Contraction assay based on surface measurement have been widely used to evaluate cell contractility in 3D models. This method is straightforward and requires no specific equipment, but it does not provide quantitative data about contraction forces generated by cells. We expanded this method with a new biomechanical model, based on the work-energy theorem, to provide non-destructive longitudinal monitoring of contraction forces generated by cells in 3D.We applied this method on hydrogels seeded with either fibroblasts or osteoblasts. Hydrogel mechanical characteristics were modulated to enhance (condition HCA$_{High}$: hydrogel contraction assay high contraction) or limit (condition HCA$_{Low}$: hydrogel contraction assay low contraction) cell contractile behaviors. Macroscopic measures were further correlated with cell contractile behavior and descriptive analysis of their physiology in response to different mechanical environments. Fibroblasts and osteoblasts contracted their matrix up to 47% and 77% respectively. Contraction stress peaked at day 5 with 1.1 10$^{-14}$Pa for fibroblasts and 3.5 10$^{-14}$Pa for osteoblasts, which correlated with cell attachment and spreading. Negligible contraction was seen in HCA$_{Low}$. Both fibroblasts and osteoblasts expressed $\alpha$-SMA contractile fibers in HCA$_{High}$ and HCA$_{Low}$. Failure to contract HCA$_{Low}$ was attributed to increased cross-linking and resistance to proteolytic degradation of the hydrogel.
Given a descriptive text query, text-based person search (TBPS) aims to retrieve the best-matched target person from an image gallery. Such a cross-modal retrieval task is quite challenging due to significant modality gap, fine-grained differences and insufficiency of annotated data. To better align the two modalities, most existing works focus on introducing sophisticated network structures and auxiliary tasks, which are complex and hard to implement. In this paper, we propose a simple yet effective dual Transformer model for text-based person search. By exploiting a hardness-aware contrastive learning strategy, our model achieves state-of-the-art performance without any special design for local feature alignment or side information. Moreover, we propose a proximity data generation (PDG) module to automatically produce more diverse data for cross-modal training. The PDG module first introduces an automatic generation algorithm based on a text-to-image diffusion model, which generates new text-image pair samples in the proximity space of original ones. Then it combines approximate text generation and feature-level mixup during training to further strengthen the data diversity. The PDG module can largely guarantee the reasonability of the generated samples that are directly used for training without any human inspection for noise rejection. It improves the performance of our model significantly, providing a feasible solution to the data insufficiency problem faced by such fine-grained visual-linguistic tasks. Extensive experiments on two popular datasets of the TBPS task (i.e., CUHK-PEDES and ICFG-PEDES) show that the proposed approach outperforms state-of-the-art approaches evidently, e.g., improving by 3.88%, 4.02%, 2.92% in terms of Top1, Top5, Top10 on CUHK-PEDES. The codes will be available at https://github.com/HCPLab-SYSU/PersonSearch-CTLG
Unexpectedness is a central concept in Simplicity Theory, a theory of cognition relating various inferential processes to the computation of Kolmogorov complexities, rather than probabilities. Its predictive power has been confirmed by several experiments with human subjects, yet its theoretical basis remains largely unexplored: why does it work? This paper lays the groundwork for three theoretical conjectures. First, unexpectedness can be seen as a generalization of Bayes' rule. Second, the frequentist core of unexpectedness can be connected to the function of tracking ergodic properties of the world. Third, unexpectedness can be seen as constituent of various measures of divergence between the entropy of the world (environment) and the variety of the observer (system). The resulting framework hints to research directions that go beyond the division between probabilistic and logical approaches, potentially bringing new insights into the extraction of causal relations, and into the role of descriptive mechanisms in learning.
