Medical image segmentation is a pivotal step in diagnostic and therapeutic processes, relying on high-quality annotated data that is often challenging and costly to obtain. Semi-supervised learning offers a promising approach to enhance model performance by leveraging unlabeled data. Although weak-to-strong consistency is a prevalent method in semi-supervised image segmentation, there is a scarcity of research on perturbation strategies specifically tailored for semi-supervised medical image segmentation tasks. To address this challenge, this paper introduces a simple yet efficient semi-supervised learning framework named Attention-Guided weak-to-strong Consistency Match (AIGCMatch). The AIGCMatch framework incorporates attention-guided perturbation strategies at both the image and feature levels to achieve weak-to-strong consistency regularization. This method not only preserves the structural information of medical images but also enhances the model's ability to process complex semantic information. Extensive experiments conducted on the ACDC and ISIC-2017 datasets have validated the effectiveness of AIGCMatch. Our method achieved a 90.4\% Dice score in the 7-case scenario on the ACDC dataset, surpassing the state-of-the-art methods and demonstrating its potential and efficacy in clinical settings. Additionally, on the ISIC-2017 dataset, we significantly outperformed our baseline, indicating the robustness and generalizability of AIGCMatch across different medical image segmentation tasks.
Image fusion is famous as an alternative solution to generate one high-quality image from multiple images in addition to image restoration from a single degraded image. The essence of image fusion is to integrate complementary information from source images. Existing fusion methods struggle with generalization across various tasks and often require labor-intensive designs, in which it is difficult to identify and extract useful information from source images due to the diverse requirements of each fusion task. Additionally, these methods develop highly specialized features for different downstream applications, hindering the adaptation to new and diverse downstream tasks. To address these limitations, we introduce DeFusion++, a novel framework that leverages self-supervised learning (SSL) to enhance the versatility of feature representation for different image fusion tasks. DeFusion++ captures the image fusion task-friendly representations from large-scale data in a self-supervised way, overcoming the constraints of limited fusion datasets. Specifically, we introduce two innovative pretext tasks: common and unique decomposition (CUD) and masked feature modeling (MFM). CUD decomposes source images into abstract common and unique components, while MFM refines these components into robust fused features. Jointly training of these tasks enables DeFusion++ to produce adaptable representations that can effectively extract useful information from various source images, regardless of the fusion task. The resulting fused representations are also highly adaptable for a wide range of downstream tasks, including image segmentation and object detection. DeFusion++ stands out by producing versatile fused representations that can enhance both the quality of image fusion and the effectiveness of downstream high-level vision tasks, simplifying the process with the elegant fusion framework.
Deep learning has brought transformative advancements to object segmentation, especially in marine robotics contexts such as waste management and subaquatic infrastructure oversight. However, a central challenge persists: calibrating the prediction confidence of the model to ensure robust and reliable outcomes, especially within the demanding underwater environment. Existing solutions for estimating uncertainty are often computationally intensive and have largely centered around Bayesian neural networks or ensemble methods. In this paper, we present a Conditional Variational Autoencoder-based framework (CVAE-SM), which is capable of generating diverse latent codes for improved uncertainty quantification in image segmentation. Our method, enhanced by a style modulator, merges content features, and latent codes more effectively, leading to refined prediction of uncertainty levels. We further introduce a dataset of perturbed underwater images to benchmark uncertainty quantification in this domain. The proposed model not only surpasses peers in segmentation metrics but also matches ensemble models in uncertainty predictions, all while being 2.5 times faster.
Semi-supervised learning (SSL) techniques address the high labeling costs in 3D medical image segmentation, with the teacher-student model being a common approach. However, using an exponential moving average (EMA) in single-teacher models may cause coupling issues, where the weights of the student and teacher models become similar, limiting the teacher's ability to provide additional knowledge for the student. Dual-teacher models were introduced to address this problem but often neglected the importance of maintaining teacher model diversity, leading to coupling issues among teachers. To address the coupling issue, we incorporate a double-copy-paste (DCP) technique to enhance the diversity among the teachers. Additionally, we introduce the Staged Selective Ensemble (SSE) module, which selects different ensemble methods based on the characteristics of the samples and enables more accurate segmentation of label boundaries, thereby improving the quality of pseudo-labels. Experimental results demonstrate the effectiveness of our proposed method in 3D medical image segmentation tasks. Here is the code link: https://github.com/Fazhan-cs/DCP.
