Prompt learning has become a prevalent strategy for adapting vision-language foundation models (VLMs) such as CLIP to downstream tasks. With the emergence of large language models (LLMs), recent studies have explored the potential of using category-related descriptions to enhance prompt effectiveness. However, conventional descriptions lack explicit structured information necessary to represent the interconnections among key elements like entities or attributes with relation to a particular category. Since existing prompt tuning methods give little consideration to managing structured knowledge, this paper advocates leveraging LLMs to construct a graph for each description to prioritize such structured knowledge. Consequently, we propose a novel approach called Hierarchical Prompt Tuning (HPT), enabling simultaneous modeling of both structured and conventional linguistic knowledge. Specifically, we introduce a relationship-guided attention module to capture pair-wise associations among entities and attributes for low-level prompt learning. In addition, by incorporating high-level and global-level prompts modeling overall semantics, the proposed hierarchical structure forges cross-level interlinks and empowers the model to handle more complex and long-term relationships. Finally, by enhancing multi-granularity knowledge generation, redesigning the relationship-driven attention re-weighting module, and incorporating consistent constraints on the hierarchical text encoder, we propose HPT++, which further improves the performance of HPT. Our experiments are conducted across a wide range of evaluation settings, including base-to-new generalization, cross-dataset evaluation, and domain generalization. Extensive results and ablation studies demonstrate the effectiveness of our methods, which consistently outperform existing SOTA methods.
Domain Generalization (DG) has been recently explored to improve the generalizability of point cloud classification (PCC) models toward unseen domains. However, they often suffer from limited receptive fields or quadratic complexity due to using convolution neural networks or vision Transformers. In this paper, we present the first work that studies the generalizability of state space models (SSMs) in DG PCC and find that directly applying SSMs into DG PCC will encounter several challenges: the inherent topology of the point cloud tends to be disrupted and leads to noise accumulation during the serialization stage. Besides, the lack of designs in domain-agnostic feature learning and data scanning will introduce unanticipated domain-specific information into the 3D sequence data. To this end, we propose a novel framework, PointDGMamba, that excels in strong generalizability toward unseen domains and has the advantages of global receptive fields and efficient linear complexity. PointDGMamba consists of three innovative components: Masked Sequence Denoising (MSD), Sequence-wise Cross-domain Feature Aggregation (SCFA), and Dual-level Domain Scanning (DDS). In particular, MSD selectively masks out the noised point tokens of the point cloud sequences, SCFA introduces cross-domain but same-class point cloud features to encourage the model to learn how to extract more generalized features. DDS includes intra-domain scanning and cross-domain scanning to facilitate information exchange between features. In addition, we propose a new and more challenging benchmark PointDG-3to1 for multi-domain generalization. Extensive experiments demonstrate the effectiveness and state-of-the-art performance of PointDGMamba.
Domain-generalized nuclei segmentation refers to the generalizability of models to unseen domains based on knowledge learned from source domains and is challenged by various image conditions, cell types, and stain strategies. Recently, the Segment Anything Model (SAM) has made great success in universal image segmentation by interactive prompt modes (e.g., point and box). Despite its strengths, the original SAM presents limited adaptation to medical images. Moreover, SAM requires providing manual bounding box prompts for each object to produce satisfactory segmentation masks, so it is laborious in nuclei segmentation scenarios. To address these limitations, we propose a domain-generalizable framework for nuclei image segmentation, abbreviated to NuSegDG. Specifically, we first devise a Heterogeneous Space Adapter (HS-Adapter) to learn multi-dimensional feature representations of different nuclei domains by injecting a small number of trainable parameters into the image encoder of SAM. To alleviate the labor-intensive requirement of manual prompts, we introduce a Gaussian-Kernel Prompt Encoder (GKP-Encoder) to generate density maps driven by a single point, which guides segmentation predictions by mixing position prompts and semantic prompts. Furthermore, we present a Two-Stage Mask Decoder (TSM-Decoder) to effectively convert semantic masks to instance maps without the manual demand for morphological shape refinement. Based on our experimental evaluations, the proposed NuSegDG demonstrates state-of-the-art performance in nuclei instance segmentation, exhibiting superior domain generalization capabilities. The source code is available at https://github.com/xq141839/NuSegDG.
Large Language Model-based Dense Retrieval (LLM-DR) optimizes over numerous heterogeneous fine-tuning collections from different domains. However, the discussion about its training data distribution is still minimal. Previous studies rely on empirically assigned dataset choices or sampling ratios, which inevitably lead to sub-optimal retrieval performances. In this paper, we propose a new task-level Distributionally Robust Optimization (tDRO) algorithm for LLM-DR fine-tuning, targeted at improving the universal domain generalization ability by end-to-end reweighting the data distribution of each task. The tDRO parameterizes the domain weights and updates them with scaled domain gradients. The optimized weights are then transferred to the LLM-DR fine-tuning to train more robust retrievers. Experiments show optimal improvements in large-scale retrieval benchmarks and reduce up to 30% dataset usage after applying our optimization algorithm with a series of different-sized LLM-DR models.
