The integration of RGB and depth modalities significantly enhances the accuracy of segmenting complex indoor scenes, with depth data from RGB-D cameras playing a crucial role in this improvement. However, collecting an RGB-D dataset is more expensive than an RGB dataset due to the need for specialized depth sensors. Aligning depth and RGB images also poses challenges due to sensor positioning and issues like missing data and noise. In contrast, Pseudo Depth (PD) from high-precision depth estimation algorithms can eliminate the dependence on RGB-D sensors and alignment processes, as well as provide effective depth information and show significant potential in semantic segmentation. Therefore, to explore the practicality of utilizing pseudo depth instead of real depth for semantic segmentation, we design an RGB-PD segmentation pipeline to integrate RGB and pseudo depth and propose a Pseudo Depth Aggregation Module (PDAM) for fully exploiting the informative clues provided by the diverse pseudo depth maps. The PDAM aggregates multiple pseudo depth maps into a single modality, making it easily adaptable to other RGB-D segmentation methods. In addition, the pre-trained diffusion model serves as a strong feature extractor for RGB segmentation tasks, but multi-modal diffusion-based segmentation methods remain unexplored. Therefore, we present a Pseudo Depth Diffusion Model (PDDM) that adopts a large-scale text-image diffusion model as a feature extractor and a simple yet effective fusion strategy to integrate pseudo depth. To verify the applicability of pseudo depth and our PDDM, we perform extensive experiments on the NYUv2 and SUNRGB-D datasets. The experimental results demonstrate that pseudo depth can effectively enhance segmentation performance, and our PDDM achieves state-of-the-art performance, outperforming other methods by +6.98 mIoU on NYUv2 and +2.11 mIoU on SUNRGB-D.
High-resolution semantic segmentation is essential for applications such as image editing, bokeh imaging, AR/VR, etc. Unfortunately, existing datasets often have limited resolution and lack precise mask details and boundaries. In this work, we build a large-scale, matting-level semantic segmentation dataset, named MaSS13K, which consists of 13,348 real-world images, all at 4K resolution. MaSS13K provides high-quality mask annotations of a number of objects, which are categorized into seven categories: human, vegetation, ground, sky, water, building, and others. MaSS13K features precise masks, with an average mask complexity 20-50 times higher than existing semantic segmentation datasets. We consequently present a method specifically designed for high-resolution semantic segmentation, namely MaSSFormer, which employs an efficient pixel decoder that aggregates high-level semantic features and low-level texture features across three stages, aiming to produce high-resolution masks with minimal computational cost. Finally, we propose a new learning paradigm, which integrates the high-quality masks of the seven given categories with pseudo labels from new classes, enabling MaSSFormer to transfer its accurate segmentation capability to other classes of objects. Our proposed MaSSFormer is comprehensively evaluated on the MaSS13K benchmark together with 14 representative segmentation models. We expect that our meticulously annotated MaSS13K dataset and the MaSSFormer model can facilitate the research of high-resolution and high-quality semantic segmentation. Datasets and codes can be found at https://github.com/xiechenxi99/MaSS13K.
Temporal action segmentation in untrimmed procedural videos aims to densely label frames into action classes. These videos inherently exhibit long-tailed distributions, where actions vary widely in frequency and duration. In temporal action segmentation approaches, we identified a bi-level learning bias. This bias encompasses (1) a class-level bias, stemming from class imbalance favoring head classes, and (2) a transition-level bias arising from variations in transitions, prioritizing commonly observed transitions. As a remedy, we introduce a constrained optimization problem to alleviate both biases. We define learning states for action classes and their associated transitions and integrate them into the optimization process. We propose a novel cost-sensitive loss function formulated as a weighted cross-entropy loss, with weights adaptively adjusted based on the learning state of actions and their transitions. Experiments on three challenging temporal segmentation benchmarks and various frameworks demonstrate the effectiveness of our approach, resulting in significant improvements in both per-class frame-wise and segment-wise performance.
