Super-resolution microscopy, or nanoscopy, enables the use of fluorescent-based molecular localization tools to study molecular structure at the nanoscale level in the intact cell, bridging the mesoscale gap to classical structural biology methodologies. Analysis of super-resolution data by artificial intelligence (AI), such as machine learning, offers tremendous potential for discovery of new biology, that, by definition, is not known and lacks ground truth. Herein, we describe the application of weakly supervised paradigms to super-resolution microscopy and its potential to enable the accelerated exploration of the nanoscale architecture of subcellular macromolecules and organelles.
Weakly supervised learning aims to empower machine learning when the perfect supervision is unavailable, which has drawn great attention from researchers. Among various types of weak supervision, one of the most challenging cases is to learn from multiple unlabeled (U) datasets with only a little knowledge of the class priors, or U$^m$ learning for short. In this paper, we study the problem of building an AUC (area under ROC curve) optimization model from multiple unlabeled datasets, which maximizes the pairwise ranking ability of the classifier. We propose U$^m$-AUC, an AUC optimization approach that converts the U$^m$ data into a multi-label AUC optimization problem, and can be trained efficiently. We show that the proposed U$^m$-AUC is effective theoretically and empirically.
The past decade has witnessed many great successes of machine learning (ML) and deep learning (DL) applications in agricultural systems, including weed control, plant disease diagnosis, agricultural robotics, and precision livestock management. Despite tremendous progresses, one downside of such ML/DL models is that they generally rely on large-scale labeled datasets for training, and the performance of such models is strongly influenced by the size and quality of available labeled data samples. In addition, collecting, processing, and labeling such large-scale datasets is extremely costly and time-consuming, partially due to the rising cost in human labor. Therefore, developing label-efficient ML/DL methods for agricultural applications has received significant interests among researchers and practitioners. In fact, there are more than 50 papers on developing and applying deep-learning-based label-efficient techniques to address various agricultural problems since 2016, which motivates the authors to provide a timely and comprehensive review of recent label-efficient ML/DL methods in agricultural applications. To this end, we first develop a principled taxonomy to organize these methods according to the degree of supervision, including weak supervision (i.e., active learning and semi-/weakly- supervised learning), and no supervision (i.e., un-/self- supervised learning), supplemented by representative state-of-the-art label-efficient ML/DL methods. In addition, a systematic review of various agricultural applications exploiting these label-efficient algorithms, such as precision agriculture, plant phenotyping, and postharvest quality assessment, is presented. Finally, we discuss the current problems and challenges, as well as future research directions. A well-classified paper list can be accessed at https://github.com/DongChen06/Label-efficient-in-Agriculture.
Recent work in vision-and-language pretraining has investigated supervised signals from object detection data to learn better, fine-grained multimodal representations. In this work, we take a step further and explore how we can tap into supervision from small-scale visual relation data. In particular, we propose two pretraining approaches to contextualise visual entities in a multimodal setup. With verbalised scene graphs, we transform visual relation triplets into structured captions, and treat them as additional image descriptions. With masked relation prediction, we further encourage relating entities from image regions with visually masked contexts. When applied to strong baselines pretrained on large amounts of Web data, zero-shot evaluations on both coarse-grained and fine-grained tasks show the efficacy of our methods in learning multimodal representations from weakly-supervised relations data.
Weakly supervised learning based on scribble annotations in target extraction of remote sensing images has drawn much interest due to scribbles' flexibility in denoting winding objects and low cost of manually labeling. However, scribbles are too sparse to identify object structure and detailed information, bringing great challenges in target localization and boundary description. To alleviate these problems, in this paper, we construct two inner structure-constraints, a deformation consistency loss and a trainable active contour loss, together with a scribble-constraint to supervise the optimization of the encoder-decoder network without introducing any auxiliary module or extra operation based on prior cues. Comprehensive experiments demonstrate our method's superiority over five state-of-the-art algorithms in this field. Source code is available at https://github.com/yitongli123/ISC-TE.
Complementary-label Learning (CLL) is a form of weakly supervised learning that trains an ordinary classifier using only complementary labels, which are the classes that certain instances do not belong to. While existing CLL studies typically use novel loss functions or training techniques to solve this problem, few studies focus on how complementary labels collectively provide information to train the ordinary classifier. In this paper, we fill the gap by analyzing the implicit sharing of complementary labels on nearby instances during training. Our analysis reveals that the efficiency of implicit label sharing is closely related to the performance of existing CLL models. Based on this analysis, we propose a novel technique that enhances the sharing efficiency via complementary-label augmentation, which explicitly propagates additional complementary labels to each instance. We carefully design the augmentation process to enrich the data with new and accurate complementary labels, which provide CLL models with fresh and valuable information to enhance the sharing efficiency. We then verify our proposed technique by conducting thorough experiments on both synthetic and real-world datasets. Our results confirm that complementary-label augmentation can systematically improve empirical performance over state-of-the-art CLL models.
