Advanced diffusion models have made notable progress in text-to-image compositional generation. However, it is still a challenge for existing models to achieve text-image alignment when confronted with complex text prompts. In this work, we highlight two factors that affect this alignment: the quality of the randomly initialized noise and the reliability of the generated controlling mask. We then propose PiCo (Pick-and-Control), a novel training-free approach with two key components to tackle these two factors. First, we develop a noise selection module to assess the quality of the random noise and determine whether the noise is suitable for the target text. A fast sampling strategy is utilized to ensure efficiency in the noise selection stage. Second, we introduce a referring mask module to generate pixel-level masks and to precisely modulate the cross-attention maps. The referring mask is applied to the standard diffusion process to guide the reasonable interaction between text and image features. Extensive experiments have been conducted to verify the effectiveness of PiCo in liberating users from the tedious process of random generation and in enhancing the text-image alignment for diverse text descriptions.
We propose a robust transformer architecture designed to prevent prompt injection attacks and ensure secure, reliable response generation. Our PICO (Prompt Isolation and Cybersecurity Oversight) framework structurally separates trusted system instructions from untrusted user inputs through dual channels that are processed independently and merged only by a controlled, gated fusion mechanism. In addition, we integrate a specialized Security Expert Agent within a Mixture-of-Experts (MoE) framework and incorporate a Cybersecurity Knowledge Graph (CKG) to supply domain-specific reasoning. Our training design further ensures that the system prompt branch remains immutable while the rest of the network learns to handle adversarial inputs safely. This PICO framework is presented via a general mathematical formulation, then elaborated in terms of the specifics of transformer architecture, and fleshed out via hypothetical case studies including Policy Puppetry attacks. While the most effective implementation may involve training transformers in a PICO-based way from scratch, we also present a cost-effective fine-tuning approach.
Implicit Neural Representations (INRs), also known as neural fields, have emerged as a powerful paradigm in deep learning, parameterizing continuous spatial fields using coordinate-based neural networks. In this paper, we propose \textbf{PICO}, an INR-based framework for static point cloud compression. Unlike prevailing encoder-decoder paradigms, we decompose the point cloud compression task into two separate stages: geometry compression and attribute compression, each with distinct INR optimization objectives. Inspired by Kolmogorov-Arnold Networks (KANs), we introduce a novel network architecture, \textbf{LeAFNet}, which leverages learnable activation functions in the latent space to better approximate the target signal's implicit function. By reformulating point cloud compression as neural parameter compression, we further improve compression efficiency through quantization and entropy coding. Experimental results demonstrate that \textbf{LeAFNet} outperforms conventional MLPs in INR-based point cloud compression. Furthermore, \textbf{PICO} achieves superior geometry compression performance compared to the current MPEG point cloud compression standard, yielding an average improvement of $4.92$ dB in D1 PSNR. In joint geometry and attribute compression, our approach exhibits highly competitive results, with an average PCQM gain of $2.7 \times 10^{-3}$.
Multimodal Large Language Models (MLLMs), which integrate vision and other modalities into Large Language Models (LLMs), significantly enhance AI capabilities but also introduce new security vulnerabilities. By exploiting the vulnerabilities of the visual modality and the long-tail distribution characteristic of code training data, we present PiCo, a novel jailbreaking framework designed to progressively bypass multi-tiered defense mechanisms in advanced MLLMs. PiCo employs a tier-by-tier jailbreak strategy, using token-level typographic attacks to evade input filtering and embedding harmful intent within programming context instructions to bypass runtime monitoring. To comprehensively assess the impact of attacks, a new evaluation metric is further proposed to assess both the toxicity and helpfulness of model outputs post-attack. By embedding harmful intent within code-style visual instructions, PiCo achieves an average Attack Success Rate (ASR) of 84.13% on Gemini-Pro Vision and 52.66% on GPT-4, surpassing previous methods. Experimental results highlight the critical gaps in current defenses, underscoring the need for more robust strategies to secure advanced MLLMs.
