Clinical decision-making is inherently complex and fast-paced, particularly in emergency departments (EDs) where critical, rapid and high-stakes decisions are made. Clinical Decision Rules (CDRs) are standardized evidence-based tools that combine signs, symptoms, and clinical variables into decision trees to make consistent and accurate diagnoses. CDR usage is often hindered by the clinician's cognitive load, limiting their ability to quickly recall and apply the appropriate rules. We introduce CDR-Agent, a novel LLM-based system designed to enhance ED decision-making by autonomously identifying and applying the most appropriate CDRs based on unstructured clinical notes. To validate CDR-Agent, we curated two novel ED datasets: synthetic and CDR-Bench, although CDR-Agent is applicable to non ED clinics. CDR-Agent achieves a 56.3\% (synthetic) and 8.7\% (CDR-Bench) accuracy gain relative to the standalone LLM baseline in CDR selection. Moreover, CDR-Agent significantly reduces computational overhead. Using these datasets, we demonstrated that CDR-Agent not only selects relevant CDRs efficiently, but makes cautious yet effective imaging decisions by minimizing unnecessary interventions while successfully identifying most positively diagnosed cases, outperforming traditional LLM prompting approaches. Code for our work can be found at: https://github.com/zhenxianglance/medagent-cdr-agent
The Vision Language Model (VLM) excels in aligning vision and language representations, and prompt learning has emerged as a key technique for adapting such models to downstream tasks. However, the application of prompt learning with VLM in federated learning (\fl{}) scenarios remains underexplored. This paper systematically investigates the behavioral differences between language prompt learning (LPT) and vision prompt learning (VPT) under data heterogeneity challenges, including label skew and domain shift. We conduct extensive experiments to evaluate the impact of various \fl{} and prompt configurations, such as client scale, aggregation strategies, and prompt length, to assess the robustness of Federated Prompt Learning (FPL). Furthermore, we explore strategies for enhancing prompt learning in complex scenarios where label skew and domain shift coexist, including leveraging both prompt types when computational resources allow. Our findings offer practical insights into optimizing prompt learning in federated settings, contributing to the broader deployment of VLMs in privacy-preserving environments.
Existing Large Language Model (LLM) serving systems prioritize maximum throughput. They often neglect Service Level Objectives (SLOs) such as Time to First Token (TTFT) and Time Per Output Token (TPOT), which leads to suboptimal SLO attainment. This paper introduces SCORPIO, an SLO-oriented LLM serving system designed to maximize system goodput and SLO attainment for workloads with heterogeneous SLOs. Our core insight is to exploit SLO heterogeneity for adaptive scheduling across admission control, queue management, and batch selection. SCORPIO features a TTFT Guard, which employs least-deadline-first reordering and rejects unattainable requests, and a TPOT Guard, which utilizes a VBS-based admission control and a novel credit-based batching mechanism. Both guards are supported by a predictive module. Evaluations demonstrate that SCORPIO improves system goodput by up to 14.4X and SLO adherence by up to 46.5% compared to state-of-the-art baselines.
