Anomaly detection has been widely studied in the context of industrial defect inspection, with numerous methods developed to tackle a range of challenges. In digital pathology, anomaly detection holds significant potential for applications such as rare disease identification, artifact detection, and biomarker discovery. However, the unique characteristics of pathology images, such as their large size, multi-scale structures, stain variability, and repetitive patterns, introduce new challenges that current anomaly detection algorithms struggle to address. In this quantitative study, we benchmark over 20 classical and prevalent anomaly detection methods through extensive experiments. We curated five digital pathology datasets, both real and synthetic, to systematically evaluate these approaches. Our experiments investigate the influence of image scale, anomaly pattern types, and training epoch selection strategies on detection performance. The results provide a detailed comparison of each method's strengths and limitations, establishing a comprehensive benchmark to guide future research in anomaly detection for digital pathology images.
Recent advances in deep generative models have led to significant progress in video generation, yet the fidelity of AI-generated videos remains limited. Synthesized content often exhibits visual artifacts such as temporally inconsistent motion, physically implausible trajectories, unnatural object deformations, and local blurring that undermine realism and user trust. Accurate detection and spatial localization of these artifacts are crucial for both automated quality control and for guiding the development of improved generative models. However, the research community currently lacks a comprehensive benchmark specifically designed for artifact localization in AI generated videos. Existing datasets either restrict themselves to video or frame level detection or lack the fine-grained spatial annotations necessary for evaluating localization methods. To address this gap, we introduce BrokenVideos, a benchmark dataset of 3,254 AI-generated videos with meticulously annotated, pixel-level masks highlighting regions of visual corruption. Each annotation is validated through detailed human inspection to ensure high quality ground truth. Our experiments show that training state of the art artifact detection models and multi modal large language models (MLLMs) on BrokenVideos significantly improves their ability to localize corrupted regions. Through extensive evaluation, we demonstrate that BrokenVideos establishes a critical foundation for benchmarking and advancing research on artifact localization in generative video models. The dataset is available at: https://broken-video-detection-datetsets.github.io/Broken-Video-Detection-Datasets.github.io/.
Text-guided image editing, fueled by recent advancements in generative AI, is becoming increasingly widespread. This trend highlights the need for a comprehensive framework to verify text-guided edits and assess their quality. To address this need, we introduce EditInspector, a novel benchmark for evaluation of text-guided image edits, based on human annotations collected using an extensive template for edit verification. We leverage EditInspector to evaluate the performance of state-of-the-art (SoTA) vision and language models in assessing edits across various dimensions, including accuracy, artifact detection, visual quality, seamless integration with the image scene, adherence to common sense, and the ability to describe edit-induced changes. Our findings indicate that current models struggle to evaluate edits comprehensively and frequently hallucinate when describing the changes. To address these challenges, we propose two novel methods that outperform SoTA models in both artifact detection and difference caption generation.
Artifacts in the electroencephalogram (EEG) degrade signal quality and impact the analysis of brain activity. Current methods for detecting artifacts in sleep EEG rely on simple threshold-based algorithms that require manual intervention, which is time-consuming and impractical due to the vast volume of data that novel mobile recording systems generate. We propose a convolutional neural network (CNN) model incorporating a convolutional block attention module (CNN-CBAM) to detect and identify the location of artifacts in the sleep EEG with attention maps. We benchmarked this model against six other machine learning and signal processing approaches. We trained/tuned all models on 72 manually annotated EEG recordings obtained during home-based monitoring from 18 healthy participants with a mean (SD) age of 68.05 y ($\pm$5.02). We tested them on 26 separate recordings from 6 healthy participants with a mean (SD) age of 68.33 y ($\pm$4.08), with contained artifacts in 4\% of epochs. CNN-CBAM achieved the highest area under the receiver operating characteristic curve (0.88), sensitivity (0.81), and specificity (0.86) when compared to the other approaches. The attention maps from CNN-CBAM localized artifacts within the epoch with a sensitivity of 0.71 and specificity of 0.67. This work demonstrates the feasibility of automating the detection and localization of artifacts in wearable sleep EEG.
