Modeling complex semiconductor fabrication processes such as Ohmic contact formation remains challenging due to high-dimensional parameter spaces and limited experimental data. While classical machine learning (CML) approaches have been successful in many domains, their performance degrades in small-sample, nonlinear scenarios. In this work, we investigate quantum machine learning (QML) as an alternative, exploiting quantum kernels to capture intricate correlations from compact datasets. Using only 159 experimental GaN HEMT samples, we develop a quantum kernel-aligned regressor (QKAR) combining a shallow Pauli-Z feature map with a trainable quantum kernel alignment (QKA) layer. All models, including seven baseline CML regressors, are evaluated under a unified PCA-based preprocessing pipeline to ensure a fair comparison. QKAR consistently outperforms classical baselines across multiple metrics (MAE, MSE, RMSE), achieving a mean absolute error of 0.338 Omega mm when validated on experimental data. We further assess noise robustness and generalization through cross-validation and new device fabrication. These findings suggest that carefully constructed QML models could provide predictive advantages in data-constrained semiconductor modeling, offering a foundation for practical deployment on near-term quantum hardware. While challenges remain for both QML and CML, this study demonstrates QML's potential as a complementary approach in complex process modeling tasks.
Coronary heart disease (CHD) is a severe cardiac disease, and hence, its early diagnosis is essential as it improves treatment results and saves money on medical care. The prevailing development of quantum computing and machine learning (ML) technologies may bring practical improvement to the performance of CHD diagnosis. Quantum machine learning (QML) is receiving tremendous interest in various disciplines due to its higher performance and capabilities. A quantum leap in the healthcare industry will increase processing power and optimise multiple models. Techniques for QML have the potential to forecast cardiac disease and help in early detection. To predict the risk of coronary heart disease, a hybrid approach utilizing an ensemble machine learning model based on QML classifiers is presented in this paper. Our approach, with its unique ability to address multidimensional healthcare data, reassures the method's robustness by fusing quantum and classical ML algorithms in a multi-step inferential framework. The marked rise in heart disease and death rates impacts worldwide human health and the global economy. Reducing cardiac morbidity and mortality requires early detection of heart disease. In this research, a hybrid approach utilizes techniques with quantum computing capabilities to tackle complex problems that are not amenable to conventional machine learning algorithms and to minimize computational expenses. The proposed method has been developed in the Raspberry Pi 5 Graphics Processing Unit (GPU) platform and tested on a broad dataset that integrates clinical and imaging data from patients suffering from CHD and healthy controls. Compared to classical machine learning models, the accuracy, sensitivity, F1 score, and specificity of the proposed hybrid QML model used with CHD are manifold higher.
Understanding of how biological neural networks process information is one of the biggest open scientific questions of our time. Advances in machine learning and artificial neural networks have enabled the modeling of neuronal behavior, but classical models often require a large number of parameters, complicating interpretability. Quantum computing offers an alternative approach through quantum machine learning, which can achieve efficient training with fewer parameters. In this work, we introduce a quantum generative model framework for generating synthetic data that captures the spatial and temporal correlations of biological neuronal activity. Our model demonstrates the ability to achieve reliable outcomes with fewer trainable parameters compared to classical methods. These findings highlight the potential of quantum generative models to provide new tools for modeling and understanding neuronal behavior, offering a promising avenue for future research in neuroscience.
This paper introduces CompressedMediQ, a novel hybrid quantum-classical machine learning pipeline specifically developed to address the computational challenges associated with high-dimensional multi-class neuroimaging data analysis. Standard neuroimaging datasets, such as large-scale MRI data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Neuroimaging in Frontotemporal Dementia (NIFD), present significant hurdles due to their vast size and complexity. CompressedMediQ integrates classical high-performance computing (HPC) nodes for advanced MRI pre-processing and Convolutional Neural Network (CNN)-PCA-based feature extraction and reduction, addressing the limited-qubit availability for quantum data encoding in the NISQ (Noisy Intermediate-Scale Quantum) era. This is followed by Quantum Support Vector Machine (QSVM) classification. By utilizing quantum kernel methods, the pipeline optimizes feature mapping and classification, enhancing data separability and outperforming traditional neuroimaging analysis techniques. Experimental results highlight the pipeline's superior accuracy in dementia staging, validating the practical use of quantum machine learning in clinical diagnostics. Despite the limitations of NISQ devices, this proof-of-concept demonstrates the transformative potential of quantum-enhanced learning, paving the way for scalable and precise diagnostic tools in healthcare and signal processing.
