The current conditional autoregressive image generation methods have shown promising results, yet their potential remains largely unexplored in the practical unsupervised image translation domain, which operates without explicit cross-domain correspondences. A critical limitation stems from the discrete quantization inherent in traditional Vector Quantization-based frameworks, which disrupts gradient flow between the Variational Autoencoder decoder and causal Transformer, impeding end-to-end optimization during adversarial training in image space. To tackle this issue, we propose using Softmax Relaxed Quantization, a novel approach that reformulates codebook selection as a continuous probability mixing process via Softmax, thereby preserving gradient propagation. Building upon this differentiable foundation, we introduce CycleVAR, which reformulates image-to-image translation as image-conditional visual autoregressive generation by injecting multi-scale source image tokens as contextual prompts, analogous to prefix-based conditioning in language models. CycleVAR exploits two modes to generate the target image tokens, including (1) serial multi-step generation, enabling iterative refinement across scales, and (2) parallel one-step generation synthesizing all resolution outputs in a single forward pass. Experimental findings indicate that the parallel one-step generation mode attains superior translation quality with quicker inference speed than the serial multi-step mode in unsupervised scenarios. Furthermore, both quantitative and qualitative results indicate that CycleVAR surpasses previous state-of-the-art unsupervised image translation models, \textit{e}.\textit{g}., CycleGAN-Turbo.
The overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cells is a key driver of HER2-positive breast cancer, a highly aggressive subtype requiring precise diagnosis and targeted therapy. Immunohistochemistry (IHC) is the standard technique for HER2 assessment but is costly, labor-intensive, and highly dependent on antibody selection. In contrast, hematoxylin and eosin (H&E) staining, a routine histopathological procedure, offers broader accessibility but lacks HER2 specificity. This study proposes an advanced deep learning-based image translation framework to generate highfidelity IHC images from H&E-stained tissue samples, enabling cost-effective and scalable HER2 assessment. By modifying the loss function of pyramid pix2pix, we mitigate mode collapse, a fundamental limitation in generative adversarial networks (GANs), and introduce a novel variance-based penalty that enforces structural diversity in generated images. Our model particularly excels in translating HER2-positive (IHC 3+) images, which have remained challenging for existing methods due to their complex morphological variations. Extensive evaluations on the BCI histopathological dataset demonstrate that our model surpasses state-of-the-art methods in terms of peak signal-tonoise ratio (PSNR), structural similarity index (SSIM), and Frechet Inception Distance (FID), particularly in accurately translating HER2-positive (IHC 3+) images. Beyond medical imaging, our model exhibits superior performance in general image-to-image translation tasks, showcasing its potential across multiple domains. This work marks a significant step toward AI-driven precision oncology, offering a reliable and efficient alternative to traditional HER2 diagnostics.
Autonomous systems rely on sensors to estimate the environment around them. However, cameras, LiDARs, and RADARs have their own limitations. In nighttime or degraded environments such as fog, mist, or dust, thermal cameras can provide valuable information regarding the presence of objects of interest due to their heat signature. They make it easy to identify humans and vehicles that are usually at higher temperatures compared to their surroundings. In this paper, we focus on the adaptation of thermal cameras for robotics and automation, where the biggest hurdle is the lack of data. Several multi-modal datasets are available for driving robotics research in tasks such as scene segmentation, object detection, and depth estimation, which are the cornerstone of autonomous systems. However, they are found to be lacking in thermal imagery. Our paper proposes a solution to augment these datasets with synthetic thermal data to enable widespread and rapid adaptation of thermal cameras. We explore the use of conditional diffusion models to convert existing RGB images to thermal images using self-attention to learn the thermal properties of real-world objects.
Prioritizing methane for near-term climate action is crucial due to its significant impact on global warming. Previous work used columnwise matched filter products from the airborne AVIRIS-NG imaging spectrometer to detect methane plume sources; convolutional neural networks (CNNs) discerned anthropogenic methane plumes from false positive enhancements. However, as an increasing number of remote sensing platforms are used for methane plume detection, there is a growing need to address cross-platform alignment. In this work, we describe model- and data-driven machine learning approaches that leverage airborne observations to improve spaceborne methane plume detection, reconciling the distributional shifts inherent with performing the same task across platforms. We develop a spaceborne methane plume classifier using data from the EMIT imaging spectroscopy mission. We refine classifiers trained on airborne imagery from AVIRIS-NG campaigns using transfer learning, outperforming the standalone spaceborne model. Finally, we use CycleGAN, an unsupervised image-to-image translation technique, to align the data distributions between airborne and spaceborne contexts. Translating spaceborne EMIT data to the airborne AVIRIS-NG domain using CycleGAN and applying airborne classifiers directly yields the best plume detection results. This methodology is useful not only for data simulation, but also for direct data alignment. Though demonstrated on the task of methane plume detection, our work more broadly demonstrates a data-driven approach to align related products obtained from distinct remote sensing instruments.
