Entity Matching (EM) is crucial for identifying equivalent data entities across different sources, a task that becomes increasingly challenging with the growth and heterogeneity of data. Blocking techniques, which reduce the computational complexity of EM, play a vital role in making this process scalable. Despite advancements in blocking methods, the issue of fairness; where blocking may inadvertently favor certain demographic groups; has been largely overlooked. This study extends traditional blocking metrics to incorporate fairness, providing a framework for assessing bias in blocking techniques. Through experimental analysis, we evaluate the effectiveness and fairness of various blocking methods, offering insights into their potential biases. Our findings highlight the importance of considering fairness in EM, particularly in the blocking phase, to ensure equitable outcomes in data integration tasks.
Medication errors significantly threaten patient safety, leading to adverse drug events and substantial economic burdens on healthcare systems. Clinical Decision Support Systems (CDSSs) aimed at mitigating these errors often face limitations, including reliance on static databases and rule-based algorithms, which can result in high false alert rates and alert fatigue among clinicians. This paper introduces HELIOT, an innovative CDSS for drug allergy management, integrating Large Language Models (LLMs) with a comprehensive pharmaceutical data repository. HELIOT leverages advanced natural language processing capabilities to interpret complex medical texts and synthesize unstructured data, overcoming the limitations of traditional CDSSs. An empirical evaluation using a synthetic patient dataset and expert-verified ground truth demonstrates HELIOT's high accuracy, precision, recall, and F1 score, uniformly reaching 100\% across multiple experimental runs. The results underscore HELIOT's potential to enhance decision support in clinical settings, offering a scalable, efficient, and reliable solution for managing drug allergies.
The complementary information found in different modalities of patient data can aid in more accurate modelling of a patient's disease state and a better understanding of the underlying biological processes of a disease. However, the analysis of multi-modal, multi-omics data presents many challenges, including high dimensionality and varying size, statistical distribution, scale and signal strength between modalities. In this work we compare the performance of a variety of ensemble machine learning algorithms that are capable of late integration of multi-class data from different modalities. The ensemble methods and their variations tested were i) a voting ensemble, with hard and soft vote, ii) a meta learner, iii) a multi-modal Adaboost model using a hard vote, a soft vote and a meta learner to integrate the modalities on each boosting round, the PB-MVBoost model and a novel application of a mixture of experts model. These were compared to simple concatenation as a baseline. We examine these methods using data from an in-house study on hepatocellular carcinoma (HCC), along with four validation datasets on studies from breast cancer and irritable bowel disease (IBD). Using the area under the receiver operating curve as a measure of performance we develop models that achieve a performance value of up to 0.85 and find that two boosted methods, PB-MVBoost and Adaboost with a soft vote were the overall best performing models. We also examine the stability of features selected, and the size of the clinical signature determined. Finally, we provide recommendations for the integration of multi-modal multi-class data.
Generative large language models (LLMs) are a promising alternative to pre-trained language models for entity matching due to their high zero-shot performance and ability to generalize to unseen entities. Existing research on using LLMs for entity matching has focused on prompt engineering and in-context learning. This paper explores the potential of fine-tuning LLMs for entity matching. We analyze fine-tuning along two dimensions: 1) the representation of training examples, where we experiment with adding different types of LLM-generated explanations to the training set, and 2) the selection and generation of training examples using LLMs. In addition to the matching performance on the source dataset, we investigate how fine-tuning affects the models ability to generalize to other in-domain datasets as well as across topical domains. Our experiments show that fine-tuning significantly improves the performance of the smaller models while the results for the larger models are mixed. Fine-tuning also improves the generalization to in-domain datasets while hurting cross-domain transfer. We show that adding structured explanations to the training set has a positive impact on the performance of three out of four LLMs, while the proposed example selection and generation methods, only improve the performance of Llama 3.1 8B while decreasing the performance of GPT-4o-mini.
Materials design often relies on human-generated hypotheses, a process inherently limited by cognitive constraints such as knowledge gaps and limited ability to integrate and extract knowledge implications, particularly when multidisciplinary expertise is required. This work demonstrates that large language models (LLMs), coupled with prompt engineering, can effectively generate non-trivial materials hypotheses by integrating scientific principles from diverse sources without explicit design guidance by human experts. These include design ideas for high-entropy alloys with superior cryogenic properties and halide solid electrolytes with enhanced ionic conductivity and formability. These design ideas have been experimentally validated in high-impact publications in 2023 not available in the LLM training data, demonstrating the LLM's ability to generate highly valuable and realizable innovative ideas not established in the literature. Our approach primarily leverages materials system charts encoding processing-structure-property relationships, enabling more effective data integration by condensing key information from numerous papers, and evaluation and categorization of numerous hypotheses for human cognition, both through the LLM. This LLM-driven approach opens the door to new avenues of artificial intelligence-driven materials discovery by accelerating design, democratizing innovation, and expanding capabilities beyond the designer's direct knowledge.
