This paper explores the application of prompt engineering to enhance the performance of large language models (LLMs) in the domain of Traditional Chinese Medicine (TCM). We propose TCM-Prompt, a framework that integrates various pre-trained language models (PLMs), templates, tokenization, and verbalization methods, allowing researchers to easily construct and fine-tune models for specific TCM-related tasks. We conducted experiments on disease classification, syndrome identification, herbal medicine recommendation, and general NLP tasks, demonstrating the effectiveness and superiority of our approach compared to baseline methods. Our findings suggest that prompt engineering is a promising technique for improving the performance of LLMs in specialized domains like TCM, with potential applications in digitalization, modernization, and personalized medicine.
Large Language Models (LLMs) are powerful computational models trained on extensive corpora of human-readable text, enabling them to perform general-purpose language understanding and generation. LLMs have garnered significant attention in both industry and academia due to their exceptional performance across various natural language processing (NLP) tasks. Despite these successes, LLMs often produce inaccuracies, commonly referred to as hallucinations. Prompt engineering, the process of designing and formulating instructions for LLMs to perform specific tasks, has emerged as a key approach to mitigating hallucinations. This paper provides a comprehensive empirical evaluation of different prompting strategies and frameworks aimed at reducing hallucinations in LLMs. Various prompting techniques are applied to a broad set of benchmark datasets to assess the accuracy and hallucination rate of each method. Additionally, the paper investigates the influence of tool-calling agents (LLMs augmented with external tools to enhance their capabilities beyond language generation) on hallucination rates in the same benchmarks. The findings demonstrate that the optimal prompting technique depends on the type of problem, and that simpler techniques often outperform more complex methods in reducing hallucinations. Furthermore, it is shown that LLM agents can exhibit significantly higher hallucination rates due to the added complexity of external tool usage.
Designing functional transition metal complexes (TMCs) faces challenges due to the vast search space of metals and ligands, requiring efficient optimization strategies. Traditional genetic algorithms (GAs) are commonly used, employing random mutations and crossovers driven by explicit mathematical objectives to explore this space. Transferring knowledge between different GA tasks, however, is difficult. We integrate large language models (LLMs) into the evolutionary optimization framework (LLM-EO) and apply it in both single- and multi-objective optimization for TMCs. We find that LLM-EO surpasses traditional GAs by leveraging the chemical knowledge of LLMs gained during their extensive pretraining. Remarkably, without supervised fine-tuning, LLMs utilize the full historical data from optimization processes, outperforming those focusing only on top-performing TMCs. LLM-EO successfully identifies eight of the top-20 TMCs with the largest HOMO-LUMO gaps by proposing only 200 candidates out of a 1.37 million TMCs space. Through prompt engineering using natural language, LLM-EO introduces unparalleled flexibility into multi-objective optimizations, thereby circumventing the necessity for intricate mathematical formulations. As generative models, LLMs can suggest new ligands and TMCs with unique properties by merging both internal knowledge and external chemistry data, thus combining the benefits of efficient optimization and molecular generation. With increasing potential of LLMs as pretrained foundational models and new post-training inference strategies, we foresee broad applications of LLM-based evolutionary optimization in chemistry and materials design.
Large language models (LLMs) represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses across diverse contexts and adapting to novel tasks following human instructions. Their potential application spans a broad range of medical tasks, such as clinical documentation, matching patients to clinical trials, and answering medical questions. In this primer paper, we propose an actionable guideline to help healthcare professionals more efficiently utilize LLMs in their work, along with a set of best practices. This approach consists of several main phases, including formulating the task, choosing LLMs, prompt engineering, fine-tuning, and deployment. We start with the discussion of critical considerations in identifying healthcare tasks that align with the core capabilities of LLMs and selecting models based on the selected task and data, performance requirements, and model interface. We then review the strategies, such as prompt engineering and fine-tuning, to adapt standard LLMs to specialized medical tasks. Deployment considerations, including regulatory compliance, ethical guidelines, and continuous monitoring for fairness and bias, are also discussed. By providing a structured step-by-step methodology, this tutorial aims to equip healthcare professionals with the tools necessary to effectively integrate LLMs into clinical practice, ensuring that these powerful technologies are applied in a safe, reliable, and impactful manner.