Producing high-quality segmentation masks for medical images is a fundamental challenge in biomedical image analysis. Recent research has explored large-scale supervised training to enable segmentation across various medical imaging modalities and unsupervised training to facilitate segmentation without dense annotations. However, constructing a model capable of segmenting diverse medical images in a zero-shot manner without any annotations remains a significant hurdle. This paper introduces the Attention Diffusion Zero-shot Unsupervised System (ADZUS), a novel approach that leverages self-attention diffusion models for zero-shot biomedical image segmentation. ADZUS harnesses the intrinsic capabilities of pre-trained diffusion models, utilizing their generative and discriminative potentials to segment medical images without requiring annotated training data or prior domain-specific knowledge. The ADZUS architecture is detailed, with its integration of self-attention mechanisms that facilitate context-aware and detail-sensitive segmentations being highlighted. Experimental results across various medical imaging datasets, including skin lesion segmentation, chest X-ray infection segmentation, and white blood cell segmentation, reveal that ADZUS achieves state-of-the-art performance. Notably, ADZUS reached Dice scores ranging from 88.7\% to 92.9\% and IoU scores from 66.3\% to 93.3\% across different segmentation tasks, demonstrating significant improvements in handling novel, unseen medical imagery. It is noteworthy that while ADZUS demonstrates high effectiveness, it demands substantial computational resources and extended processing times. The model's efficacy in zero-shot settings underscores its potential to reduce reliance on costly annotations and seamlessly adapt to new medical imaging tasks, thereby expanding the diagnostic capabilities of AI-driven medical imaging technologies.
Reasoning segmentation aims to segment target objects in complex scenes based on human intent and spatial reasoning. While recent multimodal large language models (MLLMs) have demonstrated impressive 2D image reasoning segmentation, adapting these capabilities to 3D scenes remains underexplored. In this paper, we introduce MLLM-For3D, a simple yet effective framework that transfers knowledge from 2D MLLMs to 3D scene understanding. Specifically, we utilize MLLMs to generate multi-view pseudo segmentation masks and corresponding text embeddings, then unproject 2D masks into 3D space and align them with the text embeddings. The primary challenge lies in the absence of 3D context and spatial consistency across multiple views, causing the model to hallucinate objects that do not exist and fail to target objects consistently. Training the 3D model with such irrelevant objects leads to performance degradation. To address this, we introduce a spatial consistency strategy to enforce that segmentation masks remain coherent in the 3D space, effectively capturing the geometry of the scene. Moreover, we develop a Token-for-Query approach for multimodal semantic alignment, enabling consistent identification of the same object across different views. Extensive evaluations on various challenging indoor scene benchmarks demonstrate that, even without any labeled 3D training data, MLLM-For3D outperforms existing 3D reasoning segmentation methods, effectively interpreting user intent, understanding 3D scenes, and reasoning about spatial relationships.
Variational models are widely used in image segmentation, with various models designed to address different types of images by optimizing specific objective functionals. However, traditional segmentation models primarily focus on the visual attributes of the image, often neglecting the topological properties of the target objects. This limitation can lead to segmentation results that deviate from the ground truth, particularly in images with complex topological structures. In this paper, we introduce a topology-preserving constraint into the iterative convolution-thresholding method (ICTM), resulting in the topology-preserving ICTM (TP-ICTM). Extensive experiments demonstrate that, by explicitly preserving the topological properties of target objects-such as connectivity-the proposed algorithm achieves enhanced accuracy and robustness, particularly in images with intricate structures or noise.
Semantic segmentation allows autonomous driving cars to understand the surroundings of the vehicle comprehensively. However, it is also crucial for the model to detect obstacles that may jeopardize the safety of autonomous driving systems. Based on our experiments, we find that current uni-modal anomaly segmentation frameworks tend to produce high anomaly scores for non-anomalous regions in images. Motivated by this empirical finding, we develop a multi-modal uncertainty-based anomaly segmentation framework, named MMRAS+, for autonomous driving systems. MMRAS+ effectively reduces the high anomaly outputs of non-anomalous classes by introducing text-modal using the CLIP text encoder. Indeed, MMRAS+ is the first multi-modal anomaly segmentation solution for autonomous driving. Moreover, we develop an ensemble module to further boost the anomaly segmentation performance. Experiments on RoadAnomaly, SMIYC, and Fishyscapes validation datasets demonstrate the superior performance of our method. The code is available in https://github.com/HengGao12/MMRAS_plus.
