Conventional multi-stage cell tracking approaches rely heavily on detection or segmentation in each frame as a prerequisite, requiring substantial resources for high-quality segmentation masks and increasing the overall prediction time. To address these limitations, we propose CAP, a novel end-to-end one-stage framework that reimagines cell tracking by treating Cell as Point. Unlike traditional methods, CAP eliminates the need for explicit detection or segmentation, instead jointly tracking cells for sequences in one stage by leveraging the inherent correlations among their trajectories. This simplification reduces both labeling requirements and pipeline complexity. However, directly processing the entire sequence in one stage poses challenges related to data imbalance in capturing cell division events and long sequence inference. To solve these challenges, CAP introduces two key innovations: (1) adaptive event-guided (AEG) sampling, which prioritizes cell division events to mitigate the occurrence imbalance of cell events, and (2) the rolling-as-window (RAW) inference strategy, which ensures continuous and stable tracking of newly emerging cells over extended sequences. By removing the dependency on segmentation-based preprocessing while addressing the challenges of imbalanced occurrence of cell events and long-sequence tracking, CAP demonstrates promising cell tracking performance and is 10 to 55 times more efficient than existing methods. The code and model checkpoints will be available soon.
Radiation therapy (RT) is essential in treating head and neck cancer (HNC), with magnetic resonance imaging(MRI)-guided RT offering superior soft tissue contrast and functional imaging. However, manual tumor segmentation is time-consuming and complex, and therfore remains a challenge. In this study, we present our solution as team TUMOR to the HNTS-MRG24 MICCAI Challenge which is focused on automated segmentation of primary gross tumor volumes (GTVp) and metastatic lymph node gross tumor volume (GTVn) in pre-RT and mid-RT MRI images. We utilized the HNTS-MRG2024 dataset, which consists of 150 MRI scans from patients diagnosed with HNC, including original and registered pre-RT and mid-RT T2-weighted images with corresponding segmentation masks for GTVp and GTVn. We employed two state-of-the-art models in deep learning, nnUNet and MedNeXt. For Task 1, we pretrained models on pre-RT registered and mid-RT images, followed by fine-tuning on original pre-RT images. For Task 2, we combined registered pre-RT images, registered pre-RT segmentation masks, and mid-RT data as a multi-channel input for training. Our solution for Task 1 achieved 1st place in the final test phase with an aggregated Dice Similarity Coefficient of 0.8254, and our solution for Task 2 ranked 8th with a score of 0.7005. The proposed solution is publicly available at Github Repository.
Open-vocabulary semantic segmentation aims to assign pixel-level labels to images across an unlimited range of classes. Traditional methods address this by sequentially connecting a powerful mask proposal generator, such as the Segment Anything Model (SAM), with a pre-trained vision-language model like CLIP. But these two-stage approaches often suffer from high computational costs, memory inefficiencies. In this paper, we propose ESC-Net, a novel one-stage open-vocabulary segmentation model that leverages the SAM decoder blocks for class-agnostic segmentation within an efficient inference framework. By embedding pseudo prompts generated from image-text correlations into SAM's promptable segmentation framework, ESC-Net achieves refined spatial aggregation for accurate mask predictions. ESC-Net achieves superior performance on standard benchmarks, including ADE20K, PASCAL-VOC, and PASCAL-Context, outperforming prior methods in both efficiency and accuracy. Comprehensive ablation studies further demonstrate its robustness across challenging conditions.
Accurate brain tumor segmentation remains a challenging task due to structural complexity and great individual differences of gliomas. Leveraging the pre-eminent detail resilience of CRF and spatial feature extraction capacity of V-net, we propose a multimodal 3D Volume Generative Adversarial Network (3D-vGAN) for precise segmentation. The model utilizes Pseudo-3D for V-net improvement, adds conditional random field after generator and use original image as supplemental guidance. Results, using the BraTS-2018 dataset, show that 3D-vGAN outperforms classical segmentation models, including U-net, Gan, FCN and 3D V-net, reaching specificity over 99.8%.
