We introduce CheXGenBench, a rigorous and multifaceted evaluation framework for synthetic chest radiograph generation that simultaneously assesses fidelity, privacy risks, and clinical utility across state-of-the-art text-to-image generative models. Despite rapid advancements in generative AI for real-world imagery, medical domain evaluations have been hindered by methodological inconsistencies, outdated architectural comparisons, and disconnected assessment criteria that rarely address the practical clinical value of synthetic samples. CheXGenBench overcomes these limitations through standardised data partitioning and a unified evaluation protocol comprising over 20 quantitative metrics that systematically analyse generation quality, potential privacy vulnerabilities, and downstream clinical applicability across 11 leading text-to-image architectures. Our results reveal critical inefficiencies in the existing evaluation protocols, particularly in assessing generative fidelity, leading to inconsistent and uninformative comparisons. Our framework establishes a standardised benchmark for the medical AI community, enabling objective and reproducible comparisons while facilitating seamless integration of both existing and future generative models. Additionally, we release a high-quality, synthetic dataset, SynthCheX-75K, comprising 75K radiographs generated by the top-performing model (Sana 0.6B) in our benchmark to support further research in this critical domain. Through CheXGenBench, we establish a new state-of-the-art and release our framework, models, and SynthCheX-75K dataset at https://raman1121.github.io/CheXGenBench/
We consider the problem of conditional text-to-image synthesis with diffusion models. Most recent works need to either finetune specific parts of the base diffusion model or introduce new trainable parameters, leading to deployment inflexibility due to the need for training. To address this gap in the current literature, we propose our method called TINTIN: Test-time Conditional Text-to-Image Synthesis using Diffusion Models which is a new training-free test-time only algorithm to condition text-to-image diffusion model outputs on conditioning factors such as color palettes and edge maps. In particular, we propose to interpret noise predictions during denoising as gradients of an energy-based model, leading to a flexible approach to manipulate the noise by matching predictions inferred from them to the ground truth conditioning input. This results in, to the best of our knowledge, the first approach to control model outputs with input color palettes, which we realize using a novel color distribution matching loss. We also show this test-time noise manipulation can be easily extensible to other types of conditioning, e.g., edge maps. We conduct extensive experiments using a variety of text prompts, color palettes, and edge maps and demonstrate significant improvement over the current state-of-the-art, both qualitatively and quantitatively.
We present Zero-Painter, a novel training-free framework for layout-conditional text-to-image synthesis that facilitates the creation of detailed and controlled imagery from textual prompts. Our method utilizes object masks and individual descriptions, coupled with a global text prompt, to generate images with high fidelity. Zero-Painter employs a two-stage process involving our novel Prompt-Adjusted Cross-Attention (PACA) and Region-Grouped Cross-Attention (ReGCA) blocks, ensuring precise alignment of generated objects with textual prompts and mask shapes. Our extensive experiments demonstrate that Zero-Painter surpasses current state-of-the-art methods in preserving textual details and adhering to mask shapes.
We present a Multi-Instance Generation (MIG) task, simultaneously generating multiple instances with diverse controls in one image. Given a set of predefined coordinates and their corresponding descriptions, the task is to ensure that generated instances are accurately at the designated locations and that all instances' attributes adhere to their corresponding description. This broadens the scope of current research on Single-instance generation, elevating it to a more versatile and practical dimension. Inspired by the idea of divide and conquer, we introduce an innovative approach named Multi-Instance Generation Controller (MIGC) to address the challenges of the MIG task. Initially, we break down the MIG task into several subtasks, each involving the shading of a single instance. To ensure precise shading for each instance, we introduce an instance enhancement attention mechanism. Lastly, we aggregate all the shaded instances to provide the necessary information for accurately generating multiple instances in stable diffusion (SD). To evaluate how well generation models perform on the MIG task, we provide a COCO-MIG benchmark along with an evaluation pipeline. Extensive experiments were conducted on the proposed COCO-MIG benchmark, as well as on various commonly used benchmarks. The evaluation results illustrate the exceptional control capabilities of our model in terms of quantity, position, attribute, and interaction. Code and demos will be released at https://migcproject.github.io/.
Text-to-image diffusion models produce high quality images but do not offer control over individual instances in the image. We introduce InstanceDiffusion that adds precise instance-level control to text-to-image diffusion models. InstanceDiffusion supports free-form language conditions per instance and allows flexible ways to specify instance locations such as simple single points, scribbles, bounding boxes or intricate instance segmentation masks, and combinations thereof. We propose three major changes to text-to-image models that enable precise instance-level control. Our UniFusion block enables instance-level conditions for text-to-image models, the ScaleU block improves image fidelity, and our Multi-instance Sampler improves generations for multiple instances. InstanceDiffusion significantly surpasses specialized state-of-the-art models for each location condition. Notably, on the COCO dataset, we outperform previous state-of-the-art by 20.4% AP$_{50}^\text{box}$ for box inputs, and 25.4% IoU for mask inputs.
