Autism Spectrum Disorder (ASD) significantly impacts social communication, interaction, and behavior. Early diagnosis and timely intervention can improve outcomes by enabling tailored therapeutic strategies. Electroencephalography (EEG) has emerged as a non-invasive tool to capture brain activity and facilitate the early detection of ASD using machine learning techniques. However, attaining high accuracy with minimal EEG channels remains a challenge. This study analyzed EEG data from 10 children with ASD and 10 Typically Developed (TD) children using three electrode combinations: C3-C4, C3-Cz, and C4-Cz. EEG signals were spatially filtered using a wavelet-based regularized filter bank common spatial pattern. Key features, including peak-to-peak amplitude, were extracted, and correlation-based feature selection identified the most informative features. Classification with Support Vector Machine (SVM) identified the C4-Cz pair as the most effective, achieving the highest accuracy. Further analysis applied Neural Networks (NN), Quantum Support Vector Machines (QSVM), and Quantum Neural Networks (QNN) to classify data from the C4-Cz pair. QSVM with amplitude embedding feature map outperformed others, achieving an accuracy of 94.7%. Performance was further improved by incorporating an enhanced feature set comprising peak frequency, Stockwell transform coefficients, and peak-to-peak amplitude. The proposed system, leveraging these refined features and QSVM, achieved an exceptional accuracy of 98.9%. To our knowledge, this is the first study utilizing an enhanced feature set derived from reduced brain lobes and quantum machine learning for ASD classification, offering a novel and highly accurate diagnostic approach.
The Mice Autism Detection via Ultrasound Vocalization (MADUV) Challenge introduces the first INTERSPEECH challenge focused on detecting autism spectrum disorder (ASD) in mice through their vocalizations. Participants are tasked with developing models to automatically classify mice as either wild-type or ASD models based on recordings with a high sampling rate. Our baseline system employs a simple CNN-based classification using three different spectrogram features. Results demonstrate the feasibility of automated ASD detection, with the considered audible-range features achieving the best performance (UAR of 0.600 for segment-level and 0.625 for subject-level classification). This challenge bridges speech technology and biomedical research, offering opportunities to advance our understanding of ASD models through machine learning approaches. The findings suggest promising directions for vocalization analysis and highlight the potential value of audible and ultrasound vocalizations in ASD detection.
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that encompasses a wide variety of symptoms and degrees of impairment, which makes the diagnosis and treatment challenging. Functional magnetic resonance imaging (fMRI) has been extensively used to study brain activity in ASD, and machine learning methods have been applied to analyze resting state fMRI (rs-fMRI) data. However, fewer studies have explored the recent transformer-based models on rs-fMRI data. Given the superiority of transformer models in capturing long-range dependencies in sequence data, we have developed a transformer-based self-supervised framework that directly analyzes time-series fMRI data without computing functional connectivity. To address over-fitting in small datasets and enhance the model performance, we propose self-supervised pre-training tasks to reconstruct the randomly masked fMRI time-series data, investigating the effects of various masking strategies. We then finetune the model for the ASD classification task and evaluate it using two public datasets and five-fold cross-validation with different amounts of training data. The experiments show that randomly masking entire ROIs gives better model performance than randomly masking time points in the pre-training step, resulting in an average improvement of 10.8% for AUC and 9.3% for subject accuracy compared with the transformer model trained from scratch across different levels of training data availability. Our code is available on GitHub.
Autism Spectrum Disorder (ASD) is a diverse collection of neurobiological conditions marked by challenges in social communication and reciprocal interactions, as well as repetitive and stereotypical behaviors. Atypical behavior patterns in a long, untrimmed video can serve as biomarkers for children with ASD. In this paper, we propose a video-based weakly-supervised method that takes spatio-temporal features of long videos to learn typical and atypical behaviors for autism detection. On top of that, we propose a shallow TCN-MLP network, which is designed to further categorize the severity score. We evaluate our method on actual evaluation videos of children with autism collected and annotated (for severity score) by clinical professionals. Experimental results demonstrate the effectiveness of behavioral biomarkers that could help clinicians in autism spectrum analysis.
