Background: Multiparametric breast MRI data might improve tumor diagnostics, characterization, and treatment planning. Accurate alignment and delineation of images acquired at different field strengths such as 3T and 7T, remain challenging research tasks. Purpose: To address alignment challenges and enable consistent tumor segmentation across different MRI field strengths. Study type: Retrospective. Subjects: Nine female subjects with breast tumors were involved: six histologically proven invasive ductal carcinomas (IDC) and three fibroadenomas. Field strength/sequence: Imaging was performed at 3T and 7T scanners using post-contrast T1-weighted three-dimensional time-resolved angiography with stochastic trajectories (TWIST) sequence. Assessments: The method's performance for joint image registration and tumor segmentation was evaluated using several quantitative metrics, including signal-to-noise ratio (PSNR), structural similarity index (SSIM), normalized cross-correlation (NCC), Dice coefficient, F1 score, and relative sum of squared differences (rel SSD). Statistical tests: The Pearson correlation coefficient was used to test the relationship between the registration and segmentation metrics. Results: When calculated for each subject individually, the PSNR was in a range from 27.5 to 34.5 dB, and the SSIM was from 82.6 to 92.8%. The model achieved an NCC from 96.4 to 99.3% and a Dice coefficient of 62.9 to 95.3%. The F1 score was between 55.4 and 93.2% and the rel SSD was in the range of 2.0 and 7.5%. The segmentation metrics Dice and F1 Score are highly correlated (0.995), while a moderate correlation between NCC and SSIM (0.681) was found for registration. Data conclusion: Initial results demonstrate that the proposed method may be feasible in providing joint tumor segmentation and registration of MRI data acquired at different field strengths.
Few-shot Semantic Segmentation (FSS) is a challenging task that utilizes limited support images to segment associated unseen objects in query images. However, recent FSS methods are observed to perform worse, when enlarging the number of shots. As the support set enlarges, existing FSS networks struggle to concentrate on the high-contributed supports and could easily be overwhelmed by the low-contributed supports that could severely impair the mask predictions. In this work, we study this challenging issue, called support dilution, our goal is to recognize, select, preserve, and enhance those high-contributed supports in the raw support pool. Technically, our method contains three novel parts. First, we propose a contribution index, to quantitatively estimate if a high-contributed support dilutes. Second, we develop the Symmetric Correlation (SC) module to preserve and enhance the high-contributed support features, minimizing the distraction by the low-contributed features. Third, we design the Support Image Pruning operation, to retrieve a compact and high quality subset by discarding low-contributed supports. We conduct extensive experiments on two FSS benchmarks, COCO-20i and PASCAL-5i, the segmentation results demonstrate the compelling performance of our solution over state-of-the-art FSS approaches. Besides, we apply our solution for online segmentation and real-world segmentation, convincing segmentation results showing the practical ability of our work for real-world demonstrations.
Annotating 3D medical images demands substantial time and expertise, driving the adoption of semi-supervised learning (SSL) for segmentation tasks. However, the complex anatomical structures of organs often lead to significant class imbalances, posing major challenges for deploying SSL in real-world scenarios. Despite the availability of valuable prior information, such as inter-organ relative positions and organ shape priors, existing SSL methods have yet to fully leverage these insights. To address this gap, we propose a novel approach that integrates textual anatomical knowledge (TAK) into the segmentation model. Specifically, we use GPT-4o to generate textual descriptions of anatomical priors, which are then encoded using a CLIP-based model. These encoded priors are injected into the segmentation model as parameters of the segmentation head. Additionally, contrastive learning is employed to enhance the alignment between textual priors and visual features. Extensive experiments demonstrate the superior performance of our method, significantly surpassing state-of-the-art approaches. The source code will be available at: https://github.com/Lunn88/TAK-Semi.
Dynamic urban environments, characterized by moving cameras and objects, pose significant challenges for camera trajectory estimation by complicating the distinction between camera-induced and object motion. We introduce MONA, a novel framework designed for robust moving object detection and segmentation from videos shot by dynamic cameras. MONA comprises two key modules: Dynamic Points Extraction, which leverages optical flow and tracking any point to identify dynamic points, and Moving Object Segmentation, which employs adaptive bounding box filtering, and the Segment Anything for precise moving object segmentation. We validate MONA by integrating with the camera trajectory estimation method LEAP-VO, and it achieves state-of-the-art results on the MPI Sintel dataset comparing to existing methods. These results demonstrate MONA's effectiveness for moving object detection and its potential in many other applications in the urban planning field.
