Accurate preoperative assessment of lymph node (LN) metastasis in rectal cancer guides treatment decisions, yet conventional MRI evaluation based on morphological criteria shows limited diagnostic performance. While some artificial intelligence models have been developed, they often operate as black boxes, lacking the interpretability needed for clinical trust. Moreover, these models typically evaluate nodes in isolation, overlooking the patient-level context. To address these limitations, we introduce LRMR, an LLM-Driven Relational Multi-node Ranking framework. This approach reframes the diagnostic task from a direct classification problem into a structured reasoning and ranking process. The LRMR framework operates in two stages. First, a multimodal large language model (LLM) analyzes a composite montage image of all LNs from a patient, generating a structured report that details ten distinct radiological features. Second, a text-based LLM performs pairwise comparisons of these reports between different patients, establishing a relative risk ranking based on the severity and number of adverse features. We evaluated our method on a retrospective cohort of 117 rectal cancer patients. LRMR achieved an area under the curve (AUC) of 0.7917 and an F1-score of 0.7200, outperforming a range of deep learning baselines, including ResNet50 (AUC 0.7708). Ablation studies confirmed the value of our two main contributions: removing the relational ranking stage or the structured prompting stage led to a significant performance drop, with AUCs falling to 0.6875 and 0.6458, respectively. Our work demonstrates that decoupling visual perception from cognitive reasoning through a two-stage LLM framework offers a powerful, interpretable, and effective new paradigm for assessing lymph node metastasis in rectal cancer.
The large language model (LLM) community focuses almost exclusively on decoder-only language models, since they are easier to use for text generation. However, a large subset of the community still uses encoder-only models for tasks such as classification or retrieval. Previous work has attempted to compare these architectures, but is forced to make comparisons with models that have different numbers of parameters, training techniques, and datasets. We introduce the SOTA open-data Ettin suite of models: paired encoder-only and decoder-only models ranging from 17 million parameters to 1 billion, trained on up to 2 trillion tokens. Using the same recipe for both encoder-only and decoder-only models produces SOTA recipes in both categories for their respective sizes, beating ModernBERT as an encoder and Llama 3.2 and SmolLM2 as decoders. Like previous work, we find that encoder-only models excel at classification and retrieval tasks while decoders excel at generative tasks. However, we show that adapting a decoder model to encoder tasks (and vice versa) through continued training is subpar compared to using only the reverse objective (i.e. a 400M encoder outperforms a 1B decoder on MNLI, and vice versa for generative tasks). We open-source all artifacts of this study including training data, training order segmented by checkpoint, and 200+ checkpoints to allow future work to analyze or extend all aspects of training.
Smoke is the first visible indicator of a wildfire.With the advancement of deep learning, image-based smoke detection has become a crucial method for detecting and preventing forest fires. However, the scarcity of smoke image data from forest fires is one of the significant factors hindering the detection of forest fire smoke. Image generation models offer a promising solution for synthesizing realistic smoke images. However, current inpainting models exhibit limitations in generating high-quality smoke representations, particularly manifesting as inconsistencies between synthesized smoke and background contexts. To solve these problems, we proposed a comprehensive framework for generating forest fire smoke images. Firstly, we employed the pre-trained segmentation model and the multimodal model to obtain smoke masks and image captions.Then, to address the insufficient utilization of masks and masked images by inpainting models, we introduced a network architecture guided by mask and masked image features. We also proposed a new loss function, the mask random difference loss, which enhances the consistency of the generated effects around the mask by randomly expanding and eroding the mask edges.Finally, to generate a smoke image dataset using random masks for subsequent detection tasks, we incorporated smoke characteristics and use a multimodal large language model as a filtering tool to select diverse and reasonable smoke images, thereby improving the quality of the synthetic dataset. Experiments showed that our generated smoke images are realistic and diverse, and effectively enhance the performance of forest fire smoke detection models. Code is available at https://github.com/wghr123/MFGDiffusion.