Entity matching (EM) is the problem of determining whether two records refer to same real-world entity, which is crucial in data integration, e.g., for product catalogs or address databases. A major drawback of many EM approaches is their dependence on labelled examples. We thus focus on the challenging setting of zero-shot entity matching where no labelled examples are available for an unseen target dataset. Recently, large language models (LLMs) have shown promising results for zero-shot EM, but their low throughput and high deployment cost limit their applicability and scalability. We revisit the zero-shot EM problem with AnyMatch, a small language model fine-tuned in a transfer learning setup. We propose several novel data selection techniques to generate fine-tuning data for our model, e.g., by selecting difficult pairs to match via an AutoML filter, by generating additional attribute-level examples, and by controlling label imbalance in the data. We conduct an extensive evaluation of the prediction quality and deployment cost of our model, in a comparison to thirteen baselines on nine benchmark datasets. We find that AnyMatch provides competitive prediction quality despite its small parameter size: it achieves the second-highest F1 score overall, and outperforms several other approaches that employ models with hundreds of billions of parameters. Furthermore, our approach exhibits major cost benefits: the average prediction quality of AnyMatch is within 4.4% of the state-of-the-art method MatchGPT with the proprietary trillion-parameter model GPT-4, yet AnyMatch requires four orders of magnitude less parameters and incurs a 3,899 times lower inference cost (in dollars per 1,000 tokens).
Neuroimaging studies, such as the Human Connectome Project (HCP), often collect multi-faceted and multi-block data to study the complex human brain. However, these data are often analyzed in a pairwise fashion, which can hinder our understanding of how different brain-related measures interact with each other. In this study, we comprehensively analyze the multi-block HCP data using the Data Integration via Analysis of Subspaces (DIVAS) method. We integrate structural and functional brain connectivity, substance use, cognition, and genetics in an exhaustive five-block analysis. This gives rise to the important finding that genetics is the single data modality most predictive of brain connectivity, outside of brain connectivity itself. Nearly 14\% of the variation in functional connectivity (FC) and roughly 12\% of the variation in structural connectivity (SC) is attributed to shared spaces with genetics. Moreover, investigations of shared space loadings provide interpretable associations between particular brain regions and drivers of variability, such as alcohol consumption in the substance-use data block. Novel Jackstraw hypothesis tests are developed for the DIVAS framework to establish statistically significant loadings. For example, in the (FC, SC, and Substance Use) shared space, these novel hypothesis tests highlight largely negative functional and structural connections suggesting the brain's role in physiological responses to increased substance use. Furthermore, our findings have been validated using a subset of genetically relevant siblings or twins not studied in the main analysis.
Schema matching is the process of identifying correspondences between the elements of two given schemata, essential for database management systems, data integration, and data warehousing. For datasets across different scenarios, the optimal schema matching algorithm is different. For single algorithm, hyperparameter tuning also cases multiple results. All results assigned equal probabilities are stored in probabilistic databases to facilitate uncertainty management. The substantial degree of uncertainty diminishes the efficiency and reliability of data processing, thereby precluding the provision of more accurate information for decision-makers. To address this problem, we introduce a new approach based on fine-grained correspondence verification with specific prompt of Large Language Model. Our approach is an iterative loop that consists of three main components: (1) the correspondence selection algorithm, (2) correspondence verification, and (3) the update of probability distribution. The core idea is that correspondences intersect across multiple results, thereby linking the verification of correspondences to the reduction of uncertainty in candidate results. The task of selecting an optimal correspondence set to maximize the anticipated uncertainty reduction within a fixed budgetary framework is established as an NP-hard problem. We propose a novel $(1-1/e)$-approximation algorithm that significantly outperforms brute algorithm in terms of computational efficiency. To enhance correspondence verification, we have developed two prompt templates that enable GPT-4 to achieve state-of-the-art performance across two established benchmark datasets. Our comprehensive experimental evaluation demonstrates the superior effectiveness and robustness of the proposed approach.
