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arXiv:2408.09533

AnomalyFactory: Regard Anomaly Generation as Unsupervised Anomaly Localization

Recent advances in anomaly generation approaches alleviate the effect of data insufficiency on task of anomaly localization. While effective, most of them learn multiple large generative models on different datasets and cumbersome anomaly prediction models for different classes. To address the limitations, we propose a novel scalable framework, named AnomalyFactory, that unifies unsupervised anomaly generation and localization with same network architecture. It starts with a BootGenerator that combines structure of a target edge map and appearance of a reference color image with the guidance of a learned heatmap. Then, it proceeds with a FlareGenerator that receives supervision signals from the BootGenerator and reforms the heatmap to indicate anomaly locations in the generated image. Finally, it easily transforms the same network architecture to a BlazeDetector that localizes anomaly pixels with the learned heatmap by converting the anomaly images generated by the FlareGenerator to normal images. By manipulating the target edge maps and combining them with various reference images, AnomalyFactory generates authentic and diversity samples cross domains. Comprehensive experiments carried on 5 datasets, including MVTecAD, VisA, MVTecLOCO, MADSim and RealIAD, demonstrate that our approach is superior to competitors in generation capability and scalability.

arXiv:2408.03888

Dual-Modeling Decouple Distillation for Unsupervised Anomaly Detection

Knowledge distillation based on student-teacher network is one of the mainstream solution paradigms for the challenging unsupervised Anomaly Detection task, utilizing the difference in representation capabilities of the teacher and student networks to implement anomaly localization. However, over-generalization of the student network to the teacher network may lead to negligible differences in representation capabilities of anomaly, thus affecting the detection effectiveness. Existing methods address the possible over-generalization by using differentiated students and teachers from the structural perspective or explicitly expanding distilled information from the content perspective, which inevitably result in an increased likelihood of underfitting of the student network and poor anomaly detection capabilities in anomaly center or edge. In this paper, we propose Dual-Modeling Decouple Distillation (DMDD) for the unsupervised anomaly detection. In DMDD, a Decouple Student-Teacher Network is proposed to decouple the initial student features into normality and abnormality features. We further introduce Dual-Modeling Distillation based on normal-anomaly image pairs, fitting normality features of anomalous image and the teacher features of the corresponding normal image, widening the distance between abnormality features and the teacher features in anomalous regions. Synthesizing these two distillation ideas, we achieve anomaly detection which focuses on both edge and center of anomaly. Finally, a Multi-perception Segmentation Network is proposed to achieve focused anomaly map fusion based on multiple attention. Experimental results on MVTec AD show that DMDD surpasses SOTA localization performance of previous knowledge distillation-based methods, reaching 98.85% on pixel-level AUC and 96.13% on PRO.

arXiv:2407.17705

ALMRR: Anomaly Localization Mamba on Industrial Textured Surface with Feature Reconstruction and Refinement

Unsupervised anomaly localization on industrial textured images has achieved remarkable results through reconstruction-based methods, yet existing approaches based on image reconstruction and feature reconstruc-tion each have their own shortcomings. Firstly, image-based methods tend to reconstruct both normal and anomalous regions well, which lead to over-generalization. Feature-based methods contain a large amount of distin-guishable semantic information, however, its feature structure is redundant and lacks anomalous information, which leads to significant reconstruction errors. In this paper, we propose an Anomaly Localization method based on Mamba with Feature Reconstruction and Refinement(ALMRR) which re-constructs semantic features based on Mamba and then refines them through a feature refinement module. To equip the model with prior knowledge of anomalies, we enhance it by adding artificially simulated anomalies to the original images. Unlike image reconstruction or repair, the features of synthesized defects are repaired along with those of normal areas. Finally, the aligned features containing rich semantic information are fed in-to the refinement module to obtain the anomaly map. Extensive experiments have been conducted on the MVTec-AD-Textured dataset and other real-world industrial dataset, which has demonstrated superior performance com-pared to state-of-the-art (SOTA) methods.