Crack Segmentation in industrial concrete surfaces is a challenging task because cracks usually exhibit intricate morphology with slender appearances. Traditional segmentation methods often struggle to accurately locate such cracks, leading to inefficiencies in maintenance and repair processes. In this paper, we propose a novel diffusion-based model with a cross-conditional encoder-decoder, named CrossDiff, which is the first to introduce the diffusion probabilistic model for the crack segmentation task. Specifically, CrossDiff integrates a cross-encoder and a cross-decoder into the diffusion model to constitute a cross-shaped diffusion model structure. The cross-encoder enhances the ability to retain crack details and the cross-decoder helps extract the semantic features of cracks. As a result, CrossDiff can better handle slender cracks. Extensive experiments were conducted on five challenging crack datasets including CFD, CrackTree200, DeepCrack, GAPs384, and Rissbilder. The results demonstrate that the proposed CrossDiff model achieves impressive performance, outperforming other state-of-the-art methods by 8.0% in terms of both Dice score and IoU. The code will be open-source soon.
Histopathological image analysis is a reliable method for prostate cancer identification. In this paper, we present a comparative analysis of two approaches for segmenting glandular structures in prostate images to automate Gleason grading. The first approach utilizes a hand-crafted learning technique, combining Gray Level Co-Occurrence Matrix (GLCM) and Local Binary Pattern (LBP) texture descriptors to highlight spatial dependencies and minimize information loss at the pixel level. For machine driven feature extraction, we employ a U-Net convolutional neural network to perform semantic segmentation of prostate gland stroma tissue. Support vector machine-based learning of hand-crafted features achieves impressive classification accuracies of 99.0% and 95.1% for GLCM and LBP, respectively, while the U-Net-based machine-driven features attain 94% accuracy. Furthermore, a comparative analysis demonstrates superior segmentation quality for histopathological grades 1, 2, 3, and 4 using the U-Net approach, as assessed by Jaccard and Dice metrics. This work underscores the utility of machine-driven features in clinical applications that rely on automated pixel-level segmentation in prostate tissue images.
Multi-organ segmentation is a critical yet challenging task due to complex anatomical backgrounds, blurred boundaries, and diverse morphologies. This study introduces the Gradient-aware Adaptive Momentum Evolution Deep Snake (GAMED-Snake) model, which establishes a novel paradigm for contour-based segmentation by integrating gradient-based learning with adaptive momentum evolution mechanisms. The GAMED-Snake model incorporates three major innovations: First, the Distance Energy Map Prior (DEMP) generates a pixel-level force field that effectively attracts contour points towards the true boundaries, even in scenarios with complex backgrounds and blurred edges. Second, the Differential Convolution Inception Module (DCIM) precisely extracts comprehensive energy gradients, significantly enhancing segmentation accuracy. Third, the Adaptive Momentum Evolution Mechanism (AMEM) employs cross-attention to establish dynamic features across different iterations of evolution, enabling precise boundary alignment for diverse morphologies. Experimental results on four challenging multi-organ segmentation datasets demonstrate that GAMED-Snake improves the mDice metric by approximately 2% compared to state-of-the-art methods. Code will be available at https://github.com/SYSUzrc/GAMED-Snake.
Accurate and efficient segmentation of brain tumors is critical for diagnosis, treatment planning, and monitoring in clinical practice. In this study, we present an enhanced ResUNet architecture for automatic brain tumor segmentation, integrating an EfficientNetB0 encoder, a channel attention mechanism, and an Atrous Spatial Pyramid Pooling (ASPP) module. The EfficientNetB0 encoder leverages pre-trained features to improve feature extraction efficiency, while the channel attention mechanism enhances the model's focus on tumor-relevant features. ASPP enables multiscale contextual learning, crucial for handling tumors of varying sizes and shapes. The proposed model was evaluated on two benchmark datasets: TCGA LGG and BraTS 2020. Experimental results demonstrate that our method consistently outperforms the baseline ResUNet and its EfficientNet variant, achieving Dice coefficients of 0.903 and 0.851 and HD95 scores of 9.43 and 3.54 for whole tumor and tumor core regions on the BraTS 2020 dataset, respectively. compared with state-of-the-art methods, our approach shows competitive performance, particularly in whole tumor and tumor core segmentation. These results indicate that combining a powerful encoder with attention mechanisms and ASPP can significantly enhance brain tumor segmentation performance. The proposed approach holds promise for further optimization and application in other medical image segmentation tasks.