Zero-shot audio captioning aims at automatically generating descriptive textual captions for audio content without prior training for this task. Different from speech recognition which translates audio content that contains spoken language into text, audio captioning is commonly concerned with ambient sounds, or sounds produced by a human performing an action. Inspired by zero-shot image captioning methods, we propose ZerAuCap, a novel framework for summarising such general audio signals in a text caption without requiring task-specific training. In particular, our framework exploits a pre-trained large language model (LLM) for generating the text which is guided by a pre-trained audio-language model to produce captions that describe the audio content. Additionally, we use audio context keywords that prompt the language model to generate text that is broadly relevant to sounds. Our proposed framework achieves state-of-the-art results in zero-shot audio captioning on the AudioCaps and Clotho datasets. Our code is available at https://github.com/ExplainableML/ZerAuCap.
Latest developments in Artificial Intelligence (AI) and big data gave rise to Artificial Intelligent agents like Open AI's ChatGPT, which has recently become the fastest growing application since Facebook and WhatsApp. ChatGPT has demonstrated its ability to impact students' classroom learning experience and exam outcomes. However, there is evidence that ChatGPT provides biased and erroneous information, yet students use ChatGPT in academic tasks. Therefore, an accurate understanding of ChatGPT user perception is crucial. This study has analyzed 247 Reddit top posts related to the educational use of ChatGPT from a prominent subreddit called "ChatGPT" for user perception analysis. Descriptive statistics, sentiment analysis using NLP techniques, and LDA topic modeling were used for analysis to gather a contextual understanding of the data. Results show that the majority of the users took a neutral viewpoint. However, there was more positive perception than negative regarding the usefulness of ChatGPT in education.
Animals adjust their behavioral response to sensory input adaptively depending on past experiences. The flexible brain computation is crucial for survival and is of great interest in neuroscience. The nematode C. elegans modulates its navigation behavior depending on the association of odor butanone with food (appetitive training) or starvation (aversive training), and will then climb up the butanone gradient or ignore it, respectively. However, the exact change in navigation strategy in response to learning is still unknown. Here we study the learned odor navigation in worms by combining precise experimental measurement and a novel descriptive model of navigation. Our model consists of two known navigation strategies in worms: biased random walk and weathervaning. We infer weights on these strategies by applying the model to worm navigation trajectories and the exact odor concentration it experiences. Compared to naive worms, appetitive trained worms up-regulate the biased random walk strategy, and aversive trained worms down-regulate the weathervaning strategy. The statistical model provides prediction with $>90 \%$ accuracy of the past training condition given navigation data, which outperforms the classical chemotaxis metric. We find that the behavioral variability is altered by learning, such that worms are less variable after training compared to naive ones. The model further predicts the learning-dependent response and variability under optogenetic perturbation of the olfactory neuron AWC$^\mathrm{ON}$. Lastly, we investigate neural circuits downstream from AWC$^\mathrm{ON}$ that are differentially recruited for learned odor-guided navigation. Together, we provide a new paradigm to quantify flexible navigation algorithms and pinpoint the underlying neural substrates.
Scene graphs have emerged as accurate descriptive priors for image generation and manipulation tasks, however, their complexity and diversity of the shapes and relations of objects in data make it challenging to incorporate them into the models and generate high-quality results. To address these challenges, we propose PRISM, a novel progressive multi-head image manipulation approach to improve the accuracy and quality of the manipulated regions in the scene. Our image manipulation framework is trained using an end-to-end denoising masked reconstruction proxy task, where the masked regions are progressively unmasked from the outer regions to the inner part. We take advantage of the outer part of the masked area as they have a direct correlation with the context of the scene. Moreover, our multi-head architecture simultaneously generates detailed object-specific regions in addition to the entire image to produce higher-quality images. Our model outperforms the state-of-the-art methods in the semantic image manipulation task on the CLEVR and Visual Genome datasets. Our results demonstrate the potential of our approach for enhancing the quality and precision of scene graph-based image manipulation.
