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arXiv:2406.16715v4cs.LG공식 코드 · Papers with Code

GC4NC: A Benchmark Framework for Graph Condensation on Node Classification with New Insights

Graph condensation (GC) is an emerging technique designed to learn a significantly smaller graph that retains the essential information of the original graph. This condensed graph has shown promise in accelerating graph neural networks while preserving performance comparable to those achieved with the original, larger graphs. Additionally, this technique facilitates downstream applications like neural architecture search and deepens our understanding of redundancies in large graphs. Despite the rapid development of GC methods, particularly for node classification, a unified evaluation framework is still lacking to systematically compare different GC methods or clarify key design choices for improving their effectiveness. To bridge these gaps, we introduce \textbf{GC4NC}, a comprehensive framework for evaluating diverse GC methods on node classification across multiple dimensions including performance, efficiency, privacy preservation, denoising ability, NAS effectiveness, and transferability. Our systematic evaluation offers novel insights into how condensed graphs behave and the critical design choices that drive their success. These findings pave the way for future advancements in GC methods, enhancing both performance and expanding their real-world applications. Our code is available at https://github.com/Emory-Melody/GraphSlim/tree/main/benchmark.

arXiv:2505.12074v3cs.CV

Denoising Mutual Knowledge Distillation in Bi-Directional Multiple Instance Learning

Multiple Instance Learning is the predominant method for Whole Slide Image classification in digital pathology, enabling the use of slide-level labels to supervise model training. Although MIL eliminates the tedious fine-grained annotation process for supervised learning, whether it can learn accurate bag- and instance-level classifiers remains a question. To address the issue, instance-level classifiers and instance masks were incorporated to ground the prediction on supporting patches. These methods, while practically improving the performance of MIL methods, may potentially introduce noisy labels. We propose to bridge the gap between commonly used MIL and fully supervised learning by augmenting both the bag- and instance-level learning processes with pseudo-label correction capabilities elicited from weak to strong generalization techniques. The proposed algorithm improves the performance of dual-level MIL algorithms on both bag- and instance-level predictions. Experiments on public pathology datasets showcase the advantage of the proposed methods.

arXiv:2411.09181v2cs.IR

Time Will Tell: Harness Time to Denoise Collaborative Filtering

Neural graph collaborative filtering is a powerful tool for recommendation due to its superb capability of capturing the user-item interaction. Despite the substantial progress, the noisy nature of interaction data remains a significant challenge in collaborative filtering, especially for data collected from implicit feedback. Both noisy interactions and interactions crafted by malicious users could greatly degenerate model performance. To purify the input data and enhance model robustness, it is vital to understand how noisy interactions can be identified and rectified. Existing denoising methods focus on mining the correlation between user/item embeddings and noisy interactions, neglecting the temporal dimension for denoising. However, time information bears its natural and unique advantage in revealing noisy edges as we observe in this paper. In this work, we introduce a simple yet effective mechanism for generating time-aware user/item embeddings that capture both global preferences and temporal patterns. Two strategies, reweighting adjacency matrix (Tint-A) and reweighting loss function (Tint-L), are proposed to leverage the embeddings for the task of using \underline{t}ime \underline{in}forma\underline{t}ion to denoise \underline{c}ollaborative \underline{f}iltering (TintCF). Extensive experiments have been conducted on four real-world datasets to demonstrate the efficacy of our methods and illustrate how time information indeed helps identify and rectify noisy edges. Our codes are available at \href{https://github.com/xinyuu-he/TintCF}{https://github.com/xinyuu-he/TintCF}.

arXiv:2506.04467v2physics.med-ph

Generalizable dose denoising using diffusion transformer framework for pencil beam scanning proton therapy

