Machine Learning (ML) is used to tackle various tasks, such as disease classification and prediction. The effectiveness of ML models relies heavily on having large amounts of complete data. However, healthcare data is often limited or incomplete, which can hinder model performance. Additionally, issues like the trustworthiness of solutions vary with the datasets used. The lack of transparency in some ML models further complicates their understanding and use. In healthcare, particularly in the case of Age-related Macular Degeneration (AMD), which affects millions of older adults, early diagnosis is crucial due to the absence of effective treatments for reversing progression. Diagnosing AMD involves assessing retinal images along with patients' symptom reports. There is a need for classification approaches that consider genetic, dietary, clinical, and demographic factors. Recently, we introduced the -Comprehensive Abstraction and Classification Tool for Uncovering Structures-(CACTUS), aimed at improving AMD stage classification. CACTUS offers explainability and flexibility, outperforming standard ML models. It enhances decision-making by identifying key factors and providing confidence in its results. The important features identified by CACTUS allow us to compare with existing medical knowledge. By eliminating less relevant or biased data, we created a clinical scenario for clinicians to offer feedback and address biases.
Visual image reconstruction, the decoding of perceptual content from brain activity into images, has advanced significantly with the integration of deep neural networks (DNNs) and generative models. This review traces the field's evolution from early classification approaches to sophisticated reconstructions that capture detailed, subjective visual experiences, emphasizing the roles of hierarchical latent representations, compositional strategies, and modular architectures. Despite notable progress, challenges remain, such as achieving true zero-shot generalization for unseen images and accurately modeling the complex, subjective aspects of perception. We discuss the need for diverse datasets, refined evaluation metrics aligned with human perceptual judgments, and compositional representations that strengthen model robustness and generalizability. Ethical issues, including privacy, consent, and potential misuse, are underscored as critical considerations for responsible development. Visual image reconstruction offers promising insights into neural coding and enables new psychological measurements of visual experiences, with applications spanning clinical diagnostics and brain-machine interfaces.
Hand kinematics can be measured in Human-Computer Interaction (HCI) with the intention to predict the user's intention in a reach-to-grasp action. Using multiple hand sensors, multivariate time series data are being captured. Given a number of possible actions on a number of objects, the goal is to classify the multivariate time series data, where the class shall be predicted as early as possible. Many machine-learning methods have been developed for such classification tasks, where different approaches produce favorable solutions on different data sets. We, therefore, employ an ensemble approach that includes and weights different approaches. To provide a trustworthy classification production, we present the XMTC tool that incorporates coordinated multiple-view visualizations to analyze the predictions. Temporal accuracy plots, confusion matrix heatmaps, temporal confidence heatmaps, and partial dependence plots allow for the identification of the best trade-off between early prediction and prediction quality, the detection and analysis of challenging classification conditions, and the investigation of the prediction evolution in an overview and detail manner. We employ XMTC to real-world HCI data in multiple scenarios and show that good classification predictions can be achieved early on with our classifier as well as which conditions are easy to distinguish, which multivariate time series measurements impose challenges, and which features have most impact.
Time-sensitive machine learning benefits from Sequential Probability Ratio Test (SPRT), which provides an optimal stopping time for early classification of time series. However, in finite horizon scenarios, where input lengths are finite, determining the optimal stopping rule becomes computationally intensive due to the need for backward induction, limiting practical applicability. We thus introduce FIRMBOUND, an SPRT-based framework that efficiently estimates the solution to backward induction from training data, bridging the gap between optimal stopping theory and real-world deployment. It employs density ratio estimation and convex function learning to provide statistically consistent estimators for sufficient statistic and conditional expectation, both essential for solving backward induction; consequently, FIRMBOUND minimizes Bayes risk to reach optimality. Additionally, we present a faster alternative using Gaussian process regression, which significantly reduces training time while retaining low deployment overhead, albeit with potential compromise in statistical consistency. Experiments across independent and identically distributed (i.i.d.), non-i.i.d., binary, multiclass, synthetic, and real-world datasets show that FIRMBOUND achieves optimalities in the sense of Bayes risk and speed-accuracy tradeoff. Furthermore, it advances the tradeoff boundary toward optimality when possible and reduces decision-time variance, ensuring reliable decision-making. Code is publicly available at https://github.com/Akinori-F-Ebihara/FIRMBOUND
\texttt{ml\_edm} is a Python 3 library, designed for early decision making of any learning tasks involving temporal/sequential data. The package is also modular, providing researchers an easy way to implement their own triggering strategy for classification, regression or any machine learning task. As of now, many Early Classification of Time Series (ECTS) state-of-the-art algorithms, are efficiently implemented in the library leveraging parallel computation. The syntax follows the one introduce in \texttt{scikit-learn}, making estimators and pipelines compatible with \texttt{ml\_edm}. This software is distributed over the BSD-3-Clause license, source code can be found at \url{https://github.com/ML-EDM/ml_edm}.