Mental health issues significantly impact individuals' daily lives, yet many do not receive the help they need even with available online resources. This study aims to provide diverse, accessible, stigma-free, personalized, and real-time mental health support through cutting-edge AI technologies. It makes the following contributions: (1) Conducting an extensive survey of recent mental health support methods to identify prevalent functionalities and unmet needs. (2) Introducing SouLLMate, an adaptive LLM-driven system that integrates LLM technologies, Chain, Retrieval-Augmented Generation (RAG), prompt engineering, and domain knowledge. This system offers advanced features such as Risk Detection and Proactive Guidance Dialogue, and utilizes RAG for personalized profile uploads and Conversational Information Extraction. (3) Developing novel evaluation approaches for preliminary assessments and risk detection via professionally annotated interview data and real-life suicide tendency data. (4) Proposing the Key Indicator Summarization (KIS), Proactive Questioning Strategy (PQS), and Stacked Multi-Model Reasoning (SMMR) methods to enhance model performance and usability through context-sensitive response adjustments, semantic coherence evaluations, and enhanced accuracy of long-context reasoning in language models. This study contributes to advancing mental health support technologies, potentially improving the accessibility and effectiveness of mental health care globally.
Foundation models (FMs) have achieved significant success across various tasks, leading to research on benchmarks for reasoning abilities. However, there is a lack of studies on FMs performance in exceptional scenarios, which we define as out-of-distribution (OOD) reasoning tasks. This paper is the first to address these cases, developing a novel dataset for evaluation of FMs across multiple modalities, including graphic novels, calligraphy, news articles, and lyrics. It includes tasks for instance classification, character recognition, token prediction, and text generation. The paper also proposes prompt engineering techniques like Chain-of-Thought (CoT) and CoT+Few-Shot to enhance performance. Validation of FMs using various methods revealed improvements. The code repository is accessible at: https://github.com/MLAI-Yonsei/ExceptionalBenchmark
This paper introduces a novel mobile phone control architecture, termed ``app agents", for efficient interactions and controls across various Android apps. The proposed Lightweight Multi-modal App Control (LiMAC) takes as input a textual goal and a sequence of past mobile observations, such as screenshots and corresponding UI trees, to generate precise actions. To address the computational constraints inherent to smartphones, within LiMAC, we introduce a small Action Transformer (AcT) integrated with a fine-tuned vision-language model (VLM) for real-time decision-making and task execution. We evaluate LiMAC on two open-source mobile control datasets, demonstrating the superior performance of our small-form-factor approach against fine-tuned versions of open-source VLMs, such as Florence2 and Qwen2-VL. It also significantly outperforms prompt engineering baselines utilising closed-source foundation models like GPT-4o. More specifically, LiMAC increases the overall action accuracy by up to 19% compared to fine-tuned VLMs, and up to 42% compared to prompt-engineering baselines.
There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt engineering, RAG, and zero-shot or few-shot prediction, remain challenging for DNA-based models. The key issue lies in the fact that DNA models and human natural language models are entirely separate; however, techniques like prompt engineering require the use of natural language, thereby significantly limiting the application of DNA large language models. This paper introduces a pre-trained model trained on the GPT-2 network, combining DNA sequences and English text, and uses a unified BPE tokenization method. We then convert classification and other downstream tasks into Alpaca format instruction data, and perform instruction fine-tuning on this pre-trained model to create a fine-tuned model capable of handling multiple tasks. The model has demonstrated its effectiveness in DNA related zero-shot prediction and multitask application. This research provides a highly promising direction for building a unified DNA sequence task framework.
This study addresses the gap in the literature concerning the comparative performance of LLMs in interpreting different types of figurative language across multiple languages. By evaluating LLMs using two multilingual datasets on simile and idiom interpretation, we explore the effectiveness of various prompt engineering strategies, including chain-of-thought, few-shot, and English translation prompts. We extend the language of these datasets to Persian as well by building two new evaluation sets. Our comprehensive assessment involves both closed-source (GPT-3.5, GPT-4o mini, Gemini 1.5), and open-source models (Llama 3.1, Qwen2), highlighting significant differences in performance across languages and figurative types. Our findings reveal that while prompt engineering methods are generally effective, their success varies by figurative type, language, and model. We also observe that open-source models struggle particularly with low-resource languages in similes. Additionally, idiom interpretation is nearing saturation for many languages, necessitating more challenging evaluations.
