Pathological lymph node delineation is crucial in cancer diagnosis, progression assessment, and treatment planning. The MICCAI 2023 Lymph Node Quantification Challenge published the first public dataset for pathological lymph node segmentation in the mediastinum. As lymph node annotations are expensive, the challenge was formed as a weakly supervised learning task, where only a subset of all lymph nodes in the training set have been annotated. For the challenge submission, multiple methods for training on these weakly supervised data were explored, including noisy label training, loss masking of unlabeled data, and an approach that integrated the TotalSegmentator toolbox as a form of pseudo labeling in order to reduce the number of unknown voxels. Furthermore, multiple public TCIA datasets were incorporated into the training to improve the performance of the deep learning model. Our submitted model achieved a Dice score of 0.628 and an average symmetric surface distance of 5.8~mm on the challenge test set. With our submitted model, we accomplished third rank in the MICCAI2023 LNQ challenge. A finding of our analysis was that the integration of all visible, including non-pathological, lymph nodes improved the overall segmentation performance on pathological lymph nodes of the test set. Furthermore, segmentation models trained only on clinically enlarged lymph nodes, as given in the challenge scenario, could not generalize to smaller pathological lymph nodes. The code and model for the challenge submission are available at \url{https://gitlab.lrz.de/compai/MediastinalLymphNodeSegmentation}.
Existing learning-based cortical surface reconstruction approaches heavily rely on the supervision of pseudo ground truth (pGT) cortical surfaces for training. Such pGT surfaces are generated by traditional neuroimage processing pipelines, which are time consuming and difficult to generalize well to low-resolution brain MRI, e.g., from fetuses and neonates. In this work, we present CoSeg, a learning-based cortical surface reconstruction framework weakly supervised by brain segmentations without the need for pGT surfaces. CoSeg introduces temporal attention networks to learn time-varying velocity fields from brain MRI for diffeomorphic surface deformations, which fit an initial surface to target cortical surfaces within only 0.11 seconds for each brain hemisphere. A weakly supervised loss is designed to reconstruct pial surfaces by inflating the white surface along the normal direction towards the boundary of the cortical gray matter segmentation. This alleviates partial volume effects and encourages the pial surface to deform into deep and challenging cortical sulci. We evaluate CoSeg on 1,113 adult brain MRI at 1mm and 2mm resolution. CoSeg achieves superior geometric and morphological accuracy compared to existing learning-based approaches. We also verify that CoSeg can extract high-quality cortical surfaces from fetal brain MRI on which traditional pipelines fail to produce acceptable results.
We consider a weakly supervised learning problem called Learning from Label Proportions (LLP), where examples are grouped into ``bags'' and only the average label within each bag is revealed to the learner. We study various learning rules for LLP that achieve PAC learning guarantees for classification loss. We establish that the classical Empirical Proportional Risk Minimization (EPRM) learning rule (Yu et al., 2014) achieves fast rates under realizability, but EPRM and similar proportion matching learning rules can fail in the agnostic setting. We also show that (1) a debiased proportional square loss, as well as (2) a recently proposed EasyLLP learning rule (Busa-Fekete et al., 2023) both achieve ``optimistic rates'' (Panchenko, 2002); in both the realizable and agnostic settings, their sample complexity is optimal (up to log factors) in terms of $\epsilon, \delta$, and VC dimension.
Given a ground-level query image and a geo-referenced aerial image that covers the query's local surroundings, fine-grained cross-view localization aims to estimate the location of the ground camera inside the aerial image. Recent works have focused on developing advanced networks trained with accurate ground truth (GT) locations of ground images. However, the trained models always suffer a performance drop when applied to images in a new target area that differs from training. In most deployment scenarios, acquiring fine GT, i.e. accurate GT locations, for target-area images to re-train the network can be expensive and sometimes infeasible. In contrast, collecting images with noisy GT with errors of tens of meters is often easy. Motivated by this, our paper focuses on improving the performance of a trained model in a new target area by leveraging only the target-area images without fine GT. We propose a weakly supervised learning approach based on knowledge self-distillation. This approach uses predictions from a pre-trained model as pseudo GT to supervise a copy of itself. Our approach includes a mode-based pseudo GT generation for reducing uncertainty in pseudo GT and an outlier filtering method to remove unreliable pseudo GT. Our approach is validated using two recent state-of-the-art models on two benchmarks. The results demonstrate that it consistently and considerably boosts the localization accuracy in the target area.
