Simulation of prosthetic vision with PRIMA system and enhancement of face representation

원문 초록

Objective. Patients implanted with the PRIMA photovoltaic subretinal prosthesis in geographic atrophy report form vision with the average acuity matching the 100um pixel size. Although this remarkable outcome enables them to read and write, they report difficulty with perceiving faces. This paper provides a novel, non-pixelated algorithm for simulating prosthetic vision the way it is experienced by PRIMA patients, compares the algorithm's predictions to clinical perceptual outcomes, and offers computer vision and machine learning (ML) methods to improve face representation. Approach. Our simulation algorithm integrates a grayscale filter, spatial resolution filter, and contrast filter. This accounts for the limited sampling density of the retinal implant, as well as the reduced contrast sensitivity of prosthetic vision. Patterns of Landolt C and faces created using this simulation algorithm are compared to reports from actual PRIMA users. To recover the facial features lost in prosthetic vision, we apply an ML facial landmarking model as well as contrast adjusting tone curves to the face image prior to its projection onto the implant. Main results. Simulated prosthetic vision matches the maximum letter acuity observed in clinical studies as well as patients' subjective descriptions. Application of the inversed contrast filter helps preserve the contrast in prosthetic vision. Identification of the facial features using an ML facial landmarking model and accentuating them further improve face representation. Significance. Spatial and contrast constraints of prosthetic vision limit resolvable features and degrade natural images. ML based methods and contrast adjustments mitigate some limitations and improve face representation. Even though higher spatial resolution can be expected with implants having smaller pixels, contrast enhancement still remains essential for face recognition.