RGB and thermal image fusion have great potential to exhibit improved semantic segmentation in low-illumination conditions. Existing methods typically employ a two-branch encoder framework for multimodal feature extraction and design complicated feature fusion strategies to achieve feature extraction and fusion for multimodal semantic segmentation. However, these methods require massive parameter updates and computational effort during the feature extraction and fusion. To address this issue, we propose a novel multimodal fusion network (EFNet) based on an early fusion strategy and a simple but effective feature clustering for training efficient RGB-T semantic segmentation. In addition, we also propose a lightweight and efficient multi-scale feature aggregation decoder based on Euclidean distance. We validate the effectiveness of our method on different datasets and outperform previous state-of-the-art methods with lower parameters and computation.
Augmentation by generative modelling yields a promising alternative to the accumulation of surgical data, where ethical, organisational and regulatory aspects must be considered. Yet, the joint synthesis of (image, mask) pairs for segmentation, a major application in surgery, is rather unexplored. We propose to learn semantically comprehensive yet compact latent representations of the (image, mask) space, which we jointly model with a Latent Diffusion Model. We show that our approach can effectively synthesise unseen high-quality paired segmentation data of remarkable semantic coherence. Generative augmentation is typically applied pre-training by synthesising a fixed number of additional training samples to improve downstream task models. To enhance this approach, we further propose Generative Adaptive Uncertainty-guided Diffusion-based Augmentation (GAUDA), leveraging the epistemic uncertainty of a Bayesian downstream model for targeted online synthesis. We condition the generative model on classes with high estimated uncertainty during training to produce additional unseen samples for these classes. By adaptively utilising the generative model online, we can minimise the number of additional training samples and centre them around the currently most uncertain parts of the data distribution. GAUDA effectively improves downstream segmentation results over comparable methods by an average absolute IoU of 1.6% on CaDISv2 and 1.5% on CholecSeg8k, two prominent surgical datasets for semantic segmentation.
Accurate segmentation of the aorta and its associated arch branches is crucial for diagnosing aortic diseases. While deep learning techniques have significantly improved aorta segmentation, they remain challenging due to the intricate multiscale structure and the complexity of the surrounding tissues. This paper presents a novel approach for enhancing aorta segmentation using a Bayesian neural network-based hierarchical Laplacian of Gaussian (LoG) model. Our model consists of a 3D U-Net stream and a hierarchical LoG stream: the former provides an initial aorta segmentation, and the latter enhances blood vessel detection across varying scales by learning suitable LoG kernels, enabling self-adaptive handling of different parts of the aorta vessels with significant scale differences. We employ a Bayesian method to parameterize the LoG stream and provide confidence intervals for the segmentation results, ensuring robustness and reliability of the prediction for vascular medical image analysts. Experimental results show that our model can accurately segment main and supra-aortic vessels, yielding at least a 3% gain in the Dice coefficient over state-of-the-art methods across multiple volumes drawn from two aorta datasets, and can provide reliable confidence intervals for different parts of the aorta. The code is available at https://github.com/adlsn/LoGBNet.
In this article, we improve the deep learning solution for coastline extraction from Synthetic Aperture Radar (SAR) images by proposing a two-stage model involving image classification followed by segmentation. We hypothesize that a single segmentation model usually used for coastline detection is insufficient to characterize different coastline types. We demonstrate that the need for a two-stage workflow prevails through different compression levels of these images. Our results from experiments using a combination of CNN and U-Net models on Sentinel-1 images show that the two-stage workflow, coastline classification-extraction from SAR images (CCESAR) outperforms a single U-Net segmentation model.