Segmentation of nuclei regions from histological images enables morphometric analysis of nuclei structures, which in turn helps in the detection and diagnosis of diseases under consideration. To develop a nuclei segmentation algorithm, applicable to different types of target domain representations, image-to-image translation networks can be considered as they are invariant to target domain image representations. One of the important issues with image-to-image translation models is that they fail miserably when the information content between two image domains are asymmetric in nature. In this regard, the paper introduces a new deep generative model for segmenting nuclei structures from histological images. The proposed model considers an embedding space for handling information-disparity between information-rich histological image space and information-poor segmentation map domain. Integrating judiciously the concepts of optimal transport and measure theory, the model develops an invertible generator, which provides an efficient optimization framework with lower network complexity. The concept of invertible generator automatically eliminates the need of any explicit cycle-consistency loss. The proposed model also introduces a spatially-constrained squeeze operation within the framework of invertible generator to maintain spatial continuity within the image patches. The model provides a better trade-off between network complexity and model performance compared to other existing models having complex network architectures. The performance of the proposed deep generative model, along with a comparison with state-of-the-art nuclei segmentation methods, is demonstrated on publicly available histological image data sets.
Large aperture ground based solar telescopes allow the solar atmosphere to be resolved in unprecedented detail. However, observations are limited by Earths turbulent atmosphere, requiring post image corrections. Current reconstruction methods using short exposure bursts face challenges with strong turbulence and high computational costs. We introduce a deep learning approach that reconstructs 100 short exposure images into one high quality image in real time. Using unpaired image to image translation, our model is trained on degraded bursts with speckle reconstructions as references, improving robustness and generalization. Our method shows an improved robustness in terms of perceptual quality, especially when speckle reconstructions show artifacts. An evaluation with a varying number of images per burst demonstrates that our method makes efficient use of the combined image information and achieves the best reconstructions when provided with the full image burst.
Historical maps offer an invaluable perspective into territory evolution across past centuries--long before satellite or remote sensing technologies existed. Deep learning methods have shown promising results in segmenting historical maps, but publicly available datasets typically focus on a single map type or period, require extensive and costly annotations, and are not suited for nationwide, long-term analyses. In this paper, we introduce a new dataset of historical maps tailored for analyzing large-scale, long-term land use and land cover evolution with limited annotations. Spanning metropolitan France (548,305 km^2), our dataset contains three map collections from the 18th, 19th, and 20th centuries. We provide both comprehensive modern labels and 22,878 km^2 of manually annotated historical labels for the 18th and 19th century maps. Our dataset illustrates the complexity of the segmentation task, featuring stylistic inconsistencies, interpretive ambiguities, and significant landscape changes (e.g., marshlands disappearing in favor of forests). We assess the difficulty of these challenges by benchmarking three approaches: a fully-supervised model trained with historical labels, and two weakly-supervised models that rely only on modern annotations. The latter either use the modern labels directly or first perform image-to-image translation to address the stylistic gap between historical and contemporary maps. Finally, we discuss how these methods can support long-term environment monitoring, offering insights into centuries of landscape transformation. Our official project repository is publicly available at https://github.com/Archiel19/FRAx4.git.
Image editing is an important task in computer graphics, vision, and VFX, with recent diffusion-based methods achieving fast and high-quality results. However, edits requiring significant structural changes, such as non-rigid deformations, object modifications, or content generation, remain challenging. Existing few step editing approaches produce artifacts such as irrelevant texture or struggle to preserve key attributes of the source image (e.g., pose). We introduce Cora, a novel editing framework that addresses these limitations by introducing correspondence-aware noise correction and interpolated attention maps. Our method aligns textures and structures between the source and target images through semantic correspondence, enabling accurate texture transfer while generating new content when necessary. Cora offers control over the balance between content generation and preservation. Extensive experiments demonstrate that, quantitatively and qualitatively, Cora excels in maintaining structure, textures, and identity across diverse edits, including pose changes, object addition, and texture refinements. User studies confirm that Cora delivers superior results, outperforming alternatives.
