The BRIDGE dataset: paired brightfield whole-slide images of prostate core-needle biopsies in paraffin, after deparaffinization and H&E staining

원문 초록

Computational approaches are increasingly being explored to streamline histopathology workflows, including label-free methods that aim to reduce reliance on chemical staining. Among these, deep learning-based label-free virtual staining uses images of unstained tissue to computationally generate stained images. Despite growing interest, model development and validation remain constrained by the scarcity of paired, clinically annotated whole-slide imaging datasets. We present BRIDGE, a dataset of prostate core-needle biopsies collected at the Prof. Franciszek Lukaszczyk Oncology Centre in Bydgoszcz, Poland. The dataset comprises 869 glass slides from 169 patients, each digitized sequentially after sectioning, deparaffinization, and hematoxylin and eosin staining, yielding in total 2607 whole-slide images. The dataset supports the development and external validation of label-free virtual staining, virtual unstaining, image-registration and segmentation methods. Each slide is accompanied by a Gleason score, enabling downstream analyses of cancer classification and grading concordance. The stained images can be used independently for color normalization and cross-scanner robustness studies. All images are de-identified, distributed in their native scanner format and will be available through the BioImage Archive.