Medical image segmentation is crucial for enhancing diagnostic accuracy and treatment planning in Magnetic Resonance Imaging (MRI). However, acquiring precise lesion masks for segmentation model training demands specialized expertise and significant time investment, leading to a small dataset scale in clinical practice. In this paper, we present ZECO, a ZeroFusion guided 3D MRI conditional generation framework that extracts, compresses, and generates high-fidelity MRI images with corresponding 3D segmentation masks to mitigate data scarcity. To effectively capture inter-slice relationships within volumes, we introduce a Spatial Transformation Module that encodes MRI images into a compact latent space for the diffusion process. Moving beyond unconditional generation, our novel ZeroFusion method progressively maps 3D masks to MRI images in latent space, enabling robust training on limited datasets while avoiding overfitting. ZECO outperforms state-of-the-art models in both quantitative and qualitative evaluations on Brain MRI datasets across various modalities, showcasing its exceptional capability in synthesizing high-quality MRI images conditioned on segmentation masks.
State Space Models (SSMs) have recently demonstrated outstanding performance in long-sequence modeling, particularly in natural language processing. However, their direct application to medical image segmentation poses several challenges. SSMs, originally designed for 1D sequences, struggle with 3D spatial structures in medical images due to discontinuities introduced by flattening. Additionally, SSMs have difficulty fitting high-variance data, which is common in medical imaging. In this paper, we analyze the intrinsic limitations of SSMs in medical image segmentation and propose a unified U-shaped encoder-decoder architecture, Meta Mamba UNet (MM-UNet), designed to leverage the advantages of SSMs while mitigating their drawbacks. MM-UNet incorporates hybrid modules that integrate SSMs within residual connections, reducing variance and improving performance. Furthermore, we introduce a novel bi-directional scan order strategy to alleviate discontinuities when processing medical images. Extensive experiments on the AMOS2022 and Synapse datasets demonstrate the superiority of MM-UNet over state-of-the-art methods. MM-UNet achieves a Dice score of 91.0% on AMOS2022, surpassing nnUNet by 3.2%, and a Dice score of 87.1% on Synapse. These results confirm the effectiveness of integrating SSMs in medical image segmentation through architectural design optimizations.
Accurate segmentation of pulmonary vessels plays a very critical role in diagnosing and assessing various lung diseases. Currently, many automated algorithms are primarily targeted at CTPA (Computed Tomography Pulmonary Angiography) types of data. However, the segmentation precision of these methods is insufficient, and support for NCCT (Non-Contrast Computed Tomography) types of data is also a requirement in some clinical scenarios. In this study, we propose a 3D image segmentation algorithm for automated pulmonary vessel segmentation from both contrast-enhanced and non-contrast CT images. In the network, we designed a Vessel Lumen Structure Optimization Module (VLSOM), which extracts the centerline (Cl) of vessels and adjusts the weights based on the positional information and adds a Cl-Dice Loss to supervise the stability of the vessels structure. We used 427 sets of high-precision annotated CT data from multiple vendors and countries to train the model and achieved Cl-DICE, Cl-Recall, and Recall values of 0.892, 0.861, 0.924 for CTPA data and 0.925, 0.903, 0.949 for NCCT data. This shows that our model has achieved good performance in both accuracy and completeness of pulmonary vessel segmentation. We finally conducted a clinical visual assessment on an independent external test dataset. The average score for accuracy and robustness, branch abundance, assistance for diagnosis and vascular continuity are 4.26, 4.17, 4.33, 3.83 respectively while the full score is 5. These results highlight the great potential of this method in clinical application.
Medical vision foundational models are used for a wide variety of tasks, including medical image segmentation and registration. This work evaluates the ability of these models to predict disease progression using a simple linear probe. We hypothesize that intermediate layer features of segmentation models capture structural information, while those of registration models encode knowledge of change over time. Beyond demonstrating that these features are useful for disease progression prediction, we also show that registration model features do not require spatially aligned input images. However, for segmentation models, spatial alignment is essential for optimal performance. Our findings highlight the importance of spatial alignment and the utility of foundation model features for image registration.
This paper introduces a novel approach that leverages the capabilities of vision-language models (VLMs) by integrating them with established approaches for open-vocabulary detection (OVD), instance segmentation, and tracking. We utilize VLM-generated structured descriptions to identify visible object instances, collect application-relevant attributes, and inform an open-vocabulary detector to extract corresponding bounding boxes that are passed to a video segmentation model providing precise segmentation masks and tracking capabilities. Once initialized, this model can then directly extract segmentation masks, allowing processing of image streams in real time with minimal computational overhead. Tracks can be updated online as needed by generating new structured descriptions and corresponding open-vocabulary detections. This combines the descriptive power of VLMs with the grounding capability of OVD and the pixel-level understanding and speed of video segmentation. Our evaluation across datasets and robotics platforms demonstrates the broad applicability of this approach, showcasing its ability to extract task-specific attributes from non-standard objects in dynamic environments.