Telling stories is an integral part of human communication which can evoke emotions and influence the affective states of the audience. Automatically modeling emotional trajectories in stories has thus attracted considerable scholarly interest. However, as most existing works have been limited to unsupervised dictionary-based approaches, there is no benchmark for this task. We address this gap by introducing continuous valence and arousal labels for an existing dataset of children's stories originally annotated with discrete emotion categories. We collect additional annotations for this data and map the categorical labels to the continuous valence and arousal space. For predicting the thus obtained emotionality signals, we fine-tune a DeBERTa model and improve upon this baseline via a weakly supervised learning approach. The best configuration achieves a Concordance Correlation Coefficient (CCC) of $.8221$ for valence and $.7125$ for arousal on the test set, demonstrating the efficacy of our proposed approach. A detailed analysis shows the extent to which the results vary depending on factors such as the author, the individual story, or the section within the story. In addition, we uncover the weaknesses of our approach by investigating examples that prove to be difficult to predict.
Most recent multispectral object detectors employ a two-branch structure to extract features from RGB and thermal images. While the two-branch structure achieves better performance than a single-branch structure, it overlooks inference efficiency. This conflict is increasingly aggressive, as recent works solely pursue higher performance rather than both performance and efficiency. In this paper, we address this issue by improving the performance of efficient single-branch structures. We revisit the reasons causing the performance gap between these structures. For the first time, we reveal the information interference problem in the naive early-fusion strategy adopted by previous single-branch structures. Besides, we find that the domain gap between multispectral images, and weak feature representation of the single-branch structure are also key obstacles for performance. Focusing on these three problems, we propose corresponding solutions, including a novel shape-priority early-fusion strategy, a weakly supervised learning method, and a core knowledge distillation technique. Experiments demonstrate that single-branch networks equipped with these three contributions achieve significant performance enhancements while retaining high efficiency. Our code will be available at \url{https://github.com/XueZ-phd/Efficient-RGB-T-Early-Fusion-Detection}.
Weakly supervised learning has recently achieved considerable success in reducing annotation costs and label noise. Unfortunately, existing weakly supervised learning methods are short of ability in generating reliable labels via pre-trained vision-language models (VLMs). In this paper, we propose a novel weakly supervised labeling setting, namely True-False Labels (TFLs) which can achieve high accuracy when generated by VLMs. The TFL indicates whether an instance belongs to the label, which is randomly and uniformly sampled from the candidate label set. Specifically, we theoretically derive a risk-consistent estimator to explore and utilize the conditional probability distribution information of TFLs. Besides, we propose a convolutional-based Multi-modal Prompt Retrieving (MRP) method to bridge the gap between the knowledge of VLMs and target learning tasks. Experimental results demonstrate the effectiveness of the proposed TFL setting and MRP learning method. The code to reproduce the experiments is at https://github.com/Tranquilxu/TMP.
We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique challenge as the ground truth labels are inherently weak, and the model must anticipate future events that are not directly observable in the image. To address this challenge, we propose a novel three-part framework comprising of a convolutional network based tissue segmentation algorithm for region of interest delineation, a contrastive learning module for feature extraction, and a nested multiple instance learning classification module. Our study explores the significance of various regions of interest within the histopathological slides and exploits diverse learning scenarios. The pipeline is initially validated on artificially generated data and a simpler diagnostic task. Transitioning to prognostic prediction, tasks become more challenging. Employing bladder cancer as use case, our best models yield an AUC of 0.721 and 0.678 for recurrence and treatment outcome prediction respectively.