Complementary-label learning (CLL) is a weakly-supervised learning paradigm that aims to train a multi-class classifier using only complementary labels, which indicate classes to which an instance does not belong. Despite numerous algorithmic proposals for CLL, their practical applicability remains unverified for two reasons. Firstly, these algorithms often rely on assumptions about the generation of complementary labels, and it is not clear how far the assumptions are from reality. Secondly, their evaluation has been limited to synthetic datasets. To gain insights into the real-world performance of CLL algorithms, we developed a protocol to collect complementary labels from human annotators. Our efforts resulted in the creation of four datasets: CLCIFAR10, CLCIFAR20, CLMicroImageNet10, and CLMicroImageNet20, derived from well-known classification datasets CIFAR10, CIFAR100, and TinyImageNet200. These datasets represent the very first real-world CLL datasets. Through extensive benchmark experiments, we discovered a notable decrease in performance when transitioning from synthetic datasets to real-world datasets. We investigated the key factors contributing to the decrease with a thorough dataset-level ablation study. Our analyses highlight annotation noise as the most influential factor in the real-world datasets. In addition, we discover that the biased-nature of human-annotated complementary labels and the difficulty to validate with only complementary labels are two outstanding barriers to practical CLL. These findings suggest that the community focus more research efforts on developing CLL algorithms and validation schemes that are robust to noisy and biased complementary-label distributions.
Accurate Named Entity Recognition (NER) is crucial for various information retrieval tasks in industry. However, despite significant progress in traditional NER methods, the extraction of Complex Named Entities remains a relatively unexplored area. In this paper, we propose a novel system that combines object detection for Document Layout Analysis (DLA) with weakly supervised learning to address the challenge of extracting discontinuous complex named entities in legal documents. Notably, to the best of our knowledge, this is the first work to apply weak supervision to DLA. Our experimental results show that the model trained solely on pseudo labels outperforms the supervised baseline when gold-standard data is limited, highlighting the effectiveness of our proposed approach in reducing the dependency on annotated data.
ROI extraction is an active but challenging task in remote sensing because of the complicated landform, the complex boundaries and the requirement of annotations. Weakly supervised learning (WSL) aims at learning a mapping from input image to pixel-wise prediction under image-wise labels, which can dramatically decrease the labor cost. However, due to the imprecision of labels, the accuracy and time consumption of WSL methods are relatively unsatisfactory. In this paper, we propose a two-step ROI extraction based on contractive learning. Firstly, we present to integrate multiscale Grad-CAM to obtain pseudo pixelwise annotations with well boundaries. Then, to reduce the compact of misjudgments in pseudo annotations, we construct a contrastive learning strategy to encourage the features inside ROI as close as possible and separate background features from foreground features. Comprehensive experiments demonstrate the superiority of our proposal. Code is available at https://github.com/HE-Lingfeng/ROI-Extraction
Precise segmentation of residual tumor in breast cancer (PSRTBC) after neoadjuvant chemotherapy is a fundamental key technique in the treatment process of breast cancer. However, achieving PSRTBC is still a challenge, since the breast cancer tissue and tumor cells commonly have complex and varied morphological changes after neoadjuvant chemotherapy, which inevitably increases the difficulty to produce a predictive model that has good generalization with usual supervised learning (SL). To alleviate this situation, in this paper, we propose an experts' cognition-driven safe noisy labels learning (ECDSNLL) approach. In the concept of safe noisy labels learning, which is a typical type of safe weakly supervised learning, ECDSNLL is constructed by integrating the pathology experts' cognition about identifying residual tumor in breast cancer and the artificial intelligence experts' cognition about data modeling with provided data basis. Experimental results show that, compared with usual SL, ECDSNLL can significantly improve the lower bound of a number of UNet variants with 2.42% and 4.1% respectively in recall and fIoU for PSRTBC, while being able to achieve improvements in mean value and upper bound as well.
Image segmentation is a fundamental task in the field of imaging and vision. Supervised deep learning for segmentation has achieved unparalleled success when sufficient training data with annotated labels are available. However, annotation is known to be expensive to obtain, especially for histopathology images where the target regions are usually with high morphology variations and irregular shapes. Thus, weakly supervised learning with sparse annotations of points is promising to reduce the annotation workload. In this work, we propose a contrast-based variational model to generate segmentation results, which serve as reliable complementary supervision to train a deep segmentation model for histopathology images. The proposed method considers the common characteristics of target regions in histopathology images and can be trained in an end-to-end manner. It can generate more regionally consistent and smoother boundary segmentation, and is more robust to unlabeled `novel' regions. Experiments on two different histology datasets demonstrate its effectiveness and efficiency in comparison to previous models.
