FiAt-Net: Detecting Fibroatheroma Plaque Cap in 3D Intravascular OCT Images

원문 초록

The key manifestation of coronary artery disease (CAD) is development of fibroatheromatous plaque, the cap of which may rupture and subsequently lead to coronary artery blocking and heart attack. As such, quantitative analysis of coronary plaque, its plaque cap, and consequently the cap's likelihood to rupture are of critical importance when assessing a risk of cardiovascular events. This paper reports a new deep learning based approach, called FiAt-Net, for detecting angular extent of fibroatheroma (FA) and segmenting its cap in 3D intravascular optical coherence tomography (IVOCT) images. IVOCT 2D image frames are first associated with distinct clusters and data from each cluster are used for model training. As plaque is typically focal and thus unevenly distributed, a binary partitioning method is employed to identify FA plaque areas to focus on to mitigate the data imbalance issue. Additional image representations (called auxiliary images) are generated to capture IVOCT intensity changes to help distinguish FA and non-FA areas on the coronary wall. Information in varying scales is derived from the original IVOCT and auxiliary images, and a multi-head self-attention mechanism is employed to fuse such information. Our FiAt-Net achieved high performance on a 3D IVOCT coronary image dataset, demonstrating its effectiveness in accurately detecting FA cap in IVOCT images.