Medical image segmentation poses challenges due to domain gaps, data modality variations, and dependency on domain knowledge or experts, especially for low- and middle-income countries (LMICs). Whereas for humans, given a few exemplars (with corresponding labels), we are able to segment different medical images even without exten-sive domain-specific clinical training. In addition, current SAM-based medical segmentation models use fine-grained visual prompts, such as the bounding rectangle generated from manually annotated target segmentation mask, as the bounding box (bbox) prompt during the testing phase. However, in actual clinical scenarios, no such precise prior knowledge is available. Our experimental results also reveal that previous models nearly fail to predict when given coarser bbox prompts. Considering these issues, in this paper, we introduce a domain-aware selective adaptation approach to adapt the general knowledge learned from a large model trained with natural images to the corresponding medical domains/modalities, with access to only a few (e.g. less than 5) exemplars. Our method mitigates the aforementioned limitations, providing an efficient and LMICs-friendly solution. Extensive experimental analysis showcases the effectiveness of our approach, offering potential advancements in healthcare diagnostics and clinical applications in LMICs.
Manual annotation of 3D medical images for segmentation tasks is tedious and time-consuming. Moreover, data privacy limits the applicability of crowd sourcing to perform data annotation in medical domains. As a result, training deep neural networks for medical image segmentation can be challenging. We introduce a new source-free Unsupervised Domain Adaptation (UDA) method to address this problem. Our idea is based on estimating the internally learned distribution of a relevant source domain by a base model and then generating pseudo-labels that are used for enhancing the model refinement through self-training. We demonstrate that our approach leads to SOTA performance on a real-world 3D medical dataset.
Pubic symphysis-fetal head segmentation in transperineal ultrasound images plays a critical role for the assessment of fetal head descent and progression. Existing transformer segmentation methods based on sparse attention mechanism use handcrafted static patterns, which leads to great differences in terms of segmentation performance on specific datasets. To address this issue, we introduce a dynamic, query-aware sparse attention mechanism for ultrasound image segmentation. Specifically, we propose a novel method, named BRAU-Net to solve the pubic symphysis-fetal head segmentation task in this paper. The method adopts a U-Net-like encoder-decoder architecture with bi-level routing attention and skip connections, which effectively learns local-global semantic information. In addition, we propose an inverted bottleneck patch expanding (IBPE) module to reduce information loss while performing up-sampling operations. The proposed BRAU-Net is evaluated on FH-PS-AoP and HC18 datasets. The results demonstrate that our method could achieve excellent segmentation results. The code is available on GitHub.
Achieving precise medical image segmentation is vital for effective treatment planning and accurate disease diagnosis. Traditional fully-supervised deep learning methods, though highly precise, are heavily reliant on large volumes of labeled data, which are often difficult to obtain due to the expertise required for medical annotations. This has led to the rise of semi-supervised learning approaches that utilize both labeled and unlabeled data to mitigate the label scarcity issue. In this paper, we introduce the Manifold-Aware Local Feature Modeling Network (MANet), which enhances the U-Net architecture by incorporating manifold supervision signals. This approach focuses on improving boundary accuracy, which is crucial for reliable medical diagnosis. To further extend the versatility of our method, we propose two variants: MA-Sobel and MA-Canny. The MA-Sobel variant employs the Sobel operator, which is effective for both 2D and 3D data, while the MA-Canny variant utilizes the Canny operator, specifically designed for 2D images, to refine boundary detection. These variants allow our method to adapt to various medical image modalities and dimensionalities, ensuring broader applicability. Our extensive experiments on datasets such as ACDC, LA, and Pancreas-NIH demonstrate that MANet consistently surpasses state-of-the-art methods in performance metrics like Dice and Jaccard scores. The proposed method also shows improved generalization across various semi-supervised segmentation networks, highlighting its robustness and effectiveness. Visual analysis of segmentation results confirms that MANet offers clearer and more accurate class boundaries, underscoring the value of manifold information in medical image segmentation.