Involving subject matter experts in prompt engineering can guide LLM outputs toward more helpful, accurate, and tailored content that meets the diverse needs of different domains. However, iterating towards effective prompts can be challenging without adequate interface support for systematic experimentation within specific task contexts. In this work, we introduce PromptHive, a collaborative interface for prompt authoring, designed to better connect domain knowledge with prompt engineering through features that encourage rapid iteration on prompt variations. We conducted an evaluation study with ten subject matter experts in math and validated our design through two collaborative prompt-writing sessions and a learning gain study with 358 learners. Our results elucidate the prompt iteration process and validate the tool's usability, enabling non-AI experts to craft prompts that generate content comparable to human-authored materials while reducing perceived cognitive load by half and shortening the authoring process from several months to just a few hours.
The increasing demand for spatiotemporal data and modeling tasks in geosciences has made geospatial code generation technology a critical factor in enhancing productivity. Although large language models (LLMs) have demonstrated potential in code generation tasks, they often encounter issues such as refusal to code or hallucination in geospatial code generation due to a lack of domain-specific knowledge and code corpora. To address these challenges, this paper presents and open-sources the GeoCode-PT and GeoCode-SFT corpora, along with the GeoCode-Eval evaluation dataset. Additionally, by leveraging QLoRA and LoRA for pretraining and fine-tuning, we introduce GeoCode-GPT-7B, the first LLM focused on geospatial code generation, fine-tuned from Code Llama-7B. Furthermore, we establish a comprehensive geospatial code evaluation framework, incorporating option matching, expert validation, and prompt engineering scoring for LLMs, and systematically evaluate GeoCode-GPT-7B using the GeoCode-Eval dataset. Experimental results show that GeoCode-GPT outperforms other models in multiple-choice accuracy by 9.1% to 32.1%, in code summarization ability by 1.7% to 25.4%, and in code generation capability by 1.2% to 25.1%. This paper provides a solution and empirical validation for enhancing LLMs' performance in geospatial code generation, extends the boundaries of domain-specific model applications, and offers valuable insights into unlocking their potential in geospatial code generation.
In recent years, interest in vision-language tasks has grown, especially those involving chart interactions. These tasks are inherently multimodal, requiring models to process chart images, accompanying text, underlying data tables, and often user queries. Traditionally, Chart Understanding (CU) relied on heuristics and rule-based systems. However, recent advancements that have integrated transformer architectures significantly improved performance. This paper reviews prominent research in CU, focusing on State-of-The-Art (SoTA) frameworks that employ transformers within End-to-End (E2E) solutions. Relevant benchmarking datasets and evaluation techniques are analyzed. Additionally, this article identifies key challenges and outlines promising future directions for advancing CU solutions. Following the PRISMA guidelines, a comprehensive literature search is conducted across Google Scholar, focusing on publications from Jan'20 to Jun'24. After rigorous screening and quality assessment, 32 studies are selected for in-depth analysis. The CU tasks are categorized into a three-layered paradigm based on the cognitive task required. Recent advancements in the frameworks addressing various CU tasks are also reviewed. Frameworks are categorized into single-task or multi-task based on the number of tasks solvable by the E2E solution. Within multi-task frameworks, pre-trained and prompt-engineering-based techniques are explored. This review overviews leading architectures, datasets, and pre-training tasks. Despite significant progress, challenges remain in OCR dependency, handling low-resolution images, and enhancing visual reasoning. Future directions include addressing these challenges, developing robust benchmarks, and optimizing model efficiency. Additionally, integrating explainable AI techniques and exploring the balance between real and synthetic data are crucial for advancing CU research.