Background and purpose: Intensity-modulated proton therapy (IMPT) enables conformal dose delivery for head and neck (H&N) cancers. However, its sensitivity to inter-fractional anatomical changes motivates online adaptations, where rapid and accurate Monte Carlo (MC) dose calculation remains a major bottleneck. Low-statistics MC simulations reduce computation time but introduce noise. This study aimed to develop a diffusion-transformer framework to recover high-statistics dose distributions from noisy MC simulations. Materials and methods: A diffusion-transformer-based dose denoising framework was developed. Eighty H&N patients were used for training and additional 10 H&N patients and 30 patients with lung, breast, and prostate cancers (10 per site) were used for evaluation. Noisy and high-statistics dose maps were generated using MCsquare. The model was trained using noisy dose maps and CT images as inputs and high-statistics dose maps as ground truth, with mean squared error, residual, regional mean absolute error (MAE), and dose-volume histogram (DVH) losses. Performance was evaluated using MAE, 3D gamma passing rates, and DVH indices. Results: Mean whole-body MAE ranged from 0.08 +/- 0.06 to 0.20 +/- 0.11 Gy (Relative Biological Effectiveness, RBE) (RBE = 1.1) across test cohorts. Mean whole-body 3 %/2 mm gamma passing rates ranged from 95.8 +/- 0.8 % to 97.6 +/- 0.9 %. DVH indices from high-statistics and predicted dose distributions showed close agreement for clinical target volumes and organs of interest. Conclusions: The diffusion-transformer-based framework denoised low-statistics MC dose distributions. Despite being trained on H&N data, the model generalized to lung, breast, and prostate cohorts without retraining.

arXiv:2503.06684v4cs.CV

PixelPonder: Dynamic Patch Adaptation for Enhanced Multi-Conditional Text-to-Image Generation

Recent advances in diffusion-based text-to-image generation have demonstrated promising results through visual condition control. However, existing ControlNet-like methods struggle with compositional visual conditioning - simultaneously preserving semantic fidelity across multiple heterogeneous control signals while maintaining high visual quality, where they employ separate control branches that often introduce conflicting guidance during the denoising process, leading to structural distortions and artifacts in generated images. To address this issue, we present PixelPonder, a novel unified control framework, which allows for effective control of multiple visual conditions under a single control structure. Specifically, we design a patch-level adaptive condition selection mechanism that dynamically prioritizes spatially relevant control signals at the sub-region level, enabling precise local guidance without global interference. Additionally, a time-aware control injection scheme is deployed to modulate condition influence according to denoising timesteps, progressively transitioning from structural preservation to texture refinement and fully utilizing the control information from different categories to promote more harmonious image generation. Extensive experiments demonstrate that PixelPonder surpasses previous methods across different benchmark datasets, showing superior improvement in spatial alignment accuracy while maintaining high textual semantic consistency.

arXiv:2409.16052v3hep-ex공식 코드 · Papers with Code

Denoising Graph Super-Resolution towards Improved Collider Event Reconstruction

In preparation for Higgs factories and energy-frontier facilities, future colliders are moving toward high-granularity calorimeters to improve reconstruction quality. However, the cost and construction complexity of such detectors is substantial, making software-based approaches like superresolution an attractive complementary tool. This study explores integrating superresolution techniques into an LHC-like reconstruction pipeline to effectively enhance calorimeter granularity and suppress noise. We find that this software preprocessing step significantly improves reconstruction quality at fixed detector granularity, narrowing the performance gap to a finer calorimeter without closing it. To demonstrate its impact, we propose a novel transformer-based particle-flow model that offers improved particle reconstruction quality and interpretability. Our results serve as a proof of concept, demonstrating the potential of superresolution to enhance reconstruction in collider environments.

arXiv:2505.21441

Autoencoding Random Forests

We propose a principled method for autoencoding with random forests. Our strategy builds on foundational results from nonparametric statistics and spectral graph theory to learn a low-dimensional embedding of the model that optimally represents relationships in the data. We provide exact and approximate solutions to the decoding problem via constrained optimization, split relabeling, and nearest neighbors regression. These methods effectively invert the compression pipeline, establishing a map from the embedding space back to the input space using splits learned by the ensemble's constituent trees. The resulting decoders are universally consistent under common regularity assumptions. The procedure works with supervised or unsupervised models, providing a window into conditional or joint distributions. We demonstrate various applications of this autoencoder, including powerful new tools for visualization, compression, clustering, and denoising. Experiments illustrate the ease and utility of our method in a wide range of settings, including tabular, image, and genomic data.

arXiv:2507.13344

Diffuman4D: 4D Consistent Human View Synthesis from Sparse-View Videos with Spatio-Temporal Diffusion Models