Large Language Models (LLMs) have shown promise in natural language processing tasks, with the potential to automate systematic reviews. This study evaluates the performance of three state-of-the-art LLMs in conducting systematic review tasks. We assessed GPT-4, Claude-3, and Mistral 8x7B across four systematic review tasks: study design formulation, search strategy development, literature screening, and data extraction. Sourced from a previously published systematic review, we provided reference standard including standard PICO (Population, Intervention, Comparison, Outcome) design, standard eligibility criteria, and data from 20 reference literature. Three investigators evaluated the quality of study design and eligibility criteria using 5-point Liker Scale in terms of accuracy, integrity, relevance, consistency and overall performance. For other tasks, the output is defined as accurate if it is the same as the reference standard. Search strategy performance was evaluated through accuracy and retrieval efficacy. Screening accuracy was assessed for both abstracts screening and full texts screening. Data extraction accuracy was evaluated across 1,120 data points comprising 3,360 individual fields. Claude-3 demonstrated superior overall performance in PICO design. In search strategy formulation, GPT-4 and Claude-3 achieved comparable accuracy, outperforming Mistral. For abstract screening, GPT-4 achieved the highest accuracy, followed by Mistral and Claude-3. In data extraction, GPT-4 significantly outperformed other models. LLMs demonstrate potential for automating systematic review tasks, with GPT-4 showing superior performance in search strategy formulation, literature screening and data extraction. These capabilities make them promising assistive tools for researchers and warrant further development and validation in this field.
The generation of synthetic CT (sCT) images from cone-beam CT (CBCT) data using deep learning methodologies represents a significant advancement in radiation oncology. This systematic review, following PRISMA guidelines and using the PICO model, comprehensively evaluates the literature from 2014 to 2024 on the generation of sCT images for radiation therapy planning in oncology. A total of 35 relevant studies were identified and analyzed, revealing the prevalence of deep learning approaches in the generation of sCT. This review comprehensively covers synthetic CT generation based on CBCT and proton-based studies. Some of the commonly employed architectures explored are convolutional neural networks (CNNs), generative adversarial networks (GANs), transformers, and diffusion models. Evaluation metrics including mean absolute error (MAE), root mean square error (RMSE), peak signal-to-noise ratio (PSNR) and structural similarity index (SSIM) consistently demonstrate the comparability of sCT images with gold-standard planning CTs (pCT), indicating their potential to improve treatment precision and patient outcomes. Challenges such as field-of-view (FOV) disparities and integration into clinical workflows are discussed, along with recommendations for future research and standardization efforts. In general, the findings underscore the promising role of sCT-based approaches in personalized treatment planning and adaptive radiation therapy, with potential implications for improved oncology treatment delivery and patient care.
This paper introduces a cost-effective robotic handwriting system designed to replicate human-like handwriting with high precision. Combining a Raspberry Pi Pico microcontroller, 3D-printed components, and a machine learning-based handwriting generation model implemented via TensorFlow, the system converts user-supplied text into realistic stroke trajectories. By leveraging lightweight 3D-printed materials and efficient mechanical designs, the system achieves a total hardware cost of approximately \$56, significantly undercutting commercial alternatives. Experimental evaluations demonstrate handwriting precision within $\pm$0.3 millimeters and a writing speed of approximately 200 mm/min, positioning the system as a viable solution for educational, research, and assistive applications. This study seeks to lower the barriers to personalized handwriting technologies, making them accessible to a broader audience.
In this study, we have experimentally modelled the movement of a bee colony in a hive during the winter season and developed a monitoring system that allows tracking the movement of the bee colony and honey consumption. The monitoring system consists of four load cells connected to the RP2040 controller based on the Raspberry Pi Pico board, from which data is transmitted via the MQTT protocol to the Raspberry Pi 5 microcomputer via a Wi-Fi network. The processed data from the Raspberry Pi 5 is recorded in a MySQL database. The algorithm for finding the location of the bee colony in the hive works correctly, the trajectory of movement based on the data from the sensors repeats the physical movement in the experiment, which is an imitation of the movement of the bee colony in real conditions. The proposed monitoring system provides continuous observation of the bee colony without adversely affecting its natural activities and can be integrated with various wireless data networks. This is a promising tool for improving the efficiency of beekeeping and maintaining the health of bee colonies.