The absence of adequately sufficient expert-level tumor annotations hinders the effectiveness of supervised learning based opportunistic cancer screening on medical imaging. Clinical reports (that are rich in descriptive textual details) can offer a "free lunch'' supervision information and provide tumor location as a type of weak label to cope with screening tasks, thus saving human labeling workloads, if properly leveraged. However, predicting cancer only using such weak labels can be very changeling since tumors are usually presented in small anatomical regions compared to the whole 3D medical scans. Weakly semi-supervised learning (WSSL) utilizes a limited set of voxel-level tumor annotations and incorporates alongside a substantial number of medical images that have only off-the-shelf clinical reports, which may strike a good balance between minimizing expert annotation workload and optimizing screening efficacy. In this paper, we propose a novel text-guided learning method to achieve highly accurate cancer detection results. Through integrating diagnostic and tumor location text prompts into the text encoder of a vision-language model (VLM), optimization of weakly supervised learning can be effectively performed in the latent space of VLM, thereby enhancing the stability of training. Our approach can leverage clinical knowledge by large-scale pre-trained VLM to enhance generalization ability, and produce reliable pseudo tumor masks to improve cancer detection. Our extensive quantitative experimental results on a large-scale cancer dataset, including 1,651 unique patients, validate that our approach can reduce human annotation efforts by at least 70% while maintaining comparable cancer detection accuracy to competing fully supervised methods (AUC value 0.961 versus 0.966).
In recent years, deep learning on graphs has achieved remarkable success in various domains. However, the reliance on annotated graph data remains a significant bottleneck due to its prohibitive cost and time-intensive nature. To address this challenge, self-supervised learning (SSL) on graphs has gained increasing attention and has made significant progress. SSL enables machine learning models to produce informative representations from unlabeled graph data, reducing the reliance on expensive labeled data. While SSL on graphs has witnessed widespread adoption, one critical component, Graph Contrastive Learning (GCL), has not been thoroughly investigated in the existing literature. Thus, this survey aims to fill this gap by offering a dedicated survey on GCL. We provide a comprehensive overview of the fundamental principles of GCL, including data augmentation strategies, contrastive modes, and contrastive optimization objectives. Furthermore, we explore the extensions of GCL to other aspects of data-efficient graph learning, such as weakly supervised learning, transfer learning, and related scenarios. We also discuss practical applications spanning domains such as drug discovery, genomics analysis, recommender systems, and finally outline the challenges and potential future directions in this field.
Fully supervised deep learning approaches have demonstrated impressive accuracy in sea ice classification, but their dependence on high-resolution labels presents a significant challenge due to the difficulty of obtaining such data. In response, our weakly supervised learning method provides a compelling alternative by utilizing lower-resolution regional labels from expert-annotated ice charts. This approach achieves exceptional pixel-level classification performance by introducing regional loss representations during training to measure the disparity between predicted and ice chart-derived sea ice type distributions. Leveraging the AI4Arctic Sea Ice Challenge Dataset, our method outperforms the fully supervised U-Net benchmark, the top solution of the AutoIce challenge, in both mapping resolution and class-wise accuracy, marking a significant advancement in automated operational sea ice mapping.
In this paper, we address the segmentation of tumor subtypes in whole slide images (WSI) by utilizing incomplete label proportions. Specifically, we utilize `partial' label proportions, which give the proportions among tumor subtypes but do not give the proportion between tumor and non-tumor. Partial label proportions are recorded as the standard diagnostic information by pathologists, and we, therefore, want to use them for realizing the segmentation model that can classify each WSI patch into one of the tumor subtypes or non-tumor. We call this problem ``learning from partial label proportions (LPLP)'' and formulate the problem as a weakly supervised learning problem. Then, we propose an efficient algorithm for this challenging problem by decomposing it into two weakly supervised learning subproblems: multiple instance learning (MIL) and learning from label proportions (LLP). These subproblems are optimized efficiently in the end-to-end manner. The effectiveness of our algorithm is demonstrated through experiments conducted on two WSI datasets.
Accurate classification of fine-grained images remains a challenge in backbones based on convolutional operations or self-attention mechanisms. This study proposes novel dual-current neural networks (DCNN), which combine the advantages of convolutional operations and self-attention mechanisms to improve the accuracy of fine-grained image classification. The main novel design features for constructing a weakly supervised learning backbone model DCNN include (a) extracting heterogeneous data, (b) keeping the feature map resolution unchanged, (c) expanding the receptive field, and (d) fusing global representations and local features. Experimental results demonstrated that using DCNN as the backbone network for classifying certain fine-grained benchmark datasets achieved performance advantage improvements of 13.5--19.5% and 2.2--12.9%, respectively, compared to other advanced convolution or attention-based fine-grained backbones.