This work introduces Ui2i, a novel model for unpaired image-to-image translation, trained on content-wise unpaired datasets to enable style transfer across domains while preserving content. Building on CycleGAN, Ui2i incorporates key modifications to better disentangle content and style features, and preserve content integrity. Specifically, Ui2i employs U-Net-based generators with skip connections to propagate localized shallow features deep into the generator. Ui2i removes feature-based normalization layers from all modules and replaces them with approximate bidirectional spectral normalization -- a parameter-based alternative that enhances training stability. To further support content preservation, channel and spatial attention mechanisms are integrated into the generators. Training is facilitated through image scale augmentation. Evaluation on two biomedical tasks -- domain adaptation for nuclear segmentation in immunohistochemistry (IHC) images and unmixing of biological structures superimposed in single-channel immunofluorescence (IF) images -- demonstrates Ui2i's ability to preserve content fidelity in settings that demand more accurate structural preservation than typical translation tasks. To the best of our knowledge, Ui2i is the first approach capable of separating superimposed signals in IF images using real, unpaired training data.
Image-to-image translation aims to learn a mapping between a source and a target domain, enabling tasks such as style transfer, appearance transformation, and domain adaptation. In this work, we explore a diffusion-based framework for image-to-image translation by adapting Diffusion Transformers (DiT), which combine the denoising capabilities of diffusion models with the global modeling power of transformers. To guide the translation process, we condition the model on image embeddings extracted from a pre-trained CLIP encoder, allowing for fine-grained and structurally consistent translations without relying on text or class labels. We incorporate both a CLIP similarity loss to enforce semantic consistency and an LPIPS perceptual loss to enhance visual fidelity during training. We validate our approach on two benchmark datasets: face2comics, which translates real human faces to comic-style illustrations, and edges2shoes, which translates edge maps to realistic shoe images. Experimental results demonstrate that DiT, combined with CLIP-based conditioning and perceptual similarity objectives, achieves high-quality, semantically faithful translations, offering a promising alternative to GAN-based models for paired image-to-image translation tasks.
Machine learning (ML) models rely heavily on consistent and accurate performance metrics to evaluate and compare their effectiveness. However, existing libraries often suffer from fragmentation, inconsistent implementations, and insufficient data validation protocols, leading to unreliable results. Existing libraries have often been developed independently and without adherence to a unified standard, particularly concerning the specific tasks they aim to support. As a result, each library tends to adopt its conventions for metric computation, input/output formatting, error handling, and data validation protocols. This lack of standardization leads to both implementation differences (ID) and reporting differences (RD), making it difficult to compare results across frameworks or ensure reliable evaluations. To address these issues, we introduce AllMetrics, an open-source unified Python library designed to standardize metric evaluation across diverse ML tasks, including regression, classification, clustering, segmentation, and image-to-image translation. The library implements class-specific reporting for multi-class tasks through configurable parameters to cover all use cases, while incorporating task-specific parameters to resolve metric computation discrepancies across implementations. Various datasets from domains like healthcare, finance, and real estate were applied to our library and compared with Python, Matlab, and R components to identify which yield similar results. AllMetrics combines a modular Application Programming Interface (API) with robust input validation mechanisms to ensure reproducibility and reliability in model evaluation. This paper presents the design principles, architectural components, and empirical analyses demonstrating the ability to mitigate evaluation errors and to enhance the trustworthiness of ML workflows.
Image to image translation is an active area of research in the field of computer vision, enabling the generation of new images with different styles, textures, or resolutions while preserving their characteristic properties. Recent architectures leverage Generative Adversarial Networks (GANs) to transform input images from one domain to another. In this work, we focus on the study of both paired and unpaired image translation across multiple image domains. For the paired task, we used a conditional GAN model, and for the unpaired task, we trained it using cycle consistency loss. We experimented with different types of loss functions, multiple Patch-GAN sizes, and model architectures. New quantitative metrics - precision, recall, and FID score - were used for analysis. In addition, a qualitative study of the results of different experiments was conducted.