This paper explores the properties of the plain Vision Transformer (ViT) for Weakly-supervised Semantic Segmentation (WSSS). The class activation map (CAM) is of critical importance for understanding a classification network and launching WSSS. We observe that different attention heads of ViT focus on different image areas. Thus a novel weight-based method is proposed to end-to-end estimate the importance of attention heads, while the self-attention maps are adaptively fused for high-quality CAM results that tend to have more complete objects. Besides, we propose a ViT-based gradient clipping decoder for online retraining with the CAM results to complete the WSSS task. We name this plain Transformer-based Weakly-supervised learning framework WeakTr. It achieves the state-of-the-art WSSS performance on standard benchmarks, i.e., 78.4% mIoU on the val set of PASCAL VOC 2012 and 50.3% mIoU on the val set of COCO 2014. Code is available at https://github.com/hustvl/WeakTr.
Given a 3D object, kinematic motion prediction aims to identify the mobile parts as well as the corresponding motion parameters. Due to the large variations in both topological structure and geometric details of 3D objects, this remains a challenging task and the lack of large scale labeled data also constrain the performance of deep learning based approaches. In this paper, we tackle the task of object kinematic motion prediction problem in a semi-weakly supervised manner. Our key observations are two-fold. First, although 3D dataset with fully annotated motion labels is limited, there are existing datasets and methods for object part semantic segmentation at large scale. Second, semantic part segmentation and mobile part segmentation is not always consistent but it is possible to detect the mobile parts from the underlying 3D structure. Towards this end, we propose a graph neural network to learn the map between hierarchical part-level segmentation and mobile parts parameters, which are further refined based on geometric alignment. This network can be first trained on PartNet-Mobility dataset with fully labeled mobility information and then applied on PartNet dataset with fine-grained and hierarchical part-level segmentation. The network predictions yield a large scale of 3D objects with pseudo labeled mobility information and can further be used for weakly-supervised learning with pre-existing segmentation. Our experiments show there are significant performance boosts with the augmented data for previous method designed for kinematic motion prediction on 3D partial scans.
Weakly-supervised temporal action localization aims to localize action instances in untrimmed videos with only video-level supervision. We witness that different actions record common phases, e.g., the run-up in the HighJump and LongJump. These different actions are defined as conjoint actions, whose rest parts are definite phases, e.g., leaping over the bar in a HighJump. Compared with the common phases, the definite phases are more easily localized in existing researches. Most of them formulate this task as a Multiple Instance Learning paradigm, in which the common phases are tended to be confused with the background, and affect the localization completeness of the conjoint actions. To tackle this challenge, we propose a Joint of Common and Definite phases Network (JCDNet) by improving feature discriminability of the conjoint actions. Specifically, we design a Class-Aware Discriminative module to enhance the contribution of the common phases in classification by the guidance of the coarse definite-phase features. Besides, we introduce a temporal attention module to learn robust action-ness scores via modeling temporal dependencies, distinguishing the common phases from the background. Extensive experiments on three datasets (THUMOS14, ActivityNetv1.2, and a conjoint-action subset) demonstrate that JCDNet achieves competitive performance against the state-of-the-art methods. Keywords: weakly-supervised learning, temporal action localization, conjoint action
In many real-world scenarios, obtaining large amounts of labeled data can be a daunting task. Weakly supervised learning techniques have gained significant attention in recent years as an alternative to traditional supervised learning, as they enable training models using only a limited amount of labeled data. In this paper, the performance of a weakly supervised classifier to its fully supervised counterpart is compared on the task of defect detection. Experiments are conducted on a dataset of images containing defects, and evaluate the two classifiers based on their accuracy, precision, and recall. Our results show that the weakly supervised classifier achieves comparable performance to the supervised classifier, while requiring significantly less labeled data.