In many situations, the measurements of a studied phenomenon are provided sequentially, and the prediction of its class needs to be made as early as possible so as not to incur too high a time penalty, but not too early and risk paying the cost of misclassification. This problem has been particularly studied in the case of time series, and is known as Early Classification of Time Series (ECTS). Although it has been the subject of a growing body of literature, there is still a lack of a systematic, shared evaluation protocol to compare the relative merits of the various existing methods. This document begins by situating these methods within a principle-based taxonomy. It defines dimensions for organizing their evaluation, and then reports the results of a very extensive set of experiments along these dimensions involving nine state-of-the art ECTS algorithms. In addition, these and other experiments can be carried out using an open-source library in which most of the existing ECTS algorithms have been implemented (see https://github.com/ML-EDM/ml_edm).
With 95% of Internet traffic now encrypted, an effective approach to classifying this traffic is crucial for network security and management. This paper introduces ECHO -- a novel optimization process for ML/DL-based encrypted traffic classification. ECHO targets both classification time and memory utilization and incorporates two innovative techniques. The first component, HO (Hyperparameter Optimization of binnings), aims at creating efficient traffic representations. While previous research often uses representations that map packet sizes and packet arrival times to fixed-sized bins, we show that non-uniform binnings are significantly more efficient. These non-uniform binnings are derived by employing a hyperparameter optimization algorithm in the training stage. HO significantly improves accuracy given a required representation size, or, equivalently, achieves comparable accuracy using smaller representations. Then, we introduce EC (Early Classification of traffic), which enables faster classification using a cascade of classifiers adapted for different exit times, where classification is based on the level of confidence. EC reduces the average classification latency by up to 90\%. Remarkably, this method not only maintains classification accuracy but also, in certain cases, improves it. Using three publicly available datasets, we demonstrate that the combined method, Early Classification with Hyperparameter Optimization (ECHO), leads to a significant improvement in classification efficiency.
Key-value sequence data has become ubiquitous and naturally appears in a variety of real-world applications, ranging from the user-product purchasing sequences in e-commerce, to network packet sequences forwarded by routers in networking. Classifying these key-value sequences is important in many scenarios such as user profiling and malicious applications identification. In many time-sensitive scenarios, besides the requirement of classifying a key-value sequence accurately, it is also desired to classify a key-value sequence early, in order to respond fast. However, these two goals are conflicting in nature, and it is challenging to achieve them simultaneously. In this work, we formulate a novel tangled key-value sequence early classification problem, where a tangled key-value sequence is a mixture of several concurrent key-value sequences with different keys. The goal is to classify each individual key-value sequence sharing a same key both accurately and early. To address this problem, we propose a novel method, i.e., Key-Value sequence Early Co-classification (KVEC), which leverages both inner- and inter-correlations of items in a tangled key-value sequence through key correlation and value correlation to learn a better sequence representation. Meanwhile, a time-aware halting policy decides when to stop the ongoing key-value sequence and classify it based on current sequence representation. Experiments on both real-world and synthetic datasets demonstrate that our method outperforms the state-of-the-art baselines significantly. KVEC improves the prediction accuracy by up to $4.7 - 17.5\%$ under the same prediction earliness condition, and improves the harmonic mean of accuracy and earliness by up to $3.7 - 14.0\%$.