Accurately estimating the refractive environment over multiple frequencies within the marine atmospheric boundary layer is crucial for the effective deployment of radar technologies. Traditional parabolic equation simulations, while effective, can be computationally expensive and time-intensive, limiting their practical application. This communication explores a novel approach using deep neural networks to estimate the pattern propagation factor, a critical parameter for characterizing environmental impacts on signal propagation. Image-to-image translation generators designed to ingest modified refractivity data and generate predictions of pattern propagation factors over the same domain were developed. Findings demonstrate that deep neural networks can be trained to analyze multiple frequencies and reasonably predict the pattern propagation factor, offering an alternative to traditional methods.
Comprehensive assessment of the various aspects of the brain's microstructure requires the use of complementary imaging techniques. This includes measuring the spatial distribution of cell bodies (cytoarchitecture) and nerve fibers (myeloarchitecture). The gold standard for cytoarchitectonic analysis is light microscopic imaging of cell-body stained tissue sections. To reveal the 3D orientations of nerve fibers, 3D Polarized Light Imaging (3D-PLI) has been introduced as a reliable technique providing a resolution in the micrometer range while allowing processing of series of complete brain sections. 3D-PLI acquisition is label-free and allows subsequent staining of sections after measurement. By post-staining for cell bodies, a direct link between fiber- and cytoarchitecture can potentially be established within the same section. However, inevitable distortions introduced during the staining process make a nonlinear and cross-modal registration necessary in order to study the detailed relationships between cells and fibers in the images. In addition, the complexity of processing histological sections for post-staining only allows for a limited number of samples. In this work, we take advantage of deep learning methods for image-to-image translation to generate a virtual staining of 3D-PLI that is spatially aligned at the cellular level. In a supervised setting, we build on a unique dataset of brain sections, to which Cresyl violet staining has been applied after 3D-PLI measurement. To ensure high correspondence between both modalities, we address the misalignment of training data using Fourier-based registration methods. In this way, registration can be efficiently calculated during training for local image patches of target and predicted staining. We demonstrate that the proposed method enables prediction of a Cresyl violet staining from 3D-PLI, matching individual cell instances.
Histopathological analysis is a cornerstone of cancer diagnosis, with Hematoxylin and Eosin (H&E) staining routinely acquired for every patient to visualize cell morphology and tissue architecture. On the other hand, multiplex immunofluorescence (mIF) enables more precise cell type identification via proteomic markers, but has yet to achieve widespread clinical adoption due to cost and logistical constraints. To bridge this gap, we introduce MIPHEI (Multiplex Immunofluorescence Prediction from H&E), a U-Net-inspired architecture that integrates state-of-the-art ViT foundation models as encoders to predict mIF signals from H&E images. MIPHEI targets a comprehensive panel of markers spanning nuclear content, immune lineages (T cells, B cells, myeloid), epithelium, stroma, vasculature, and proliferation. We train our model using the publicly available ORION dataset of restained H&E and mIF images from colorectal cancer tissue, and validate it on two independent datasets. MIPHEI achieves accurate cell-type classification from H&E alone, with F1 scores of 0.88 for Pan-CK, 0.57 for CD3e, 0.56 for SMA, 0.36 for CD68, and 0.30 for CD20, substantially outperforming both a state-of-the-art baseline and a random classifier for most markers. Our results indicate that our model effectively captures the complex relationships between nuclear morphologies in their tissue context, as visible in H&E images and molecular markers defining specific cell types. MIPHEI offers a promising step toward enabling cell-type-aware analysis of large-scale H&E datasets, in view of uncovering relationships between spatial cellular organization and patient outcomes.
Collecting large-scale crop disease images in the field is labor-intensive and time-consuming. Generative models (GMs) offer an alternative by creating synthetic samples that resemble real-world images. However, existing research primarily relies on Generative Adversarial Networks (GANs)-based image-to-image translation and lack a comprehensive analysis of computational requirements in agriculture. Therefore, this research explores a multi-modal text-to-image approach for generating synthetic crop disease images and is the first to provide computational benchmarking in this context. We trained three Stable Diffusion (SD) variants-SDXL, SD3.5M (medium), and SD3.5L (large)-and fine-tuned them using Dreambooth and Low-Rank Adaptation (LoRA) fine-tuning techniques to enhance generalization. SD3.5M outperformed the others, with an average memory usage of 18 GB, power consumption of 180 W, and total energy use of 1.02 kWh/500 images (0.002 kWh per image) during inference task. Our results demonstrate SD3.5M's ability to generate 500 synthetic images from just 36 in-field samples in 1.5 hours. We recommend SD3.5M for efficient crop disease data generation.
