Longitudinal analysis has great potential to reveal developmental trajectories and monitor disease progression in medical imaging. This process relies on consistent and robust joint 4D segmentation. Traditional techniques are dependent on the similarity of images over time and the use of subject-specific priors to reduce random variation and improve the robustness and sensitivity of the overall longitudinal analysis. This is however slow and computationally intensive as subject-specific templates need to be rebuilt every time. The focus of this work to accelerate this analysis with the use of deep learning. The proposed approach is based on deep CNNs and incorporates semantic segmentation and provides a longitudinal relationship for the same subject. The proposed approach is based on deep CNNs and incorporates semantic segmentation and provides a longitudinal relationship for the same subject. The state of art using 3D patches as inputs to modified Unet provides results around ${0.91 \pm 0.5}$ Dice and using multi-view atlas in CNNs provide around the same results. In this work, different models are explored, each offers better accuracy and fast results while increasing the segmentation quality. These methods are evaluated on 135 scans from the EADC-ADNI Harmonized Hippocampus Protocol. Proposed CNN based segmentation approaches demonstrate how 2D segmentation using prior slices can provide similar results to 3D segmentation while maintaining good continuity in the 3D dimension and improved speed. Just using 2D modified sagittal slices provide us a better Dice and longitudinal analysis for a given subject. For the ADNI dataset, using the simple UNet CNN technique gives us ${0.84 \pm 0.5}$ and while using modified CNN techniques on the same input yields ${0.89 \pm 0.5}$. Rate of atrophy and RMS error are calculated for several test cases using various methods and analyzed.
In many robotics and VR/AR applications, 3D-videos are readily-available sources of input (a continuous sequence of depth images, or LIDAR scans). However, those 3D-videos are processed frame-by-frame either through 2D convnets or 3D perception algorithms. In this work, we propose 4-dimensional convolutional neural networks for spatio-temporal perception that can directly process such 3D-videos using high-dimensional convolutions. For this, we adopt sparse tensors and propose the generalized sparse convolution that encompasses all discrete convolutions. To implement the generalized sparse convolution, we create an open-source auto-differentiation library for sparse tensors that provides extensive functions for high-dimensional convolutional neural networks. We create 4D spatio-temporal convolutional neural networks using the library and validate them on various 3D semantic segmentation benchmarks and proposed 4D datasets for 3D-video perception. To overcome challenges in the 4D space, we propose the hybrid kernel, a special case of the generalized sparse convolution, and the trilateral-stationary conditional random field that enforces spatio-temporal consistency in the 7D space-time-chroma space. Experimentally, we show that convolutional neural networks with only generalized 3D sparse convolutions can outperform 2D or 2D-3D hybrid methods by a large margin. Also, we show that on 3D-videos, 4D spatio-temporal convolutional neural networks are robust to noise, outperform 3D convolutional neural networks and are faster than the 3D counterpart in some cases.
Spatio-temporal prediction plays an important role in many application areas especially in traffic domain. However, due to complicated spatio-temporal dependency and high non-linear dynamics in road networks, traffic prediction task is still challenging. Existing works either exhibit heavy training cost or fail to accurately capture the spatio-temporal patterns, also ignore the correlation between distant roads that share the similar patterns. In this paper, we propose a novel deep learning framework to overcome these issues: 3D Temporal Graph Convolutional Networks (3D-TGCN). Two novel components of our model are introduced. (1) Instead of constructing the road graph based on spatial information, we learn it by comparing the similarity between time series for each road, thus providing a spatial information free framework. (2) We propose an original 3D graph convolution model to model the spatio-temporal data more accurately. Empirical results show that 3D-TGCN could outperform state-of-the-art baselines.