The rapid advancements in generative technology have emerged as a double-edged sword. While offering powerful tools that enhance convenience, they also pose significant social concerns. As defenders, current synthetic image detection methods often lack artifact-level textual interpretability and are overly focused on image manipulation detection, and current datasets usually suffer from outdated generators and a lack of fine-grained annotations. In this paper, we introduce SynthScars, a high-quality and diverse dataset consisting of 12,236 fully synthetic images with human-expert annotations. It features 4 distinct image content types, 3 categories of artifacts, and fine-grained annotations covering pixel-level segmentation, detailed textual explanations, and artifact category labels. Furthermore, we propose LEGION (LEarning to Ground and explain for Synthetic Image detectiON), a multimodal large language model (MLLM)-based image forgery analysis framework that integrates artifact detection, segmentation, and explanation. Building upon this capability, we further explore LEGION as a controller, integrating it into image refinement pipelines to guide the generation of higher-quality and more realistic images. Extensive experiments show that LEGION outperforms existing methods across multiple benchmarks, particularly surpassing the second-best traditional expert on SynthScars by 3.31% in mIoU and 7.75% in F1 score. Moreover, the refined images generated under its guidance exhibit stronger alignment with human preferences. The code, model, and dataset will be released.
In intracoronary optical coherence tomography (OCT), blood residues and gas bubbles cause attenuation artifacts that can obscure critical vessel structures. The presence and severity of these artifacts may warrant re-acquisition, prolonging procedure time and increasing use of contrast agent. Accurate detection of these artifacts can guide targeted re-acquisition, reducing the amount of repeated scans needed to achieve diagnostically viable images. However, the highly heterogeneous appearance of these artifacts poses a challenge for the automated detection of the affected image regions. To enable automatic detection of the attenuation artifacts caused by blood residues and gas bubbles based on their severity, we propose a convolutional neural network that performs classification of the attenuation lines (A-lines) into three classes: no artifact, mild artifact and severe artifact. Our model extracts and merges features from OCT images in both Cartesian and polar coordinates, where each column of the image represents an A-line. Our method detects the presence of attenuation artifacts in OCT frames reaching F-scores of 0.77 and 0.94 for mild and severe artifacts, respectively. The inference time over a full OCT scan is approximately 6 seconds. Our experiments show that analysis of images represented in both Cartesian and polar coordinate systems outperforms the analysis in polar coordinates only, suggesting that these representations contain complementary features. This work lays the foundation for automated artifact assessment and image acquisition guidance in intracoronary OCT imaging.
EEG signals convey important information about brain activity both in healthy and pathological conditions. However, they are inherently noisy, which poses significant challenges for accurate analysis and interpretation. Traditional EEG artifact removal methods, while effective, often require extensive expert intervention. This study presents LSTEEG, a novel LSTM-based autoencoder designed for the detection and correction of artifacts in EEG signals. Leveraging deep learning, particularly LSTM layers, LSTEEG captures non-linear dependencies in sequential EEG data. LSTEEG demonstrates superior performance in both artifact detection and correction tasks compared to other state-of-the-art convolutional autoencoders. Our methodology enhances the interpretability and utility of the autoencoder's latent space, enabling data-driven automated artefact removal in EEG its application in downstream tasks. This research advances the field of efficient and accurate multi-channel EEG preprocessing, and promotes the implementation and usage of automated EEG analysis pipelines for brain health applications.
Fingerprint mosaicking, which is the process of combining multiple fingerprint images into a single master fingerprint, is an essential process in modern biometric systems. However, it is prone to errors that can significantly degrade fingerprint image quality. This paper proposes a novel deep learning-based approach to detect and score mosaicking artifacts in fingerprint images. Our method leverages a self-supervised learning framework to train a model on large-scale unlabeled fingerprint data, eliminating the need for manual artifact annotation. The proposed model effectively identifies mosaicking errors, achieving high accuracy on various fingerprint modalities, including contactless, rolled, and pressed fingerprints and furthermore proves to be robust to different data sources. Additionally, we introduce a novel mosaicking artifact score to quantify the severity of errors, enabling automated evaluation of fingerprint images. By addressing the challenges of mosaicking artifact detection, our work contributes to improving the accuracy and reliability of fingerprint-based biometric systems.
Artifact detection algorithms are crucial to correcting the output generated by diffusion models. However, because of the variety of artifact forms, existing methods require substantial annotated data for training. This requirement limits their scalability and efficiency, which restricts their wide application. This paper shows that the similarity of denoised images between consecutive time steps during the sampling process is related to the severity of artifacts in images generated by diffusion models. Building on this observation, we introduce the concept of Similarity Trajectory to characterize the sampling process and its correlation with the image artifacts presented. Using an annotated data set of 680 images, which is only 0.1% of the amount of data used in the prior work, we trained a classifier on these trajectories to predict the presence of artifacts in images. By performing 10-fold validation testing on the balanced annotated data set, the classifier can achieve an accuracy of 72.35%, highlighting the connection between the Similarity Trajectory and the occurrence of artifacts. This approach enables differentiation between artifact-exhibiting and natural-looking images using limited training data.