Handwritten Mathematical Expression Recognition (HMER) remains a persistent challenge in Optical Character Recognition (OCR) due to the inherent freedom of symbol layout and variability in handwriting styles. Prior methods have faced performance bottlenecks, proposing isolated architectural modifications that are difficult to integrate coherently into a unified framework. Meanwhile, recent advances in pretrained vision-language models (VLMs) have demonstrated strong cross-task generalization, offering a promising foundation for developing unified solutions. In this paper, we introduce Uni-MuMER, which fully fine-tunes a VLM for the HMER task without modifying its architecture, effectively injecting domain-specific knowledge into a generalist framework. Our method integrates three data-driven tasks: Tree-Aware Chain-of-Thought (Tree-CoT) for structured spatial reasoning, Error-Driven Learning (EDL) for reducing confusion among visually similar characters, and Symbol Counting (SC) for improving recognition consistency in long expressions. Experiments on the CROHME and HME100K datasets show that Uni-MuMER achieves new state-of-the-art performance, surpassing the best lightweight specialized model SSAN by 16.31% and the top-performing VLM Gemini2.5-flash by 24.42% in the zero-shot setting. Our datasets, models, and code are open-sourced at: https://github.com/BFlameSwift/Uni-MuMER
Video captions play a crucial role in text-to-video generation tasks, as their quality directly influences the semantic coherence and visual fidelity of the generated videos. Although large vision-language models (VLMs) have demonstrated significant potential in caption generation, existing benchmarks inadequately address fine-grained evaluation, particularly in capturing spatial-temporal details critical for video generation. To address this gap, we introduce the Fine-grained Video Caption Evaluation Benchmark (VCapsBench), the first large-scale fine-grained benchmark comprising 5,677 (5K+) videos and 109,796 (100K+) question-answer pairs. These QA-pairs are systematically annotated across 21 fine-grained dimensions (e.g., camera movement, and shot type) that are empirically proven critical for text-to-video generation. We further introduce three metrics (Accuracy (AR), Inconsistency Rate (IR), Coverage Rate (CR)), and an automated evaluation pipeline leveraging large language model (LLM) to verify caption quality via contrastive QA-pairs analysis. By providing actionable insights for caption optimization, our benchmark can advance the development of robust text-to-video models. The dataset and codes are available at website: https://github.com/GXYM/VCapsBench.
Large language models (LLMs) have introduced new paradigms for recommender systems by enabling richer semantic understanding and incorporating implicit world knowledge. In this study, we propose a systematic taxonomy that classifies existing approaches into two categories: (1) Pure LLM Recommenders, which rely solely on LLMs, and (2) Augmented LLM Recommenders, which integrate additional non-LLM techniques to enhance performance. This taxonomy provides a novel lens through which to examine the evolving landscape of LLM-based recommendation. To support fair comparison, we introduce a unified evaluation platform that benchmarks representative models under consistent experimental settings, highlighting key design choices that impact effectiveness. We conclude by discussing open challenges and outlining promising directions for future research. This work offers both a comprehensive overview and practical guidance for advancing next-generation LLM-powered recommender.
Reliable uncertainty estimation is critical for deploying neural networks (NNs) in real-world applications. While existing calibration techniques often rely on post-hoc adjustments or coarse-grained binning methods, they remain limited in scalability, differentiability, and generalization across domains. In this work, we introduce CLUE (Calibration via Learning Uncertainty-Error Alignment), a novel approach that explicitly aligns predicted uncertainty with observed error during training, grounded in the principle that well-calibrated models should produce uncertainty estimates that match their empirical loss. CLUE adopts a novel loss function that jointly optimizes predictive performance and calibration, using summary statistics of uncertainty and loss as proxies. The proposed method is fully differentiable, domain-agnostic, and compatible with standard training pipelines. Through extensive experiments on vision, regression, and language modeling tasks, including out-of-distribution and domain-shift scenarios, we demonstrate that CLUE achieves superior calibration quality and competitive predictive performance with respect to state-of-the-art approaches without imposing significant computational overhead.
Ride-hailing platforms face significant challenges in optimizing order dispatching and driver repositioning operations in dynamic urban environments. Traditional approaches based on combinatorial optimization, rule-based heuristics, and reinforcement learning often overlook driver income fairness, interpretability, and adaptability to real-world dynamics. To address these gaps, we propose LLM-ODDR, a novel framework leveraging Large Language Models (LLMs) for joint Order Dispatching and Driver Repositioning (ODDR) in ride-hailing services. LLM-ODDR framework comprises three key components: (1) Multi-objective-guided Order Value Refinement, which evaluates orders by considering multiple objectives to determine their overall value; (2) Fairness-aware Order Dispatching, which balances platform revenue with driver income fairness; and (3) Spatiotemporal Demand-Aware Driver Repositioning, which optimizes idle vehicle placement based on historical patterns and projected supply. We also develop JointDR-GPT, a fine-tuned model optimized for ODDR tasks with domain knowledge. Extensive experiments on real-world datasets from Manhattan taxi operations demonstrate that our framework significantly outperforms traditional methods in terms of effectiveness, adaptability to anomalous conditions, and decision interpretability. To our knowledge, this is the first exploration of LLMs as decision-making agents in ride-hailing ODDR tasks, establishing foundational insights for integrating advanced language models within intelligent transportation systems.