arXiv:2407.16684

AutoRG-Brain: Grounded Report Generation for Brain MRI

Radiologists are tasked with interpreting a large number of images in a daily base, with the responsibility of generating corresponding reports. This demanding workload elevates the risk of human error, potentially leading to treatment delays, increased healthcare costs, revenue loss, and operational inefficiencies. To address these challenges, we initiate a series of work on grounded Automatic Report Generation (AutoRG), starting from the brain MRI interpretation system, which supports the delineation of brain structures, the localization of anomalies, and the generation of well-organized findings. We make contributions from the following aspects, first, on dataset construction, we release a comprehensive dataset encompassing segmentation masks of anomaly regions and manually authored reports, termed as RadGenome-Brain MRI. This data resource is intended to catalyze ongoing research and development in the field of AI-assisted report generation systems. Second, on system design, we propose AutoRG-Brain, the first brain MRI report generation system with pixel-level grounded visual clues. Third, for evaluation, we conduct quantitative assessments and human evaluations of brain structure segmentation, anomaly localization, and report generation tasks to provide evidence of its reliability and accuracy. This system has been integrated into real clinical scenarios, where radiologists were instructed to write reports based on our generated findings and anomaly segmentation masks. The results demonstrate that our system enhances the report-writing skills of junior doctors, aligning their performance more closely with senior doctors, thereby boosting overall productivity.

arXiv:2407.06519

F2PAD: A General Optimization Framework for Feature-Level to Pixel-Level Anomaly Detection

Image-based inspection systems have been widely deployed in manufacturing production lines. Due to the scarcity of defective samples, unsupervised anomaly detection that only leverages normal samples during training to detect various defects is popular. Existing feature-based methods, utilizing deep features from pretrained neural networks, show their impressive performance in anomaly localization and the low demand for the sample size for training. However, the detected anomalous regions of these methods always exhibit inaccurate boundaries, which impedes the downstream tasks. This deficiency is caused: (i) The decreased resolution of high-level features compared with the original image, and (ii) The mixture of adjacent normal and anomalous pixels during feature extraction. To address them, we propose a novel unified optimization framework (F2PAD) that leverages the Feature-level information to guide the optimization process for Pixel-level Anomaly Detection in the inference stage. The proposed framework is universal and plug-and-play, which can enhance various feature-based methods with limited assumptions. Case studies are provided to demonstrate the effectiveness of our strategy, particularly when applied to three popular backbone methods: PaDiM, CFLOW-AD, and PatchCore.

arXiv:2407.00148공식 코드 · Papers with Code

Localizing Anomalies via Multiscale Score Matching Analysis

Anomaly detection and localization in medical imaging remain critical challenges in healthcare. This paper introduces Spatial-MSMA (Multiscale Score Matching Analysis), a novel unsupervised method for anomaly localization in volumetric brain MRIs. Building upon the MSMA framework, our approach incorporates spatial information and conditional likelihoods to enhance anomaly detection capabilities. We employ a flexible normalizing flow model conditioned on patch positions and global image features to estimate patch-wise anomaly scores. The method is evaluated on a dataset of 1,650 T1- and T2-weighted brain MRIs from typically developing children, with simulated lesions added to the test set. Spatial-MSMA significantly outperforms existing methods, including reconstruction-based, generative-based, and interpretation-based approaches, in lesion detection and segmentation tasks. Our model achieves superior performance in both distance-based metrics (99th percentile Hausdorff Distance: $7.05 \pm 0.61$, Mean Surface Distance: $2.10 \pm 0.43$) and component-wise metrics (True Positive Rate: $0.83 \pm 0.01$, Positive Predictive Value: $0.96 \pm 0.01$). These results demonstrate Spatial-MSMA's potential for accurate and interpretable anomaly localization in medical imaging, with implications for improved diagnosis and treatment planning in clinical settings. Our code is available at~\url{https://github.com/ahsanMah/sade/}.

arXiv:2406.18012

View-Invariant Pixelwise Anomaly Detection in Multi-object Scenes with Adaptive View Synthesis

The built environment, encompassing critical infrastructure such as bridges and buildings, requires diligent monitoring of unexpected anomalies or deviations from a normal state in captured imagery. Anomaly detection methods could aid in automating this task; however, deploying anomaly detection effectively in such environments presents significant challenges that have not been evaluated before. These challenges include camera viewpoints that vary, the presence of multiple objects within a scene, and the absence of labeled anomaly data for training. To address these comprehensively, we introduce and formalize Scene Anomaly Detection (Scene AD) as the task of unsupervised, pixel-wise anomaly localization under these specific real-world conditions. Evaluating progress in Scene AD required the development of ToyCity, the first multi-object, multi-view real-image dataset, for unsupervised anomaly detection. Our initial evaluations using ToyCity revealed that established anomaly detection baselines struggle to achieve robust pixel-level localization. To address this, two data augmentation strategies were created to generate additional synthetic images of non-anomalous regions to enhance generalizability. However, the addition of these synthetic images alone only provided minor improvements. Thus, OmniAD, a refinement of the Reverse Distillation methodology, was created to establish a stronger baseline. Our experiments demonstrate that OmniAD, when used with augmented views, yields a 64.33\% increase in pixel-wise \(F_1\) score over Reverse Distillation with no augmentation. Collectively, this work offers the Scene AD task definition, the ToyCity benchmark, the view synthesis augmentation approaches, and the OmniAD method. Project Page: https://drags99.github.io/OmniAD/