Modern reconstruction techniques can effectively model complex 3D scenes from sparse 2D views. However, automatically assessing the quality of novel views and identifying artifacts is challenging due to the lack of ground truth images and the limitations of No-Reference image metrics in predicting reliable artifact maps. The absence of such metrics hinders the assessment of the quality of novel views and limits the adoption of post-processing techniques, such as inpainting, to enhance reconstruction quality. To tackle this, recent work has established a new category of metrics (Cross-Reference), predicting image quality solely by leveraging context from alternate viewpoint captures (arXiv:2404.14409). In this work, we propose a new Cross-Reference metric, Puzzle Similarity, which is designed to localize artifacts in novel views. Our approach utilizes image patch statistics from the input views to establish a scene-specific distribution, later used to identify poorly reconstructed regions in the novel views. Given the lack of good measures to evaluate Cross-Reference methods in the context of 3D reconstruction, we collected a novel human-labeled dataset of artifact and distortion maps in unseen reconstructed views. Through this dataset, we demonstrate that our method achieves state-of-the-art localization of artifacts in novel views, correlating with human assessment, even without aligned references. We can leverage our new metric to enhance applications like automatic image restoration, guided acquisition, or 3D reconstruction from sparse inputs. Find the project page at https://nihermann.github.io/puzzlesim/ .
Despite recent advancements, text-to-image generation models often produce images containing artifacts, especially in human figures. These artifacts appear as poorly generated human bodies, including distorted, missing, or extra body parts, leading to visual inconsistencies with typical human anatomy and greatly impairing overall fidelity. In this study, we address this challenge by curating Human Artifact Dataset (HAD), the first large-scale dataset specifically designed to identify and localize human artifacts. HAD comprises over 37,000 images generated by several popular text-to-image models, annotated for human artifact localization. Using this dataset, we train the Human Artifact Detection Models (HADM), which can identify diverse artifact types across multiple generative domains and demonstrate strong generalization, even on images from unseen generators. Additionally, to further improve generators' perception of human structural coherence, we use the predictions from our HADM as feedback for diffusion model finetuning. Our experiments confirm a reduction in human artifacts in the resulting model. Furthermore, we showcase a novel application of our HADM in an iterative inpainting framework to correct human artifacts in arbitrary images directly, demonstrating its utility in improving image quality. Our dataset and detection models are available at: \url{https://github.com/wangkaihong/HADM}.
Objective. Electroencephalography (EEG) is a widely used neuroimaging technique known for its cost-effectiveness and user-friendliness. However, various artifacts, particularly biological artifacts like Electromyography (EMG) signals, lead to a poor signal-to-noise ratio, limiting the precision of analyses and applications. The currently reported EEG data cleaning performance largely depends on the data used for validation, and in the case of machine learning approaches, also on the data used for training. The data are typically gathered either by recruiting subjects to perform specific artifact tasks or by integrating existing datasets. Prevailing approaches, however, tend to rely on intuitive, concept-oriented data collection with minimal justification for the selection of artifacts and their quantities. Given the substantial costs associated with biological data collection and the pressing need for effective data utilization, we propose an optimization procedure for data-oriented data collection design using deep learning-based artifact detection. Approach. We apply a binary classification between artifact epochs (time intervals containing artifacts) and non-artifact epochs (time intervals containing no artifact) using three different neural architectures. Our aim is to minimize data collection efforts while preserving the cleaning efficiency. Main results. We were able to reduce the number of artifact tasks from twelve to three and decrease repetitions of isometric contraction tasks from ten to three or sometimes even just one. Significance. Our work addresses the need for effective data utilization in biological data collection, offering a systematic and dynamic quantitative approach. By providing clear justifications for the choices of artifacts and their quantity, we aim to guide future studies toward more effective and economical data collection in EEG and EMG research.