Brain-to-Image reconstruction aims to recover visual stimuli perceived by humans from brain activity. However, the reconstructed visual stimuli often missing details and semantic inconsistencies, which may be attributed to insufficient semantic information. To address this issue, we propose an approach named Fine-grained Brain-to-Image reconstruction (FgB2I), which employs fine-grained text as bridge to improve image reconstruction. FgB2I comprises three key stages: detail enhancement, decoding fine-grained text descriptions, and text-bridged brain-to-image reconstruction. In the detail-enhancement stage, we leverage large vision-language models to generate fine-grained captions for visual stimuli and experimentally validate its importance. We propose three reward metrics (object accuracy, text-image semantic similarity, and image-image semantic similarity) to guide the language model in decoding fine-grained text descriptions from fMRI signals. The fine-grained text descriptions can be integrated into existing reconstruction methods to achieve fine-grained Brain-to-Image reconstruction.
Text-to-image generation increasingly demands access to domain-specific, fine-grained, and rapidly evolving knowledge that pretrained models cannot fully capture. Existing Retrieval-Augmented Generation (RAG) methods attempt to address this by retrieving globally relevant images, but they fail when no single image contains all desired elements from a complex user query. We propose Cross-modal RAG, a novel framework that decomposes both queries and images into sub-dimensional components, enabling subquery-aware retrieval and generation. Our method introduces a hybrid retrieval strategy - combining a sub-dimensional sparse retriever with a dense retriever - to identify a Pareto-optimal set of images, each contributing complementary aspects of the query. During generation, a multimodal large language model is guided to selectively condition on relevant visual features aligned to specific subqueries, ensuring subquery-aware image synthesis. Extensive experiments on MS-COCO, Flickr30K, WikiArt, CUB, and ImageNet-LT demonstrate that Cross-modal RAG significantly outperforms existing baselines in both retrieval and generation quality, while maintaining high efficiency.
Generating informative and knowledge-rich image captions remains a challenge for many existing captioning models, which often produce generic descriptions that lack specificity and contextual depth. To address this limitation, we propose KRCapVLM, a knowledge replay-based novel image captioning framework using vision-language model. We incorporate beam search decoding to generate more diverse and coherent captions. We also integrate attention-based modules into the image encoder to enhance feature representation. Finally, we employ training schedulers to improve stability and ensure smoother convergence during training. These proposals accelerate substantial gains in both caption quality and knowledge recognition. Our proposed model demonstrates clear improvements in both the accuracy of knowledge recognition and the overall quality of generated captions. It shows a stronger ability to generalize to previously unseen knowledge concepts, producing more informative and contextually relevant descriptions. These results indicate the effectiveness of our approach in enhancing the model's capacity to generate meaningful, knowledge-grounded captions across a range of scenarios.
Photo retouching is integral to photographic art, extending far beyond simple technical fixes to heighten emotional expression and narrative depth. While artists leverage expertise to create unique visual effects through deliberate adjustments, non-professional users often rely on automated tools that produce visually pleasing results but lack interpretative depth and interactive transparency. In this paper, we introduce PhotoArtAgent, an intelligent system that combines Vision-Language Models (VLMs) with advanced natural language reasoning to emulate the creative process of a professional artist. The agent performs explicit artistic analysis, plans retouching strategies, and outputs precise parameters to Lightroom through an API. It then evaluates the resulting images and iteratively refines them until the desired artistic vision is achieved. Throughout this process, PhotoArtAgent provides transparent, text-based explanations of its creative rationale, fostering meaningful interaction and user control. Experimental results show that PhotoArtAgent not only surpasses existing automated tools in user studies but also achieves results comparable to those of professional human artists.