Regular physics-informed neural networks (PINNs) predict the solution of partial differential equations using sparse labeled data but only over a single domain. On the other hand, fully supervised learning models are first trained usually over a few thousand domains with known solutions (i.e., labeled data) and then predict the solution over a few hundred unseen domains. Physics-informed PointNet (PIPN) is primarily designed to fill this gap between PINNs (as weakly supervised learning models) and fully supervised learning models. In this article, we demonstrate that PIPN predicts the solution of desired partial differential equations over a few hundred domains simultaneously, while it only uses sparse labeled data. This framework benefits fast geometric designs in the industry when only sparse labeled data are available. Particularly, we show that PIPN predicts the solution of a plane stress problem over more than 500 domains with different geometries, simultaneously. Moreover, we pioneer implementing the concept of remarkable batch size (i.e., the number of geometries fed into PIPN at each sub-epoch) into PIPN. Specifically, we try batch sizes of 7, 14, 19, 38, 76, and 133. Additionally, the effect of the PIPN size, symmetric function in the PIPN architecture, and static and dynamic weights for the component of the sparse labeled data in the loss function are investigated.
Head MRI pre-processing involves converting raw images to an intensity-normalized, skull-stripped brain in a standard coordinate space. In this paper, we propose an end-to-end weakly supervised learning approach, called Neural Pre-processing (NPP), for solving all three sub-tasks simultaneously via a neural network, trained on a large dataset without individual sub-task supervision. Because the overall objective is highly under-constrained, we explicitly disentangle geometric-preserving intensity mapping (skull-stripping and intensity normalization) and spatial transformation (spatial normalization). Quantitative results show that our model outperforms state-of-the-art methods which tackle only a single sub-task. Our ablation experiments demonstrate the importance of the architecture design we chose for NPP. Furthermore, NPP affords the user the flexibility to control each of these tasks at inference time. The code and model are freely-available at \url{https://github.com/Novestars/Neural-Pre-processing}.
Partial-label learning (PLL) is an important weakly supervised learning problem, which allows each training example to have a candidate label set instead of a single ground-truth label. Identification-based methods have been widely explored to tackle label ambiguity issues in PLL, which regard the true label as a latent variable to be identified. However, identifying the true labels accurately and completely remains challenging, causing noise in pseudo labels during model training. In this paper, we propose a new method called CroSel, which leverages historical predictions from the model to identify true labels for most training examples. First, we introduce a cross selection strategy, which enables two deep models to select true labels of partially labeled data for each other. Besides, we propose a novel consistency regularization term called co-mix to avoid sample waste and tiny noise caused by false selection. In this way, CroSel can pick out the true labels of most examples with high precision. Extensive experiments demonstrate the superiority of CroSel, which consistently outperforms previous state-of-the-art methods on benchmark datasets. Additionally, our method achieves over 90\% accuracy and quantity for selecting true labels on CIFAR-type datasets under various settings.
Multiple Instance Learning (MIL), a powerful strategy for weakly supervised learning, is able to perform various prediction tasks on gigapixel Whole Slide Images (WSIs). However, the tens of thousands of patches in WSIs usually incur a vast computational burden for image augmentation, limiting the MIL model's improvement in performance. Currently, the feature augmentation-based MIL framework is a promising solution, while existing methods such as Mixup often produce unrealistic features. To explore a more efficient and practical augmentation method, we introduce the Diffusion Model (DM) into MIL for the first time and propose a feature augmentation framework called AugDiff. Specifically, we employ the generation diversity of DM to improve the quality of feature augmentation and the step-by-step generation property to control the retention of semantic information. We conduct extensive experiments over three distinct cancer datasets, two different feature extractors, and three prevalent MIL algorithms to evaluate the performance of AugDiff. Ablation study and visualization further verify the effectiveness. Moreover, we highlight AugDiff's higher-quality augmented feature over image augmentation and its superiority over self-supervised learning. The generalization over external datasets indicates its broader applications.
Self-paced learning has been beneficial for tasks where some initial knowledge is available, such as weakly supervised learning and domain adaptation, to select and order the training sample sequence, from easy to complex. However its applicability remains unexplored in unsupervised learning, whereby the knowledge of the task matures during training. We propose a novel HYperbolic Self-Paced model (HYSP) for learning skeleton-based action representations. HYSP adopts self-supervision: it uses data augmentations to generate two views of the same sample, and it learns by matching one (named online) to the other (the target). We propose to use hyperbolic uncertainty to determine the algorithmic learning pace, under the assumption that less uncertain samples should be more strongly driving the training, with a larger weight and pace. Hyperbolic uncertainty is a by-product of the adopted hyperbolic neural networks, it matures during training and it comes with no extra cost, compared to the established Euclidean SSL framework counterparts. When tested on three established skeleton-based action recognition datasets, HYSP outperforms the state-of-the-art on PKU-MMD I, as well as on 2 out of 3 downstream tasks on NTU-60 and NTU-120. Additionally, HYSP only uses positive pairs and bypasses therefore the complex and computationally-demanding mining procedures required for the negatives in contrastive techniques. Code is available at https://github.com/paolomandica/HYSP.