Objective: Extracting PICO elements -- Participants, Intervention, Comparison, and Outcomes -- from clinical trial literature is essential for clinical evidence retrieval, appraisal, and synthesis. Existing approaches do not distinguish the attributes of PICO entities. This study aims to develop a named entity recognition (NER) model to extract PICO entities with fine granularities. Materials and Methods: Using a corpus of 2,511 abstracts with PICO mentions from 4 public datasets, we developed a semi-supervised method to facilitate the training of a NER model, FinePICO, by combining limited annotated data of PICO entities and abundant unlabeled data. For evaluation, we divided the entire dataset into two subsets: a smaller group with annotations and a larger group without annotations. We then established the theoretical lower and upper performance bounds based on the performance of supervised learning models trained solely on the small, annotated subset and on the entire set with complete annotations, respectively. Finally, we evaluated FinePICO on both the smaller annotated subset and the larger, initially unannotated subset. We measured the performance of FinePICO using precision, recall, and F1. Results: Our method achieved precision/recall/F1 of 0.567/0.636/0.60, respectively, using a small set of annotated samples, outperforming the baseline model (F1: 0.437) by more than 16\%. The model demonstrates generalizability to a different PICO framework and to another corpus, which consistently outperforms the benchmark in diverse experimental settings (p-value \textless0.001). Conclusion: This study contributes a generalizable and effective semi-supervised approach to named entity recognition leveraging large unlabeled data together with small, annotated data. It also initially supports fine-grained PICO extraction.
Growth of the older adult population has led to an increasing interest in technology-supported aged care. However, the area has some challenges such as a lack of caregivers and limitations in understanding the emotional, social, physical, and mental well-being needs of seniors. Furthermore, there is a gap in the understanding between developers and ageing people of their requirements. Digital health can be important in supporting older adults wellbeing, emotional requirements, and social needs. Requirements Engineering (RE) is a major software engineering field, which can help to identify, elicit and prioritize the requirements of stakeholders and ensure that the systems meet standards for performance, reliability, and usability. We carried out a systematic review of the literature on RE for older adult digital health software. This was necessary to show the representatives of the current stage of understanding the needs of older adults in aged care digital health. Using established guidelines outlined by the Kitchenham method, the PRISMA and the PICO guideline, we developed a protocol, followed by the systematic exploration of eight databases. This resulted in 69 primary studies of high relevance, which were subsequently subjected to data extraction, synthesis, and reporting. We highlight key RE processes in digital health software for ageing people. It explored the utilization of technology for older user well-being and care, and the evaluations of such solutions. The review also identified key limitations found in existing primary studies that inspire future research opportunities. The results indicate that requirement gathering and understanding have a significant variation between different studies. The differences are in the quality, depth, and techniques adopted for requirement gathering and these differences are largely due to uneven adoption of RE methods.
In recent years, there has been a surge in the publication of clinical trial reports, making it challenging to conduct systematic reviews. Automatically extracting Population, Intervention, Comparator, and Outcome (PICO) from clinical trial studies can alleviate the traditionally time-consuming process of manually scrutinizing systematic reviews. Existing approaches of PICO frame extraction involves supervised approach that relies on the existence of manually annotated data points in the form of BIO label tagging. Recent approaches, such as In-Context Learning (ICL), which has been shown to be effective for a number of downstream NLP tasks, require the use of labeled examples. In this work, we adopt ICL strategy by employing the pretrained knowledge of Large Language Models (LLMs), gathered during the pretraining phase of an LLM, to automatically extract the PICO-related terminologies from clinical trial documents in unsupervised set up to bypass the availability of large number of annotated data instances. Additionally, to showcase the highest effectiveness of LLM in oracle scenario where large number of annotated samples are available, we adopt the instruction tuning strategy by employing Low Rank Adaptation (LORA) to conduct the training of gigantic model in low resource environment for the PICO frame extraction task. Our empirical results show that our proposed ICL-based framework produces comparable results on all the version of EBM-NLP datasets and the proposed instruction tuned version of our framework produces state-of-the-art results on all the different EBM-NLP datasets. Our project is available at \url{https://github.com/shrimonmuke0202/AlpaPICO.git}.
This paper describes a rapid feasibility study of using GPT-4, a large language model (LLM), to (semi)automate data extraction in systematic reviews. Despite the recent surge of interest in LLMs there is still a lack of understanding of how to design LLM-based automation tools and how to robustly evaluate their performance. During the 2023 Evidence Synthesis Hackathon we conducted two feasibility studies. Firstly, to automatically extract study characteristics from human clinical, animal, and social science domain studies. We used two studies from each category for prompt-development; and ten for evaluation. Secondly, we used the LLM to predict Participants, Interventions, Controls and Outcomes (PICOs) labelled within 100 abstracts in the EBM-NLP dataset. Overall, results indicated an accuracy of around 80%, with some variability between domains (82% for human clinical, 80% for animal, and 72% for studies of human social sciences). Causal inference methods and study design were the data extraction items with the most errors. In the PICO study, participants and intervention/control showed high accuracy (>80%), outcomes were more challenging. Evaluation was done manually; scoring methods such as BLEU and ROUGE showed limited value. We observed variability in the LLMs predictions and changes in response quality. This paper presents a template for future evaluations of LLMs in the context of data extraction for systematic review automation. Our results show that there might be value in using LLMs, for example as second or third reviewers. However, caution is advised when integrating models such as GPT-4 into tools. Further research on stability and reliability in practical settings is warranted for each type of data that is processed by the LLM.