High-resolution (HR) remote sensing imagery plays a vital role in a wide range of applications, including urban planning and environmental monitoring. However, due to limitations in sensors and data transmission links, the images acquired in practice often suffer from resolution degradation. Remote Sensing Image Super-Resolution (RSISR) aims to reconstruct HR images from low-resolution (LR) inputs, providing a cost-effective and efficient alternative to direct HR image acquisition. Existing RSISR methods primarily focus on low-level characteristics in pixel space, while neglecting the high-level understanding of remote sensing scenes. This may lead to semantically inconsistent artifacts in the reconstructed results. Motivated by this observation, our work aims to explore the role of high-level semantic knowledge in improving RSISR performance. We propose a Semantic-Guided Super-Resolution framework, SeG-SR, which leverages Vision-Language Models (VLMs) to extract semantic knowledge from input images and uses it to guide the super resolution (SR) process. Specifically, we first design a Semantic Feature Extraction Module (SFEM) that utilizes a pretrained VLM to extract semantic knowledge from remote sensing images. Next, we propose a Semantic Localization Module (SLM), which derives a series of semantic guidance from the extracted semantic knowledge. Finally, we develop a Learnable Modulation Module (LMM) that uses semantic guidance to modulate the features extracted by the SR network, effectively incorporating high-level scene understanding into the SR pipeline. We validate the effectiveness and generalizability of SeG-SR through extensive experiments: SeG-SR achieves state-of-the-art performance on two datasets and consistently delivers performance improvements across various SR architectures. Codes can be found at https://github.com/Mr-Bamboo/SeG-SR.
Existing PLMs generate protein sequences based on a single-condition constraint from a specific modality, struggling to simultaneously satisfy multiple constraints across different modalities. In this work, we introduce CFP-Gen, a novel diffusion language model for Combinatorial Functional Protein GENeration. CFP-Gen facilitates the de novo protein design by integrating multimodal conditions with functional, sequence, and structural constraints. Specifically, an Annotation-Guided Feature Modulation (AGFM) module is introduced to dynamically adjust the protein feature distribution based on composable functional annotations, e.g., GO terms, IPR domains and EC numbers. Meanwhile, the Residue-Controlled Functional Encoding (RCFE) module captures residue-wise interaction to ensure more precise control. Additionally, off-the-shelf 3D structure encoders can be seamlessly integrated to impose geometric constraints. We demonstrate that CFP-Gen enables high-throughput generation of novel proteins with functionality comparable to natural proteins, while achieving a high success rate in designing multifunctional proteins. Code and data available at https://github.com/yinjunbo/cfpgen.
Inspired by the great success of Masked Language Modeling (MLM) in the natural language domain, the paradigm of self-supervised pre-training and fine-tuning has also achieved remarkable progress in the field of DNA sequence modeling. However, previous methods often relied on massive pre-training data or large-scale base models with huge parameters, imposing a significant computational burden. To address this, many works attempted to use more compact models to achieve similar outcomes but still fell short by a considerable margin. In this work, we propose a Hybrid Architecture Distillation (HAD) approach, leveraging both distillation and reconstruction tasks for more efficient and effective pre-training. Specifically, we employ the NTv2-500M as the teacher model and devise a grouping masking strategy to align the feature embeddings of visible tokens while concurrently reconstructing the invisible tokens during MLM pre-training. To validate the effectiveness of our proposed method, we conducted comprehensive experiments on the Nucleotide Transformer Benchmark and Genomic Benchmark. Compared to models with similar parameters, our model achieved excellent performance. More surprisingly, it even surpassed the distillation ceiling-teacher model on some sub-tasks, which is more than 500 $\times$ larger. Lastly, we utilize t-SNE for more intuitive visualization, which shows that our model can gain a sophisticated understanding of the intrinsic representation pattern in genomic sequences.
