A Stage-Wise Explainable Pipeline for Arteriolar-to-Venular Ratio Estimation and Retinopathy Screening

원문 초록

The arteriolar-to-venular diameter ratio (AVR) is a clinically motivated marker of retinal vascular health. We present a five-stage pipeline for AVR estimation and exploratory retinopathy screening from fundus images, with inspectable intermediate outputs at each stage. The pipeline combines vessel and artery-vein masks, optic-disc localization, vessel-calibre estimation using a minimal-chord boundary walk, and AVR computation from dominant arterial and venular branches. An explicit threshold-based rule produces the screening decision, enabling errors to be traced to individual processing stages. On an exploratory cohort of 30 HRF images, we report 96.7% accuracy, an F1-score of 0.968 and ROC-AUC of 0.978. Ablation studies and an exploratory comparison with VascX examine the effects of vessel pairing, calibre measurement and aggregation. Interpretation is limited by the small cohort, proxy disease labels and absence of independent reference calibre measurements. The pipeline provides a transparent framework for investigating retinal vascular biomarkers, with further validation needed on larger, clinically graded cohorts.