Autism Spectrum Disorder (ASD) represents a multifaceted neurodevelopmental condition marked by difficulties in social interaction, communication impediments, and repetitive behaviors. Despite progress in understanding ASD, its diagnosis and treatment continue to pose significant challenges due to the variability in symptomatology and the necessity for multidisciplinary care approaches. This paper investigates the potential of Artificial Intelligence (AI) to augment the capabilities of healthcare professionals and caregivers in managing ASD. We have developed a sophisticated algorithm designed to analyze facial and bodily expressions during daily activities of both autistic and non-autistic children, leading to the development of a powerful deep learning-based autism detection system. Our study demonstrated that AI models, specifically the Xception and ResNet50V2 architectures, achieved high accuracy in diagnosing Autism Spectrum Disorder (ASD). This research highlights the transformative potential of AI in improving the diagnosis, treatment, and comprehensive management of ASD. Our study revealed that AI models, notably the Xception and ResNet50V2 architectures, demonstrated high accuracy in diagnosing ASD.
In response to the global need for efficient early diagnosis of Autism Spectrum Disorder (ASD), this paper bridges the gap between traditional, time-consuming diagnostic methods and potential automated solutions. We propose a multi-atlas deep ensemble network, MADE-for-ASD, that integrates multiple atlases of the brain's functional magnetic resonance imaging (fMRI) data through a weighted deep ensemble network. Our approach integrates demographic information into the prediction workflow, which enhances ASD diagnosis performance and offers a more holistic perspective on patient profiling. We experiment with the well-known publicly available ABIDE (Autism Brain Imaging Data Exchange) I dataset, consisting of resting state fMRI data from 17 different laboratories around the globe. Our proposed system achieves 75.20% accuracy on the entire dataset and 96.40% on a specific subset $-$ both surpassing reported ASD diagnosis accuracy in ABIDE I fMRI studies. Specifically, our model improves by 4.4 percentage points over prior works on the same amount of data. The model exhibits a sensitivity of 82.90% and a specificity of 69.70% on the entire dataset, and 91.00% and 99.50%, respectively, on the specific subset. We leverage the F-score to pinpoint the top 10 ROI in ASD diagnosis, such as precuneus and anterior cingulate/ventromedial. The proposed system can potentially pave the way for more cost-effective, efficient and scalable strategies in ASD diagnosis. Codes and evaluations are publicly available at https://github.com/hasan-rakibul/MADE-for-ASD.
Code-switching is a common communication phenomenon where individuals alternate between two or more languages or linguistic styles within a single conversation. Autism Spectrum Disorder (ASD) is a developmental disorder posing challenges in social interaction, communication, and repetitive behaviors. Detecting ASD in individuals with code-switch scenario presents unique challenges. In this paper, we address this problem by building an application NeuRO which aims to detect potential signs of autism in code-switched conversations, facilitating early intervention and support for individuals with ASD.
Machine learning (ML) has advanced quickly, particularly throughout the area of health care. The diagnosis of neurodevelopment problems using ML is a very important area of healthcare. Autism spectrum disorder (ASD) is one of the developmental disorders that is growing the fastest globally. The clinical screening tests used to identify autistic symptoms are expensive and time-consuming. But now that ML has been advanced, it's feasible to identify autism early on. Previously, many different techniques have been used in investigations. Still, none of them have produced the anticipated outcomes when it comes to the capacity to predict autistic features utilizing a clinically validated Indian ASD database. Therefore, this study aimed to develop a simple, quick, and inexpensive technique for identifying ASD by using ML. Various machine learning classifiers, including Adaboost (AB), Gradient Boost (GB), Decision Tree (DT), Logistic Regression (LR), Random Forest (RF), Gaussian Naive Bayes (GNB), Linear Discriminant Analysis (LDA), Quadratic Discriminant Analysis (QDA), K-Nearest Neighbors (KNN), and Support Vector Machine (SVM), were used to develop the autism prediction model. The proposed method was tested with records from the AIIMS Modified INDT-ASD (AMI) database, which were collected through an application developed by AIIMS in Delhi, India. Feature engineering has been applied to make the proposed solution easier than already available solutions. Using the proposed model, we succeeded in predicting ASD using a minimized set of 20 questions rather than the 28 questions presented in AMI with promising accuracy. In a comparative evaluation, SVM emerged as the superior model among others, with 100 $\pm$ 0.05\% accuracy, higher recall by 5.34\%, and improved accuracy by 2.22\%-6.67\% over RF. We have also introduced a web-based solution supporting both Hindi and English.