The emergence of Multimodal Large Language Models (MLLMs) has revolutionized image understanding by bridging textual and visual modalities. However, these models often struggle with capturing fine-grained semantic information, such as the precise identification and analysis of object keypoints. Keypoints, as structure-aware, pixel-level, and compact representations of objects, particularly articulated ones, play a crucial role in applications such as fine-grained image analysis, object retrieval, and behavior recognition. In this paper, we propose KptLLM++, a novel multimodal large language model that specifically designed for generic keypoint comprehension through the integration of diverse input modalities guided by user-defined instructions. By unifying keypoint detection across varied contexts, KptLLM++ establishes itself as an advanced interface, fostering more effective human-AI collaboration. The model is built upon a novel identify-then-detect paradigm, which first interprets keypoint semantics and subsequently localizes their precise positions through a structured chain-of-thought reasoning mechanism. To push the boundaries of performance, we have scaled up the training dataset to over 500K samples, encompassing diverse objects, keypoint categories, image styles, and scenarios with complex occlusions. This extensive scaling enables KptLLM++ to unlock its potential, achieving remarkable accuracy and generalization. Comprehensive experiments on multiple keypoint detection benchmarks demonstrate its state-of-the-art performance, underscoring its potential as a unified solution for fine-grained image understanding and its transformative implications for human-AI interaction.
In multiple unmanned ground vehicle confrontations, autonomously evolving multi-agent tactical decisions from situational awareness remain a significant challenge. Traditional handcraft rule-based methods become vulnerable in the complicated and transient battlefield environment, and current reinforcement learning methods mainly focus on action manipulation instead of strategic decisions due to lack of interpretability. Here, we propose a vision-language model-based commander to address the issue of intelligent perception-to-decision reasoning in autonomous confrontations. Our method integrates a vision language model for scene understanding and a lightweight large language model for strategic reasoning, achieving unified perception and decision within a shared semantic space, with strong adaptability and interpretability. Unlike rule-based search and reinforcement learning methods, the combination of the two modules establishes a full-chain process, reflecting the cognitive process of human commanders. Simulation and ablation experiments validate that the proposed approach achieves a win rate of over 80% compared with baseline models.
Human pose estimation traditionally relies on architectures that encode keypoint priors, limiting their generalization to novel poses or unseen keypoints. Recent language-guided approaches like LocLLM reformulate keypoint localization as a vision-language task, enabling zero-shot generalization through textual descriptions. However, LocLLM's linear projector fails to capture complex spatial-textual interactions critical for high-precision localization. To address this, we propose PoseLLM, the first Large Language Model (LLM)-based pose estimation framework that replaces the linear projector with a nonlinear MLP vision-language connector. This lightweight two-layer MLP with GELU activation enables hierarchical cross-modal feature transformation, enhancing the fusion of visual patches and textual keypoint descriptions. Trained exclusively on COCO data, PoseLLM achieves 77.8 AP on the COCO validation set, outperforming LocLLM by +0.4 AP, while maintaining strong zero-shot generalization on Human-Art and MPII. Our work demonstrates that a simple yet powerful nonlinear connector significantly boosts localization accuracy without sacrificing generalization, advancing the state-of-the-art in language-guided pose estimation. Code is available at https://github.com/Ody-trek/PoseLLM.
The rapid adoption of Large Language Model (LLM) agents and multi-agent systems enables unprecedented capabilities in natural language processing and generation. However, these systems have introduced unprecedented security vulnerabilities that extend beyond traditional prompt injection attacks. This paper presents the first comprehensive evaluation of LLM agents as attack vectors capable of achieving complete computer takeover through the exploitation of trust boundaries within agentic AI systems where autonomous entities interact and influence each other. We demonstrate that adversaries can leverage three distinct attack surfaces - direct prompt injection, RAG backdoor attacks, and inter-agent trust exploitation - to coerce popular LLMs (including GPT-4o, Claude-4 and Gemini-2.5) into autonomously installing and executing malware on victim machines. Our evaluation of 17 state-of-the-art LLMs reveals an alarming vulnerability hierarchy: while 41.2% of models succumb to direct prompt injection, 52.9% are vulnerable to RAG backdoor attacks, and a critical 82.4% can be compromised through inter-agent trust exploitation. Notably, we discovered that LLMs which successfully resist direct malicious commands will execute identical payloads when requested by peer agents, revealing a fundamental flaw in current multi-agent security models. Our findings demonstrate that only 5.9% of tested models (1/17) proved resistant to all attack vectors, with the majority exhibiting context-dependent security behaviors that create exploitable blind spots. Our findings also highlight the need to increase awareness and research on the security risks of LLMs, showing a paradigm shift in cybersecurity threats, where AI tools themselves become sophisticated attack vectors.