Accurate segmentation of the ventricles from cardiac magnetic resonance images (CMRIs) is crucial for enhancing the diagnosis and analysis of heart conditions. Deep learning-based segmentation methods have recently garnered significant attention due to their impressive performance. However, these segmentation methods are typically good at partitioning regularly shaped organs, such as the left ventricle (LV) and the myocardium (MYO), whereas they perform poorly on irregularly shaped organs, such as the right ventricle (RV). In this study, we argue that this limitation of segmentation models stems from their insufficient generalization ability to address the distribution shift of segmentation targets across slices, cardiac phases, and disease conditions. To overcome this issue, we present a Multi-Disease-Aware Training Strategy (MTS) and restructure the introduced CMRI datasets into multi-disease datasets. Additionally, we propose a specialized data processing technique for preprocessing input images to support the MTS. To validate the effectiveness of our method, we performed control group experiments and cross-validation tests. The experimental results show that (1) network models trained using our proposed strategy achieved superior segmentation performance, particularly in RV segmentation, and (2) these networks exhibited robust performance even when applied to data from unknown diseases.
Lung cancer is a leading cause of cancer-related deaths globally. PET-CT is crucial for imaging lung tumors, providing essential metabolic and anatomical information, while it faces challenges such as poor image quality, motion artifacts, and complex tumor morphology. Deep learning-based models are expected to address these problems, however, existing small-scale and private datasets limit significant performance improvements for these methods. Hence, we introduce a large-scale PET-CT lung tumor segmentation dataset, termed PCLT20K, which comprises 21,930 pairs of PET-CT images from 605 patients. Furthermore, we propose a cross-modal interactive perception network with Mamba (CIPA) for lung tumor segmentation in PET-CT images. Specifically, we design a channel-wise rectification module (CRM) that implements a channel state space block across multi-modal features to learn correlated representations and helps filter out modality-specific noise. A dynamic cross-modality interaction module (DCIM) is designed to effectively integrate position and context information, which employs PET images to learn regional position information and serves as a bridge to assist in modeling the relationships between local features of CT images. Extensive experiments on a comprehensive benchmark demonstrate the effectiveness of our CIPA compared to the current state-of-the-art segmentation methods. We hope our research can provide more exploration opportunities for medical image segmentation. The dataset and code are available at https://github.com/mj129/CIPA.
Segmenting transparent structures in images is challenging since they are difficult to distinguish from the background. Common examples are drinking glasses, which are a ubiquitous part of our lives and appear in many different shapes and sizes. In this work we propose TransCaGNet, a modified version of the zero-shot model CaGNet. We exchange the segmentation backbone with the architecture of Trans4Trans to be capable of segmenting transparent objects. Since some glasses are rarely captured, we use zeroshot learning to be able to create semantic segmentations of glass categories not given during training. We propose a novel synthetic dataset covering a diverse set of different environmental conditions. Additionally we capture a real-world evaluation dataset since most applications take place in the real world. Comparing our model with Zeg-Clip we are able to show that TransCaGNet produces better mean IoU and accuracy values while ZegClip outperforms it mostly for unseen classes. To improve the segmentation results, we combine the semantic segmentation of the models with the segmentation results of SAM 2. Our evaluation emphasizes that distinguishing between different classes is challenging for the models due to similarity, points of view, or coverings. Taking this behavior into account, we assign glasses multiple possible categories. The modification leads to an improvement up to 13.68% for the mean IoU and up to 17.88% for the mean accuracy values on the synthetic dataset. Using our difficult synthetic dataset for training, the models produce even better results on the real-world dataset. The mean IoU is improved up to 5.55% and the mean accuracy up to 5.72% on the real-world dataset.