Individuals with Autism Spectrum Disorder (ASD) often experience challenges in health, communication, and sensory processing; therefore, early diagnosis is necessary for proper treatment and care. In this work, we consider the problem of detecting or classifying ASD children to aid medical professionals in early diagnosis. We develop a deep learning model that analyzes video clips of children reacting to sensory stimuli, with the intent of capturing key differences in reactions and behavior between ASD and non-ASD participants. Unlike many recent studies in ASD classification with MRI data, which require expensive specialized equipment, our method utilizes a powerful but relatively affordable GPU, a standard computer setup, and a video camera for inference. Results show that our model effectively generalizes and understands key differences in the distinct movements of the children. It is noteworthy that our model exhibits successful classification performance despite the limited amount of data for a deep learning problem and limited temporal information available for learning, even with the motion artifacts.
There has been a range of studies of how autism is displayed in voice, speech, and language. We analyse studies from the biomedical, as well as the psychological domain, but also from the NLP domain in order to find linguistic, prosodic and acoustic cues that could indicate autism. Our survey looks at all three domains. We define autism and which comorbidities might influence the correct detection of the disorder. We especially look at observations such as verbal and semantic fluency, prosodic features, but also disfluencies and speaking rate. We also show word-based approaches and describe machine learning and transformer-based approaches both on the audio data as well as the transcripts. Lastly, we conclude, while there already is a lot of research, female patients seem to be severely under-researched. Also, most NLP research focuses on traditional machine learning methods instead of transformers which could be beneficial in this context. Additionally, we were unable to find research combining both features from audio and transcripts.
Graph neural networks (GNN) are a powerful tool for combining imaging and non-imaging medical information for node classification tasks. Cross-network node classification extends GNN techniques to account for domain drift, allowing for node classification on an unlabeled target network. In this paper we present OTGCN, a powerful, novel approach to cross-network node classification. This approach leans on concepts from graph convolutional networks to harness insights from graph data structures while simultaneously applying strategies rooted in optimal transport to correct for the domain drift that can occur between samples from different data collection sites. This blended approach provides a practical solution for scenarios with many distinct forms of data collected across different locations and equipment. We demonstrate the effectiveness of this approach at classifying Autism Spectrum Disorder subjects using a blend of imaging and non-imaging data.
Autism diagnosis presents a major challenge due to the vast heterogeneity of the condition and the elusive nature of early detection. Atypical gait and gesture patterns are dominant behavioral characteristics of autism and can provide crucial insights for diagnosis. Furthermore, these data can be collected efficiently in a non-intrusive way, facilitating early intervention to optimize positive outcomes. Existing research mainly focuses on associating facial and eye-gaze features with autism. However, very few studies have investigated movement and gesture patterns which can reveal subtle variations and characteristics that are specific to autism. To address this gap, we present an analysis of gesture and gait activity in videos to identify children with autism and quantify the severity of their condition by regressing autism diagnostic observation schedule scores. Our proposed architecture addresses two key factors: (1) an effective feature representation to manifest irregular gesture patterns and (2) a two-stream co-learning framework to enable a comprehensive understanding of its relation to autism from diverse perspectives without explicitly using additional data modality. Experimental results demonstrate the efficacy of utilizing gesture and gait-activity videos for autism analysis.