Spoken language models (SLMs) operate on acoustic units obtained by discretizing self-supervised speech representations. Although the characteristics of these units directly affect performance, the interaction between codebook size and unit coarseness (i.e., duration) remains unexplored. We investigate SLM performance as we vary codebook size and unit coarseness using the simple duration-penalized dynamic programming (DPDP) method. New analyses are performed across different linguistic levels. At the phone and word levels, coarseness provides little benefit, as long as the codebook size is chosen appropriately. However, when producing whole sentences in a resynthesis task, SLMs perform better with coarser units. In lexical and syntactic language modeling tasks, coarser units also give higher accuracies at lower bitrates. We therefore show that coarser units aren't always better, but that DPDP is a simple and efficient way to obtain coarser units for the tasks where they are beneficial.
Exceptional behavior tests (EBTs) are crucial in software development for verifying that code correctly handles unwanted events and throws appropriate exceptions. However, prior research has shown that developers often prioritize testing "happy paths", e.g., paths without unwanted events over exceptional scenarios. We present exLong, a framework that automatically generates EBTs to address this gap. exLong leverages a large language model (LLM) fine-tuned from CodeLlama and incorporates reasoning about exception-throwing traces, conditional expressions that guard throw statements, and non-exceptional behavior tests that execute similar traces. Our demonstration video illustrates how exLong can effectively assist developers in creating comprehensive EBTs for their project (available at https://youtu.be/Jro8kMgplZk).
The ever-growing scale of deep learning models and datasets underscores the critical importance of efficient optimization methods. While preconditioned gradient methods such as Adam and AdamW are the de facto optimizers for training neural networks and large language models, structure-aware preconditioned optimizers like Shampoo and Muon, which utilize the matrix structure of gradients, have demonstrated promising evidence of faster convergence. In this paper, we introduce a unifying framework for analyzing "matrix-aware" preconditioned methods, which not only sheds light on the effectiveness of Muon and related optimizers but also leads to a class of new structure-aware preconditioned methods. A key contribution of this framework is its precise distinction between preconditioning strategies that treat neural network weights as vectors (addressing curvature anisotropy) versus those that consider their matrix structure (addressing gradient anisotropy). This perspective provides new insights into several empirical phenomena in language model pre-training, including Adam's training instabilities, Muon's accelerated convergence, and the necessity of learning rate warmup for Adam. Building upon this framework, we introduce PolarGrad, a new class of preconditioned optimization methods based on the polar decomposition of matrix-valued gradients. As a special instance, PolarGrad includes Muon with updates scaled by the nuclear norm of the gradients. We provide numerical implementations of these methods, leveraging efficient numerical polar decomposition algorithms for enhanced convergence. Our extensive evaluations across diverse matrix optimization problems and language model pre-training tasks demonstrate that PolarGrad outperforms both Adam and Muon.
We present the first provable method for identifying symmetric linear dynamical systems (LDS) with accuracy guarantees that are independent of the systems' state dimension or effective memory. Our approach builds upon recent work that represents symmetric LDSs as convolutions learnable via fixed spectral transformations. We show how to invert this representation, thereby recovering an LDS model from its spectral transform and yielding an end-to-end convex optimization procedure. This distillation preserves predictive accuracy while enabling constant-time and constant-space inference per token, independent of sequence length. We evaluate our method, SpectraLDS, as a component in sequence prediction architectures and demonstrate that accuracy is preserved while inference efficiency is improved on tasks such as language modeling.
Statistical n-gram language models are widely used for context-biasing tasks in Automatic Speech Recognition (ASR). However, existing implementations lack computational efficiency due to poor parallelization, making context-biasing less appealing for industrial use. This work rethinks data structures for statistical n-gram language models to enable fast and parallel operations for GPU-optimized inference. Our approach, named NGPU-LM, introduces customizable greedy decoding for all major ASR model types - including transducers, attention encoder-decoder models, and CTC - with less than 7% computational overhead. The proposed approach can eliminate more than 50% of the accuracy gap between greedy and beam search for out-of-domain scenarios while avoiding significant slowdown caused by beam search. The implementation of the proposed NGPU-LM is open-sourced.