Quantum Machine Learning (QML) has emerged as a promising field that combines the power of quantum computing with the principles of machine learning. One of the significant challenges in QML is dealing with noise in quantum systems, especially in the Noisy Intermediate-Scale Quantum (NISQ) era. Noise in quantum systems can introduce errors in quantum computations and degrade the performance of quantum algorithms. In this paper, we propose a framework for learning observables that are robust against noisy channels in quantum systems. We demonstrate that it is possible to learn observables that remain invariant under the effects of noise and show that this can be achieved through a machine-learning approach. We present a toy example using a Bell state under a depolarization channel to illustrate the concept of robust observables. We then describe a machine-learning framework for learning such observables across six two-qubit quantum circuits and five noisy channels. Our results show that it is possible to learn observables that are more robust to noise than conventional observables. We discuss the implications of this finding for quantum machine learning, including potential applications in enhancing the stability of QML models in noisy environments. By developing techniques for learning robust observables, we can improve the performance and reliability of quantum machine learning models in the presence of noise, contributing to the advancement of practical QML applications in the NISQ era.
Despite the mounting anticipation for the quantum revolution, the success of Quantum Machine Learning (QML) in the Noisy Intermediate-Scale Quantum (NISQ) era hinges on a largely unexplored factor: the generalization error bound, a cornerstone of robust and reliable machine learning models. Current QML research, while exploring novel algorithms and applications extensively, is predominantly situated in the context of noise-free, ideal quantum computers. However, Quantum Circuit (QC) operations in NISQ-era devices are susceptible to various noise sources and errors. In this article, we conduct a Systematic Mapping Study (SMS) to explore the state-of-the-art generalization bound for supervised QML in NISQ-era and analyze the latest practices in the field. Our study systematically summarizes the existing computational platforms with quantum hardware, datasets, optimization techniques, and the common properties of the bounds found in the literature. We further present the performance accuracy of various approaches in classical benchmark datasets like the MNIST and IRIS datasets. The SMS also highlights the limitations and challenges in QML in the NISQ era and discusses future research directions to advance the field. Using a detailed Boolean operators query in five reliable indexers, we collected 544 papers and filtered them to a small set of 37 relevant articles. This filtration was done following the best practice of SMS with well-defined research questions and inclusion and exclusion criteria.
Based on the linearity of quantum unitary operations, we propose a method that runs the parameterized quantum circuits before encoding the input data. This enables a dataset owner to train machine learning models on quantum cloud computation platforms, without the risk of leaking the information about the data. It is also capable of encoding a vast amount of data effectively at a later time using classical computations, thus saving runtime on quantum computation devices. The trained quantum machine learning models can be run completely on classical computers, meaning the dataset owner does not need to have any quantum hardware, nor even quantum simulators. Moreover, our method mitigates the encoding bottleneck by reducing the required circuit depth from $O(2^{n})$ to $O(n)$, and relax the tolerance on the precision of the quantum gates for the encoding. These results demonstrate yet another advantage of quantum and quantum-inspired machine learning models over existing classical neural networks, and broaden the approaches to data security.