Scientific databases aggregate vast amounts of quantitative data alongside descriptive text. In biochemistry, molecule screening assays evaluate the functional responses of candidate molecules against disease targets. Unstructured text that describes the biological mechanisms through which these targets operate, experimental screening protocols, and other attributes of assays offer rich information for new drug discovery campaigns but has been untapped because of that unstructured format. We present Assay2Mol, a large language model-based workflow that can capitalize on the vast existing biochemical screening assays for early-stage drug discovery. Assay2Mol retrieves existing assay records involving targets similar to the new target and generates candidate molecules using in-context learning with the retrieved assay screening data. Assay2Mol outperforms recent machine learning approaches that generate candidate ligand molecules for target protein structures, while also promoting more synthesizable molecule generation.
Open-vocabulary 3D visual grounding aims to localize target objects based on free-form language queries, which is crucial for embodied AI applications such as autonomous navigation, robotics, and augmented reality. Learning 3D language fields through neural representations enables accurate understanding of 3D scenes from limited viewpoints and facilitates the localization of target objects in complex environments. However, existing language field methods struggle to accurately localize instances using spatial relations in language queries, such as ``the book on the chair.'' This limitation mainly arises from inadequate reasoning about spatial relations in both language queries and 3D scenes. In this work, we propose SpatialReasoner, a novel neural representation-based framework with large language model (LLM)-driven spatial reasoning that constructs a visual properties-enhanced hierarchical feature field for open-vocabulary 3D visual grounding. To enable spatial reasoning in language queries, SpatialReasoner fine-tunes an LLM to capture spatial relations and explicitly infer instructions for the target, anchor, and spatial relation. To enable spatial reasoning in 3D scenes, SpatialReasoner incorporates visual properties (opacity and color) to construct a hierarchical feature field. This field represents language and instance features using distilled CLIP features and masks extracted via the Segment Anything Model (SAM). The field is then queried using the inferred instructions in a hierarchical manner to localize the target 3D instance based on the spatial relation in the language query. Extensive experiments show that our framework can be seamlessly integrated into different neural representations, outperforming baseline models in 3D visual grounding while empowering their spatial reasoning capability.
Photo retouching has become integral to contemporary visual storytelling, enabling users to capture aesthetics and express creativity. While professional tools such as Adobe Lightroom offer powerful capabilities, they demand substantial expertise and manual effort. In contrast, existing AI-based solutions provide automation but often suffer from limited adjustability and poor generalization, failing to meet diverse and personalized editing needs. To bridge this gap, we introduce JarvisArt, a multi-modal large language model (MLLM)-driven agent that understands user intent, mimics the reasoning process of professional artists, and intelligently coordinates over 200 retouching tools within Lightroom. JarvisArt undergoes a two-stage training process: an initial Chain-of-Thought supervised fine-tuning to establish basic reasoning and tool-use skills, followed by Group Relative Policy Optimization for Retouching (GRPO-R) to further enhance its decision-making and tool proficiency. We also propose the Agent-to-Lightroom Protocol to facilitate seamless integration with Lightroom. To evaluate performance, we develop MMArt-Bench, a novel benchmark constructed from real-world user edits. JarvisArt demonstrates user-friendly interaction, superior generalization, and fine-grained control over both global and local adjustments, paving a new avenue for intelligent photo retouching. Notably, it outperforms GPT-4o with a 60% improvement in average pixel-level metrics on MMArt-Bench for content fidelity, while maintaining comparable instruction-following capabilities. Project Page: https://jarvisart.vercel.app/.