Autism Spectrum Disorder (ASD) is one neuro developmental disorder that is now widespread in the world. ASD persists throughout the life of an individual, impacting the way they behave and communicate, resulting to notable deficits consisting of social life retardation, repeated behavioural traits and a restriction in their interests. Early detection of the disorder helps in the onset treatment and helps one to lead a normal life. There are clinical approaches used in detection of autism, relying on behavioural data and in worst cases, neuroimaging. Quantitative methods involving machine learning have been studied and developed to overcome issues with clinical approaches. These quantitative methods rely on machine learning, with some complex methods based on deep learning developed to accelerate detection and diagnosis of ASD. These literature is aimed at exploring most state-of-the-art probabilistic methods in use today, characterizing them with the type of dataset they're most applied on, their accuracy according to their novel research and how well they are suited in ASD classification. The findings will purposely serve as a benchmark in selection of the model to use when performing ASD detection.
Diagnosis of Autism Spectrum Disorder (ASD) using clinical evaluation (cognitive tests) is challenging due to wide variations amongst individuals. Since no effective treatment exists, prompt and reliable ASD diagnosis can enable the effective preparation of treatment regimens. This paper proposes structural Magnetic Resonance Imaging (sMRI)-based ASD diagnosis via an outlier detection approach. To learn Spatio-temporal patterns in structural brain connectivity, a Generative Adversarial Network (GAN) is trained exclusively with sMRI scans of healthy subjects. Given a stack of three adjacent slices as input, the GAN generator reconstructs the next three adjacent slices; the GAN discriminator then identifies ASD sMRI scan reconstructions as outliers. This model is compared against two other baselines -- a simpler UNet and a sophisticated Self-Attention GAN. Axial, Coronal, and Sagittal sMRI slices from the multi-site ABIDE II dataset are used for evaluation. Extensive experiments reveal that our ASD detection framework performs comparably with the state-of-the-art with far fewer training data. Furthermore, longitudinal data (two scans per subject over time) achieve 17-28% higher accuracy than cross-sectional data (one scan per subject). Among other findings, metrics employed for model training as well as reconstruction loss computation impact detection performance, and the coronal modality is found to best encode structural information for ASD detection.
A formal autism diagnosis can be an inefficient and lengthy process. Families may wait months or longer before receiving a diagnosis for their child despite evidence that earlier intervention leads to better treatment outcomes. Digital technologies which detect the presence of behaviors related to autism can scale access to pediatric diagnoses. This work aims to demonstrate the feasibility of deep learning technologies for detecting hand flapping from unstructured home videos as a first step towards validating whether models and digital technologies can be leveraged to aid with autism diagnoses. We used the Self-Stimulatory Behavior Dataset (SSBD), which contains 75 videos of hand flapping, head banging, and spinning exhibited by children. From all the hand flapping videos, we extracted 100 positive and control videos of hand flapping, each between 2 to 5 seconds in duration. Utilizing both landmark-driven-approaches and MobileNet V2's pretrained convolutional layers, our highest performing model achieved a testing F1 score of 84% (90% precision and 80% recall) when evaluating with 5-fold cross validation 100 times. This work provides the first step towards developing precise deep learning methods for activity detection of autism-related behaviors.
Autism often remains undiagnosed in adolescents and adults. Prior research has indicated that an autistic individual often shows atypical fixation and gaze patterns. In this short paper, we demonstrate that by monitoring a user's gaze as they watch commonplace (i.e., not specialized, structured or coded) video, we can identify individuals with autism spectrum disorder. We recruited 35 autistic and 25 non-autistic individuals, and captured their gaze using an off-the-shelf eye tracker connected to a laptop. Within 15 seconds, our approach was 92.5% accurate at identifying individuals with an autism diagnosis. We envision such automatic detection being applied during e.g., the consumption of web media, which could allow for passive screening and adaptation of user interfaces.