Timely and precise classification and segmentation of gastric bleeding in endoscopic imagery are pivotal for the rapid diagnosis and intervention of gastric complications, which is critical in life-saving medical procedures. Traditional methods grapple with the challenge posed by the indistinguishable intensity values of bleeding tissues adjacent to other gastric structures. Our study seeks to revolutionize this domain by introducing a novel deep learning model, the Dual Spatial Kernelized Constrained Fuzzy C-Means (Deep DuS-KFCM) clustering algorithm. This Hybrid Neuro-Fuzzy system synergizes Neural Networks with Fuzzy Logic to offer a highly precise and efficient identification of bleeding regions. Implementing a two-fold coarse-to-fine strategy for segmentation, this model initially employs the Spatial Kernelized Fuzzy C-Means (SKFCM) algorithm enhanced with spatial intensity profiles and subsequently harnesses the state-of-the-art DeepLabv3+ with ResNet50 architecture to refine the segmentation output. Through extensive experiments across mainstream gastric bleeding and red spots datasets, our Deep DuS-KFCM model demonstrated unprecedented accuracy rates of 87.95%, coupled with a specificity of 96.33%, outperforming contemporary segmentation methods. The findings underscore the model's robustness against noise and its outstanding segmentation capabilities, particularly for identifying subtle bleeding symptoms, thereby presenting a significant leap forward in medical image processing.
Medical image segmentation is crucial for accurate clinical diagnoses, yet it faces challenges such as low contrast between lesions and normal tissues, unclear boundaries, and high variability across patients. Deep learning has improved segmentation accuracy and efficiency, but it still relies heavily on expert annotations and struggles with the complexities of medical images. The small size of medical image datasets and the high cost of data acquisition further limit the performance of segmentation networks. Diffusion models, with their iterative denoising process, offer a promising alternative for better detail capture in segmentation. However, they face difficulties in accurately segmenting small targets and maintaining the precision of boundary details. This article discusses the importance of medical image segmentation, the limitations of current deep learning approaches, and the potential of diffusion models to address these challenges.
Deep learning-based segmentation methods are widely utilized for detecting lesions in ultrasound images. Throughout the imaging procedure, the attenuation and scattering of ultrasound waves cause contour blurring and the formation of artifacts, limiting the clarity of the acquired ultrasound images. To overcome this challenge, we propose a contour-based probabilistic segmentation model CP-UNet, which guides the segmentation network to enhance its focus on contour during decoding. We design a novel down-sampling module to enable the contour probability distribution modeling and encoding stages to acquire global-local features. Furthermore, the Gaussian Mixture Model utilizes optimized features to model the contour distribution, capturing the uncertainty of lesion boundaries. Extensive experiments with several state-of-the-art deep learning segmentation methods on three ultrasound image datasets show that our method performs better on breast and thyroid lesions segmentation.
The recent development in multimodal learning has greatly advanced the research in 3D scene understanding in various real-world tasks such as embodied AI. However, most existing work shares two typical constraints: 1) they are short of reasoning ability for interaction and interpretation of human intension and 2) they focus on scenarios with single-category objects only which leads to over-simplified textual descriptions due to the negligence of multi-object scenarios and spatial relations among objects. We bridge the research gaps by proposing a 3D reasoning segmentation task for multiple objects in scenes. The task allows producing 3D segmentation masks and detailed textual explanations as enriched by 3D spatial relations among objects. To this end, we create ReasonSeg3D, a large-scale and high-quality benchmark that integrates 3D spatial relations with generated question-answer pairs and 3D segmentation masks. In addition, we design MORE3D, a simple yet effective method that enables multi-object 3D reasoning segmentation with user questions and textual outputs. Extensive experiments show that MORE3D excels in reasoning and segmenting complex multi-object 3D scenes, and the created ReasonSeg3D offers a valuable platform for future exploration of 3D reasoning segmentation. The dataset and code will be released.