arXiv:2406.12235공식 코드 · Papers with Code

Holmes-VAD: Towards Unbiased and Explainable Video Anomaly Detection via Multi-modal LLM

Towards open-ended Video Anomaly Detection (VAD), existing methods often exhibit biased detection when faced with challenging or unseen events and lack interpretability. To address these drawbacks, we propose Holmes-VAD, a novel framework that leverages precise temporal supervision and rich multimodal instructions to enable accurate anomaly localization and comprehensive explanations. Firstly, towards unbiased and explainable VAD system, we construct the first large-scale multimodal VAD instruction-tuning benchmark, i.e., VAD-Instruct50k. This dataset is created using a carefully designed semi-automatic labeling paradigm. Efficient single-frame annotations are applied to the collected untrimmed videos, which are then synthesized into high-quality analyses of both abnormal and normal video clips using a robust off-the-shelf video captioner and a large language model (LLM). Building upon the VAD-Instruct50k dataset, we develop a customized solution for interpretable video anomaly detection. We train a lightweight temporal sampler to select frames with high anomaly response and fine-tune a multimodal large language model (LLM) to generate explanatory content. Extensive experimental results validate the generality and interpretability of the proposed Holmes-VAD, establishing it as a novel interpretable technique for real-world video anomaly analysis. To support the community, our benchmark and model will be publicly available at https://holmesvad.github.io.

arXiv:2405.13199

TauAD: MRI-free Tau Anomaly Detection in PET Imaging via Conditioned Diffusion Models

The emergence of tau PET imaging over the last decade has enabled Alzheimer's disease (AD) researchers to examine tau pathology in vivo and more effectively characterize the disease trajectories of AD. Current tau PET analysis methods, however, typically perform inferences on large cortical ROIs and are limited in the detection of localized tau pathology that varies across subjects. Furthermore, a high-resolution MRI is required to carry out conventional tau PET analysis, which is not commonly acquired in clinical practices and may not be acquired for many elderly patients with dementia due to strong motion artifacts, claustrophobia, or certain metal implants. In this work, we propose a novel conditional diffusion model to perform MRI-free anomaly detection from tau PET imaging data. By including individualized conditions and two complementary loss maps from pseudo-healthy and pseudo-unhealthy reconstructions, our model computes an anomaly map across the entire brain area that allows simply training a support vector machine (SVM) for classifying disease severity. We train our model on ADNI subjects (n=534) and evaluate its performance on a separate dataset from the preclinical subjects of the A4 clinical trial (n=447). We demonstrate that our method outperforms baseline generative models and the conventional Z-score-based method in anomaly localization without mis-detecting off-target bindings in sub-cortical and out-of-brain areas. By classifying the A4 subjects according to their anomaly map using the SVM trained on ADNI data, we show that our method can successfully group preclinical subjects with significantly different cognitive functions, which further demonstrates the effectiveness of our method in capturing biologically relevant anomaly in tau PET imaging.

arXiv:2405.09148

A Hierarchically Feature Reconstructed Autoencoder for Unsupervised Anomaly Detection

Anomaly detection and localization without any manual annotations and prior knowledge is a challenging task under the setting of unsupervised learning. The existing works achieve excellent performance in the anomaly detection, but with complex networks or cumbersome pipelines. To address this issue, this paper explores a simple but effective architecture in the anomaly detection. It consists of a well pre-trained encoder to extract hierarchical feature representations and a decoder to reconstruct these intermediate features from the encoder. In particular, it does not require any data augmentations and anomalous images for training. The anomalies can be detected when the decoder fails to reconstruct features well, and then errors of hierarchical feature reconstruction are aggregated into an anomaly map to achieve anomaly localization. The difference comparison between those features of encoder and decode lead to more accurate and robust localization results than the comparison in single feature or pixel-by-pixel comparison in the conventional works. Experiment results show that the proposed method outperforms the state-of-the-art methods on MNIST, Fashion-MNIST, CIFAR-10, and MVTec Anomaly Detection datasets on both anomaly detection and localization.