Accurate forecasting of the EUR/USD exchange rate is crucial for investors, businesses, and policymakers. This paper proposes a novel framework, IUS, that integrates unstructured textual data from news and analysis with structured data on exchange rates and financial indicators to enhance exchange rate prediction. The IUS framework employs large language models for sentiment polarity scoring and exchange rate movement classification of texts. These textual features are combined with quantitative features and input into a Causality-Driven Feature Generator. An Optuna-optimized Bi-LSTM model is then used to forecast the EUR/USD exchange rate. Experiments demonstrate that the proposed method outperforms benchmark models, reducing MAE by 10.69% and RMSE by 9.56% compared to the best performing baseline. Results also show the benefits of data fusion, with the combination of unstructured and structured data yielding higher accuracy than structured data alone. Furthermore, feature selection using the top 12 important quantitative features combined with the textual features proves most effective. The proposed IUS framework and Optuna-Bi-LSTM model provide a powerful new approach for exchange rate forecasting through multi-source data integration.
We propose a feasibility study for real-time automated data standardization leveraging Large Language Models (LLMs) to enhance seamless positioning systems in IoT environments. By integrating and standardizing heterogeneous sensor data from smartphones, IoT devices, and dedicated systems such as Ultra-Wideband (UWB), our study ensures data compatibility and improves positioning accuracy using the Extended Kalman Filter (EKF). The core components include the Intelligent Data Standardization Module (IDSM), which employs a fine-tuned LLM to convert varied sensor data into a standardized format, and the Transformation Rule Generation Module (TRGM), which automates the creation of transformation rules and scripts for ongoing data standardization. Evaluated in real-time environments, our study demonstrates adaptability and scalability, enhancing operational efficiency and accuracy in seamless navigation. This study underscores the potential of advanced LLMs in overcoming sensor data integration complexities, paving the way for more scalable and precise IoT navigation solutions.
Cancer is a highly heterogeneous disease with significant variability in molecular features and clinical outcomes, making diagnosis and treatment challenging. In recent years, high-throughput omic technologies have facilitated the discovery of mechanisms underlying various cancer subtypes by providing diverse omics data, such as gene expression, DNA methylation, and miRNA expression. However, the complexity and heterogeneity of multi-omics data present significant challenges for their integration in exploring cancer subtypes. Various methods have been proposed to address these challenges. In this paper, we propose a novel and straightforward approach for identifying cancer subtypes by integrating patient-specific subnetworks features from different omics data. We construct patient-specific induced subnetwork using a random walk with restart algorithm from patient similarity networks (PSNs) and compute nine structural properties that capture essential network topology. These features are integrated across the three omic datasets to form comprehensive patient profiles. K-means clustering is then applied for cancer subtype identification. We evaluate our approach on five cancer datasets, including breast invasive carcinoma, colon adenocarcinoma, glioblastoma multiforme, kidney renal clear cell carcinoma, and lung squamous cell carcinoma, for three different omic data types. The evaluation shows that our method produces promising and effective results, demonstrating competitive or superior performance compared to existing methods and underscoring its potential for advancing personalized cancer diagnosis and treatment.
Accurate delineation of the boundaries between the renal cortex and medulla is crucial for subsequent functional structural analysis and disease diagnosis. Training high-quality deep-learning models for layer segmentation relies on the availability of large amounts of annotated data. However, due to the patient's privacy of medical data and scarce clinical cases, constructing pathological datasets from clinical sources is relatively difficult and expensive. Moreover, using external natural image datasets introduces noise during the domain generalization process. Cross-species homologous data, such as mouse kidney data, which exhibits high structural and feature similarity to human kidneys, has the potential to enhance model performance on human datasets. In this study, we incorporated the collected private Periodic Acid-Schiff (PAS) stained mouse kidney dataset into the human kidney dataset for joint training. The results showed that after introducing cross-species homologous data, the semantic segmentation models based on CNN and Transformer architectures achieved an average increase of 1.77% and 1.24% in mIoU, and 1.76% and 0.89% in Dice score for the human renal cortex and medulla datasets, respectively. This approach is also capable of enhancing the model's generalization ability. This indicates that cross-species homologous data, as a low-noise trainable data source, can help improve model performance under conditions of limited clinical samples. Code is available at https://github.com/hrlblab/layer_segmentation.