This study presents a novel approach to enhance the cost-to-quality ratio of image generation with diffusion models. We hypothesize that differences between distilled (e.g. FLUX.1-schnell) and baseline (e.g. FLUX.1-dev) models are consistent and, therefore, learnable within a specialized domain, like portrait generation. We generate a synthetic paired dataset and train a fast image-to-image translation head. Using two sets of low- and high-quality synthetic images, our model is trained to refine the output of a distilled generator (e.g., FLUX.1-schnell) to a level comparable to a baseline model like FLUX.1-dev, which is more computationally intensive. Our results show that the pipeline, which combines a distilled version of a large generative model with our enhancement layer, delivers similar photorealistic portraits to the baseline version with up to an 82% decrease in computational cost compared to FLUX.1-dev. This study demonstrates the potential for improving the efficiency of AI solutions involving large-scale image generation.
Although recent deep learning-based algorithms have achieved significant performance improvements in various image enhancement tasks, most approaches have been developed using image-to-image translation, which is challenging to interpret and analyze the enhancement processes. Several attempts have been made to use the image-to-transformation function approach for better interpretability; however, they often fail to generate complex color mappings, degrading image quality. In this work, we develop a novel transformation function-based algorithm that estimates multiple transformation functions with different properties by exploiting both the spatial and statistical characteristics of the input image to describe complex color mapping. First, we extract the image features that capture spatial information, considering their channel correlations. Next, we estimate multiple transformation functions utilizing a cross-attention block to capture the relevance between spatial and statistical information in the input image and its histogram, respectively. We then estimate the weight maps indicating the pixel-wise contribution of each transformation function by exploiting the spatial correlation between the input and transformed images obtained by each transformation function. Finally, we obtain an enhanced image by taking the weighted sum of the transformed images and the corresponding weight maps. Experimental results demonstrate that the proposed algorithm outperforms state-of-the-art algorithms on various image enhancement tasks.
Healthy urban forests comprising of diverse trees and shrubs play a crucial role in mitigating climate change. They provide several key advantages such as providing shade for energy conservation, and intercepting rainfall to reduce flood runoff and soil erosion. Traditional approaches for monitoring the health of urban forests require instrumented inspection techniques, often involving a high amount of human labor and subjective evaluations. As a result, they are not scalable for cities which lack extensive resources. Recent approaches involving multi-spectral imaging data based on terrestrial sensing and satellites, are constrained respectively with challenges related to dedicated deployments and limited spatial resolutions. In this work, we propose an alternative approach for monitoring the urban forests using simplified inputs: street view imagery, tree inventory data and meteorological conditions. We propose to use image-to-image translation networks to estimate two urban forest health parameters, namely, NDVI and CTD. Finally, we aim to compare the generated results with ground truth data using an onsite campaign utilizing handheld multi-spectral and thermal imaging sensors. With the advent and expansion of street view imagery platforms such as Google Street View and Mapillary, this approach should enable effective management of urban forests for the authorities in cities at scale.
Multimodal remote sensing image registration aligns images from different sensors for data fusion and analysis. However, current methods often fail to extract modality-invariant features when aligning image pairs with large nonlinear radiometric differences. To address this issues, we propose OSDM-MReg, a novel multimodal image registration framework based image-to-image translation to eliminate the gap of multimodal images. Firstly, we propose a novel one-step unaligned target-guided conditional denoising diffusion probabilistic models(UTGOS-CDDPM)to translate multimodal images into a unified domain. In the inference stage, traditional conditional DDPM generate translated source image by a large number of iterations, which severely slows down the image registration task. To address this issues, we use the unaligned traget image as a condition to promote the generation of low-frequency features of the translated source image. Furthermore, during the training stage, we add the inverse process of directly predicting the translated image to ensure that the translated source image can be generated in one step during the testing stage. Additionally, to supervised the detail features of translated source image, we propose a new perceptual loss that focuses on the high-frequency feature differences between the translated and ground-truth images. Finally, a multimodal multiscale image registration network (MM-Reg) fuse the multimodal feature of the unimodal images and multimodal images by proposed multimodal feature fusion strategy. Experiments demonstrate superior accuracy and efficiency across various multimodal registration tasks, particularly for SAR-optical image pairs.