Multivariate time series data are ubiquitous in the application of machine learning to problems in the physical sciences. Chemiresistive sensor arrays are highly promising in chemical detection tasks relevant to industrial, safety, and military applications. Sensor arrays are an inherently multivariate time series data collection tool which demand rapid and accurate classification of arbitrary chemical analytes. Previous research has benchmarked data-agnostic multivariate time series classifiers across diverse multivariate time series supervised tasks in order to find general-purpose classification algorithms. To our knowledge, there has yet to be an effort to survey machine learning and time series classification approaches to chemiresistive hardware sensor arrays for the detection of chemical analytes. In addition to benchmarking existing approaches to multivariate time series classifiers, we incorporate findings from a model survey to propose the novel \textit{ChemTime} approach to sensor array classification for chemical sensing. We design experiments addressing the unique challenges of hardware sensor arrays classification including the rapid classification ability of classifiers and minimization of inference time while maintaining performance for deployed lightweight hardware sensing devices. We find that \textit{ChemTime} is uniquely positioned for the chemical sensing task by combining rapid and early classification of time series with beneficial inference and high accuracy.
Alzheimer's disease is a progressive neurological disorder characterized by cognitive impairment and memory loss. With the increasing aging population, the incidence of AD is continuously rising, making early diagnosis and intervention an urgent need. In recent years, a considerable number of teams have applied computer-aided diagnostic techniques to early classification research of AD. Most studies have utilized imaging modalities such as magnetic resonance imaging (MRI), positron emission tomography (PET), and electroencephalogram (EEG). However, there have also been studies that attempted to use other modalities as input features for the models, such as sound, posture, biomarkers, cognitive assessment scores, and their fusion. Experimental results have shown that the combination of multiple modalities often leads to better performance compared to a single modality. Therefore, this paper will focus on different modalities and their fusion, thoroughly elucidate the mechanisms of various modalities, explore which methods should be combined to better harness their utility, analyze and summarize the literature in the field of early classification of AD in recent years, in order to explore more possibilities of modality combinations.
Deep neural networks (DNNs) have been successfully applied in various fields. In DNNs, a large number of multiply-accumulate (MAC) operations are required to be performed, posing critical challenges in applying them in resource-constrained platforms, e.g., edge devices. To address this challenge, in this paper, we propose a class-based early-exit for dynamic inference. Instead of pushing DNNs to make a dynamic decision at intermediate layers, we take advantage of the learned features in these layers to exclude as many irrelevant classes as possible, so that later layers only have to determine the target class among the remaining classes. When only one class remains at a layer, this class is the corresponding classification result. Experimental results demonstrate the computational cost of DNNs in inference can be reduced significantly with the proposed early-exit technique. The codes can be found at https://github.com/HWAI-TUDa/EarlyClassExclusion.
Deep learning (DL) has been successfully applied to encrypted network traffic classification in experimental settings. However, in production use, it has been shown that a DL classifier's performance inevitably decays over time. Re-training the model on newer datasets has been shown to only partially improve its performance. Manually re-tuning the model architecture to meet the performance expectations on newer datasets is time-consuming and requires domain expertise. We propose AutoML4ETC, a novel tool to automatically design efficient and high-performing neural architectures for encrypted traffic classification. We define a novel, powerful search space tailored specifically for the early classification of encrypted traffic using packet header bytes. We show that with different search strategies over our search space, AutoML4ETC generates neural architectures that outperform the state-of-the-art encrypted traffic classifiers on several datasets, including public benchmark datasets and real-world TLS and QUIC traffic collected from the Orange mobile network. In addition to being more accurate, AutoML4ETC's architectures are significantly more efficient and lighter in terms of the number of parameters. Finally, we make AutoML4ETC publicly available for future research.