Associating driver attention with driving scene across two fields of views (FOVs) is a hard cross-domain perception problem, which requires comprehensive consideration of cross-view mapping, dynamic driving scene analysis, and driver status tracking. Previous methods typically focus on a single view or map attention to the scene via estimated gaze, failing to exploit the implicit connection between them. Moreover, simple fusion modules are insufficient for modeling the complex relationships between the two views, making information integration challenging. To address these issues, we propose a novel method for end-to-end scene-associated driver attention estimation, called EraW-Net. This method enhances the most discriminative dynamic cues, refines feature representations, and facilitates semantically aligned cross-domain integration through a W-shaped architecture, termed W-Net. Specifically, a Dynamic Adaptive Filter Module (DAF-Module) is proposed to address the challenges of frequently changing driving environments by extracting vital regions. It suppresses the indiscriminately recorded dynamics and highlights crucial ones by innovative joint frequency-spatial analysis, enhancing the model's ability to parse complex dynamics. Additionally, to track driver states during non-fixed facial poses, we propose a Global Context Sharing Module (GCS-Module) to construct refined feature representations by capturing hierarchical features that adapt to various scales of head and eye movements. Finally, W-Net achieves systematic cross-view information integration through its "Encoding-Independent Partial Decoding-Fusion Decoding" structure, addressing semantic misalignment in heterogeneous data integration. Experiments demonstrate that the proposed method robustly and accurately estimates the mapping of driver attention in scene on large public datasets.
The importance of recommender systems is growing rapidly due to the exponential increase in the volume of content generated daily. This surge in content presents unique challenges for designing effective recommender systems. Key among these challenges is the need to effectively leverage the vast amounts of natural language data and images that represent user preferences. This paper presents a novel approach to enhancing recommender systems by leveraging Large Language Models (LLMs) and deep learning techniques. The proposed framework aims to improve the accuracy and relevance of recommendations by incorporating multi-modal information processing and by the use of unified latent space representation. The study explores the potential of LLMs to better understand and utilize natural language data in recommendation contexts, addressing the limitations of previous methods. The framework efficiently extracts and integrates text and image information through LLMs, unifying diverse modalities in a latent space to simplify the learning process for the ranking model. Experimental results demonstrate the enhanced discriminative power of the model when utilizing multi-modal information. This research contributes to the evolving field of recommender systems by showcasing the potential of LLMs and multi-modal data integration to create more personalized and contextually relevant recommendations.
This study analyzes hybrid AI systems' design patterns and their effectiveness in clinical decision-making using the boxology framework. It categorizes and copares various architectures combining machine learning and rule-based reasoning to provide insights into their structural foundations and healthcare applications. Addressing two main questions, how to categorize these systems againts established design patterns and how to extract insights through comparative analysis, the study uses design patterns from software engineering to understand and optimize healthcare AI systems. Boxology helps identify commonalities and create reusable solutions, enhancing these systems' scalability, reliability, and performance. Five primary architectures are examined: REML, MLRB, RBML, RMLT, and PERML. Each has unique strengths and weaknesses, highlighting the need for tailored approaches in clinical tasks. REML excels in high-accuracy prediction for datasets with limited data; MLRB in handling large datasets and complex data integration; RBML in explainability and trustworthiness; RMLT in managing high-dimensional data; and PERML, though limited in analysis, shows promise in urgent care scenarios. The study introduces four new patterns, creates five abstract categorization patterns, and refines those five further to specific systems. These contributions enhance Boxlogy's taxonomical organization and offer novel approaches to integrating expert knowledge with machine learning. Boxology's structured, modular apporach offers significant advantages in developing and analyzing hybrid AI systems, revealing commonalities, and promoting reusable solutions. In conclusion, this study underscores hybrid AI systems' crucial role in advancing healthcare and Boxology's potential to drive further innovation in AI integration, ultimately improving clinical decision support and patient outcomes.
Current research on trajectory prediction primarily relies on data collected by onboard sensors of an ego vehicle. With the rapid advancement in connected technologies, such as vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communication, valuable information from alternate views becomes accessible via wireless networks. The integration of information from alternative views has the potential to overcome the inherent limitations associated with a single viewpoint, such as occlusions and limited field of view. In this work, we introduce V2INet, a novel trajectory prediction framework designed to model multi-view data by extending existing single-view models. Unlike previous approaches where the multi-view data is manually fused or formulated as a separate training stage, our model supports end-to-end training, enhancing both flexibility and performance. Moreover, the predicted multimodal trajectories are calibrated by a post-hoc conformal prediction module to get valid and efficient confidence regions. We evaluated the entire framework using the real-world V2I dataset V2X-Seq. Our results demonstrate superior performance in terms of Final Displacement Error (FDE) and Miss Rate (MR) using a single GPU. The code is publicly available at: \url{https://github.com/xichennn/V2I_trajectory_prediction}.