Recent breakthroughs in artificial intelligence have driven a paradigm shift, where large language models (LLMs) with billions or trillions of parameters are trained on vast datasets, achieving unprecedented success across a series of language tasks. However, despite these successes, LLMs still rely on probabilistic modeling, which often captures spurious correlations rooted in linguistic patterns and social stereotypes, rather than the true causal relationships between entities and events. This limitation renders LLMs vulnerable to issues such as demographic biases, social stereotypes, and LLM hallucinations. These challenges highlight the urgent need to integrate causality into LLMs, moving beyond correlation-driven paradigms to build more reliable and ethically aligned AI systems. While many existing surveys and studies focus on utilizing prompt engineering to activate LLMs for causal knowledge or developing benchmarks to assess their causal reasoning abilities, most of these efforts rely on human intervention to activate pre-trained models. How to embed causality into the training process of LLMs and build more general and intelligent models remains unexplored. Recent research highlights that LLMs function as causal parrots, capable of reciting causal knowledge without truly understanding or applying it. These prompt-based methods are still limited to human interventional improvements. This survey aims to address this gap by exploring how causality can enhance LLMs at every stage of their lifecycle-from token embedding learning and foundation model training to fine-tuning, alignment, inference, and evaluation-paving the way for more interpretable, reliable, and causally-informed models. Additionally, we further outline six promising future directions to advance LLM development, enhance their causal reasoning capabilities, and address the current limitations these models face.
Accurate short-term forecasts of passenger flow in metro systems under delay conditions are crucial for emergency response and service recovery, which pose significant challenges and are currently under-researched. Due to the rare occurrence of delay events, the limited sample size under delay condictions make it difficult for conventional models to effectively capture the complex impacts of delays on passenger flow, resulting in low forecasting accuracy. Recognizing the strengths of large language models (LLMs) in few-shot learning due to their powerful pre-training, contextual understanding, ability to perform zero-shot and few-shot reasoning, to address the issues that effectively generalize and adapt with minimal data, we propose a passenger flow forecasting framework under delay conditions that synthesizes an LLM with carefully designed prompt engineering. By Refining prompt design, we enable the LLM to understand delay event information and the pattern from historical passenger flow data, thus overcoming the challenges of passenger flow forecasting under delay conditions. The propmpt engineering in the framework consists of two main stages: systematic prompt generation and prompt refinement. In the prompt generation stage, multi-source data is transformed into descriptive texts understandable by the LLM and stored. In the prompt refinement stage, we employ the multidimensional Chain of Thought (CoT) method to refine the prompts. We verify the proposed framework by conducting experiments using real-world datasets specifically targeting passenger flow forecasting under delay conditions of Shenzhen metro in China. The experimental results demonstrate that the proposed model performs particularly well in forecasting passenger flow under delay conditions.
With the recent surge in popularity of Large Language Models (LLMs), there is the rising risk of users blindly trusting the information in the response, even in cases where the LLM recommends actions that have potential legal implications and this may put the user in danger. We provide an empirical analysis on multiple existing LLMs showing the urgency of the problem. Hence, we propose a short-term solution consisting in an approach for isolating these legal issues through prompt re-engineering. We further analyse the outcomes but also the limitations of the prompt engineering based approach and we highlight the need of additional resources for fully solving the problem We also propose a framework powered by a legal knowledge graph (KG) to generate legal citations for these legal issues, enriching the response of the LLM.
Text documents with numerical values involved are widely used in various applications such as scientific research, economy, public health and journalism. However, it is difficult for readers to quickly interpret such data-involved texts and gain deep insights. To fill this research gap, this work aims to automatically generate charts to accurately convey the underlying data and ideas to readers, which is essentially a challenging task. The challenges originate from text ambiguities, intrinsic sparsity and uncertainty of data in text documents, and subjective sentiment differences. Specifically, we propose ChartifyText, a novel fully-automated approach that leverages Large Language Models (LLMs) to convert complex data-involved texts to expressive charts. It consists of two major modules: tabular data inference and expressive chart generation. The tabular data inference module employs systematic prompt engineering to guide the LLM (e.g., GPT-4) to infer table data, where data ranges, uncertainties, missing data values and corresponding subjective sentiments are explicitly considered. The expressive chart generation module augments standard charts with intuitive visual encodings and concise texts to accurately convey the underlying data and insights. We extensively evaluate the effectiveness of ChartifyText on real-world data-involved text documents through case studies, in-depth interviews with three visualization experts, and a carefully-designed user study with 15 participants. The results demonstrate the usefulness and effectiveness of ChartifyText in helping readers efficiently and effectively make sense of data-involved texts.