This paper addresses the challenge of high-fidelity view synthesis of humans with sparse-view videos as input. Previous methods solve the issue of insufficient observation by leveraging 4D diffusion models to generate videos at novel viewpoints. However, the generated videos from these models often lack spatio-temporal consistency, thus degrading view synthesis quality. In this paper, we propose a novel sliding iterative denoising process to enhance the spatio-temporal consistency of the 4D diffusion model. Specifically, we define a latent grid in which each latent encodes the image, camera pose, and human pose for a certain viewpoint and timestamp, then alternately denoising the latent grid along spatial and temporal dimensions with a sliding window, and finally decode the videos at target viewpoints from the corresponding denoised latents. Through the iterative sliding, information flows sufficiently across the latent grid, allowing the diffusion model to obtain a large receptive field and thus enhance the 4D consistency of the output, while making the GPU memory consumption affordable. The experiments on the DNA-Rendering and ActorsHQ datasets demonstrate that our method is able to synthesize high-quality and consistent novel-view videos and significantly outperforms the existing approaches. See our project page for interactive demos and video results: https://diffuman4d.github.io/ .

arXiv:2507.13146

fastWDM3D: Fast and Accurate 3D Healthy Tissue Inpainting

Healthy tissue inpainting has significant applications, including the generation of pseudo-healthy baselines for tumor growth models and the facilitation of image registration. In previous editions of the BraTS Local Synthesis of Healthy Brain Tissue via Inpainting Challenge, denoising diffusion probabilistic models (DDPMs) demonstrated qualitatively convincing results but suffered from low sampling speed. To mitigate this limitation, we adapted a 2D image generation approach, combining DDPMs with generative adversarial networks (GANs) and employing a variance-preserving noise schedule, for the task of 3D inpainting. Our experiments showed that the variance-preserving noise schedule and the selected reconstruction losses can be effectively utilized for high-quality 3D inpainting in a few time steps without requiring adversarial training. We applied our findings to a different architecture, a 3D wavelet diffusion model (WDM3D) that does not include a GAN component. The resulting model, denoted as fastWDM3D, obtained a SSIM of 0.8571, a MSE of 0.0079, and a PSNR of 22.26 on the BraTS inpainting test set. Remarkably, it achieved these scores using only two time steps, completing the 3D inpainting process in 1.81 s per image. When compared to other DDPMs used for healthy brain tissue inpainting, our model is up to 800 x faster while still achieving superior performance metrics. Our proposed method, fastWDM3D, represents a promising approach for fast and accurate healthy tissue inpainting. Our code is available at https://github.com/AliciaDurrer/fastWDM3D.

arXiv:2507.13366

Leveraging the Spatial Hierarchy: Coarse-to-fine Trajectory Generation via Cascaded Hybrid Diffusion

Urban mobility data has significant connections with economic growth and plays an essential role in various smart-city applications. However, due to privacy concerns and substantial data collection costs, fine-grained human mobility trajectories are difficult to become publicly available on a large scale. A promising solution to address this issue is trajectory synthesizing. However, existing works often ignore the inherent structural complexity of trajectories, unable to handle complicated high-dimensional distributions and generate realistic fine-grained trajectories. In this paper, we propose Cardiff, a coarse-to-fine Cascaded hybrid diffusion-based trajectory synthesizing framework for fine-grained and privacy-preserving mobility generation. By leveraging the hierarchical nature of urban mobility, Cardiff decomposes the generation process into two distinct levels, i.e., discrete road segment-level and continuous fine-grained GPS-level: (i) In the segment-level, to reduce computational costs and redundancy in raw trajectories, we first encode the discrete road segments into low-dimensional latent embeddings and design a diffusion transformer-based latent denoising network for segment-level trajectory synthesis. (ii) Taking the first stage of generation as conditions, we then design a fine-grained GPS-level conditional denoising network with a noise augmentation mechanism to achieve robust and high-fidelity generation. Additionally, the Cardiff framework not only progressively generates high-fidelity trajectories through cascaded denoising but also flexibly enables a tunable balance between privacy preservation and utility. Experimental results on three large real-world trajectory datasets demonstrate that our method outperforms state-of-the-art baselines in various metrics.

arXiv:2506.22456

WISVA: Generative AI for 5G Network Optimization in Smart Warehouses

The next decade will usher in a profound transformation of wireless communication, driven by the ever-increasing demand for data-intensive applications and the rapid adoption of emerging technologies. To fully unlock the potential of 5G and beyond, substantial advancements are required in signal processing techniques, innovative network architectures, and efficient spectrum utilization strategies. These advancements facilitate seamless integration of emerging technologies, driving industrial digital transformation and connectivity. This paper introduces a novel Variational Autoencoder (VAE)-based framework, Wireless Infrastructure for Smart Warehouses using VAE (WISVA), designed for accurate indoor radio propagation modeling in automated Industry 4.0 environments such as warehouses and factory floors operating within 5G wireless bands. The research delves into the meticulous creation of training data tensors, capturing complex electromagnetic (EM) wave behaviors influenced by diverse obstacles, and outlines the architecture and training methodology of the proposed VAE model. The model's robustness and adaptability are showcased through its ability to predict signal-to-interference-plus-noise ratio (SINR) heatmaps across various scenarios, including denoising tasks, validation datasets, extrapolation to unseen configurations, and previously unencountered warehouse layouts. Compelling reconstruction error heatmaps are presented, highlighting the superior accuracy of WISVA compared to traditional autoencoder models. The paper also analyzes the model's performance in handling complex smart warehouse environments, demonstrating its potential as a key enabler for optimizing wireless infrastructure in Industry 4.0.

