MambaPD: Bidirectional Selective State Space Model for Parkinson's Disease Detection from Resting-State EEG

원문 초록

Typical diagnosis of Parkinson's disease (PD) occurs only after significant dopaminergic loss, while resting-state EEG abnormalities like alpha slowing and reduced coherence occur earlier. While many published EEG-based PD detectors claim accuracy greater than 95%, many use epoch-level splits which leak subject identity. I introduce MambaPD, a bidirectional selective state space model for resting-state EEG-based PD detection, blending the channel mixing, patch tokenization and bidirectional Mamba encoder. It is compared with four baselines (TCN, BiLSTM with attention, EEGNet and a patch Transformer) in two public datasets (UNM, SanDiego) using subject-independent 5-fold cross-validation (checkpoints were selected on the held-out fold, so absolute estimates are optimistic). On UNM the accuracy is between 0.67 and 0.71, and MambaPD (0.714) is not statistically distinguishable from the Transformer (0.715), and TCN (0.708), with the highest sensitivity (0.82), while the lowest specificity (0.52). For the smaller SanDiego cohort, accuracy is in the range of 0.60 to 0.70, with the highest scores (0.703) from TCN and the lowest (0.601) from EEGNet, while MambaPD scores 0.631, with the lowest specificity (0.46) among the five models. The differences among the models on UNM are minor compared to the differences among folds. I report the whole pipeline, per-fold results, and the shortcomings of the protocol.