It is especially challenging to achieve real-time human motion tracking on a standalone VR Head-Mounted Display (HMD) such as Meta Quest and PICO. In this paper, we propose HMD-Poser, the first unified approach to recover full-body motions using scalable sparse observations from HMD and body-worn IMUs. In particular, it can support a variety of input scenarios, such as HMD, HMD+2IMUs, HMD+3IMUs, etc. The scalability of inputs may accommodate users' choices for both high tracking accuracy and easy-to-wear. A lightweight temporal-spatial feature learning network is proposed in HMD-Poser to guarantee that the model runs in real-time on HMDs. Furthermore, HMD-Poser presents online body shape estimation to improve the position accuracy of body joints. Extensive experimental results on the challenging AMASS dataset show that HMD-Poser achieves new state-of-the-art results in both accuracy and real-time performance. We also build a new free-dancing motion dataset to evaluate HMD-Poser's on-device performance and investigate the performance gap between synthetic data and real-captured sensor data. Finally, we demonstrate our HMD-Poser with a real-time Avatar-driving application on a commercial HMD. Our code and free-dancing motion dataset are available https://pico-ai-team.github.io/hmd-poser
Plain language summarization with LLMs can be useful for improving textual accessibility of technical content. But how factual are these summaries in a high-stakes domain like medicine? This paper presents FactPICO, a factuality benchmark for plain language summarization of medical texts describing randomized controlled trials (RCTs), which are the basis of evidence-based medicine and can directly inform patient treatment. FactPICO consists of 345 plain language summaries of RCT abstracts generated from three LLMs (i.e., GPT-4, Llama-2, and Alpaca), with fine-grained evaluation and natural language rationales from experts. We assess the factuality of critical elements of RCTs in those summaries: Populations, Interventions, Comparators, Outcomes (PICO), as well as the reported findings concerning these. We also evaluate the correctness of the extra information (e.g., explanations) added by LLMs. Using FactPICO, we benchmark a range of existing factuality metrics, including the newly devised ones based on LLMs. We find that plain language summarization of medical evidence is still challenging, especially when balancing between simplicity and factuality, and that existing metrics correlate poorly with expert judgments on the instance level.
Existing large language models (LLMs) evaluation methods typically focus on testing the performance on some closed-environment and domain-specific benchmarks with human annotations. In this paper, we explore a novel unsupervised evaluation direction, utilizing peer-review mechanisms to measure LLMs automatically. In this setting, both open-source and closed-source LLMs lie in the same environment, capable of answering unlabeled questions and evaluating each other, where each LLM's response score is jointly determined by other anonymous ones. To obtain the ability hierarchy among these models, we assign each LLM a learnable capability parameter to adjust the final ranking. We formalize it as a constrained optimization problem, intending to maximize the consistency of each LLM's capabilities and scores. The key assumption behind is that high-level LLM can evaluate others' answers more accurately than low-level ones, while higher-level LLM can also achieve higher response scores. Moreover, we propose three metrics called PEN, CIN, and LIS to evaluate the gap in aligning human rankings. We perform experiments on multiple datasets with these metrics, validating the effectiveness of the proposed approach.
Objectives Extraction of PICO (Populations, Interventions, Comparison, and Outcomes) entities is fundamental to evidence retrieval. We present a novel method PICOX to extract overlapping PICO entities. Materials and Methods PICOX first identifies entities by assessing whether a word marks the beginning or conclusion of an entity. Then it uses a multi-label classifier to assign one or more PICO labels to a span candidate. PICOX was evaluated using one of the best-performing baselines, EBM-NLP, and three more datasets, i.e., PICO-Corpus, and RCT publications on Alzheimer's Disease or COVID-19, using entity-level precision, recall, and F1 scores. Results PICOX achieved superior precision, recall, and F1 scores across the board, with the micro F1 score improving from 45.05 to 50.87 (p << 0.01). On the PICO-Corpus, PICOX obtained higher recall and F1 scores than the baseline and improved the micro recall score from 56.66 to 67.33. On the COVID-19 dataset, PICOX also outperformed the baseline and improved the micro F1 score from 77.10 to 80.32. On the AD dataset, PICOX demonstrated comparable F1 scores with higher precision when compared to the baseline. Conclusion PICOX excels in identifying overlapping entities and consistently surpasses a leading baseline across multiple datasets. Ablation studies reveal that its data augmentation strategy effectively minimizes false positives and improves precision.