Voice Activity Detection (VAD) is the process of automatically determining whether a person is speaking and identifying the timing of their speech in an audiovisual data. Traditionally, this task has been tackled by processing either audio signals or visual data, or by combining both modalities through fusion or joint learning. In our study, drawing inspiration from recent advancements in visual-language models, we introduce a novel approach leveraging Contrastive Language-Image Pretraining (CLIP) models. The CLIP visual encoder analyzes video segments composed of the upper body of an individual, while the text encoder handles textual descriptions automatically generated through prompt engineering. Subsequently, embeddings from these encoders are fused through a deep neural network to perform VAD. Our experimental analysis across three VAD benchmarks showcases the superior performance of our method compared to existing visual VAD approaches. Notably, our approach outperforms several audio-visual methods despite its simplicity, and without requiring pre-training on extensive audio-visual datasets.
This paper describes a new spatial correspondence representation based on paired regions-of-interest (ROIs), for medical image registration. The distinct properties of the proposed ROI-based correspondence are discussed, in the context of potential benefits in clinical applications following image registration, compared with alternative correspondence-representing approaches, such as those based on sampled displacements and spatial transformation functions. These benefits include a clear connection between learning-based image registration and segmentation, which in turn motivates two cases of image registration approaches using (pre-)trained segmentation networks. Based on the segment anything model (SAM), a vision foundation model for segmentation, we develop a new registration algorithm SAMReg, which does not require any training (or training data), gradient-based fine-tuning or prompt engineering. The proposed SAMReg models are evaluated across five real-world applications, including intra-subject registration tasks with cardiac MR and lung CT, challenging inter-subject registration scenarios with prostate MR and retinal imaging, and an additional evaluation with a non-clinical example with aerial image registration. The proposed methods outperform both intensity-based iterative algorithms and DDF-predicting learning-based networks across tested metrics including Dice and target registration errors on anatomical structures, and further demonstrates competitive performance compared to weakly-supervised registration approaches that rely on fully-segmented training data. Open source code and examples are available at: https://github.com/sqhuang0103/SAMReg.git.
We introduce Controller-Embedded Language Model Interactions (CELI), a framework that integrates control logic directly within language model (LM) prompts, facilitating complex, multi-stage task execution. CELI addresses limitations of existing prompt engineering and workflow optimization techniques by embedding control logic directly within the operational context of language models, enabling dynamic adaptation to evolving task requirements. Our framework transfers control from the traditional programming execution environment to the LMs, allowing them to autonomously manage computational workflows while maintaining seamless interaction with external systems and functions. CELI supports arbitrary function calls with variable arguments, bridging the gap between LMs' adaptive reasoning capabilities and conventional software paradigms' structured control mechanisms. To evaluate CELI's versatility and effectiveness, we conducted case studies in two distinct domains: code generation (HumanEval benchmark) and multi-stage content generation (Wikipedia-style articles). The results demonstrate notable performance improvements across a range of domains. CELI achieved a 4.9 percentage point improvement over the best reported score of the baseline GPT-4 model on the HumanEval code generation benchmark. In multi-stage content generation, 94.4% of CELI-produced Wikipedia-style articles met or exceeded first draft quality when optimally configured, with 44.4% achieving high quality. These outcomes underscore CELI's potential for optimizing AI-driven workflows across diverse computational domains.
Instruction-following is crucial for building AI agents with large language models (LLMs), as these models must adhere strictly to user-provided constraints and guidelines. However, LLMs often fail to follow even simple and clear instructions. To improve instruction-following behavior and prevent undesirable outputs, a deeper understanding of how LLMs' internal states relate to these outcomes is required. In this work, we investigate whether LLMs encode information in their representations that correlate with instruction-following success - a property we term knowing internally. Our analysis identifies a direction in the input embedding space, termed the instruction-following dimension, that predicts whether a response will comply with a given instruction. We find that this dimension generalizes well across unseen tasks but not across unseen instruction types. We demonstrate that modifying representations along this dimension improves instruction-following success rates compared to random changes, without compromising response quality. Further investigation reveals that this dimension is more closely related to the phrasing of prompts rather than the inherent difficulty of the task or instructions. This work provides insight into the internal workings of LLMs' instruction-following, paving the way for reliable LLM agents.