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arXiv:1812.00475 등록 2018-12-02

Multiple Instance Learning for ECG Risk Stratification

Patients who suffer an acute coronary syndrome are at elevated risk for adverse cardiovascular events such as myocardial infarction and cardiovascular death. Accurate assessment of this risk is crucial to their course of care. We focus on estimating a patient's risk of cardiovascular death after an acute coronary syndrome based on a patient's raw electrocardiogram (ECG) signal. Learning from this signal is challenging for two reasons: 1) positive examples signifying a downstream cardiovascular event are scarce, causing drastic class imbalance, and 2) each patient's ECG signal consists of thousands of heartbeats, accompanied by a single label for the downstream outcome. Machine learning has been previously applied to this task, but most approaches rely on hand-crafted features and domain knowledge. We propose a method that learns a representation from the raw ECG signal by using a multiple instance learning framework. We present a learned risk score for cardiovascular death that outperforms existing risk metrics in predicting cardiovascular death within 30, 60, 90, and 365 days on a dataset of 5000 patients.

arXiv 원문 상세

arXiv:1806.11078 등록 2018-06-28

A probabilistic constrained clustering for transfer learning and image category discovery

Neural network-based clustering has recently gained popularity, and in particular a constrained clustering formulation has been proposed to perform transfer learning and image category discovery using deep learning. The core idea is to formulate a clustering objective with pairwise constraints that can be used to train a deep clustering network; therefore the cluster assignments and their underlying feature representations are jointly optimized end-to-end. In this work, we provide a novel clustering formulation to address scalability issues of previous work in terms of optimizing deeper networks and larger amounts of categories. The proposed objective directly minimizes the negative log-likelihood of cluster assignment with respect to the pairwise constraints, has no hyper-parameters, and demonstrates improved scalability and performance on both supervised learning and unsupervised transfer learning.

arXiv 원문 상세