We introduce FaithScore (Faithfulness to Atomic Image Facts Score), a reference-free and fine-grained evaluation metric that measures the faithfulness of the generated free-form answers from large vision-language models (LVLMs). The FaithScore evaluation first identifies sub-sentences containing descriptive statements that need to be verified, then extracts a comprehensive list of atomic facts from these sub-sentences, and finally conducts consistency verification between fine-grained atomic facts and the input image. Meta-evaluation demonstrates that our metric highly correlates with human judgments of faithfulness. We collect two benchmark datasets (i.e. LLaVA-1k and MSCOCO-Cap) for evaluating LVLMs instruction-following hallucinations. We measure hallucinations in state-of-the-art LVLMs with FaithScore on the datasets. Results reveal that current systems are prone to generate hallucinated content unfaithful to the image, which leaves room for future improvements. We hope our metric FaithScore can help evaluate future LVLMs in terms of faithfulness and provide insightful advice for enhancing LVLMs' faithfulness.
This work conducts an evaluation of GPT-4V's multimodal capability for medical image analysis, with a focus on three representative tasks of radiology report generation, medical visual question answering, and medical visual grounding. For the evaluation, a set of prompts is designed for each task to induce the corresponding capability of GPT-4V to produce sufficiently good outputs. Three evaluation ways including quantitative analysis, human evaluation, and case study are employed to achieve an in-depth and extensive evaluation. Our evaluation shows that GPT-4V excels in understanding medical images and is able to generate high-quality radiology reports and effectively answer questions about medical images. Meanwhile, it is found that its performance for medical visual grounding needs to be substantially improved. In addition, we observe the discrepancy between the evaluation outcome from quantitative analysis and that from human evaluation. This discrepancy suggests the limitations of conventional metrics in assessing the performance of large language models like GPT-4V and the necessity of developing new metrics for automatic quantitative analysis.
Consider learning a decision support assistant to serve as an intermediary between (oracle) expert behavior and (imperfect) human behavior: At each time, the algorithm observes an action chosen by a fallible agent, and decides whether to *accept* that agent's decision, *intervene* with an alternative, or *request* the expert's opinion. For instance, in clinical diagnosis, fully-autonomous machine behavior is often beyond ethical affordances, thus real-world decision support is often limited to monitoring and forecasting. Instead, such an intermediary would strike a prudent balance between the former (purely prescriptive) and latter (purely descriptive) approaches, while providing an efficient interface between human mistakes and expert feedback. In this work, we first formalize the sequential problem of *online decision mediation* -- that is, of simultaneously learning and evaluating mediator policies from scratch with *abstentive feedback*: In each round, deferring to the oracle obviates the risk of error, but incurs an upfront penalty, and reveals the otherwise hidden expert action as a new training data point. Second, we motivate and propose a solution that seeks to trade off (immediate) loss terms against (future) improvements in generalization error; in doing so, we identify why conventional bandit algorithms may fail. Finally, through experiments and sensitivities on a variety of datasets, we illustrate consistent gains over applicable benchmarks on performance measures with respect to the mediator policy, the learned model, and the decision-making system as a whole.
Decision analysis deals with modeling and enhancing decision processes. A principal challenge in improving behavior is in obtaining a transparent description of existing behavior in the first place. In this paper, we develop an expressive, unifying perspective on inverse decision modeling: a framework for learning parameterized representations of sequential decision behavior. First, we formalize the forward problem (as a normative standard), subsuming common classes of control behavior. Second, we use this to formalize the inverse problem (as a descriptive model), generalizing existing work on imitation/reward learning -- while opening up a much broader class of research problems in behavior representation. Finally, we instantiate this approach with an example (inverse bounded rational control), illustrating how this structure enables learning (interpretable) representations of (bounded) rationality -- while naturally capturing intuitive notions of suboptimal actions, biased beliefs, and imperfect knowledge of environments.
Semantic text similarity plays an important role in software engineering tasks in which engineers are requested to clarify the semantics of descriptive labels (e.g., business terms, table column names) that are often consists of too short or too generic words and appears in their IT systems. We formulate this type of problem as a task of matching descriptive labels to glossary descriptions. We then propose a framework to leverage an existing semantic text similarity measurement (STS) and augment it using semantic label enrichment and set-based collective contextualization where the former is a method to retrieve sentences relevant to a given label and the latter is a method to compute similarity between two contexts each of which is derived from a set of texts (e.g., column names in the same table). We performed an experiment on two datasets derived from publicly available data sources. The result indicated that the proposed methods helped the underlying STS correctly match more descriptive labels with the descriptions.