Video object segmentation is crucial for the efficient analysis of complex medical video data, yet it faces significant challenges in data availability and annotation. We introduce the task of one-shot medical video object segmentation, which requires separating foreground and background pixels throughout a video given only the mask annotation of the first frame. To address this problem, we propose a temporal contrastive memory network comprising image and mask encoders to learn feature representations, a temporal contrastive memory bank that aligns embeddings from adjacent frames while pushing apart distant ones to explicitly model inter-frame relationships and stores these features, and a decoder that fuses encoded image features and memory readouts for segmentation. We also collect a diverse, multi-source medical video dataset spanning various modalities and anatomies to benchmark this task. Extensive experiments demonstrate state-of-the-art performance in segmenting both seen and unseen structures from a single exemplar, showing ability to generalize from scarce labels. This highlights the potential to alleviate annotation burdens for medical video analysis. Code is available at https://github.com/MedAITech/TCMN.
Few-shot video object segmentation aims to reduce annotation costs; however, existing methods still require abundant dense frame annotations for training, which are scarce in the medical domain. We investigate an extremely low-data regime that utilizes annotations from only a few video frames and leverages existing labeled images to minimize costly video annotations. Specifically, we propose a two-phase framework. First, we learn a few-shot segmentation model using labeled images. Subsequently, to improve performance without full supervision, we introduce a spatiotemporal consistency relearning approach on medical videos that enforces consistency between consecutive frames. Constraints are also enforced between the image model and relearning model at both feature and prediction levels. Experiments demonstrate the superiority of our approach over state-of-the-art few-shot segmentation methods. Our model bridges the gap between abundant annotated medical images and scarce, sparsely labeled medical videos to achieve strong video segmentation performance in this low data regime. Code is available at https://github.com/MedAITech/RAB.
The increasing demand for high-accuracy depth estimation in autonomous driving and augmented reality applications necessitates advanced neural architectures capable of effectively leveraging multiple data modalities. In this context, we introduce the Unified Segmentation Attention Mechanism Network (USAM-Net), a novel convolutional neural network that integrates stereo image inputs with semantic segmentation maps and attention to enhance depth estimation performance. USAM-Net employs a dual-pathway architecture, which combines a pre-trained segmentation model (SAM) and a depth estimation model. The segmentation pathway preprocesses the stereo images to generate semantic masks, which are then concatenated with the stereo images as inputs to the depth estimation pathway. This integration allows the model to focus on important features such as object boundaries and surface textures which are crucial for accurate depth perception. Empirical evaluation on the DrivingStereo dataset demonstrates that USAM-Net achieves superior performance metrics, including a Global Difference (GD) of 3.61\% and an End-Point Error (EPE) of 0.88, outperforming traditional models such as CFNet, SegStereo, and iResNet. These results underscore the effectiveness of integrating segmentation information into stereo depth estimation tasks, highlighting the potential of USAM-Net in applications demanding high-precision depth data.
Solving fish segmentation in underwater videos, a real-world problem of great practical value in marine and aquaculture industry, is a challenging task due to the difficulty of the filming environment, poor visibility and limited existing annotated underwater fish data. In order to overcome these obstacles, we introduce a novel two stage unsupervised segmentation approach that requires no human annotations and combines artificially created and real images. Our method generates challenging synthetic training data, by placing virtual fish in real-world underwater habitats, after performing fish transformations such as Thin Plate Spline shape warping and color Histogram Matching, which realistically integrate synthetic fish into the backgrounds, making the generated images increasingly closer to the real world data with every stage of our approach. While we validate our unsupervised method on the popular DeepFish dataset, obtaining a performance close to a fully-supervised SoTA model, we further show its effectiveness on the specific case of salmon segmentation in underwater videos, for which we introduce DeepSalmon, the largest dataset of its kind in the literature (30 GB). Moreover, on both datasets we prove the capability of our approach to boost the performance of the fully-supervised SoTA model.
Referring medical image segmentation targets delineating lesions indicated by textual descriptions. Aligning visual and textual cues is challenging due to their distinct data properties. Inspired by large-scale pre-trained vision-language models, we propose CausalCLIPSeg, an end-to-end framework for referring medical image segmentation that leverages CLIP. Despite not being trained on medical data, we enforce CLIP's rich semantic space onto the medical domain by a tailored cross-modal decoding method to achieve text-to-pixel alignment. Furthermore, to mitigate confounding bias that may cause the model to learn spurious correlations instead of meaningful causal relationships, CausalCLIPSeg introduces a causal intervention module which self-annotates confounders and excavates causal features from inputs for segmentation judgments. We also devise an adversarial min-max game to optimize causal features while penalizing confounding ones. Extensive experiments demonstrate the state-of-the-art performance of our proposed method. Code is available at https://github.com/WUTCM-Lab/CausalCLIPSeg.