Triple-Phase Sequential Fusion Network with Contrast Enhancement Kinetics for Hepatobiliary-Phase Liver MRI Synthesis

원문 초록

Gadoxetate disodium-enhanced MRI is essential for the detection and characterization of hepatocellular carcinoma. However, acquisition of the hepatobiliary phase (HBP) requires a prolonged post-contrast delay, which reduces workflow efficiency and increases the risk of motion artifacts. In this study, we propose a Triple-Phase Sequential Fusion Network (TriPF-Net) with contrast enhancement kinetics to synthesize HBP images by leveraging the sequential information from pre-HBP sequences: while T1-weighted imaging serves as the indispensable baseline, the model adaptively integrates arterial-phase (AP) and venous-phase (VP) features when available. By modeling the tissue-specific contrast uptake and excretion dynamics across these three phases, TriPF-Net ensures robust HBP synthesis even under the stochastic absence of one or both dynamic contrast-enhanced sequences. In addition, clinical variables, including age, sex, total bilirubin, and albumin, are incorporated to enhance physiological consistency. Compared with conventional methods, TriPF-Net achieved superior performance on datasets from two centers. On the first-center dataset, the model achieved an MAE of 10.65, a PSNR of 23.27, and an SSIM of 0.76. On the second-center dataset, the model was trained independently, and the corresponding values were 12.41, 23.11, and 0.78, respectively. Moreover, lesion-level evaluation showed that the synthesized images achieved contrast comparable to that of real HBP images, with no significant difference in CNR (P = 0.2699). Blinded evaluations confirmed synthesized images were visually comparable to real HBP, with TriPF-Net remaining robust to missing input phases. This flexible solution enhances clinical workflow and lesion depiction, and may also serve as an automated quality control reference to flag real HBP acquisitions that warrant closer inspection.