Energy load forecasting plays a crucial role in optimizing resource allocation and managing energy consumption in buildings and cities. In this paper, we propose a novel approach that leverages language models for energy load forecasting. We employ prompting techniques to convert energy consumption data into descriptive sentences, enabling fine-tuning of language models. By adopting an autoregressive generating approach, our proposed method enables predictions of various horizons of future energy load consumption. Through extensive experiments on real-world datasets, we demonstrate the effectiveness and accuracy of our proposed method. Our results indicate that utilizing language models for energy load forecasting holds promise for enhancing energy efficiency and facilitating intelligent decision-making in energy systems.
Although large language models (LLMs) have apparently acquired a certain level of grammatical knowledge and the ability to make generalizations, they fail to interpret negation, a crucial step in Natural Language Processing. We try to clarify the reasons for the sub-optimal performance of LLMs understanding negation. We introduce a large semi-automatically generated dataset of circa 400,000 descriptive sentences about commonsense knowledge that can be true or false in which negation is present in about 2/3 of the corpus in different forms. We have used our dataset with the largest available open LLMs in a zero-shot approach to grasp their generalization and inference capability and we have also fine-tuned some of the models to assess whether the understanding of negation can be trained. Our findings show that, while LLMs are proficient at classifying affirmative sentences, they struggle with negative sentences and lack a deep understanding of negation, often relying on superficial cues. Although fine-tuning the models on negative sentences improves their performance, the lack of generalization in handling negation is persistent, highlighting the ongoing challenges of LLMs regarding negation understanding and generalization. The dataset and code are publicly available.
Vision-language models (VLMs) classify the query video by calculating a similarity score between the visual features and text-based class label representations. Recently, large language models (LLMs) have been used to enrich the text-based class labels by enhancing the descriptiveness of the class names. However, these improvements are restricted to the text-based classifier only, and the query visual features are not considered. In this paper, we propose a framework which combines pre-trained discriminative VLMs with pre-trained generative video-to-text and text-to-text models. We introduce two key modifications to the standard zero-shot setting. First, we propose language-guided visual feature enhancement and employ a video-to-text model to convert the query video to its descriptive form. The resulting descriptions contain vital visual cues of the query video, such as what objects are present and their spatio-temporal interactions. These descriptive cues provide additional semantic knowledge to VLMs to enhance their zeroshot performance. Second, we propose video-specific prompts to LLMs to generate more meaningful descriptions to enrich class label representations. Specifically, we introduce prompt techniques to create a Tree Hierarchy of Categories for class names, offering a higher-level action context for additional visual cues, We demonstrate the effectiveness of our approach in video understanding across three different zero-shot settings: 1) video action recognition, 2) video-to-text and textto-video retrieval, and 3) time-sensitive video tasks. Consistent improvements across multiple benchmarks and with various VLMs demonstrate the effectiveness of our proposed framework. Our code will be made publicly available.
An improved version of the sparse multiway kernel spectral clustering (KSC) is presented in this brief. The original algorithm is derived from weighted kernel principal component (KPCA) analysis formulated within the primal-dual least-squares support vector machine (LS-SVM) framework. Sparsity is achieved then by the combination of the incomplete Cholesky decomposition (ICD) based low rank approximation of the kernel matrix with the so called reduced set method. The original ICD based sparse KSC algorithm was reported to be computationally far too demanding, especially when applied on large scale data clustering problems that actually it was designed for, which has prevented to gain more than simply theoretical relevance so far. This is altered by the modifications reported in this brief that drastically improve the computational characteristics. Solving the alternative, symmetrized version of the computationally most demanding core eigenvalue problem eliminates the necessity of forming and SVD of large matrices during the model construction. This results in solving clustering problems now within seconds that were reported to require hours without altering the results. Furthermore, sparsity is also improved significantly, leading to more compact model representation, increasing further not only the computational efficiency but also the descriptive power. These transform the original, only theoretically relevant ICD based sparse KSC algorithm applicable for large scale practical clustering problems. Theoretical results and improvements are demonstrated by computational experiments on carefully selected synthetic data as well as on real life problems such as image segmentation.