Since the entry of kernel theory in the field of quantum machine learning, quantum kernel methods (QKMs) have gained increasing attention with regard to both probing promising applications and delivering intriguing research insights. Two common approaches for computing the underlying Gram matrix have emerged: fidelity quantum kernels (FQKs) and projected quantum kernels (PQKs). Benchmarking these methods is crucial to gain robust insights and to understand their practical utility. In this work, we present a comprehensive large-scale study examining QKMs based on FQKs and PQKs across a manifold of design choices. Our investigation encompasses both classification and regression tasks for five dataset families and 64 datasets, systematically comparing the use of FQKs and PQKs quantum support vector machines and kernel ridge regression. This resulted in over 20,000 models that were trained and optimized using a state-of-the-art hyperparameter search to ensure robust and comprehensive insights. We delve into the importance of hyperparameters on model performance scores and support our findings through rigorous correlation analyses. In this, we also closely inspect two data encoding strategies. Moreover, we provide an in-depth analysis addressing the design freedom of PQKs and explore the underlying principles responsible for learning. Our goal is not to identify the best-performing model for a specific task but to uncover the mechanisms that lead to effective QKMs and reveal universal patterns.
In the current Noisy Intermediate Scale Quantum (NISQ) era, the presence of noise deteriorates the performance of quantum computing algorithms. Quantum Reservoir Computing (QRC) is a type of Quantum Machine Learning algorithm, which, however, can benefit from different types of tuned noise. In this paper, we analyse the effect that finite-sampling noise has on the chaotic time-series prediction capabilities of QRC and Recurrence-free Quantum Reservoir Computing (RF-QRC). First, we show that, even without a recurrent loop, RF-QRC contains temporal information about previous reservoir states using leaky integrated neurons. This makes RF-QRC different from Quantum Extreme Learning Machines (QELM). Second, we show that finite sampling noise degrades the prediction capabilities of both QRC and RF-QRC while affecting QRC more due to the propagation of noise. Third, we optimize the training of the finite-sampled quantum reservoir computing framework using two methods: (a) Singular Value Decomposition (SVD) applied to the data matrix containing noisy reservoir activation states; and (b) data-filtering techniques to remove the high-frequencies from the noisy reservoir activation states. We show that denoising reservoir activation states improve the signal-to-noise ratios with smaller training loss. Finally, we demonstrate that the training and denoising of the noisy reservoir activation signals in RF-QRC are highly parallelizable on multiple Quantum Processing Units (QPUs) as compared to the QRC architecture with recurrent connections. The analyses are numerically showcased on prototypical chaotic dynamical systems with relevance to turbulence. This work opens opportunities for using quantum reservoir computing with finite samples for time-series forecasting on near-term quantum hardware.
We consider the problem of distinguishing two vectors (visualized as images or barcodes) and learning if they are related to one another. For this, we develop a geometric quantum machine learning (GQML) approach with embedded symmetries that allows for the classification of similar and dissimilar pairs based on global correlations, and enables generalization from just a few samples. Unlike GQML algorithms developed to date, we propose to focus on symmetry-aware measurement adaptation that outperforms unitary parametrizations. We compare GQML for similarity testing against classical deep neural networks and convolutional neural networks with Siamese architectures. We show that quantum networks largely outperform their classical counterparts. We explain this difference in performance by analyzing correlated distributions used for composing our dataset. We relate the similarity testing with problems that showcase a proven maximal separation between the BQP complexity class and the polynomial hierarchy. While the ability to achieve advantage largely depends on how data are loaded, we discuss how similar problems can benefit from quantum machine learning.
Anomaly detection is a crucial task in cyber security. Technological advancement brings new cyber-physical threats like network intrusion, financial fraud, identity theft, and property invasion. In the rapidly changing world, with frequently emerging new types of anomalies, classical machine learning models are insufficient to prevent all the threats. Quantum Machine Learning (QML) is emerging as a powerful computational tool that can detect anomalies more efficiently. In this work, we have introduced QML and its applications for anomaly detection in consumer electronics. We have shown a generic framework for applying QML algorithms in anomaly detection tasks. We have also briefly discussed popular supervised, unsupervised, and reinforcement learning-based QML algorithms and included five case studies of recent works to show their applications in anomaly detection in the consumer electronics field.