Large language model (LLM) personalization aims to align model outputs with individuals' unique preferences and opinions. While recent efforts have implemented various personalization methods, a unified theoretical framework that can systematically understand the drivers of effective personalization is still lacking. In this work, we integrate the well-established cognitive dual-memory model into LLM personalization, by mirroring episodic memory to historical user engagements and semantic memory to long-term, evolving user beliefs. Specifically, we systematically investigate memory instantiations and introduce a unified framework, PRIME, using episodic and semantic memory mechanisms. We further augment PRIME with a novel personalized thinking capability inspired by the slow thinking strategy. Moreover, recognizing the absence of suitable benchmarks, we introduce a dataset using Change My View (CMV) from Reddit, specifically designed to evaluate long-context personalization. Extensive experiments validate PRIME's effectiveness across both long- and short-context scenarios. Further analysis confirms that PRIME effectively captures dynamic personalization beyond mere popularity biases.
Can a pretrained neural network adapt its architecture to different inputs without any finetuning? Do we need all layers for simple tasks, and are they adequate for challenging tasks? We found that the layers of a pretrained large language model (LLM) can be manipulated as separate modules to build a better and even shallower model customized for each test sample. In particular, each layer from the pretrained model can be skipped/pruned or repeated multiple times as recurrent neural networks (RNN), and stacked with others in arbitrary orders, yielding a chain-of-layers (CoLa) per sample. This compositional space greatly expands the scope of existing works on looped/recurrent pretrained modules, layer pruning, or early-exit networks. We develop a Monte Carlo Tree Search (MCTS) protocol to explore and identify the optimal CoLa for each sample from math and commonsense reasoning benchmarks. Compared to a static model of a fixed depth, CoLa allows shortcut paths (fast thinking), recurrence of the same layer(s) (slow thinking), and combining both, offering more flexible, dynamic architectures for different inputs. We conduct an extensive analysis of the MCTS-optimized CoLa, which leads to two key findings: (1) For >75% of samples with correct predictions by the original LLM, we can find shorter CoLa, suggesting a large space for improving inference efficiency; (2) For >60% of samples with originally incorrect predictions, we can identify CoLa achieving correct predictions, suggesting a large space of performance enhancement. Our results highlight the shortcomings of using a fixed architecture of pre-trained LLMs for inference on different samples and pave the way to unlock the generalization power of test-time depth adaptation.
Large Language Model (LLM) agents are commonly tuned with supervised finetuning on ReAct-style expert trajectories or preference optimization over pairwise rollouts. Most of these methods focus on imitating specific expert behaviors or promoting chosen reasoning thoughts and actions over rejected ones. However, without reasoning and comparing over alternatives actions, LLM agents finetuned with these methods may over-commit towards seemingly plausible but suboptimal actions due to limited action space exploration. To address this, in this paper we propose Self-taught ActioN Deliberation (SAND) framework, enabling LLM agents to explicitly deliberate over candidate actions before committing to one. To tackle the challenges of when and what to deliberate given large action space and step-level action evaluation, we incorporate self-consistency action sampling and execution-guided action critique to help synthesize step-wise action deliberation thoughts using the base model of the LLM agent. In an iterative manner, the deliberation trajectories are then used to finetune the LLM agent itself. Evaluating on two representative interactive agent tasks, SAND achieves an average 20% improvement over initial supervised finetuning and also outperforms state-of-the-art agent tuning approaches.