Imitation Learning (IL) has emerged as a powerful approach in robotics, allowing robots to acquire new skills by mimicking human actions. Despite its potential, the data collection process for IL remains a significant challenge due to the logistical difficulties and high costs associated with obtaining high-quality demonstrations. To address these issues, we propose a large-scale data generation from a handful of demonstrations through data augmentation in simulation. Our approach leverages affordable hardware and visual processing techniques to collect demonstrations, which are then augmented to create extensive training datasets for imitation learning. By utilizing both real and simulated environments, along with human-in-the-loop corrections, we enhance the generalizability and robustness of the learned policies. We evaluated our method through several rounds of experiments in both simulated and real-robot settings, focusing on tasks of varying complexity, including bottle collecting, stacking objects, and hammering. Our experimental results validate the effectiveness of our approach in learning robust robot policies from simulated data, significantly improved by human-in-the-loop corrections and real-world data integration. Additionally, we demonstrate the framework's capability to generalize to new tasks, such as setting a drink tray, showcasing its adaptability and potential for handling a wide range of real-world manipulation tasks. A video of the experiments can be found at: https://youtu.be/YeVAMRqRe64?si=R179xDlEGc7nPu8i
The prediction of surrounding vehicle trajectories is crucial for collision-free path planning. In this study, we focus on a scenario where a connected and autonomous vehicle (CAV) serves as the central agent, utilizing both sensors and communication technologies to perceive its surrounding traffics consisting of autonomous vehicles (AVs), connected vehicles (CVs), and human-driven vehicles (HDVs). Our trajectory prediction task is aimed at all the detected surrounding vehicles. To effectively integrate the multi-source data from both sensor and communication technologies, we propose a deep learning framework called MSMA utilizing a cross-attention module for multi-source data fusion. Vector map data is utilized to provide contextual information. The trajectory dataset is collected in CARLA simulator with synthesized data errors introduced. Numerical experiments demonstrate that in a mixed traffic flow scenario, the integration of data from different sources enhances our understanding of the environment. This notably improves trajectory prediction accuracy, particularly in situations with a high CV market penetration rate. The code is available at: https://github.com/xichennn/MSMA.
Process mining, as a high-level field in data mining, plays a crucial role in enhancing operational efficiency and decision-making across organizations. In this survey paper, we delve into the growing significance and ongoing trends in the field of process mining, advocating a specific viewpoint on its contents, application, and development in modern businesses and process management, particularly in cross-organizational settings. We first summarize the framework of process mining, common industrial applications, and the latest advances combined with artificial intelligence, such as workflow optimization, compliance checking, and performance analysis. Then, we propose a holistic framework for intelligent process analysis and outline initial methodologies in cross-organizational settings, highlighting both challenges and opportunities. This particular perspective aims to revolutionize process mining by leveraging artificial intelligence to offer sophisticated solutions for complex, multi-organizational data analysis. By integrating advanced machine learning techniques, we can enhance predictive capabilities, streamline processes, and facilitate real-time decision-making. Furthermore, we pinpoint avenues for future investigations within the research community, encouraging the exploration of innovative algorithms, data integration strategies, and privacy-preserving methods to fully harness the potential of process mining in diverse, interconnected business environments.
This article focuses on a multi-modal imaging data application where structural/anatomical information from gray matter (GM) and brain connectivity information in the form of a brain connectome network from functional magnetic resonance imaging (fMRI) are available for a number of subjects with different degrees of primary progressive aphasia (PPA), a neurodegenerative disorder (ND) measured through a speech rate measure on motor speech loss. The clinical/scientific goal in this study becomes the identification of brain regions of interest significantly related to the speech rate measure to gain insight into ND patterns. Viewing the brain connectome network and GM images as objects, we develop an integrated object response regression framework of network and GM images on the speech rate measure. A novel integrated prior formulation is proposed on network and structural image coefficients in order to exploit network information of the brain connectome while leveraging the interconnections among the two objects. The principled Bayesian framework allows the characterization of uncertainty in ascertaining a region being actively related to the speech rate measure. Our framework yields new insights into the relationship of brain regions associated with PPA, offering a deeper understanding of neuro-degenerative patterns of PPA. The supplementary file adds details about posterior computation and additional empirical results.