Recent text-to-image diffusion models have demonstrated an astonishing capacity to generate high-quality images. However, researchers mainly studied the way of synthesizing images with only text prompts. While some works have explored using other modalities as conditions, considerable paired data, e.g., box/mask-image pairs, and fine-tuning time are required for nurturing models. As such paired data is time-consuming and labor-intensive to acquire and restricted to a closed set, this potentially becomes the bottleneck for applications in an open world. This paper focuses on the simplest form of user-provided conditions, e.g., box or scribble. To mitigate the aforementioned problem, we propose a training-free method to control objects and contexts in the synthesized images adhering to the given spatial conditions. Specifically, three spatial constraints, i.e., Inner-Box, Outer-Box, and Corner Constraints, are designed and seamlessly integrated into the denoising step of diffusion models, requiring no additional training and massive annotated layout data. Extensive experimental results demonstrate that the proposed constraints can control what and where to present in the images while retaining the ability of Diffusion models to synthesize with high fidelity and diverse concept coverage. The code is publicly available at https://github.com/showlab/BoxDiff.
Text-to-image (T2I) research has grown explosively in the past year, owing to the large-scale pre-trained diffusion models and many emerging personalization and editing approaches. Yet, one pain point persists: the text prompt engineering, and searching high-quality text prompts for customized results is more art than science. Moreover, as commonly argued: "an image is worth a thousand words" - the attempt to describe a desired image with texts often ends up being ambiguous and cannot comprehensively cover delicate visual details, hence necessitating more additional controls from the visual domain. In this paper, we take a bold step forward: taking "Text" out of a pre-trained T2I diffusion model, to reduce the burdensome prompt engineering efforts for users. Our proposed framework, Prompt-Free Diffusion, relies on only visual inputs to generate new images: it takes a reference image as "context", an optional image structural conditioning, and an initial noise, with absolutely no text prompt. The core architecture behind the scene is Semantic Context Encoder (SeeCoder), substituting the commonly used CLIP-based or LLM-based text encoder. The reusability of SeeCoder also makes it a convenient drop-in component: one can also pre-train a SeeCoder in one T2I model and reuse it for another. Through extensive experiments, Prompt-Free Diffusion is experimentally found to (i) outperform prior exemplar-based image synthesis approaches; (ii) perform on par with state-of-the-art T2I models using prompts following the best practice; and (iii) be naturally extensible to other downstream applications such as anime figure generation and virtual try-on, with promising quality. Our code and models are open-sourced at https://github.com/SHI-Labs/Prompt-Free-Diffusion.
Diffusion models have demonstrated impressive abilities in generating photo-realistic and creative images. To offer more controllability for the generation process, existing studies, termed as early-constraint methods in this paper, leverage extra conditions and incorporate them into pre-trained diffusion models. Particularly, some of them adopt condition-specific modules to handle conditions separately, where they struggle to generalize across other conditions. Although follow-up studies present unified solutions to solve the generalization problem, they also require extra resources to implement, e.g., additional inputs or parameter optimization, where more flexible and efficient solutions are expected to perform steerable guided image synthesis. In this paper, we present an alternative paradigm, namely Late-Constraint Diffusion (LaCon), to simultaneously integrate various conditions into pre-trained diffusion models. Specifically, LaCon establishes an alignment between the external condition and the internal features of diffusion models, and utilizes the alignment to incorporate the target condition, guiding the sampling process to produce tailored results. Experimental results on COCO dataset illustrate the effectiveness and superior generalization capability of LaCon under various conditions and settings. Ablation studies investigate the functionalities of different components in LaCon, and illustrate its great potential to serve as an efficient solution to offer flexible controllability for diffusion models.
Large-scale text-to-image diffusion models have made amazing advances. However, the status quo is to use text input alone, which can impede controllability. In this work, we propose GLIGEN, Grounded-Language-to-Image Generation, a novel approach that builds upon and extends the functionality of existing pre-trained text-to-image diffusion models by enabling them to also be conditioned on grounding inputs. To preserve the vast concept knowledge of the pre-trained model, we freeze all of its weights and inject the grounding information into new trainable layers via a gated mechanism. Our model achieves open-world grounded text2img generation with caption and bounding box condition inputs, and the grounding ability generalizes well to novel spatial configurations and concepts. GLIGEN's zero-shot performance on COCO and LVIS outperforms that of existing supervised layout-to-image baselines by a large margin.
Recently, large-scale text-to-image (T2I) models have shown impressive performance in generating high-fidelity images, but with limited controllability, e.g., precisely specifying the content in a specific region with a free-form text description. In this paper, we propose an effective technique for such regional control in T2I generation. We augment T2I models' inputs with an extra set of position tokens, which represent the quantized spatial coordinates. Each region is specified by four position tokens to represent the top-left and bottom-right corners, followed by an open-ended natural language regional description. Then, we fine-tune a pre-trained T2I model with such new input interface. Our model, dubbed as ReCo (Region-Controlled T2I), enables the region control for arbitrary objects described by open-ended regional texts rather than by object labels from a constrained category set. Empirically, ReCo achieves better image quality than the T2I model strengthened by positional words (FID: 8.82->7.36, SceneFID: 15.54->6.51 on COCO), together with objects being more accurately placed, amounting to a 20.40% region classification accuracy improvement on COCO. Furthermore, we demonstrate that ReCo can better control the object count, spatial relationship, and region attributes such as color/size, with the free-form regional description. Human evaluation on PaintSkill shows that ReCo is +19.28% and +17.21% more accurate in generating images with correct object count and spatial relationship than the T2I model.