The Segment-Anything Model (SAM) is a vision foundation model for segmentation with a prompt-driven framework. SAM generates class-agnostic masks based on user-specified instance-referring prompts. However, adapting SAM for automated segmentation -- where manual input is absent -- of specific object classes often requires additional model training. We present Segment Any Class (SAC), a novel, training-free approach that task-adapts SAM for Multi-class segmentation. SAC generates Class-Region Proposals (CRP) on query images which allows us to automatically generate class-aware prompts on probable locations of class instances. CRPs are derived from elementary intra-class and inter-class feature distinctions without any additional training. Our method is versatile, accommodating any N-way K-shot configurations for the multi-class few-shot semantic segmentation (FSS) task. Unlike gradient-learning adaptation of generalist models which risk the loss of generalization and potentially suffer from catastrophic forgetting, SAC solely utilizes automated prompting and achieves superior results over state-of-the-art methods on the COCO-20i benchmark, particularly excelling in high N-way class scenarios. SAC is an interesting demonstration of a prompt-only approach to adapting foundation models for novel tasks with small, limited datasets without any modifications to the foundation model itself. This method offers interesting benefits such as intrinsic immunity to concept or feature loss and rapid, online task adaptation of foundation models.
Contrastive Language-Image Pre-training (CLIP) exhibits strong zero-shot classification ability on various image-level tasks, leading to the research to adapt CLIP for pixel-level open-vocabulary semantic segmentation without additional training. The key is to improve spatial representation of image-level CLIP, such as replacing self-attention map at last layer with self-self attention map or vision foundation model based attention map. In this paper, we present a novel hierarchical framework, named CLIPer, that hierarchically improves spatial representation of CLIP. The proposed CLIPer includes an early-layer fusion module and a fine-grained compensation module. We observe that, the embeddings and attention maps at early layers can preserve spatial structural information. Inspired by this, we design the early-layer fusion module to generate segmentation map with better spatial coherence. Afterwards, we employ a fine-grained compensation module to compensate the local details using the self-attention maps of diffusion model. We conduct the experiments on seven segmentation datasets. Our proposed CLIPer achieves the state-of-the-art performance on these datasets. For instance, using ViT-L, CLIPer has the mIoU of 69.8% and 43.3% on VOC and COCO Object, outperforming ProxyCLIP by 9.2% and 4.1% respectively.
Cloud segmentation is a critical challenge in remote sensing image interpretation, as its accuracy directly impacts the effectiveness of subsequent data processing and analysis. Recently, vision foundation models (VFM) have demonstrated powerful generalization capabilities across various visual tasks. In this paper, we present a parameter-efficient adaptive approach, termed Cloud-Adapter, designed to enhance the accuracy and robustness of cloud segmentation. Our method leverages a VFM pretrained on general domain data, which remains frozen, eliminating the need for additional training. Cloud-Adapter incorporates a lightweight spatial perception module that initially utilizes a convolutional neural network (ConvNet) to extract dense spatial representations. These multi-scale features are then aggregated and serve as contextual inputs to an adapting module, which modulates the frozen transformer layers within the VFM. Experimental results demonstrate that the Cloud-Adapter approach, utilizing only 0.6% of the trainable parameters of the frozen backbone, achieves substantial performance gains. Cloud-Adapter consistently achieves state-of-the-art performance across various cloud segmentation datasets from multiple satellite sources, sensor series, data processing levels, land cover scenarios, and annotation granularities. We have released the code and model checkpoints at https://xavierjiezou.github.io/Cloud-Adapter/ to support further research.
Interactive Medical Image Segmentation (IMIS) has long been constrained by the limited availability of large-scale, diverse, and densely annotated datasets, which hinders model generalization and consistent evaluation across different models. In this paper, we introduce the IMed-361M benchmark dataset, a significant advancement in general IMIS research. First, we collect and standardize over 6.4 million medical images and their corresponding ground truth masks from multiple data sources. Then, leveraging the strong object recognition capabilities of a vision foundational model, we automatically generated dense interactive masks for each image and ensured their quality through rigorous quality control and granularity management. Unlike previous datasets, which are limited by specific modalities or sparse annotations, IMed-361M spans 14 modalities and 204 segmentation targets, totaling 361 million masks-an average of 56 masks per image. Finally, we developed an IMIS baseline network on this dataset that supports high-quality mask generation through interactive inputs, including clicks, bounding boxes, text prompts, and their combinations. We evaluate its performance on medical image segmentation tasks from multiple perspectives, demonstrating superior accuracy and scalability compared to existing interactive segmentation models. To facilitate research on foundational models in medical computer vision, we release the IMed-361M and model at https://github.com/uni-medical/IMIS-Bench.