arXiv:2405.06875

LogicAL: Towards logical anomaly synthesis for unsupervised anomaly localization

Anomaly localization is a practical technology for improving industrial production line efficiency. Due to anomalies are manifold and hard to be collected, existing unsupervised researches are usually equipped with anomaly synthesis methods. However, most of them are biased towards structural defects synthesis while ignoring the underlying logical constraints. To fill the gap and boost anomaly localization performance, we propose an edge manipulation based anomaly synthesis framework, named LogicAL, that produces photo-realistic both logical and structural anomalies. We introduce a logical anomaly generation strategy that is adept at breaking logical constraints and a structural anomaly generation strategy that complements to the structural defects synthesis. We further improve the anomaly localization performance by introducing edge reconstruction into the network structure. Extensive experiments on the challenge MVTecLOCO, MVTecAD, VisA and MADsim datasets verify the advantage of proposed LogicAL on both logical and structural anomaly localization.

arXiv:2404.12246공식 코드 · Papers with Code

Blind Localization and Clustering of Anomalies in Textures

Anomaly detection and localization in images is a growing field in computer vision. In this area, a seemingly understudied problem is anomaly clustering, i.e., identifying and grouping different types of anomalies in a fully unsupervised manner. In this work, we propose a novel method for clustering anomalies in largely stationary images (textures) in a blind setting. That is, the input consists of normal and anomalous images without distinction and without labels. What contributes to the difficulty of the task is that anomalous regions are often small and may present only subtle changes in appearance, which can be easily overshadowed by the genuine variance in the texture. Moreover, each anomaly type may have a complex appearance distribution. We introduce a novel scheme for solving this task using a combination of blind anomaly localization and contrastive learning. By identifying the anomalous regions with high fidelity, we can restrict our focus to those regions of interest; then, contrastive learning is employed to increase the separability of different anomaly types and reduce the intra-class variation. Our experiments show that the proposed solution yields significantly better results compared to prior work, setting a new state of the art. Project page: https://reality.tf.fau.de/pub/ardelean2024blind.html.

arXiv:2404.09654

Do LLMs Understand Visual Anomalies? Uncovering LLM's Capabilities in Zero-shot Anomaly Detection

Large vision-language models (LVLMs) are markedly proficient in deriving visual representations guided by natural language. Recent explorations have utilized LVLMs to tackle zero-shot visual anomaly detection (VAD) challenges by pairing images with textual descriptions indicative of normal and abnormal conditions, referred to as anomaly prompts. However, existing approaches depend on static anomaly prompts that are prone to cross-semantic ambiguity, and prioritize global image-level representations over crucial local pixel-level image-to-text alignment that is necessary for accurate anomaly localization. In this paper, we present ALFA, a training-free approach designed to address these challenges via a unified model. We propose a run-time prompt adaptation strategy, which first generates informative anomaly prompts to leverage the capabilities of a large language model (LLM). This strategy is enhanced by a contextual scoring mechanism for per-image anomaly prompt adaptation and cross-semantic ambiguity mitigation. We further introduce a novel fine-grained aligner to fuse local pixel-level semantics for precise anomaly localization, by projecting the image-text alignment from global to local semantic spaces. Extensive evaluations on MVTec and VisA datasets confirm ALFA's effectiveness in harnessing the language potential for zero-shot VAD, achieving significant PRO improvements of 12.1% on MVTec and 8.9% on VisA compared to state-of-the-art approaches.

arXiv:2404.04935

Anomaly Detection in Electrocardiograms: Advancing Clinical Diagnosis Through Self-Supervised Learning

