Mining Adverse Drug Reactions from Unstructured Mediums at Scale

원문 초록

Adverse drug reactions / events (ADR/ADE) have a major impact on patient health and health care costs. Detecting ADR's as early as possible and sharing them with regulators, pharma companies, and healthcare providers can prevent morbidity and save many lives. While most ADR's are not reported via formal channels, they are often documented in a variety of unstructured conversations such as social media posts by patients, customer support call transcripts, or CRM notes of meetings between healthcare providers and pharma sales reps. In this paper, we propose a natural language processing (NLP) solution that detects ADR's in such unstructured free-text conversations, which improves on previous work in three ways. First, a new Named Entity Recognition (NER) model obtains new state-of-the-art accuracy for ADR and Drug entity extraction on the ADE, CADEC, and SMM4H benchmark datasets (91.75%, 78.76%, and 83.41% F1 scores respectively). Second, two new Relation Extraction (RE) models are introduced - one based on BioBERT while the other utilizing crafted features over a Fully Connected Neural Network (FCNN) - are shown to perform on par with existing state-of-the-art models, and outperform them when trained with a supplementary clinician-annotated RE dataset. Third, a new text classification model, for deciding if a conversation includes an ADR, obtains new state-of-the-art accuracy on the CADEC dataset (86.69% F1 score). The complete solution is implemented as a unified NLP pipeline in a production-grade library built on top of Apache Spark, making it natively scalable and able to process millions of batch or streaming records on commodity clusters.