Nowadays, the deployment of deep learning models on edge devices for addressing real-world classification problems is becoming more prevalent. Moreover, there is a growing popularity in the approach of early classification, a technique that involves classifying the input data after observing only an early portion of it, aiming to achieve reduced communication and computation requirements, which are crucial parameters in edge intelligence environments. While early classification in the field of time series analysis has been broadly researched, existing solutions for multivariate time series problems primarily focus on early classification along the temporal dimension, treating the multiple input channels in a collective manner. In this study, we propose a more flexible early classification pipeline that offers a more granular consideration of input channels and extends the early classification paradigm to the channel dimension. To implement this method, we utilize reinforcement learning techniques and introduce constraints to ensure the feasibility and practicality of our objective. To validate its effectiveness, we conduct experiments using synthetic data and we also evaluate its performance on real datasets. The comprehensive results from our experiments demonstrate that, for multiple datasets, our method can enhance the early classification paradigm by achieving improved accuracy for equal input utilization.
Early exiting has become a promising approach to improving the inference efficiency of deep networks. By structuring models with multiple classifiers (exits), predictions for ``easy'' samples can be generated at earlier exits, negating the need for executing deeper layers. Current multi-exit networks typically implement linear classifiers at intermediate layers, compelling low-level features to encapsulate high-level semantics. This sub-optimal design invariably undermines the performance of later exits. In this paper, we propose Dynamic Perceiver (Dyn-Perceiver) to decouple the feature extraction procedure and the early classification task with a novel dual-branch architecture. A feature branch serves to extract image features, while a classification branch processes a latent code assigned for classification tasks. Bi-directional cross-attention layers are established to progressively fuse the information of both branches. Early exits are placed exclusively within the classification branch, thus eliminating the need for linear separability in low-level features. Dyn-Perceiver constitutes a versatile and adaptable framework that can be built upon various architectures. Experiments on image classification, action recognition, and object detection demonstrate that our method significantly improves the inference efficiency of different backbones, outperforming numerous competitive approaches across a broad range of computational budgets. Evaluation on both CPU and GPU platforms substantiate the superior practical efficiency of Dyn-Perceiver. Code is available at https://www.github.com/LeapLabTHU/Dynamic_Perceiver.
Often pieces of information are received sequentially over time. When did one collect enough such pieces to classify? Trading wait time for decision certainty leads to early classification problems that have recently gained attention as a means of adapting classification to more dynamic environments. However, so far results have been limited to unimodal sequences. In this pilot study, we expand into early classifying multimodal sequences by combining existing methods. We show our new method yields experimental AUC advantages of up to 8.7%.
Theoretically-inspired sequential density ratio estimation (SDRE) algorithms are proposed for the early classification of time series. Conventional SDRE algorithms can fail to estimate DRs precisely due to the internal overnormalization problem, which prevents the DR-based sequential algorithm, Sequential Probability Ratio Test (SPRT), from reaching its asymptotic Bayes optimality. Two novel SPRT-based algorithms, B2Bsqrt-TANDEM and TANDEMformer, are designed to avoid the overnormalization problem for precise unsupervised regression of SDRs. The two algorithms statistically significantly reduce DR estimation errors and classification errors on an artificial sequential Gaussian dataset and real datasets (SiW, UCF101, and HMDB51), respectively. The code is available at: https://github.com/Akinori-F-Ebihara/LLR_saturation_problem.
Early classification algorithms help users react faster to their machine learning model's predictions. Early warning systems in hospitals, for example, let clinicians improve their patients' outcomes by accurately predicting infections. While early classification systems are advancing rapidly, a major gap remains: existing systems do not consider irregular time series, which have uneven and often-long gaps between their observations. Such series are notoriously pervasive in impactful domains like healthcare. We bridge this gap and study early classification of irregular time series, a new setting for early classifiers that opens doors to more real-world problems. Our solution, Stop&Hop, uses a continuous-time recurrent network to model ongoing irregular time series in real time, while an irregularity-aware halting policy, trained with reinforcement learning, predicts when to stop and classify the streaming series. By taking real-valued step sizes, the halting policy flexibly decides exactly when to stop ongoing series in real time. This way, Stop&Hop seamlessly integrates information contained in the timing of observations, a new and vital source for early classification in this setting, with the time series values to provide early classifications for irregular time series. Using four synthetic and three real-world datasets, we demonstrate that Stop&Hop consistently makes earlier and more-accurate predictions than state-of-the-art alternatives adapted to this new problem. Our code is publicly available at https://github.com/thartvigsen/StopAndHop.