Reinforcement Learning (RL) has demonstrated its potential to improve the reasoning ability of Large Language Models (LLMs). One major limitation of most existing Reinforcement Finetuning (RFT) methods is that they are on-policy RL in nature, i.e., data generated during the past learning process is not fully utilized. This inevitably comes at a significant cost of compute and time, posing a stringent bottleneck on continuing economic and efficient scaling. To this end, we launch the renaissance of off-policy RL and propose Reincarnating Mix-policy Proximal Policy Gradient (ReMix), a general approach to enable on-policy RFT methods like PPO and GRPO to leverage off-policy data. ReMix consists of three major components: (1) Mix-policy proximal policy gradient with an increased Update-To-Data (UTD) ratio for efficient training; (2) KL-Convex policy constraint to balance the trade-off between stability and flexibility; (3) Policy reincarnation to achieve a seamless transition from efficient early-stage learning to steady asymptotic improvement. In our experiments, we train a series of ReMix models upon PPO, GRPO and 1.5B, 7B base models. ReMix shows an average Pass@1 accuracy of 52.10% (for 1.5B model) with 0.079M response rollouts, 350 training steps and achieves 63.27%/64.39% (for 7B model) with 0.007M/0.011M response rollouts, 50/75 training steps, on five math reasoning benchmarks (i.e., AIME'24, AMC'23, Minerva, OlympiadBench, and MATH500). Compared with 15 recent advanced models, ReMix shows SOTA-level performance with an over 30x to 450x reduction in training cost in terms of rollout data volume. In addition, we reveal insightful findings via multifaceted analysis, including the implicit preference for shorter responses due to the Whipping Effect of off-policy discrepancy, the collapse mode of self-reflection behavior under the presence of severe off-policyness, etc.
Recent benchmarks for Large Language Model (LLM) agents primarily focus on evaluating reasoning, planning, and execution capabilities, while another critical component-memory, encompassing how agents memorize, update, and retrieve long-term information-is under-evaluated due to the lack of benchmarks. We term agents with memory mechanisms as memory agents. In this paper, we identify four core competencies essential for memory agents: accurate retrieval, test-time learning, long-range understanding, and conflict resolution. Existing datasets either rely on limited context lengths or are tailored for static, long-context settings like book-based QA, which do not reflect the interactive, multi-turn nature of memory agents that incrementally accumulate information. Furthermore, no existing benchmarks cover all four competencies. Therefore, we introduce MemoryAgentBench, a new benchmark specifically designed for memory agents. Our benchmark combines reformulated existing datasets with newly constructed ones, covering the above four memory competencies, providing a systematic and challenging testbed for assessing memory quality. We evaluate a diverse set of memory agents, ranging from simple context-based and retrieval-augmented generation (RAG) systems to advanced agents with external memory modules and tool integration. Empirical results reveal that current methods fall short of mastering all four competencies, underscoring the need for further research into comprehensive memory mechanisms for LLM agents.
Document level Machine Translation (DocMT) approaches often struggle with effectively capturing discourse level phenomena. Existing approaches rely on heuristic rules to segment documents into discourse units, which rarely align with the true discourse structure required for accurate translation. Otherwise, they fail to maintain consistency throughout the document during translation. To address these challenges, we propose Graph Augmented Agentic Framework for Document Level Translation (GRAFT), a novel graph based DocMT system that leverages Large Language Model (LLM) agents for document translation. Our approach integrates segmentation, directed acyclic graph (DAG) based dependency modelling, and discourse aware translation into a cohesive framework. Experiments conducted across eight translation directions and six diverse domains demonstrate that GRAFT achieves significant performance gains over state of the art DocMT systems. Specifically, GRAFT delivers an average improvement of 2.8 d BLEU on the TED test sets from IWSLT2017 over strong baselines and 2.3 d BLEU for domain specific translation from English to Chinese. Moreover, our analyses highlight the consistent ability of GRAFT to address discourse level phenomena, yielding coherent and contextually accurate translations.
Open-domain table question answering traditionally relies on a two-stage pipeline: static table retrieval followed by a closed-domain answer. In contrast, we propose an end-to-end agentic framework that embeds multi-turn tool calls-using a BM25+-based search API and a SQLite SQL executor-directly into a large language model. To further adapt a compact 4B-parameter model, we introduce a two-stage fine-tuning process: supervised cold-start on easy questions, then Async GRPO reinforcement learning on harder cases with LoRA adapters and a rollout buffer. This unified approach enables the model to jointly retrieve, reason, and execute queries, yielding a dramatic accuracy improvement from single-digit zero-shot performance to over 0.86 exact match on a held-out test set. Our results underscore the effectiveness of integrating structured tool calls with targeted RL fine-tuning for scalable, accurate table QA. The code is available at https://github.com/TabibitoQZP/OpenTableR1.