Why don't we have foundation models in 3D yet? A key limitation is data scarcity. For 3D object part segmentation, existing datasets are small in size and lack diversity. We show that it is possible to break this data barrier by building a data engine powered by 2D foundation models. Our data engine automatically annotates any number of object parts: 1755x more unique part types than existing datasets combined. By training on our annotated data with a simple contrastive objective, we obtain an open-world model that generalizes to any part in any object based on any text query. Even when evaluated zero-shot, we outperform existing methods on the datasets they train on. We achieve 260% improvement in mIoU and boost speed by 6x to 300x. Our scaling analysis confirms that this generalization stems from the data scale, which underscores the impact of our data engine. Finally, to advance general-category open-world 3D part segmentation, we release a benchmark covering a wide range of objects and parts. Project website: https://ziqi-ma.github.io/find3dsite/
Detecting disasters in underground mining, such as explosions and structural damage, has been a persistent challenge over the years. This problem is compounded for first responders, who often have no clear information about the extent or nature of the damage within the mine. The poor-light or even total darkness inside the mines makes rescue efforts incredibly difficult, leading to a tragic loss of life. In this paper, we propose a novel instance segmentation method called DIS-Mine, specifically designed to identify disaster-affected areas within underground mines under low-light or poor visibility conditions, aiding first responders in rescue efforts. DIS-Mine is capable of detecting objects in images, even in complete darkness, by addressing challenges such as high noise, color distortions, and reduced contrast. The key innovations of DIS-Mine are built upon four core components: i) Image brightness improvement, ii) Instance segmentation with SAM integration, iii) Mask R-CNN-based segmentation, and iv) Mask alignment with feature matching. On top of that, we have collected real-world images from an experimental underground mine, introducing a new dataset named ImageMine, specifically gathered in low-visibility conditions. This dataset serves to validate the performance of DIS-Mine in realistic, challenging environments. Our comprehensive experiments on the ImageMine dataset, as well as on various other datasets demonstrate that DIS-Mine achieves a superior F1 score of 86.0% and mIoU of 72.0%, outperforming state-of-the-art instance segmentation methods, with at least 15x improvement and up to 80% higher precision in object detection.
Large-scale 2D datasets have been instrumental in advancing machine learning; however, progress in 3D vision tasks has been relatively slow. This disparity is largely due to the limited availability of 3D benchmarking datasets. In particular, creating real-world point cloud datasets for indoor scene semantic segmentation presents considerable challenges, including data collection within confined spaces and the costly, often inaccurate process of per-point labeling to generate ground truths. While synthetic datasets address some of these challenges, they often fail to replicate real-world conditions, particularly the occlusions that occur in point clouds collected from real environments. Existing 3D benchmarking datasets typically evaluate deep learning models under the assumption that training and test data are independently and identically distributed (IID), which affects the models' usability for real-world point cloud segmentation. To address these challenges, we introduce the BelHouse3D dataset, a new synthetic point cloud dataset designed for 3D indoor scene semantic segmentation. This dataset is constructed using real-world references from 32 houses in Belgium, ensuring that the synthetic data closely aligns with real-world conditions. Additionally, we include a test set with data occlusion to simulate out-of-distribution (OOD) scenarios, reflecting the occlusions commonly encountered in real-world point clouds. We evaluate popular point-based semantic segmentation methods using our OOD setting and present a benchmark. We believe that BelHouse3D and its OOD setting will advance research in 3D point cloud semantic segmentation for indoor scenes, providing valuable insights for the development of more generalizable models.
Existing methodologies in open vocabulary 3D semantic segmentation primarily concentrate on establishing a unified feature space encompassing 3D, 2D, and textual modalities. Nevertheless, traditional techniques such as global feature alignment or vision-language model distillation tend to impose only approximate correspondence, struggling notably with delineating fine-grained segmentation boundaries. To address this gap, we propose a more meticulous mask-level alignment between 3D features and the 2D-text embedding space through a cross-modal mask reasoning framework, XMask3D. In our approach, we developed a mask generator based on the denoising UNet from a pre-trained diffusion model, leveraging its capability for precise textual control over dense pixel representations and enhancing the open-world adaptability of the generated masks. We further integrate 3D global features as implicit conditions into the pre-trained 2D denoising UNet, enabling the generation of segmentation masks with additional 3D geometry awareness. Subsequently, the generated 2D masks are employed to align mask-level 3D representations with the vision-language feature space, thereby augmenting the open vocabulary capability of 3D geometry embeddings. Finally, we fuse complementary 2D and 3D mask features, resulting in competitive performance across multiple benchmarks for 3D open vocabulary semantic segmentation. Code is available at https://github.com/wangzy22/XMask3D.