In this paper, we describe a novel turbine failsafe system designed for a pico-hydroelectric power generation. We designed and built a pico-hydroelectric system in a remote rural Himalayan village. We developed a Prioritized Load Control System (PLCS) that diverts excess electrical power to useful purposes such as heating up bath water and the air in the community center when the electrical demand from the village is low; instead of dumping the excess electricity back into the river in the form of heat. A critical part of the PLCS system is the failsafe mechanism where the turbines and electrical components on the grid are protected in case any part of the PLCS system stops functioning, possibly intermittently. Our novel failsafe system contains the following enhancements compared to previous systems: (1) adjustable threshold voltage, (2) controllable fractional power diversion with adjustable parameters, (3) automatic reset with adjustable parameters. In addition, the failsafe subsystem uses the widely available Arduino platform and programming environment, and JSON for human readable and writable communications, demonstrating their suitability for critical applications.
This paper proposes a novel three-dimensional (3D) theoretical regular-shaped geometry-based stochastic model (RS-GBSM) and the corresponding sum-of-sinusoids (SoS) simulation model for non-isotropic multiple-input multiple-output (MIMO) vehicle-to-vehicle (V2V) Ricean fading channels. The proposed RS-GBSM, combining line-of-sight (LoS) components, a two-sphere model, and an elliptic-cylinder model, has the ability to study the impact of the vehicular traffic density (VTD) on channel statistics, and jointly considers the azimuth and elevation angles by using the von Mises Fisher distribution. Moreover, a novel parameter computation method is proposed for jointly calculating the azimuth and elevation angles in the SoS channel simulator. Based on the proposed 3D theoretical RS-GBSM and its SoS simulation model, statistical properties are derived and thoroughly investigated. The impact of the elevation angle in the 3D model on key statistical properties is investigated by comparing with those of the corresponding two-dimensional (2D) model. It is demonstrated that the 3D model is more accurate to characterize real V2V channels, in particular for pico cell scenarios. Finally, close agreement is achieved between the theoretical model, SoS simulation model, and simulation results, demonstrating the utility of the proposed models.
This paper explores the significant impact of AI-based medical devices, including wearables, telemedicine, large language models, and digital twins, on clinical decision support systems. It emphasizes the importance of producing outcomes that are not only accurate but also interpretable and understandable to clinicians, addressing the risk that lack of interpretability poses in terms of mistrust and reluctance to adopt these technologies in healthcare. The paper reviews interpretable AI processes, methods, applications, and the challenges of implementation in healthcare, focusing on quality control to facilitate responsible communication between AI systems and clinicians. It breaks down the interpretability process into data pre-processing, model selection, and post-processing, aiming to foster a comprehensive understanding of the crucial role of a robust interpretability approach in healthcare and to guide future research in this area. with insights for creating responsible clinician-AI tools for healthcare, as well as to offer a deeper understanding of the challenges they might face. Our research questions, eligibility criteria and primary goals were identified using Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline and PICO method; PubMed, Scopus and Web of Science databases were systematically searched using sensitive and specific search strings. In the end, 52 publications were selected for data extraction which included 8 existing reviews and 44 related experimental studies. The paper offers general concepts of interpretable AI in healthcare and discuss three-levels interpretability process. Additionally, it provides a comprehensive discussion of evaluating robust interpretability AI in healthcare. Moreover, this survey introduces a step-by-step roadmap for implementing responsible AI in healthcare.
Medical systematic reviews can be very costly and resource intensive. We explore how Large Language Models (LLMs) can support and be trained to perform literature screening when provided with a detailed set of selection criteria. Specifically, we instruction tune LLaMA and Guanaco models to perform abstract screening for medical systematic reviews. Our best model, Bio-SIEVE, outperforms both ChatGPT and trained traditional approaches, and generalises better across medical domains. However, there remains the challenge of adapting the model to safety-first scenarios. We also explore the impact of multi-task training with Bio-SIEVE-Multi, including tasks such as PICO extraction and exclusion reasoning, but find that it is unable to match single-task Bio-SIEVE's performance. We see Bio-SIEVE as an important step towards specialising LLMs for the biomedical systematic review process and explore its future developmental opportunities. We release our models, code and a list of DOIs to reconstruct our dataset for reproducibility.