Blood vessels (BVs) play a critical role in the Tumor Micro-Environment (TME), potentially influencing cancer progression and treatment response. However, manually quantifying BVs in Hematoxylin and Eosin (H&E) stained images is challenging and labor-intensive due to their heterogeneous appearances. We propose a novel approach of constructing guiding maps to improve the performance of state-of-the-art segmentation models for BV segmentation, the guiding maps encourage the models to learn representative features of BVs. This is particularly beneficial for computational pathology, where labeled training data is often limited and large models are prone to overfitting. We have quantitative and qualitative results to demonstrate the efficacy of our approach in improving segmentation accuracy. In future, we plan to validate this method to segment BVs across various tissue types and investigate the role of cellular structures in relation to BVs in the TME.
Unsupervised anomaly detection (UAD) from images strives to model normal data distributions, creating discriminative representations to distinguish and precisely localize anomalies. Despite recent advancements in the efficient and unified one-for-all scheme, challenges persist in accurately segmenting anomalies for further monitoring. Moreover, this problem is obscured by the widely-used AUROC metric under imbalanced UAD settings. This motivates us to emphasize the significance of precise segmentation of anomaly pixels using pAP and DSC as metrics. To address the unsolved segmentation task, we introduce the Unified Anomaly Segmentation (UniAS). UniAS presents a multi-level hybrid pipeline that progressively enhances normal information from coarse to fine, incorporating a novel multi-granularity gated CNN (MGG-CNN) into Transformer layers to explicitly aggregate local details from different granularities. UniAS achieves state-of-the-art anomaly segmentation performance, attaining 65.12/59.33 and 40.06/32.50 in pAP/DSC on the MVTec-AD and VisA datasets, respectively, surpassing previous methods significantly. The codes are shared at https://github.com/Mwxinnn/UniAS.
Cross-entropy (CE) loss is the de-facto standard for training deep neural networks to perform classification. However, CE-trained deep neural networks struggle with robustness and generalisation issues. To alleviate these issues, we propose high error margin (HEM) loss, a variant of multi-class margin loss that overcomes the training issues of other margin-based losses. We evaluate HEM extensively on a range of architectures and datasets. We find that HEM loss is more effective than cross-entropy loss across a wide range of tasks: unknown class rejection, adversarial robustness, learning with imbalanced data, continual learning, and semantic segmentation (a pixel-level classification task). Despite all training hyper-parameters being chosen for CE loss, HEM is inferior to CE only in terms of clean accuracy and this difference is insignificant. We also compare HEM to specialised losses that have previously been proposed to improve performance on specific tasks. LogitNorm, a loss achieving state-of-the-art performance on unknown class rejection, produces similar performance to HEM for this task, but is much poorer for continual learning and semantic segmentation. Logit-adjusted loss, designed for imbalanced data, has superior results to HEM for that task, but performs more poorly on unknown class rejection and semantic segmentation. DICE, a popular loss for semantic segmentation, is inferior to HEM loss on all tasks, including semantic segmentation. Thus, HEM often out-performs specialised losses, and in contrast to them, is a general-purpose replacement for CE loss.
Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models or adapting them to a new condition is costly due to the need for (manually) labeled data. The emergence of vision foundation models, especially Segment Anything, offers a path to universal segmentation for medical images, overcoming these issues. Here, we study how to improve Segment Anything for medical images by comparing different finetuning strategies on a large and diverse dataset. We evaluate the finetuned models on a wide range of interactive and (automatic) semantic segmentation tasks. We find that the performance can be clearly improved for interactive segmentation. However, semantic segmentation does not benefit from pretraining on medical images. Our best model, MedicoSAM, is publicly available at https://github.com/computational-cell-analytics/medico-sam. We show that it is compatible with existing tools for data annotation and believe that it will be of great practical value.
