Head MRI pre-processing involves converting raw images to an intensity-normalized, skull-stripped brain in a standard coordinate space. In this paper, we propose an end-to-end weakly supervised learning approach, called Neural Pre-processing (NPP), for solving all three sub-tasks simultaneously via a neural network, trained on a large dataset without individual sub-task supervision. Because the overall objective is highly under-constrained, we explicitly disentangle geometric-preserving intensity mapping (skull-stripping and intensity normalization) and spatial transformation (spatial normalization). Quantitative results show that our model outperforms state-of-the-art methods which tackle only a single sub-task. Our ablation experiments demonstrate the importance of the architecture design we chose for NPP. Furthermore, NPP affords the user the flexibility to control each of these tasks at inference time. The code and model are freely-available at \url{https://github.com/Novestars/Neural-Pre-processing}.
A large body of recent work targets semantically conditioned image generation. Most such methods focus on the narrower task of pose transfer and ignore the more challenging task of subject transfer that consists in not only transferring the pose but also the appearance and background. In this work, we introduce SCAM (Semantic Cross Attention Modulation), a system that encodes rich and diverse information in each semantic region of the image (including foreground and background), thus achieving precise generation with emphasis on fine details. This is enabled by the Semantic Attention Transformer Encoder that extracts multiple latent vectors for each semantic region, and the corresponding generator that exploits these multiple latents by using semantic cross attention modulation. It is trained only using a reconstruction setup, while subject transfer is performed at test time. Our analysis shows that our proposed architecture is successful at encoding the diversity of appearance in each semantic region. Extensive experiments on the iDesigner and CelebAMask-HD datasets show that SCAM outperforms SEAN and SPADE; moreover, it sets the new state of the art on subject transfer.