The electrocardiogram (ECG) is an essential tool for diagnosing heart disease, with computer-aided systems improving diagnostic accuracy and reducing healthcare costs. Despite advancements, existing systems often miss rare cardiac anomalies that could be precursors to serious, life-threatening issues or alterations in the cardiac macro/microstructure. We address this gap by focusing on self-supervised anomaly detection (AD), training exclusively on normal ECGs to recognize deviations indicating anomalies. We introduce a novel self-supervised learning framework for ECG AD, utilizing a vast dataset of normal ECGs to autonomously detect and localize cardiac anomalies. It proposes a novel masking and restoration technique alongside a multi-scale cross-attention module, enhancing the model's ability to integrate global and local signal features. The framework emphasizes accurate localization of anomalies within ECG signals, ensuring the method's clinical relevance and reliability. To reduce the impact of individual variability, the approach further incorporates crucial patient-specific information from ECG reports, such as age and gender, thus enabling accurate identification of a broad spectrum of cardiac anomalies, including rare ones. Utilizing an extensive dataset of 478,803 ECG graphic reports from real-world clinical practice, our method has demonstrated exceptional effectiveness in AD across all tested conditions, regardless of their frequency of occurrence, significantly outperforming existing models. It achieved superior performance metrics, including an AUROC of 91.2%, an F1 score of 83.7%, a sensitivity rate of 84.2%, a specificity of 83.0%, and a precision of 75.6% with a fixed recall rate of 90%. It has also demonstrated robust localization capabilities, with an AUROC of 76.5% and a Dice coefficient of 65.3% for anomaly localization.

arXiv:2402.17372공식 코드 · Papers with Code

Coupled Laplacian Eigenmaps for Locally-Aware 3D Rigid Point Cloud Matching

Point cloud matching, a crucial technique in computer vision, medical and robotics fields, is primarily concerned with finding correspondences between pairs of point clouds or voxels. In some practical scenarios, emphasizing local differences is crucial for accurately identifying a correct match, thereby enhancing the overall robustness and reliability of the matching process. Commonly used shape descriptors have several limitations and often fail to provide meaningful local insights about the paired geometries. In this work, we propose a new technique, based on graph Laplacian eigenmaps, to match point clouds by taking into account fine local structures. To deal with the order and sign ambiguity of Laplacian eigenmaps, we introduce a new operator, called Coupled Laplacian (https://github.com/matteo-bastico/CoupLap), that allows to easily generate aligned eigenspaces for multiple registered geometries. We show that the similarity between those aligned high-dimensional spaces provides a locally meaningful score to match shapes. We firstly evaluate the performance of the proposed technique in a point-wise manner, focusing on the task of object anomaly localization on the MVTec 3D-AD dataset. Additionally, we define a new medical task, called automatic Bone Side Estimation (BSE), which we address through a global similarity score derived from coupled eigenspaces. In order to test it, we propose a benchmark collecting bone surface structures from various public datasets. Our matching technique, based on Coupled Laplacian, outperforms other methods by reaching an impressive accuracy on both tasks.

arXiv:2402.14246

Reconstruction-Based Anomaly Localization via Knowledge-Informed Self-Training

Anomaly localization, which involves localizing anomalous regions within images, is a significant industrial task. Reconstruction-based methods are widely adopted for anomaly localization because of their low complexity and high interpretability. Most existing reconstruction-based methods only use normal samples to construct model. If anomalous samples are appropriately utilized in the process of anomaly localization, the localization performance can be improved. However, usually only weakly labeled anomalous samples are available, which limits the improvement. In many cases, we can obtain some knowledge of anomalies summarized by domain experts. Taking advantage of such knowledge can help us better utilize the anomalous samples and thus further improve the localization performance. In this paper, we propose a novel reconstruction-based method named knowledge-informed self-training (KIST) which integrates knowledge into reconstruction model through self-training. Specifically, KIST utilizes weakly labeled anomalous samples in addition to the normal ones and exploits knowledge to yield pixel-level pseudo-labels of the anomalous samples. Based on the pseudo labels, a novel loss which promotes the reconstruction of normal pixels while suppressing the reconstruction of anomalous pixels is used. We conduct experiments on different datasets and demonstrate the advantages of KIST over the existing reconstruction-based methods.

arXiv:2401.12665공식 코드 · Papers with Code

ClipSAM: CLIP and SAM Collaboration for Zero-Shot Anomaly Segmentation

Recently, foundational models such as CLIP and SAM have shown promising performance for the task of Zero-Shot Anomaly Segmentation (ZSAS). However, either CLIP-based or SAM-based ZSAS methods still suffer from non-negligible key drawbacks: 1) CLIP primarily focuses on global feature alignment across different inputs, leading to imprecise segmentation of local anomalous parts; 2) SAM tends to generate numerous redundant masks without proper prompt constraints, resulting in complex post-processing requirements. In this work, we innovatively propose a CLIP and SAM collaboration framework called ClipSAM for ZSAS. The insight behind ClipSAM is to employ CLIP's semantic understanding capability for anomaly localization and rough segmentation, which is further used as the prompt constraints for SAM to refine the anomaly segmentation results. In details, we introduce a crucial Unified Multi-scale Cross-modal Interaction (UMCI) module for interacting language with visual features at multiple scales of CLIP to reason anomaly positions. Then, we design a novel Multi-level Mask Refinement (MMR) module, which utilizes the positional information as multi-level prompts for SAM to acquire hierarchical levels of masks and merges them. Extensive experiments validate the effectiveness of our approach, achieving the optimal segmentation performance on the MVTec-AD and VisA datasets.