Large language models (LLMs) have exhibited remarkable capabilities across diverse open-domain tasks, yet their application in specialized domains such as civil engineering remains largely unexplored. This paper starts bridging this gap by evaluating and enhancing the reliability and robustness of LLMs in structural analysis of beams. Reliability is assessed through the accuracy of correct outputs under repetitive runs of the same problems, whereas robustness is evaluated via the performance across varying load and boundary conditions. A benchmark dataset, comprising eight beam analysis problems, is created to test the Llama-3.3 70B Instruct model. Results show that, despite a qualitative understanding of structural mechanics, the LLM lacks the quantitative reliability and robustness for engineering applications. To address these limitations, a shift is proposed that reframes the structural analysis as code generation tasks. Accordingly, an LLM-empowered agent is developed that (a) integrates chain-of-thought and few-shot prompting to generate accurate OpeeSeesPy code, and (b) automatically executes the code to produce structural analysis results. Experimental results demonstrate that the agent achieves accuracy exceeding 99.0% on the benchmark dataset, exhibiting reliable and robust performance across diverse conditions. Ablation studies highlight the complete example and function usage examples as the primary contributors to the agent's enhanced performance.
We present a modular framework powered by large language models (LLMs) that automates and streamlines key tasks across the early-stage computational drug discovery pipeline. By combining LLM reasoning with domain-specific tools, the framework performs biomedical data retrieval, domain-specific question answering, molecular generation, property prediction, property-aware molecular refinement, and 3D protein-ligand structure generation. In a case study targeting BCL-2 in lymphocytic leukemia, the agent autonomously retrieved relevant biomolecular information-including FASTA sequences, SMILES representations, and literature-and answered mechanistic questions with improved contextual accuracy over standard LLMs. It then generated chemically diverse seed molecules and predicted 67 ADMET-related properties, which guided iterative molecular refinement. Across two refinement rounds, the number of molecules with QED > 0.6 increased from 34 to 55, and those passing at least four out of five empirical drug-likeness rules rose from 29 to 52, within a pool of 194 molecules. The framework also employed Boltz-2 to generate 3D protein-ligand complexes and provide rapid binding affinity estimates for candidate compounds. These results demonstrate that the approach effectively supports molecular screening, prioritization, and structure evaluation. Its modular design enables flexible integration of evolving tools and models, providing a scalable foundation for AI-assisted therapeutic discovery.
Service robots are increasingly deployed in diverse and dynamic environments, where both physical layouts and social contexts change over time and across locations. In these unstructured settings, conventional navigation systems that rely on fixed parameters often fail to generalize across scenarios, resulting in degraded performance and reduced social acceptance. Although recent approaches have leveraged reinforcement learning to enhance traditional planners, these methods often fail in real-world deployments due to poor generalization and limited simulation diversity, which hampers effective sim-to-real transfer. To tackle these issues, we present LE-Nav, an interpretable and scene-aware navigation framework that leverages multi-modal large language model reasoning and conditional variational autoencoders to adaptively tune planner hyperparameters. To achieve zero-shot scene understanding, we utilize one-shot exemplars and chain-of-thought prompting strategies. Additionally, a conditional variational autoencoder captures the mapping between natural language instructions and navigation hyperparameters, enabling expert-level tuning. Experiments show that LE-Nav can generate hyperparameters achieving human-level tuning across diverse planners and scenarios. Real-world navigation trials and a user study on a smart wheelchair platform demonstrate that it outperforms state-of-the-art methods on quantitative metrics such as success rate, efficiency, safety, and comfort, while receiving higher subjective scores for perceived safety and social acceptance. Code is available at https://github.com/Cavendish518/LE-Nav.