arXiv:2507.07907

A statistical physics framework for optimal learning

Learning is a complex dynamical process shaped by a range of interconnected decisions. Careful design of hyperparameter schedules for artificial neural networks or efficient allocation of cognitive resources by biological learners can dramatically affect performance. Yet, theoretical understanding of optimal learning strategies remains sparse, especially due to the intricate interplay between evolving meta-parameters and nonlinear learning dynamics. The search for optimal protocols is further hindered by the high dimensionality of the learning space, often resulting in predominantly heuristic, difficult to interpret, and computationally demanding solutions. Here, we combine statistical physics with control theory in a unified theoretical framework to identify optimal protocols in prototypical neural network models. In the high-dimensional limit, we derive closed-form ordinary differential equations that track online stochastic gradient descent through low-dimensional order parameters. We formulate the design of learning protocols as an optimal control problem directly on the dynamics of the order parameters with the goal of minimizing the generalization error at the end of training. This framework encompasses a variety of learning scenarios, optimization constraints, and control budgets. We apply it to representative cases, including optimal curricula, adaptive dropout regularization and noise schedules in denoising autoencoders. We find nontrivial yet interpretable strategies highlighting how optimal protocols mediate crucial learning tradeoffs, such as maximizing alignment with informative input directions while minimizing noise fitting. Finally, we show how to apply our framework to real datasets. Our results establish a principled foundation for understanding and designing optimal learning protocols and suggest a path toward a theory of meta-learning grounded in statistical physics.

arXiv:2507.11515

AirLLM: Diffusion Policy-based Adaptive LoRA for Remote Fine-Tuning of LLM over the Air

Operating Large Language Models (LLMs) on edge devices is increasingly challenged by limited communication bandwidth and strained computational and memory costs. Thus, cloud-assisted remote fine-tuning becomes indispensable. Nevertheless, existing Low-Rank Adaptation (LoRA) approaches typically employ fixed or heuristic rank configurations, and the subsequent over-the-air transmission of all LoRA parameters could be rather inefficient. To address this limitation, we develop AirLLM, a hierarchical diffusion policy framework for communication-aware LoRA adaptation. Specifically, AirLLM models the rank configuration as a structured action vector that spans all LoRA-inserted projections. To solve the underlying high-dimensional sequential decision-making problem, a Proximal Policy Optimization (PPO) agent generates coarse-grained decisions by jointly observing wireless states and linguistic complexity, which are then refined via Denoising Diffusion Implicit Models (DDIM) to produce high-resolution, task- and channel-adaptive rank vectors. The two modules are optimized alternatively, with the DDIM trained under the Classifier-Free Guidance (CFG) paradigm to maintain alignment with PPO rewards. Experiments under varying signal-to-noise ratios demonstrate that AirLLM consistently enhances fine-tuning performance while significantly reducing transmission costs, highlighting the effectiveness of reinforcement-driven, diffusion-refined rank adaptation for scalable and efficient remote fine-tuning over the air.

arXiv:2507.11474

HUG-VAS: A Hierarchical NURBS-Based Generative Model for Aortic Geometry Synthesis and Controllable Editing

Accurate characterization of vascular geometry is essential for cardiovascular diagnosis and treatment planning. Traditional statistical shape modeling (SSM) methods rely on linear assumptions, limiting their expressivity and scalability to complex topologies such as multi-branch vascular structures. We introduce HUG-VAS, a Hierarchical NURBS Generative model for Vascular geometry Synthesis, which integrates NURBS surface parameterization with diffusion-based generative modeling to synthesize realistic, fine-grained aortic geometries. Trained with 21 patient-specific samples, HUG-VAS generates anatomically faithful aortas with supra-aortic branches, yielding biomarker distributions that closely match those of the original dataset. HUG-VAS adopts a hierarchical architecture comprising a denoising diffusion model that generates centerlines and a guided diffusion model that synthesizes radial profiles conditioned on those centerlines, thereby capturing two layers of anatomical variability. Critically, the framework supports zero-shot conditional generation from image-derived priors, enabling practical applications such as interactive semi-automatic segmentation, robust reconstruction under degraded imaging conditions, and implantable device optimization. To our knowledge, HUG-VAS is the first SSM framework to bridge image-derived priors with generative shape modeling via a unified integration of NURBS parameterization and hierarchical diffusion processes.