The MEDIQA-M3G 2024 challenge necessitates novel solutions for Multilingual & Multimodal Medical Answer Generation in dermatology (wai Yim et al., 2024a). This paper addresses the limitations of traditional methods by proposing a weakly supervised learning approach for open-ended medical question-answering (QA). Our system leverages readily available MEDIQA-M3G images via a VGG16-CNN-SVM model, enabling multilingual (English, Chinese, Spanish) learning of informative skin condition representations. Using pre-trained QA models, we further bridge the gap between visual and textual information through multimodal fusion. This approach tackles complex, open-ended questions even without predefined answer choices. We empower the generation of comprehensive answers by feeding the ViT-CLIP model with multiple responses alongside images. This work advances medical QA research, paving the way for clinical decision support systems and ultimately improving healthcare delivery.
Weakly-supervised learning approaches have gained significant attention due to their ability to reduce the effort required for human annotations in training neural networks. This paper investigates a framework for weakly-supervised object localization, which aims to train a neural network capable of predicting both the object class and its location using only images and their image-level class labels. The proposed framework consists of a shared feature extractor, a classifier, and a localizer. The localizer predicts pixel-level class probabilities, while the classifier predicts the object class at the image level. Since image-level class labels are insufficient for training the localizer, weakly-supervised object localization methods often encounter challenges in accurately localizing the entire object region. To address this issue, the proposed method incorporates adversarial erasing and pseudo labels to improve localization accuracy. Specifically, novel losses are designed to utilize adversarially erased foreground features and adversarially erased feature maps, reducing dependence on the most discriminative region. Additionally, the proposed method employs pseudo labels to suppress activation values in the background while increasing them in the foreground. The proposed method is applied to two backbone networks (MobileNetV1 and InceptionV3) and is evaluated on three publicly available datasets (ILSVRC-2012, CUB-200-2011, and PASCAL VOC 2012). The experimental results demonstrate that the proposed method outperforms previous state-of-the-art methods across all evaluated metrics.
Robot-assisted catheterization has garnered a good attention for its potentials in treating cardiovascular diseases. However, advancing surgeon-robot collaboration still requires further research, particularly on task-specific automation. For instance, automated tool segmentation can assist surgeons in visualizing and tracking of endovascular tools during cardiac procedures. While learning-based models have demonstrated state-of-the-art segmentation performances, generating ground-truth labels for fully-supervised methods is both labor-intensive time consuming, and costly. In this study, we propose a weakly-supervised learning method with multi-lateral pseudo labeling for tool segmentation in cardiovascular angiogram datasets. The method utilizes a modified U-Net architecture featuring one encoder and multiple laterally branched decoders. The decoders generate diverse pseudo labels under different perturbations, augmenting available partial labels. The pseudo labels are self-generated using a mixed loss function with shared consistency across the decoders. The weakly-supervised model was trained end-to-end and validated using partially annotated angiogram data from three cardiovascular catheterization procedures. Validation results show that the model could perform closer to fully-supervised models. Also, the proposed weakly-supervised multi-lateral method outperforms three well known methods used for weakly-supervised learning, offering the highest segmentation performance across the three angiogram datasets. Furthermore, numerous ablation studies confirmed the model's consistent performance under different parameters. Finally, the model was applied for tool segmentation in a robot-assisted catheterization experiments. The model enhanced visualization with high connectivity indices for guidewire and catheter, and a mean processing time of 35 ms per frame.