In the realm of high-resolution (HR), fine-grained image segmentation, the primary challenge is balancing broad contextual awareness with the precision required for detailed object delineation, capturing intricate details and the finest edges of objects. Diffusion models, trained on vast datasets comprising billions of image-text pairs, such as SD V2.1, have revolutionized text-to-image synthesis by delivering exceptional quality, fine detail resolution, and strong contextual awareness, making them an attractive solution for high-resolution image segmentation. To this end, we propose DiffDIS, a diffusion-driven segmentation model that taps into the potential of the pre-trained U-Net within diffusion models, specifically designed for high-resolution, fine-grained object segmentation. By leveraging the robust generalization capabilities and rich, versatile image representation prior of the SD models, coupled with a task-specific stable one-step denoising approach, we significantly reduce the inference time while preserving high-fidelity, detailed generation. Additionally, we introduce an auxiliary edge generation task to not only enhance the preservation of fine details of the object boundaries, but reconcile the probabilistic nature of diffusion with the deterministic demands of segmentation. With these refined strategies in place, DiffDIS serves as a rapid object mask generation model, specifically optimized for generating detailed binary maps at high resolutions, while demonstrating impressive accuracy and swift processing. Experiments on the DIS5K dataset demonstrate the superiority of DiffDIS, achieving state-of-the-art results through a streamlined inference process. Our code will be made publicly available.
Multimodal Large Language Models (MLLMs) have shown exceptional capabilities in vision-language tasks; however, effectively integrating image segmentation into these models remains a significant challenge. In this paper, we introduce Text4Seg, a novel text-as-mask paradigm that casts image segmentation as a text generation problem, eliminating the need for additional decoders and significantly simplifying the segmentation process. Our key innovation is semantic descriptors, a new textual representation of segmentation masks where each image patch is mapped to its corresponding text label. This unified representation allows seamless integration into the auto-regressive training pipeline of MLLMs for easier optimization. We demonstrate that representing an image with $16\times16$ semantic descriptors yields competitive segmentation performance. To enhance efficiency, we introduce the Row-wise Run-Length Encoding (R-RLE), which compresses redundant text sequences, reducing the length of semantic descriptors by 74% and accelerating inference by $3\times$, without compromising performance. Extensive experiments across various vision tasks, such as referring expression segmentation and comprehension, show that Text4Seg achieves state-of-the-art performance on multiple datasets by fine-tuning different MLLM backbones. Our approach provides an efficient, scalable solution for vision-centric tasks within the MLLM framework.
The high cost of obtaining accurate annotations for image segmentation and localization makes the use of one and few shot algorithms attractive. Several state-of-the-art methods for few-shot segmentation have emerged, including text-based prompting for the task but suffer from sub-optimal performance for medical images. Leveraging sub-pixel level features of existing Vision Transformer (ViT) based foundation models for identifying similar region of interest (RoI) based on a single template image have been shown to be very effective for one shot segmentation and localization in medical images across modalities. However, such methods rely on assumption that template image and test image are well matched and simple correlation is sufficient to obtain correspondences. In practice, however such an approach can fail to generalize in clinical data due to patient pose changes, inter-protocol variations even within a single modality or extend to 3D data using single template image. Moreover, for multi-label tasks, the RoI identification has to be performed sequentially. In this work, we propose foundation model (FM) based adapters for single label, multi-label localization and segmentation to address these concerns. We demonstrate the efficacy of the proposed method for multiple segmentation and localization tasks for both 2D and 3D data as we well as clinical data with different poses and evaluate against the state of the art few shot segmentation methods.
Exploring the potential of quantum hardware for enhancing classical and real-world applications is an ongoing challenge. This study evaluates the performance of quantum and quantum-inspired methods compared to classical models for crack segmentation. Using annotated gray-scale image patches of concrete samples, we benchmark a classical mean Gaussian mixture technique, a quantum-inspired fermion-based method, Q-Seg a quantum annealing-based method, and a U-Net deep learning architecture. Our results indicate that quantum-inspired and quantum methods offer a promising alternative for image segmentation, particularly for complex crack patterns, and could be applied in near-future applications.
