and across various datasets. The proposed validation achieves a relative accuracy improvement over the standard validation equal to 15.4% or 1.6% when used for method selection or learning rate tuning, respectively. Furthermore, we introduce a novel family of methods that increase the shape bias through enhanced edge maps. To benefit from the augmentations during training and preserve the independence of the validation set, a k-fold validation process is designed to separate the augmentation types used in training and validation. The method that achieves the best performance on the augmented validation is selected from the proposed family. It achieves state-of-the-art performance on various standard benchmarks. Code at: https://github.com/NikosEfth/crafting-shifts
Deep learning based methods often suffer from performance degradation caused by domain shift. In recent years, many sophisticated network structures have been designed to tackle this problem. However, the advent of large model trained on massive data, with its exceptional segmentation capability, introduces a new perspective for solving medical segmentation problems. In this paper, we propose a novel Domain-Adaptive Prompt framework for fine-tuning the Segment Anything Model (termed as DAPSAM) to address single-source domain generalization (SDG) in segmenting medical images. DAPSAM not only utilizes a more generalization-friendly adapter to fine-tune the large model, but also introduces a self-learning prototype-based prompt generator to enhance model's generalization ability. Specifically, we first merge the important low-level features into intermediate features before feeding to each adapter, followed by an attention filter to remove redundant information. This yields more robust image embeddings. Then, we propose using a learnable memory bank to construct domain-adaptive prototypes for prompt generation, helping to achieve generalizable medical image segmentation. Extensive experimental results demonstrate that our DAPSAM achieves state-of-the-art performance on two SDG medical image segmentation tasks with different modalities. The code is available at https://github.com/wkklavis/DAPSAM.
The field of medical image segmentation is challenged by domain generalization (DG) due to domain shifts in clinical datasets. The DG challenge is exacerbated by the scarcity of medical data and privacy concerns. Traditional single-source domain generalization (SSDG) methods primarily rely on stacking data augmentation techniques to minimize domain discrepancies. In this paper, we propose Random Amplitude Spectrum Synthesis (RASS) as a training augmentation for medical images. RASS enhances model generalization by simulating distribution changes from a frequency perspective. This strategy introduces variability by applying amplitude-dependent perturbations to ensure broad coverage of potential domain variations. Furthermore, we propose random mask shuffle and reconstruction components, which can enhance the ability of the backbone to process structural information and increase resilience intra- and cross-domain changes. The proposed Random Amplitude Spectrum Synthesis for Single-Source Domain Generalization (RAS^4DG) is validated on 3D fetal brain images and 2D fundus photography, and achieves an improved DG segmentation performance compared to other SSDG models.
Domain generalization achieves fault diagnosis on unseen modes. In process industrial systems, fault samples are limited, and only single-mode fault data can be obtained. Extracting domain-invariant fault features from single-mode data for unseen mode fault diagnosis poses challenges. Existing methods utilize a generator module to simulate samples of unseen modes. However, multi-mode samples contain complex spatiotemporal information, which brings significant difficulties to accurate sample generation. Therefore, double gradient reversal network (DGRN) is proposed. First, the model is pre-trained to acquire fault knowledge from the single seen mode. Then, pseudo-fault feature generation strategy is designed by Adaptive instance normalization, to simulate fault features of unseen mode. The dual adversarial training strategy is created to enhance the diversity of pseudo-fault features, which models unseen modes with significant distribution differences. Subsequently, domain-invariant feature extraction strategy is constructed by contrastive learning and adversarial learning. This strategy extracts common features of faults and helps multi-mode fault diagnosis. Finally, the experiments were conducted on Tennessee Eastman process and continuous stirred-tank reactor. The experiments demonstrate that DGRN achieves high classification accuracy on unseen modes while maintaining a small model size.
Single-source domain generalization (SDG) in medical image segmentation (MIS) aims to generalize a model using data from only one source domain to segment data from an unseen target domain. Despite substantial advances in SDG with data augmentation, existing methods often fail to fully consider the details and uncertain areas prevalent in MIS, leading to mis-segmentation. This paper proposes a Fourier-based semantic augmentation method called FIESTA using uncertainty guidance to enhance the fundamental goals of MIS in an SDG context by manipulating the amplitude and phase components in the frequency domain. The proposed Fourier augmentative transformer addresses semantic amplitude modulation based on meaningful angular points to induce pertinent variations and harnesses the phase spectrum to ensure structural coherence. Moreover, FIESTA employs epistemic uncertainty to fine-tune the augmentation process, improving the ability of the model to adapt to diverse augmented data and concentrate on areas with higher ambiguity. Extensive experiments across three cross-domain scenarios demonstrate that FIESTA surpasses recent state-of-the-art SDG approaches in segmentation performance and significantly contributes to boosting the applicability of the model in medical imaging modalities.