In the field of medical image segmentation, challenges such as indistinct lesion features, ambiguous boundaries,and multi-scale characteristics have long revailed. This paper proposes an improved method named Intensity-Spatial Dual Masked AutoEncoder (ISD-MAE). Based on the tissue-contrast semi-masked autoencoder, a Masked AutoEncoder (MAE) branch is introduced to perform intensity masking and spatial masking operations on chest CT images for multi-scale feature learning and segmentation tasks. The model utilizes a dual-branch structure and contrastive learning to enhance the ability to learn tissue features and boundary details. Experiments are conducted on multiple 2D and 3D datasets. The results show that ISD-MAE significantly outperforms other methods in 2D pneumonia and mediastinal tumor segmentation tasks. For example, the Dice score reaches 90.10% on the COVID19 LESION dataset, and the performance is relatively stable. However, there is still room for improvement on 3D datasets. In response to this, improvement directions are proposed, including optimizing the loss function, using enhanced 3D convolution blocks, and processing datasets from multiple perspectives.Our code is available at:https://github.com/prowontheus/ISD-MAE.
Semi-supervised learning (SSL) has made notable advancements in medical image segmentation (MIS), particularly in scenarios with limited labeled data and significantly enhancing data utilization efficiency. Previous methods primarily focus on complex training strategies to utilize unlabeled data but neglect the importance of graph structural information. Different from existing methods, we propose a graph-based clustering for semi-supervised medical image segmentation (GraphCL) by jointly modeling graph data structure in a unified deep model. The proposed GraphCL model enjoys several advantages. Firstly, to the best of our knowledge, this is the first work to model the data structure information for semi-supervised medical image segmentation (SSMIS). Secondly, to get the clustered features across different graphs, we integrate both pairwise affinities between local image features and raw features as inputs. Extensive experimental results on three standard benchmarks show that the proposed GraphCL algorithm outperforms state-of-the-art semi-supervised medical image segmentation methods.
This research presents an advanced AI-powered ultrasound imaging system that incorporates real-time image processing, organ tracking, and voice commands to enhance the efficiency and accuracy of diagnoses in clinical practice. Traditional ultrasound diagnostics often require significant time and introduce a degree of subjectivity due to user interaction. The goal of this innovative solution is to provide Sonologists with a more predictable and productive imaging procedure utilizing artificial intelligence, computer vision, and voice technology. The functionality of the system employs computer vision and deep learning algorithms, specifically adopting the Mask R-CNN model from Detectron2 for semantic segmentation of organs and key landmarks. This automation improves diagnostic accuracy by enabling the extraction of valuable information with minimal human input. Additionally, it includes a voice recognition feature that allows for hands-free operation, enabling users to control the system with commands such as freeze or liver, all while maintaining their focus on the patient. The architecture comprises video processing and real-time segmentation modules that prepare the system to perform essential imaging functions, such as freezing and zooming in on frames. The liver histopathology module, optimized for detecting fibrosis, achieved an impressive accuracy of 98.6%. Furthermore, the organ segmentation module produces output confidence levels between 50% and 95%, demonstrating its efficacy in organ detection.
Microscopy structure segmentation, such as detecting cells or nuclei, generally requires a human to draw a ground truth contour around each instance. Weakly supervised approaches (e.g. consisting of only single point labels) have the potential to reduce this workload significantly. Our approach uses individual point labels for an entropy estimation to approximate an underlying distribution of cell pixels. We infer full cell masks from this distribution, and use Mask-RCNN to produce an instance segmentation output. We compare this point--annotated approach with training on the full ground truth masks. We show that our method achieves a comparatively good level of performance, despite a 95% reduction in pixel labels.