Histopathology whole slide images (WSIs) are being widely used to develop deep learning-based diagnostic solutions, especially for precision oncology. Most of these diagnostic softwares are vulnerable to biases and impurities in the training and test data which can lead to inaccurate diagnoses. For instance, WSIs contain multiple types of tissue regions, at least some of which might not be relevant to the diagnosis. We introduce HistoROI, a robust yet lightweight deep learning-based classifier to segregate WSI into six broad tissue regions -- epithelium, stroma, lymphocytes, adipose, artifacts, and miscellaneous. HistoROI is trained using a novel human-in-the-loop and active learning paradigm that ensures variations in training data for labeling-efficient generalization. HistoROI consistently performs well across multiple organs, despite being trained on only a single dataset, demonstrating strong generalization. Further, we have examined the utility of HistoROI in improving the performance of downstream deep learning-based tasks using the CAMELYON breast cancer lymph node and TCGA lung cancer datasets. For the former dataset, the area under the receiver operating characteristic curve (AUC) for metastasis versus normal tissue of a neural network trained using weakly supervised learning increased from 0.88 to 0.92 by filtering the data using HistoROI. Similarly, the AUC increased from 0.88 to 0.93 for the classification between adenocarcinoma and squamous cell carcinoma on the lung cancer dataset. We also found that the performance of the HistoROI improves upon HistoQC for artifact detection on a test dataset of 93 annotated WSIs. The limitations of the proposed model are analyzed, and potential extensions are also discussed.
Diffusion magnetic resonance imaging (dMRI) is a crucial technique in neuroimaging studies, allowing for the non-invasive probing of the underlying structures of brain tissues. Clinical dMRI data is susceptible to various artifacts during acquisition, which can lead to unreliable subsequent analyses. Therefore, dMRI preprocessing is essential for improving image quality, and manual inspection is often required to ensure that the preprocessed data is sufficiently corrected. However, manual inspection requires expertise and is time-consuming, especially with large-scale dMRI datasets. Given these challenges, an automated dMRI artifact detection tool is necessary to increase the productivity and reliability of dMRI data analysis. To this end, we propose a novel unsupervised deep learning framework called $\textbf{U}$nsupervised $\textbf{d}$MRI $\textbf{A}$rtifact $\textbf{D}$etection via $\textbf{A}$ngular Resolution Enhancement and $\textbf{C}$ycle Consistency Learning (UdAD-AC). UdAD-AC leverages dMRI angular resolution enhancement and cycle consistency learning to capture the effective representation of artifact-free dMRI data during training, and it identifies data containing artifacts using designed confidence score during inference. To assess the capability of UdAD-AC, several commonly reported dMRI artifacts, including bias field, susceptibility distortion, and corrupted volume, were added to the testing data. Experimental results demonstrate that UdAD-AC achieves the best performance compared to competitive methods in unsupervised dMRI artifact detection.
The problem of artifacts in whole slide image acquisition, prevalent in both clinical workflows and research-oriented settings, necessitates human intervention and re-scanning. Overcoming this challenge requires developing quality control algorithms, that are hindered by the limited availability of relevant annotated data in histopathology. The manual annotation of ground-truth for artifact detection methods is expensive and time-consuming. This work addresses the issue by proposing a method dedicated to augmenting whole slide images with artifacts. The tool seamlessly generates and blends artifacts from an external library to a given histopathology dataset. The augmented datasets are then utilized to train artifact classification methods. The evaluation shows their usefulness in classification of the artifacts, where they show an improvement from 0.10 to 0.01 AUROC depending on the artifact type. The framework, model, weights, and ground-truth annotations are freely released to facilitate open science and reproducible research.
This study delves into the effectiveness of various learning methods in improving Transformer models, focusing particularly on the Gated Residual Network Transformer (GRN-Transformer) in the context of pediatric intensive care units (PICU) with limited data availability. Our findings indicate that Transformers trained via supervised learning are less effective compared to MLP, CNN, and LSTM networks in such environments. Yet, leveraging unsupervised and self-supervised learning on unannotated data, with subsequent fine-tuning on annotated data, notably enhances Transformer performance, although not to the level of the GRN-Transformer. Central to our research is the analysis of different activation functions for the Gated Linear Unit (GLU), a crucial element of the GRN structure. We also employ Mutual Information Neural Estimation (MINE) to evaluate the GRN's contribution. Additionally, the study examines the effects of integrating GRN within the Transformer's Attention mechanism versus using it as a separate intermediary layer. Our results highlight that GLU with sigmoid activation stands out, achieving 0.98 accuracy, 0.91 precision, 0.96 recall, and 0.94 F1 score. The MINE analysis supports the hypothesis that GRN enhances the mutual information between the hidden representations and the output. Moreover, the use of GRN as an intermediate filter layer proves more beneficial than incorporating it within the Attention mechanism. In summary, this research clarifies how GRN bolsters GRN-Transformer's performance, surpassing other learning techniques. These findings offer a promising avenue for adopting sophisticated models like Transformers in data-constrained environments, such as PPG artifact detection in PICU settings.