Quantum machine learning (QML) is a rapidly emerging area of research, driven by the capabilities of Noisy Intermediate-Scale Quantum (NISQ) devices. With the progress in the research of QML models, there is a rise in third-party quantum cloud services to cater to the increasing demand for resources. New security concerns surface, specifically regarding the protection of intellectual property (IP) from untrustworthy service providers. One of the most pressing risks is the potential for reverse engineering (RE) by malicious actors who may steal proprietary quantum IPs such as trained parameters and QML architecture, modify them to remove additional watermarks or signatures and re-transpile them for other quantum hardware. Prior work presents a brute force approach to RE the QML parameters which takes exponential time overhead. In this paper, we introduce an autoencoder-based approach to extract the parameters from transpiled QML models deployed on untrusted third-party vendors. We experiment on multi-qubit classifiers and note that they can be reverse-engineered under restricted conditions with a mean error of order 10^-1. The amount of time taken to prepare the dataset and train the model to reverse engineer the QML circuit being of the order 10^3 seconds (which is 10^2x better than the previously reported value for 4-layered 4-qubit classifiers) makes the threat of RE highly potent, underscoring the need for continued development of effective defenses.
Deep Learning algorithms, such as those used in Reinforcement Learning, often require large quantities of data to train effectively. In most cases, the availability of data is not a significant issue. However, for some contexts, such as in autonomous cyber defence, we require data efficient methods. Recently, Quantum Machine Learning and Boltzmann Machines have been proposed as solutions to this challenge. In this work we build upon the pre-existing work to extend the use of Deep Boltzmann Machines to the cutting edge algorithm Proximal Policy Optimisation in a Reinforcement Learning cyber defence environment. We show that this approach, when solved using a D-WAVE quantum annealer, can lead to a two-fold increase in data efficiency. We therefore expect it to be used by the machine learning and quantum communities who are hoping to capitalise on data-efficient Reinforcement Learning methods.
Variational quantum algorithms (VQAs) have shown potential for quantum advantage with noisy intermediate-scale quantum (NISQ) devices for quantum machine learning (QML). However, given the high cost and limited availability of quantum resources, delegating VQAs via cloud networks is a more practical solution for clients with limited quantum capabilities. Recently, Shingu et al.[Physical Review A, 105, 022603 (2022)] proposed a variational secure cloud quantum computing protocol, utilizing ancilla-driven quantum computation (ADQC) for cloud-based VQAs with minimal quantum resource consumption. However, their protocol lacks verifiability, which exposes it to potential malicious behaviors by the server. Additionally, channel loss requires frequent re-delegation as the size of the delegated variational circuit grows, complicating verification due to increased circuit complexity. This paper introduces a new protocol to address these challenges and enhance both verifiability and tolerance to channel loss in cloud-based VQAs.
Quantum Convolutional Neural Networks (QCNNs) are widely regarded as a promising model for Quantum Machine Learning (QML). In this work we tie their heuristic success to two facts. First, that when randomly initialized, they can only operate on the information encoded in low-bodyness measurements of their input states. And second, that they are commonly benchmarked on "locally-easy'' datasets whose states are precisely classifiable by the information encoded in these low-bodyness observables subspace. We further show that the QCNN's action on this subspace can be efficiently classically simulated by a classical algorithm equipped with Pauli shadows on the dataset. Indeed, we present a shadow-based simulation of QCNNs on up-to $1024$ qubits for phases of matter classification. Our results can then be understood as highlighting a deeper symptom of QML: Models could only be showing heuristic success because they are benchmarked on simple problems, for which their action can be classically simulated. This insight points to the fact that non-trivial datasets are a truly necessary ingredient for moving forward with QML. To finish, we discuss how our results can be extrapolated to classically simulate other architectures.
Quantum computing promises to revolutionize machine learning, offering significant efficiency gains in tasks such as clustering and distance estimation. Additionally, it provides enhanced security through fundamental principles like the measurement postulate and the no-cloning theorem, enabling secure protocols such as quantum teleportation and quantum key distribution. While advancements in secure quantum machine learning are notable, the development of secure and distributed quantum analogues of kernel-based machine learning techniques remains underexplored. In this work, we present a novel approach for securely computing common kernels, including polynomial, radial basis function (RBF), and Laplacian kernels, when data is distributed, using quantum feature maps. Our methodology introduces a robust framework that leverages quantum teleportation to ensure secure and distributed kernel learning. The proposed architecture is validated using IBM's Qiskit Aer Simulator on various public datasets.