In this paper, we study multimodal coreference resolution, specifically where a longer descriptive text, i.e., a narration is paired with an image. This poses significant challenges due to fine-grained image-text alignment, inherent ambiguity present in narrative language, and unavailability of large annotated training sets. To tackle these challenges, we present a data efficient semi-supervised approach that utilizes image-narration pairs to resolve coreferences and narrative grounding in a multimodal context. Our approach incorporates losses for both labeled and unlabeled data within a cross-modal framework. Our evaluation shows that the proposed approach outperforms strong baselines both quantitatively and qualitatively, for the tasks of coreference resolution and narrative grounding.
We present a novel system that automatically extracts and generates informative and descriptive sentences from the biomedical corpus and facilitates the efficient search for relational knowledge. Unlike previous search engines or exploration systems that retrieve unconnected passages, our system organizes descriptive sentences as a relational graph, enabling researchers to explore closely related biomedical entities (e.g., diseases treated by a chemical) or indirectly connected entities (e.g., potential drugs for treating a disease). Our system also uses ChatGPT and a fine-tuned relation synthesis model to generate concise and reliable descriptive sentences from retrieved information, reducing the need for extensive human reading effort. With our system, researchers can easily obtain both high-level knowledge and detailed references and interactively steer to the information of interest. We spotlight the application of our system in COVID-19 research, illustrating its utility in areas such as drug repurposing and literature curation.
Radon is a carcinogenic, radioactive gas that can accumulate indoors. Therefore, accurate knowledge of indoor radon concentration is crucial for assessing radon-related health effects or identifying radon-prone areas. Indoor radon concentration at the national scale is usually estimated on the basis of extensive measurement campaigns. However, characteristics of the sample often differ from the characteristics of the population due to the large number of relevant factors that control the indoor radon concentration such as the availability of geogenic radon or floor level. Furthermore, the sample size usually does not allow estimation with high spatial resolution. We propose a model-based approach that allows a more realistic estimation of indoor radon distribution with a higher spatial resolution than a purely data-based approach. A two-stage modelling approach was applied: 1) a quantile regression forest using environmental and building data as predictors was applied to estimate the probability distribution function of indoor radon for each floor level of each residential building in Germany; (2) a probabilistic Monte Carlo sampling technique enabled the combination and population weighting of floor-level predictions. In this way, the uncertainty of the individual predictions is effectively propagated into the estimate of variability at the aggregated level. The results show an approximate lognormal distribution with an arithmetic mean of 63 Bq/m3, a geometric mean of 41 Bq/m3 and a 95 %ile of 180 Bq/m3. The exceedance probability for 100 Bq/m3 and 300 Bq/m3 are 12.5 % (10.5 million people) and 2.2 % (1.9 million people), respectively.
Math word problem (MWP) solving aims to understand the descriptive math problem and calculate the result, for which previous efforts are mostly devoted to upgrade different technical modules. This paper brings a different perspective of \textit{reexamination process} during training by introducing a pseudo-dual task to enhance the MWP solving. We propose a pseudo-dual (PseDual) learning scheme to model such process, which is model-agnostic thus can be adapted to any existing MWP solvers. The pseudo-dual task is specifically defined as filling the numbers in the expression back into the original word problem with numbers masked. To facilitate the effective joint learning of the two tasks, we further design a scheduled fusion strategy for the number infilling task, which smoothly switches the input from the ground-truth math expressions to the predicted ones. Our pseudo-dual learning scheme has been tested and proven effective when being equipped in several representative MWP solvers through empirical studies. \textit{The codes and trained models are available at:} \url{https://github.com/steven640pixel/PsedualMWP}. \end{abstract}