Foundation models have become a cornerstone in deep learning, with techniques like Low-Rank Adaptation (LoRA) offering efficient fine-tuning of large models. Similarly, methods such as Retrieval-Augmented Generation (RAG), which leverage vectorized databases, have further improved model performance by grounding outputs in external information. While these approaches have demonstrated notable success, they often require extensive training or labeled data, which can limit their adaptability in resource-constrained environments. To address these challenges, we introduce Retrieval-based Parameter Ensemble (RPE), a new method that creates a vectorized database of LoRAs, enabling efficient retrieval and application of model adaptations to new tasks. RPE minimizes the need for extensive training and eliminates the requirement for labeled data, making it particularly effective for zero-shot learning. Additionally, RPE is well-suited for privacy-sensitive domains like healthcare, as it modifies model parameters without accessing raw data. When applied to tasks such as medical report generation and image segmentation, RPE not only proved effective but also surpassed supervised fine-tuning methods in certain cases, highlighting its potential to enhance both computational efficiency and privacy in deep learning applications.
The combination of semi-supervised learning (SemiSL) and contrastive learning (CL) has been successful in medical image segmentation with limited annotations. However, these works often rely on pretext tasks that lack the specificity required for pixel-level segmentation, and still face overfitting issues due to insufficient supervision signals resulting from too few annotations. Therefore, this paper proposes an affinity-graph-guided semi-supervised contrastive learning framework (Semi-AGCL) by establishing additional affinity-graph-based supervision signals between the student and teacher network, to achieve medical image segmentation with minimal annotations without pretext. The framework first designs an average-patch-entropy-driven inter-patch sampling method, which can provide a robust initial feature space without relying on pretext tasks. Furthermore, the framework designs an affinity-graph-guided loss function, which can improve the quality of the learned representation and the model generalization ability by exploiting the inherent structure of the data, thus mitigating overfitting. Our experiments indicate that with merely 10% of the complete annotation set, our model approaches the accuracy of the fully annotated baseline, manifesting a marginal deviation of only 2.52%. Under the stringent conditions where only 5% of the annotations are employed, our model exhibits a significant enhancement in performance surpassing the second best baseline by 23.09% on the dice metric and achieving an improvement of 26.57% on the notably arduous CRAG and ACDC datasets.
Image segmentation is a crucial vision task that groups pixels within an image into semantically meaningful segments, which is pivotal in obtaining a fine-grained understanding of real-world scenes. However, an increasing privacy concern exists regarding training large-scale image segmentation models on unauthorized private data. In this work, we exploit the concept of unlearnable examples to make images unusable to model training by generating and adding unlearnable noise into the original images. Particularly, we propose a novel Unlearnable Segmentation (UnSeg) framework to train a universal unlearnable noise generator that is capable of transforming any downstream images into their unlearnable version. The unlearnable noise generator is finetuned from the Segment Anything Model (SAM) via bilevel optimization on an interactive segmentation dataset towards minimizing the training error of a surrogate model that shares the same architecture with SAM but is trained from scratch. We empirically verify the effectiveness of UnSeg across 6 mainstream image segmentation tasks, 10 widely used datasets, and 7 different network architectures, and show that the unlearnable images can reduce the segmentation performance by a large margin. Our work provides useful insights into how to leverage foundation models in a data-efficient and computationally affordable manner to protect images against image segmentation models.
In this paper, we study weakly-supervised laparoscopic image segmentation with sparse annotations. We introduce a novel Bayesian deep learning approach designed to enhance both the accuracy and interpretability of the model's segmentation, founded upon a comprehensive Bayesian framework, ensuring a robust and theoretically validated method. Our approach diverges from conventional methods that directly train using observed images and their corresponding weak annotations. Instead, we estimate the joint distribution of both images and labels given the acquired data. This facilitates the sampling of images and their high-quality pseudo-labels, enabling the training of a generalizable segmentation model. Each component of our model is expressed through probabilistic formulations, providing a coherent and interpretable structure. This probabilistic nature benefits accurate and practical learning from sparse annotations and equips our model with the ability to quantify uncertainty. Extensive evaluations with two public laparoscopic datasets demonstrated the efficacy of our method, which consistently outperformed existing methods. Furthermore, our method was adapted for scribble-supervised cardiac multi-structure segmentation, presenting competitive performance compared to previous methods. The code is available at https://github.com/MoriLabNU/Bayesian_WSS.