3D models surpass 2D models in CT/MRI segmentation by effectively capturing inter-slice relationships. However, the added depth dimension substantially increases memory consumption. While patch-based training alleviates memory constraints, it significantly slows down the inference speed due to the sliding window (SW) approach. We propose No-More-Sliding-Window (NMSW), a novel end-to-end trainable framework that enhances the efficiency of generic 3D segmentation backbone during an inference step by eliminating the need for SW. NMSW employs a differentiable Top-k module to selectively sample only the most relevant patches, thereby minimizing redundant computations. When patch-level predictions are insufficient, the framework intelligently leverages coarse global predictions to refine results. Evaluated across 3 tasks using 3 segmentation backbones, NMSW achieves competitive accuracy compared to SW inference while significantly reducing computational complexity by 91% (88.0 to 8.00 TMACs). Moreover, it delivers a 9.1x faster inference on the H100 GPU (99.0 to 8.3 sec) and a 11.1x faster inference on the Xeon Gold CPU (2110 to 189 sec). NMSW is model-agnostic, further boosting efficiency when integrated with any existing efficient segmentation backbones.
Semi-supervised learning offers an appealing solution for remote sensing (RS) image segmentation to relieve the burden of labor-intensive pixel-level labeling. However, RS images pose unique challenges, including rich multi-scale features and high inter-class similarity. To address these problems, this paper proposes a novel semi-supervised Multi-Scale Uncertainty and Cross-Teacher-Student Attention (MUCA) model for RS image semantic segmentation tasks. Specifically, MUCA constrains the consistency among feature maps at different layers of the network by introducing a multi-scale uncertainty consistency regularization. It improves the multi-scale learning capability of semi-supervised algorithms on unlabeled data. Additionally, MUCA utilizes a Cross-Teacher-Student attention mechanism to guide the student network, guiding the student network to construct more discriminative feature representations through complementary features from the teacher network. This design effectively integrates weak and strong augmentations (WA and SA) to further boost segmentation performance. To verify the effectiveness of our model, we conduct extensive experiments on ISPRS-Potsdam and LoveDA datasets. The experimental results show the superiority of our method over state-of-the-art semi-supervised methods. Notably, our model excels in distinguishing highly similar objects, showcasing its potential for advancing semi-supervised RS image segmentation tasks.
Visual anomaly detection is a highly challenging task, often categorized as a one-class classification and segmentation problem. Recent studies have demonstrated that the student-teacher (S-T) framework effectively addresses this challenge. However, most S-T frameworks rely solely on pre-trained teacher networks to guide student networks in learning multi-scale similar features, overlooking the potential of the student networks to enhance learning through multi-scale feature fusion. In this study, we propose a novel model named PFADSeg, which integrates a pre-trained teacher network, a denoising student network with multi-scale feature fusion, and a guided anomaly segmentation network into a unified framework. By adopting a unique teacher-encoder and student-decoder denoising mode, the model improves the student network's ability to learn from teacher network features. Furthermore, an adaptive feature fusion mechanism is introduced to train a self-supervised segmentation network that synthesizes anomaly masks autonomously, significantly increasing detection performance. Evaluated on the MVTec AD dataset, PFADSeg achieves state-of-the-art results with an image-level AUC of 98.9%, a pixel-level mean precision of 76.4%, and an instance-level mean precision of 78.7%.
Structural integrity is vital for maintaining the safety and longevity of concrete infrastructures such as bridges, tunnels, and walls. Traditional methods for detecting damages like cracks and spalls are labor-intensive, time-consuming, and prone to human error. To address these challenges, this study explores advanced data-driven techniques using deep learning for automated damage detection and analysis. Two state-of-the-art instance segmentation models, YOLO-v7 instance segmentation and Mask R-CNN, were evaluated using a dataset comprising 400 images, augmented to 10,995 images through geometric and color-based transformations to enhance robustness. The models were trained and validated using a dataset split into 90% training set, validation and test set 10%. Performance metrics such as precision, recall, mean average precision ([email omitted]), and frames per second (FPS) were used for evaluation. YOLO-v7 achieved a superior [email omitted] of 96.1% and processed 40 FPS, outperforming Mask R-CNN, which achieved a [email omitted] of 92.1% with a slower processing speed of 18 FPS. The findings recommend YOLO-v7 instance segmentation model for real-time, high-speed structural health monitoring, while Mask R-CNN is better suited for detailed offline assessments. This study demonstrates the potential of deep learning to revolutionize infrastructure maintenance, offering a scalable and efficient solution for automated damage detection.