CURRENT: A Recurrent Neural Network for Concurrent Spatial and Temporal Super-Resolution of 4D Flow MRI

원문 초록

Objective: To improve the spatial and temporal resolution of aortic 4D flow MRI through a unified deep learning framework for post-acquisition super-resolution (SR) of reconstructed velocity vector fields. Methods: We propose CURRENT, a recurrent neural network that performs spatial and temporal SR with a single network architecture. Supervised training was conducted using paired low- and high-resolution datasets generated by embedding computational fluid dynamics simulations of aortic flow into in vivo thoracic MRI backgrounds, followed by controlled spatial and temporal downsampling. CURRENT was evaluated for two-fold spatial and temporal SR against 4DFlowNet and for two-fold spatiotemporal SR against sequential spatial and temporal SR pipelines based on 4DFlowNet. Image-based and k-space-based quantitative metrics were considered and conventional interpolation were used as baselines. In addition, the impact of CURRENT's spatiotemporal SR on physics-informed relative pressure estimation was assessed. Finally, the ability of CURRENT to generalize from synthetic training data to in vivo acquisitions was investigated. Results: CURRENT achieved superior spatial SR performance and comparable temporal SR performance to dedicated 4DFlowNet models while providing a unified solution for both tasks. Simultaneous spatiotemporal SR using CURRENT yielded more accurate relative pressure estimates than either spatial or temporal SR alone and outperformed sequential 4DFlowNet-based spatial and temporal SR approaches. Furthermore, the proposed model demonstrated promising generalization to in vivo 4D flow MRI data despite being trained exclusively on synthetic datasets. Conclusion: CURRENT provides a unified framework for spatial and temporal SR of 4D flow MRI. The proposed approach has the potential to enhance physics-based analysis and broaden the applicability of accelerated 4D flow MRI.