Many image processing applications rely on partitioning an image into disjoint regions whose pixels are 'similar.' The watershed and waterfall transforms are established mathematical morphology pixel clustering techniques. They are both relevant to modern applications where groups of pixels are to be decided upon in one go, or where adjacency information is relevant. We introduce three new parallel partitioning algorithms for GPUs. By repeatedly applying watershed algorithms, we produce waterfall results which form a hierarchy of partition regions over an input image. Our watershed algorithms attain competitive execution times in both 2D and 3D, processing an 800 megavoxel image in less than 1.4 sec. We also show how to use this fully deterministic image partitioning as a pre-processing step to machine learning based semantic segmentation. This replaces the role of superpixel algorithms, and results in comparable accuracy and faster training times.
Video segmentation is essential for advancing robotics and autonomous driving, particularly in open-world settings where continuous perception and object association across video frames are critical. While the Segment Anything Model (SAM) has excelled in static image segmentation, extending its capabilities to video segmentation poses significant challenges. We tackle two major hurdles: a) SAM's embedding limitations in associating objects across frames, and b) granularity inconsistencies in object segmentation. To this end, we introduce VideoSAM, an end-to-end framework designed to address these challenges by improving object tracking and segmentation consistency in dynamic environments. VideoSAM integrates an agglomerated backbone, RADIO, enabling object association through similarity metrics and introduces Cycle-ack-Pairs Propagation with a memory mechanism for stable object tracking. Additionally, we incorporate an autoregressive object-token mechanism within the SAM decoder to maintain consistent granularity across frames. Our method is extensively evaluated on the UVO and BURST benchmarks, and robotic videos from RoboTAP, demonstrating its effectiveness and robustness in real-world scenarios. All codes will be available.
Given a natural language expression and a remote sensing image, the goal of referring remote sensing image segmentation (RRSIS) is to generate a pixel-level mask of the target object identified by the referring expression. In contrast to natural scenarios, expressions in RRSIS often involve complex geospatial relationships, with target objects of interest that vary significantly in scale and lack visual saliency, thereby increasing the difficulty of achieving precise segmentation. To address the aforementioned challenges, a novel RRSIS framework is proposed, termed the cross-modal bidirectional interaction model (CroBIM). Specifically, a context-aware prompt modulation (CAPM) module is designed to integrate spatial positional relationships and task-specific knowledge into the linguistic features, thereby enhancing the ability to capture the target object. Additionally, a language-guided feature aggregation (LGFA) module is introduced to integrate linguistic information into multi-scale visual features, incorporating an attention deficit compensation mechanism to enhance feature aggregation. Finally, a mutual-interaction decoder (MID) is designed to enhance cross-modal feature alignment through cascaded bidirectional cross-attention, thereby enabling precise segmentation mask prediction. To further forster the research of RRSIS, we also construct RISBench, a new large-scale benchmark dataset comprising 52,472 image-language-label triplets. Extensive benchmarking on RISBench and two other prevalent datasets demonstrates the superior performance of the proposed CroBIM over existing state-of-the-art (SOTA) methods. The source code for CroBIM and the RISBench dataset will be publicly available at https://github.com/HIT-SIRS/CroBIM
Video segmentation is a popular task, but applying image segmentation models frame-by-frame to videos does not preserve temporal consistency. In this paper, we propose a method to extend a query-based image segmentation model to video using feature shift and query matching. The method uses a query-based architecture, where decoded queries represent segmentation masks. These queries should be matched before performing the feature shift to ensure that the shifted queries represent the same mask across different frames. Experimental results on CityScapes-VPS and VSPW show significant improvements from the baselines, highlighting the method's effectiveness in enhancing segmentation quality while efficiently reusing pre-trained weights.