arXiv:2507.11866

Similarity-Guided Diffusion for Contrastive Sequential Recommendation

In sequential recommendation systems, data augmentation and contrastive learning techniques have recently been introduced using diffusion models to achieve robust representation learning. However, most of the existing approaches use random augmentation, which risk damaging the contextual information of the original sequence. Accordingly, we propose a Similarity-Guided Diffusion for Contrastive Sequential Recommendation. Our method leverages the similarity between item embedding vectors to generate semantically consistent noise. Moreover, we utilize high confidence score in the denoising process to select our augmentation positions. This approach more effectively reflects contextual and structural information compared to augmentation at random positions. From a contrastive learning perspective, the proposed augmentation technique provides more discriminative positive and negative samples, simultaneously improving training efficiency and recommendation performance. Experimental results on five benchmark datasets show that SimDiffRec outperforms the existing baseline models.

arXiv:2507.04623공식 코드 · Papers with Code

Hierarchical Intent-guided Optimization with Pluggable LLM-Driven Semantics for Session-based Recommendation

Session-based Recommendation (SBR) aims to predict the next item a user will likely engage with, using their interaction sequence within an anonymous session. Existing SBR models often focus only on single-session information, ignoring inter-session relationships and valuable cross-session insights. Some methods try to include inter-session data but struggle with noise and irrelevant information, reducing performance. Additionally, most models rely on item ID co-occurrence and overlook rich semantic details, limiting their ability to capture fine-grained item features. To address these challenges, we propose a novel hierarchical intent-guided optimization approach with pluggable LLM-driven semantic learning for session-based recommendations, called HIPHOP. First, we introduce a pluggable embedding module based on large language models (LLMs) to generate high-quality semantic representations, enhancing item embeddings. Second, HIPHOP utilizes graph neural networks (GNNs) to model item transition relationships and incorporates a dynamic multi-intent capturing module to address users' diverse interests within a session. Additionally, we design a hierarchical inter-session similarity learning module, guided by user intent, to capture global and local session relationships, effectively exploring users' long-term and short-term interests. To mitigate noise, an intent-guided denoising strategy is applied during inter-session learning. Finally, we enhance the model's discriminative capability by using contrastive learning to optimize session representations. Experiments on multiple datasets show that HIPHOP significantly outperforms existing methods, demonstrating its effectiveness in improving recommendation quality. Our code is available: https://github.com/hjx159/HIPHOP.

arXiv:2506.22246공식 코드 · Papers with Code

EAMamba: Efficient All-Around Vision State Space Model for Image Restoration

Image restoration is a key task in low-level computer vision that aims to reconstruct high-quality images from degraded inputs. The emergence of Vision Mamba, which draws inspiration from the advanced state space model Mamba, marks a significant advancement in this field. Vision Mamba demonstrates excellence in modeling long-range dependencies with linear complexity, a crucial advantage for image restoration tasks. Despite its strengths, Vision Mamba encounters challenges in low-level vision tasks, including computational complexity that scales with the number of scanning sequences and local pixel forgetting. To address these limitations, this study introduces Efficient All-Around Mamba (EAMamba), an enhanced framework that incorporates a Multi-Head Selective Scan Module (MHSSM) with an all-around scanning mechanism. MHSSM efficiently aggregates multiple scanning sequences, which avoids increases in computational complexity and parameter count. The all-around scanning strategy implements multiple patterns to capture holistic information and resolves the local pixel forgetting issue. Our experimental evaluations validate these innovations across several restoration tasks, including super resolution, denoising, deblurring, and dehazing. The results validate that EAMamba achieves a significant 31-89% reduction in FLOPs while maintaining favorable performance compared to existing low-level Vision Mamba methods.

arXiv:2507.06078공식 코드 · Papers with Code

ScoreAdv: Score-based Targeted Generation of Natural Adversarial Examples via Diffusion Models