arXiv:2311.14897공식 코드 · Papers with Code

Towards Scalable 3D Anomaly Detection and Localization: A Benchmark via 3D Anomaly Synthesis and A Self-Supervised Learning Network

Recently, 3D anomaly detection, a crucial problem involving fine-grained geometry discrimination, is getting more attention. However, the lack of abundant real 3D anomaly data limits the scalability of current models. To enable scalable anomaly data collection, we propose a 3D anomaly synthesis pipeline to adapt existing large-scale 3Dmodels for 3D anomaly detection. Specifically, we construct a synthetic dataset, i.e., Anomaly-ShapeNet, basedon ShapeNet. Anomaly-ShapeNet consists of 1600 point cloud samples under 40 categories, which provides a rich and varied collection of data, enabling efficient training and enhancing adaptability to industrial scenarios. Meanwhile,to enable scalable representation learning for 3D anomaly localization, we propose a self-supervised method, i.e., Iterative Mask Reconstruction Network (IMRNet). During training, we propose a geometry-aware sample module to preserve potentially anomalous local regions during point cloud down-sampling. Then, we randomly mask out point patches and sent the visible patches to a transformer for reconstruction-based self-supervision. During testing, the point cloud repeatedly goes through the Mask Reconstruction Network, with each iteration's output becoming the next input. By merging and contrasting the final reconstructed point cloud with the initial input, our method successfully locates anomalies. Experiments show that IMRNet outperforms previous state-of-the-art methods, achieving 66.1% in I-AUC on Anomaly-ShapeNet dataset and 72.5% in I-AUC on Real3D-AD dataset. Our dataset will be released at https://github.com/Chopper-233/Anomaly-ShapeNet

arXiv:2310.06420

AnoDODE: Anomaly Detection with Diffusion ODE

Anomaly detection is the process of identifying atypical data samples that significantly deviate from the majority of the dataset. In the realm of clinical screening and diagnosis, detecting abnormalities in medical images holds great importance. Typically, clinical practice provides access to a vast collection of normal images, while abnormal images are relatively scarce. We hypothesize that abnormal images and their associated features tend to manifest in low-density regions of the data distribution. Following this assumption, we turn to diffusion ODEs for unsupervised anomaly detection, given their tractability and superior performance in density estimation tasks. More precisely, we propose a new anomaly detection method based on diffusion ODEs by estimating the density of features extracted from multi-scale medical images. Our anomaly scoring mechanism depends on computing the negative log-likelihood of features extracted from medical images at different scales, quantified in bits per dimension. Furthermore, we propose a reconstruction-based anomaly localization suitable for our method. Our proposed method not only identifie anomalies but also provides interpretability at both the image and pixel levels. Through experiments on the BraTS2021 medical dataset, our proposed method outperforms existing methods. These results confirm the effectiveness and robustness of our method.

arXiv:2310.02576공식 코드 · Papers with Code

A Prototype-Based Neural Network for Image Anomaly Detection and Localization

Image anomaly detection and localization perform not only image-level anomaly classification but also locate pixel-level anomaly regions. Recently, it has received much research attention due to its wide application in various fields. This paper proposes ProtoAD, a prototype-based neural network for image anomaly detection and localization. First, the patch features of normal images are extracted by a deep network pre-trained on nature images. Then, the prototypes of the normal patch features are learned by non-parametric clustering. Finally, we construct an image anomaly localization network (ProtoAD) by appending the feature extraction network with $L2$ feature normalization, a $1\times1$ convolutional layer, a channel max-pooling, and a subtraction operation. We use the prototypes as the kernels of the $1\times1$ convolutional layer; therefore, our neural network does not need a training phase and can conduct anomaly detection and localization in an end-to-end manner. Extensive experiments on two challenging industrial anomaly detection datasets, MVTec AD and BTAD, demonstrate that ProtoAD achieves competitive performance compared to the state-of-the-art methods with a higher inference speed. The source code is available at: https://github.com/98chao/ProtoAD.