Running deep neural networks for large medical images is a resource-hungry and time-consuming task with centralized computing. Outsourcing such medical image processing tasks to hybrid clouds has benefits, such as a significant reduction of execution time and monetary cost. However, due to privacy concerns, it is still challenging to process sensitive medical images over clouds, which would hinder their deployment in many real-world applications. To overcome this, we first formulate the overall optimization objectives of the privacy-preserving distributed system model, i.e., minimizing the amount of information about the private data learned by the adversaries throughout the process, reducing the maximum execution time and cost under the user budget constraint. We propose a novel privacy-preserving and cost-effective method called PriCE to solve this multi-objective optimization problem. We performed extensive simulation experiments for artifact detection tasks on medical images using an ensemble of five deep convolutional neural network inferences as the workflow task. Experimental results show that PriCE successfully splits a wide range of input gigapixel medical images with graph-coloring-based strategies, yielding desired output utility and lowering the privacy risk, makespan, and monetary cost under user's budget.
This paper proposes to use cepstrum for artifact detection, recognition and removal in prefrontal EEG. This work focuses on the artifact caused by eye movement. A database containing artifact-free EEG and eye movement contaminated EEG from different subjects is established. A cepstral analysis-based feature extraction with support vector machine (SVM) based classifier is designed to identify the artifacts from the target EEG signals. The proposed method achieves an accuracy of 99.62% on the artifact detection task and a 82.79% accuracy on the 6-category eye movement classification task. A statistical value-based artifact removal method is proposed and evaluated on a public EEG database, where an accuracy improvement of 3.46% is obtained on the 3-category emotion classification task. In order to make a confident decision of each 5s EEG segment, the algorithm requires only 0.66M multiplication operations. Compared to the state-of-the-art approaches in artifact detection and removal, the proposed method features higher detection accuracy and lower computational cost, which makes it a more suitable solution to be integrated into a real-time and artifact robust Brain-Machine Interface (BMI).
Histological tissue examination has been a longstanding practice for cancer diagnosis where pathologists identify the presence of tumors on glass slides. Slides acquired from laboratory routine may contain unintentional artifacts due to complications in surgical resection. Blood and damaged tissue artifacts are two common problems associated with transurethral resection of the bladder tumor. Differences in histotechnical procedures among laboratories may also result in color variations and minor inconsistencies in outcome. A digitized version of a glass slide known as a whole slide image (WSI) holds enormous potential for automated diagnostics. The presence of irrelevant areas in a WSI undermines diagnostic value for pathologists as well as computational pathology (CPATH) systems. Therefore, automatic detection and exclusion of diagnostically irrelevant areas may lead to more reliable predictions. In this paper, we are detecting blood and damaged tissue against diagnostically relevant tissue. We gauge the effectiveness of transfer learning against training from scratch. Best models give 0.99 and 0.89 F1 scores for blood and damaged tissue detection. Since blood and damaged tissue have subtle color differences, we assess the impact of color processing methods on the binary classification performance of five well-known architectures. Finally, we remove the color to understand its importance against morphology on classification performance.
Histopathology is a gold standard for cancer diagnosis under a microscopic examination. However, histological tissue processing procedures result in artifacts, which are ultimately transferred to the digitized version of glass slides, known as whole slide images (WSIs). Artifacts are diagnostically irrelevant areas and may result in wrong deep learning (DL) algorithms predictions. Therefore, detecting and excluding artifacts in the computational pathology (CPATH) system is essential for reliable automated diagnosis. In this paper, we propose a mixture of experts (MoE) scheme for detecting five notable artifacts, including damaged tissue, blur, folded tissue, air bubbles, and histologically irrelevant blood from WSIs. First, we train independent binary DL models as experts to capture particular artifact morphology. Then, we ensemble their predictions using a fusion mechanism. We apply probabilistic thresholding over the final probability distribution to improve the sensitivity of the MoE. We developed DL pipelines using two MoEs and two multiclass models of state-of-the-art deep convolutional neural networks (DCNNs) and vision transformers (ViTs). DCNNs-based MoE and ViTs-based MoE schemes outperformed simpler multiclass models and were tested on datasets from different hospitals and cancer types, where MoE using DCNNs yielded the best results. The proposed MoE yields 86.15% F1 and 97.93% sensitivity scores on unseen data, retaining less computational cost for inference than MoE using ViTs. This best performance of MoEs comes with relatively higher computational trade-offs than multiclass models. The proposed artifact detection pipeline will not only ensure reliable CPATH predictions but may also provide quality control.