The diagnosis of primary liver cancers (PLCs) can be challenging, especially on biopsies and for combined hepatocellular-cholangiocarcinoma (cHCC-CCA). We automatically classified PLCs on routine-stained biopsies using a weakly supervised learning method. Weak tumour/non-tumour annotations served as labels for training a Resnet18 neural network, and the network's last convolutional layer was used to extract new tumour tile features. Without knowledge of the precise labels of the malignancies, we then applied an unsupervised clustering algorithm. Our model identified specific features of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Despite no specific features of cHCC-CCA being recognized, the identification of HCC and iCCA tiles within a slide could facilitate the diagnosis of primary liver cancers, particularly cHCC-CCA. Method and results: 166 PLC biopsies were divided into training, internal and external validation sets: 90, 29 and 47 samples. Two liver pathologists reviewed each whole-slide hematein eosin saffron (HES)-stained image (WSI). After annotating the tumour/non-tumour areas, 256x256 pixel tiles were extracted from the WSIs and used to train a ResNet18. The network was used to extract new tile features. An unsupervised clustering algorithm was then applied to the new tile features. In a two-cluster model, Clusters 0 and 1 contained mainly HCC and iCCA histological features. The diagnostic agreement between the pathological diagnosis and the model predictions in the internal and external validation sets was 100% (11/11) and 96% (25/26) for HCC and 78% (7/9) and 87% (13/15) for iCCA, respectively. For cHCC-CCA, we observed a highly variable proportion of tiles from each cluster (Cluster 0: 5-97%; Cluster 1: 2-94%).
Procedure Planning in instructional videos entails generating a sequence of action steps based on visual observations of the initial and target states. Despite the rapid progress in this task, there remain several critical challenges to be solved: (1) Adaptive procedures: Prior works hold an unrealistic assumption that the number of action steps is known and fixed, leading to non-generalizable models in real-world scenarios where the sequence length varies. (2) Temporal relation: Understanding the step temporal relation knowledge is essential in producing reasonable and executable plans. (3) Annotation cost: Annotating instructional videos with step-level labels (i.e., timestamp) or sequence-level labels (i.e., action category) is demanding and labor-intensive, limiting its generalizability to large-scale datasets. In this work, we propose a new and practical setting, called adaptive procedure planning in instructional videos, where the procedure length is not fixed or pre-determined. To address these challenges, we introduce Retrieval-Augmented Planner (RAP) model. Specifically, for adaptive procedures, RAP adaptively determines the conclusion of actions using an auto-regressive model architecture. For temporal relation, RAP establishes an external memory module to explicitly retrieve the most relevant state-action pairs from the training videos and revises the generated procedures. To tackle high annotation cost, RAP utilizes a weakly-supervised learning manner to expand the training dataset to other task-relevant, unannotated videos by generating pseudo labels for action steps. Experiments on CrossTask and COIN benchmarks show the superiority of RAP over traditional fixed-length models, establishing it as a strong baseline solution for adaptive procedure planning.
Long-tailed data is prevalent in real-world classification tasks and heavily relies on supervised information, which makes the annotation process exceptionally labor-intensive and time-consuming. Unfortunately, despite being a common approach to mitigate labeling costs, existing weakly supervised learning methods struggle to adequately preserve supervised information for tail samples, resulting in a decline in accuracy for the tail classes. To alleviate this problem, we introduce a novel weakly supervised labeling setting called Reduced Label. The proposed labeling setting not only avoids the decline of supervised information for the tail samples, but also decreases the labeling costs associated with long-tailed data. Additionally, we propose an straightforward and highly efficient unbiased framework with strong theoretical guarantees to learn from these Reduced Labels. Extensive experiments conducted on benchmark datasets including ImageNet validate the effectiveness of our approach, surpassing the performance of state-of-the-art weakly supervised methods.
We introduce InternVideo2, a new family of video foundation models (ViFM) that achieve the state-of-the-art results in video recognition, video-text tasks, and video-centric dialogue. Our core design is a progressive training approach that unifies the masked video modeling, crossmodal contrastive learning, and next token prediction, scaling up the video encoder size to 6B parameters. At the data level, we prioritize spatiotemporal consistency by semantically segmenting videos and generating video-audio-speech captions. This improves the alignment between video and text. Through extensive experiments, we validate our designs and demonstrate superior performance on over 60 video and audio tasks. Notably, our model outperforms others on various video-related dialogue and long video understanding benchmarks, highlighting its ability to reason and comprehend longer contexts. Code and models are available at https://github.com/OpenGVLab/InternVideo/tree/main/InternVideo2/.