In numerous applications, for instance in predictive maintenance, there is a pression to predict events ahead of time with as much accuracy as possible while not delaying the decision unduly. This translates in the optimization of a trade-off between earliness and accuracy of the decisions, that has been the subject of research for time series of finite length and with a unique label. And this has led to powerful algorithms for Early Classification of Time Series (ECTS). This paper, for the first time, investigates such a trade-off when events of different classes occur in a streaming fashion, with no predefined end. In the Early Classification in Open Time Series problem (ECOTS), the task is to predict events, i.e. their class and time interval, at the moment that optimizes the accuracy vs. earliness trade-off. Interestingly, we find that ECTS algorithms can be sensibly adapted in a principled way to this new problem. We illustrate our methodology by transforming two state-of-the-art ECTS algorithms for the ECOTS scenario. Among the wide variety of applications that this new approach opens up, we develop a predictive maintenance use case that optimizes alarm triggering times, thus demonstrating the power of this new approach.
In astronomical surveys, such as the Zwicky Transient Facility, supernovae (SNe) are relatively uncommon objects compared to other classes of variable events. Along with this scarcity, the processing of multi-band light-curves is a challenging task due to the highly irregular cadence, long time gaps, missing-values, few observations, etc. These issues are particularly detrimental to the analysis of transient events: SN-like light-curves. We offer three main contributions: 1) Based on temporal modulation and attention mechanisms, we propose a Deep attention model (TimeModAttn) to classify multi-band light-curves of different SN types, avoiding photometric or hand-crafted feature computations, missing-value assumptions, and explicit imputation/interpolation methods. 2) We propose a model for the synthetic generation of SN multi-band light-curves based on the Supernova Parametric Model, allowing us to increase the number of samples and the diversity of cadence. Thus, the TimeModAttn model is first pre-trained using synthetic light-curves. Then, a fine-tuning process is performed. The TimeModAttn model outperformed other Deep Learning models, based on Recurrent Neural Networks, in two scenarios: late-classification and early-classification. Also, the TimeModAttn model outperformed a Balanced Random Forest (BRF) classifier (trained with real data), increasing the balanced-$F_1$score from $\approx.525$ to $\approx.596$. When training the BRF with synthetic data, this model achieved similar performance to the TimeModAttn model proposed while still maintaining extra advantages. 3) We conducted interpretability experiments. High attention scores were obtained for observations earlier than and close to the SN brightness peaks. This also correlated with an early highly variability of the learned temporal modulation.
In recent years, deep learning has successfully been applied to automate a wide variety of tasks in diagnostic histopathology. However, fast and reliable localization of small-scale regions-of-interest (ROI) has remained a key challenge, as discriminative morphologic features often occupy only a small fraction of a gigapixel-scale whole-slide image (WSI). In this paper, we propose a sparse WSI analysis method for the rapid identification of high-power ROI for WSI-level classification. We develop an evaluation framework inspired by the early classification literature, in order to quantify the tradeoff between diagnostic performance and inference time for sparse analytic approaches. We test our method on a common but time-consuming task in pathology - that of diagnosing gastric intestinal metaplasia (GIM) on hematoxylin and eosin (H&E)-stained slides from endoscopic biopsy specimens. GIM is a well-known precursor lesion along the pathway to development of gastric cancer. We performed a thorough evaluation of the performance and inference time of our approach on a test set of GIM-positive and GIM-negative WSI, finding that our method successfully detects GIM in all positive WSI, with a WSI-level classification area under the receiver operating characteristic curve (AUC) of 0.98 and an average precision (AP) of 0.95. Furthermore, we show that our method can attain these metrics in under one minute on a standard CPU. Our results are applicable toward the goal of developing neural networks that can easily be deployed in clinical settings to support pathologists in quickly localizing and diagnosing small-scale morphologic features in WSI.