Deep learning models usually suffer from domain shift issues, where models trained on one source domain do not generalize well to other unseen domains. In this work, we investigate the single-source domain generalization problem: training a deep network that is robust to unseen domains, under the condition that training data is only available from one source domain, which is common in medical imaging applications. We tackle this problem in the context of cross-domain medical image segmentation. Under this scenario, domain shifts are mainly caused by different acquisition processes. We propose a simple causality-inspired data augmentation approach to expose a segmentation model to synthesized domain-shifted training examples. Specifically, 1) to make the deep model robust to discrepancies in image intensities and textures, we employ a family of randomly-weighted shallow networks. They augment training images using diverse appearance transformations. 2) Further we show that spurious correlations among objects in an image are detrimental to domain robustness. These correlations might be taken by the network as domain-specific clues for making predictions, and they may break on unseen domains. We remove these spurious correlations via causal intervention. This is achieved by resampling the appearances of potentially correlated objects independently. The proposed approach is validated on three cross-domain segmentation tasks: cross-modality (CT-MRI) abdominal image segmentation, cross-sequence (bSSFP-LGE) cardiac MRI segmentation, and cross-center prostate MRI segmentation. The proposed approach yields consistent performance gains compared with competitive methods when tested on unseen domains.
Domain generalization (DG) aims to generalize a model trained on multiple source (i.e., training) domains to a distributionally different target (i.e., test) domain. In contrast to the conventional DG that strictly requires the availability of multiple source domains, this paper considers a more realistic yet challenging scenario, namely Single Domain Generalization (Single-DG), where only one source domain is available for training. In this scenario, the limited diversity may jeopardize the model generalization on unseen target domains. To tackle this problem, we propose a style-complement module to enhance the generalization power of the model by synthesizing images from diverse distributions that are complementary to the source ones. More specifically, we adopt a tractable upper bound of mutual information (MI) between the generated and source samples and perform a two-step optimization iteratively: (1) by minimizing the MI upper bound approximation for each sample pair, the generated images are forced to be diversified from the source samples; (2) subsequently, we maximize the MI between the samples from the same semantic category, which assists the network to learn discriminative features from diverse-styled images. Extensive experiments on three benchmark datasets demonstrate the superiority of our approach, which surpasses the state-of-the-art single-DG methods by up to 25.14%.
Traditional deep learning algorithms often fail to generalize when they are tested outside of the domain of the training data. The issue can be mitigated by using unlabeled data from the target domain at training time, but because data distributions can change dynamically in real-life applications once a learned model is deployed, it is critical to create networks robust to unknown and unforeseen domain shifts. In this paper we focus on one of the reasons behind the inability of neural networks to be so: deep networks focus only on the most obvious, potentially spurious, clues to make their predictions and are blind to useful but slightly less efficient or more complex patterns. This behaviour has been identified and several methods partially addressed the issue. To investigate their effectiveness and limits, we first design a publicly available MNIST-based benchmark to precisely measure the ability of an algorithm to find the ''hidden'' patterns. Then, we evaluate state-of-the-art algorithms through our benchmark and show that the issue is largely unsolved. Finally, we propose a partially reversed contrastive loss to encourage intra-class diversity and find less strongly correlated patterns, whose efficiency is demonstrated by our experiments.
In general, an experimental environment for deep learning assumes that the training and the test dataset are sampled from the same distribution. However, in real-world situations, a difference in the distribution between two datasets, domain shift, may occur, which becomes a major factor impeding the generalization performance of the model. The research field to solve this problem is called domain generalization, and it alleviates the domain shift problem by extracting domain-invariant features explicitly or implicitly. In recent studies, contrastive learning-based domain generalization approaches have been proposed and achieved high performance. These approaches require sampling of the negative data pair. However, the performance of contrastive learning fundamentally depends on quality and quantity of negative data pairs. To address this issue, we propose a new regularization method for domain generalization based on contrastive learning, self-supervised contrastive regularization (SelfReg). The proposed approach use only positive data pairs, thus it resolves various problems caused by negative pair sampling. Moreover, we propose a class-specific domain perturbation layer (CDPL), which makes it possible to effectively apply mixup augmentation even when only positive data pairs are used. The experimental results show that the techniques incorporated by SelfReg contributed to the performance in a compatible manner. In the recent benchmark, DomainBed, the proposed method shows comparable performance to the conventional state-of-the-art alternatives. Codes are available at https://github.com/dnap512/SelfReg.
Convolutional Neural Networks (CNNs) often fail to maintain their performance when they confront new test domains, which is known as the problem of domain shift. Recent studies suggest that one of the main causes of this problem is CNNs' strong inductive bias towards image styles (i.e. textures) which are sensitive to domain changes, rather than contents (i.e. shapes). Inspired by this, we propose to reduce the intrinsic style bias of CNNs to close the gap between domains. Our Style-Agnostic Networks (SagNets) disentangle style encodings from class categories to prevent style biased predictions and focus more on the contents. Extensive experiments show that our method effectively reduces the style bias and makes the model more robust under domain shift. It achieves remarkable performance improvements in a wide range of cross-domain tasks including domain generalization, unsupervised domain adaptation, and semi-supervised domain adaptation on multiple datasets.