Quantum-enhanced machine learning is a rapidly evolving field that aims to leverage the unique properties of quantum mechanics to enhance classical machine learning. However, the practical applicability of these methods remains an open question, particularly beyond the context of specifically-crafted toy problems, and given the current limitations of quantum hardware. This study focuses on quantum kernel methods in the context of classification tasks. In particular, it examines the performance of Quantum Kernel Estimation (QKE) and Quantum Kernel Training (QKT) in connection with two quantum feature mappings, namely ZZFeatureMap and CovariantFeatureMap. Remarkably, these feature maps have been proposed in the literature under the conjecture of possible near-term quantum advantage and have shown promising performance in ad-hoc datasets. In this study, we aim to evaluate their versatility and generalization capabilities in a more general benchmark, encompassing both artificial and established reference datasets. Classical machine learning methods, specifically Support Vector Machines (SVMs) and logistic regression, are also incorporated as baseline comparisons. Experimental results indicate that quantum methods exhibit varying performance across different datasets. Despite outperforming classical methods in ad-hoc datasets, mixed results are obtained for the general case among standard classical benchmarks. Our experiments call into question a general added value of applying QKT optimization, for which the additional computational cost does not necessarily translate into improved classification performance. Instead, it is suggested that a careful choice of the quantum feature map in connection with proper hyperparameterization may prove more effective.
Quantum machine learning, which involves running machine learning algorithms on quantum devices, may be one of the most significant flagship applications for these devices. Unlike its classical counterparts, the role of data in quantum machine learning has not been fully understood. In this work, we quantify the performances of quantum machine learning in the landscape of quantum data. Provided that the encoding of quantum data is sufficiently random, the performance, we find that the training efficiency and generalization capabilities in quantum machine learning will be exponentially suppressed with the increase in the number of qubits, which we call "the curse of random quantum data". Our findings apply to both the quantum kernel method and the large-width limit of quantum neural networks. Conversely, we highlight that through meticulous design of quantum datasets, it is possible to avoid these curses, thereby achieving efficient convergence and robust generalization. Our conclusions are corroborated by extensive numerical simulations.
Quantum machine learning (QML) is a category of algorithms that employ variational quantum circuits (VQCs) to tackle machine learning tasks. Recent discoveries have shown that QML models can effectively generalize from limited training data samples. This capability has sparked increased interest in deploying these models to address practical, real-world challenges, resulting in the emergence of Quantum Machine Learning as a Service (QMLaaS). QMLaaS represents a hybrid model that utilizes both classical and quantum computing resources. Classical computers play a crucial role in this setup, handling initial pre-processing and subsequent post-processing of data to compensate for the current limitations of quantum hardware. Since this is a new area, very little work exists to paint the whole picture of QMLaaS in the context of known security threats in the domain of classical and quantum machine learning. This SoK paper is aimed to bridge this gap by outlining the complete QMLaaS workflow, which encompasses both the training and inference phases and highlighting significant security concerns involving untrusted classical or quantum providers. QML models contain several sensitive assets, such as the model architecture, training/testing data, encoding techniques, and trained parameters. Unauthorized access to these components could compromise the model's integrity and lead to intellectual property (IP) theft. We pinpoint the critical security issues that must be considered to pave the way for a secure QMLaaS deployment.
Quantum machine learning (QML) has recently made significant advancements in various topics. Despite the successes, the safety and interpretability of QML applications have not been thoroughly investigated. This work proposes using Variational Quantum Circuits (VQCs) for activation mapping to enhance model transparency, introducing the Quantum Gradient Class Activation Map (QGrad-CAM). This hybrid quantum-classical computing framework leverages both quantum and classical strengths and gives access to the derivation of an explicit formula of feature map importance. Experimental results demonstrate significant, fine-grained, class-discriminative visual explanations generated across both image and speech datasets.