Benchmarking CNNs, Vision Transformers, and Foundation Models for Explainable Brain Tumor MRI Classification: Calibration, Decision Analysis, and External Validation

원문 초록

Deep learning models for brain tumor MRI classification are usually compared by accuracy alone, on public datasets whose independence is rarely checked. We benchmarked six architectures: two convolutional networks (EfficientNetV2-M and ConvNeXt-V2-Tiny), two vision transformers (Swin-V2-S and ViT-L/16), and two foundation models (DINOv2-L and MedSigLIP-448), for four-class classification of 7,216 public MRI images. We assessed accuracy, calibration, explainability, ensembles, and decision curves, with every fitted quantity estimated on validation data only. Pixel-verified duplicate screening showed that 36% of the test images had a near-duplicate in the training data. Test accuracy ranged from 94.5% to 95.6%, with no pairwise difference after Holm correction, and fell to 90.3% to 91.7% on the 773 test images free of duplicates and shared patients. Ensembles did not outperform the best single model. Attribution maps passed a model-randomization test but localized expert-annotated tumors poorly. On 1,675 external BDNeuro-MRI images that did not duplicate the training data, accuracy ranged from 77.6% (MedSigLIP-448) to 95.0% (ViT-L/16), and 12 of 15 pairwise differences were significant. Internal accuracy on this public collection therefore did not distinguish the architectures, whereas the duplicate-filtered external test did.