Despite the success of deep learning across various domains, it remains vulnerable to adversarial attacks. Although many existing adversarial attack methods achieve high success rates, they typically rely on $\ell_{p}$-norm perturbation constraints, which do not align with human perceptual capabilities. Consequently, researchers have shifted their focus toward generating natural, unrestricted adversarial examples (UAEs). GAN-based approaches suffer from inherent limitations, such as poor image quality due to instability and mode collapse. Meanwhile, diffusion models have been employed for UAE generation, but they still rely on iterative PGD perturbation injection, without fully leveraging their central denoising capabilities. In this paper, we introduce a novel approach for generating UAEs based on diffusion models, named ScoreAdv. This method incorporates an interpretable adversarial guidance mechanism to gradually shift the sampling distribution towards the adversarial distribution, while using an interpretable saliency map to inject the visual information of a reference image into the generated samples. Notably, our method is capable of generating an unlimited number of natural adversarial examples and can attack not only classification models but also retrieval models. We conduct extensive experiments on ImageNet and CelebA datasets, validating the performance of ScoreAdv across ten target models in both black-box and white-box settings. Our results demonstrate that ScoreAdv achieves state-of-the-art attack success rates and image quality. Furthermore, the dynamic balance between denoising and adversarial perturbation enables ScoreAdv to remain robust even under defensive measures.

arXiv:2507.05798

SPADE: Spatial-Aware Denoising Network for Open-vocabulary Panoptic Scene Graph Generation with Long- and Local-range Context Reasoning

Panoptic Scene Graph Generation (PSG) integrates instance segmentation with relation understanding to capture pixel-level structural relationships in complex scenes. Although recent approaches leveraging pre-trained vision-language models (VLMs) have significantly improved performance in the open-vocabulary setting, they commonly ignore the inherent limitations of VLMs in spatial relation reasoning, such as difficulty in distinguishing object relative positions, which results in suboptimal relation prediction. Motivated by the denoising diffusion model's inversion process in preserving the spatial structure of input images, we propose SPADE (SPatial-Aware Denoising-nEtwork) framework -- a novel approach for open-vocabulary PSG. SPADE consists of two key steps: (1) inversion-guided calibration for the UNet adaptation, and (2) spatial-aware context reasoning. In the first step, we calibrate a general pre-trained teacher diffusion model into a PSG-specific denoising network with cross-attention maps derived during inversion through a lightweight LoRA-based fine-tuning strategy. In the second step, we develop a spatial-aware relation graph transformer that captures both local and long-range contextual information, facilitating the generation of high-quality relation queries. Extensive experiments on benchmark PSG and Visual Genome datasets demonstrate that SPADE outperforms state-of-the-art methods in both closed- and open-set scenarios, particularly for spatial relationship prediction.

arXiv:2507.06140공식 코드 · Papers with Code

LangMamba: A Language-driven Mamba Framework for Low-dose CT Denoising with Vision-language Models

Low-dose computed tomography (LDCT) reduces radiation exposure but often degrades image quality, potentially compromising diagnostic accuracy. Existing deep learning-based denoising methods focus primarily on pixel-level mappings, overlooking the potential benefits of high-level semantic guidance. Recent advances in vision-language models (VLMs) suggest that language can serve as a powerful tool for capturing structured semantic information, offering new opportunities to improve LDCT reconstruction. In this paper, we introduce LangMamba, a Language-driven Mamba framework for LDCT denoising that leverages VLM-derived representations to enhance supervision from normal-dose CT (NDCT). LangMamba follows a two-stage learning strategy. First, we pre-train a Language-guided AutoEncoder (LangAE) that leverages frozen VLMs to map NDCT images into a semantic space enriched with anatomical information. Second, we synergize LangAE with two key components to guide LDCT denoising: Semantic-Enhanced Efficient Denoiser (SEED), which enhances NDCT-relevant local semantic while capturing global features with efficient Mamba mechanism, and Language-engaged Dual-space Alignment (LangDA) Loss, which ensures that denoised images align with NDCT in both perceptual and semantic spaces. Extensive experiments on two public datasets demonstrate that LangMamba outperforms conventional state-of-the-art methods, significantly improving detail preservation and visual fidelity. Remarkably, LangAE exhibits strong generalizability to unseen datasets, thereby reducing training costs. Furthermore, LangDA loss improves explainability by integrating language-guided insights into image reconstruction and offers a plug-and-play fashion. Our findings shed new light on the potential of language as a supervisory signal to advance LDCT denoising. The code is publicly available on https://github.com/hao1635/LangMamba.