Accurate delineation of the boundaries between the renal cortex and medulla is crucial for subsequent functional structural analysis and disease diagnosis. Training high-quality deep-learning models for layer segmentation relies on the availability of large amounts of annotated data. However, due to the patient's privacy of medical data and scarce clinical cases, constructing pathological datasets from clinical sources is relatively difficult and expensive. Moreover, using external natural image datasets introduces noise during the domain generalization process. Cross-species homologous data, such as mouse kidney data, which exhibits high structural and feature similarity to human kidneys, has the potential to enhance model performance on human datasets. In this study, we incorporated the collected private Periodic Acid-Schiff (PAS) stained mouse kidney dataset into the human kidney dataset for joint training. The results showed that after introducing cross-species homologous data, the semantic segmentation models based on CNN and Transformer architectures achieved an average increase of 1.77% and 1.24% in mIoU, and 1.76% and 0.89% in Dice score for the human renal cortex and medulla datasets, respectively. This approach is also capable of enhancing the model's generalization ability. This indicates that cross-species homologous data, as a low-noise trainable data source, can help improve model performance under conditions of limited clinical samples. Code is available at https://github.com/hrlblab/layer_segmentation.
In real-world applications, the sample distribution at the inference stage often differs from the one at the training stage, causing performance degradation of trained deep models. The research on domain generalization (DG) aims to develop robust algorithms that can improve the generalized performance in unseen domains by training on a few domains. However, the domain-agnostic vision model, trained on a limited number of domains using traditional domain generalization methods, cannot guarantee its effectiveness in dealing with unseen domains. The introduction of language can break the closed cognition space of the vision model, providing additional semantic information that cannot be inferred from vision-only datasets. In this paper, we propose to overcome the challenge in previous DG methods by introducing the style prompt in the language modality to adapt the trained model dynamically. In particular, we train a style prompter to extract style information of the current image into an embedding in the token embedding space and place it in front of the candidate category words as prior knowledge to prompt the model. Our open space partition of the style token embedding space and the hand-crafted style regularization enable the trained style prompter to handle data from unknown domains effectively. Extensive experiments verify the effectiveness of our method and demonstrate state-of-the-art performances on multiple public datasets. Codes will be available after the acceptance of this paper.
Recent advancements in pre-trained Vision-Language Models (VLMs) have highlighted the significant potential of prompt tuning for adapting these models to a wide range of downstream tasks. However, existing prompt tuning methods typically map an image to a single representation, limiting the model's ability to capture the diverse ways an image can be described. To address this limitation, we investigate the impact of visual prompts on the model's generalization capability and introduce a novel method termed Multi-Representation Guided Prompt Tuning (MePT). Specifically, MePT employs a three-branch framework that focuses on diverse salient regions, uncovering the inherent knowledge within images which is crucial for robust generalization. Further, we employ efficient self-ensemble techniques to integrate these versatile image representations, allowing MePT to learn all conditional, marginal, and fine-grained distributions effectively. We validate the effectiveness of MePT through extensive experiments, demonstrating significant improvements on both base-to-novel class prediction and domain generalization tasks.
Achieving the generalization of an invariant classifier from training domains to shifted test domains while simultaneously considering model fairness is a substantial and complex challenge in machine learning. Existing methods address the problem of fairness-aware domain generalization, focusing on either covariate shift or correlation shift, but rarely consider both at the same time. In this paper, we introduce a novel approach that focuses on learning a fairness-aware domain-invariant predictor within a framework addressing both covariate and correlation shifts simultaneously, ensuring its generalization to unknown test domains inaccessible during training. In our approach, data are first disentangled into content and style factors in latent spaces. Furthermore, fairness-aware domain-invariant content representations can be learned by mitigating sensitive information and retaining as much other information as possible. Extensive empirical studies on benchmark datasets demonstrate that our approach surpasses state-of-the-art methods with respect to model accuracy as well as both group and individual fairness.
Objectives: To evaluate the zero-shot performance of Segment Anything Model 2 (SAM 2) in 3D segmentation of abdominal organs in CT scans, and to investigate the effects of prompt settings on segmentation results. Materials and Methods: In this retrospective study, we used a subset of the TotalSegmentator CT dataset from eight institutions to assess SAM 2's ability to segment eight abdominal organs. Segmentation was initiated from three different z-coordinate levels (caudal, mid, and cranial levels) of each organ. Performance was measured using the Dice similarity coefficient (DSC). We also analyzed the impact of "negative prompts," which explicitly exclude certain regions from the segmentation process, on accuracy. Results: 123 patients (mean age, 60.7 \pm 15.5 years; 63 men, 60 women) were evaluated. As a zero-shot approach, larger organs with clear boundaries demonstrated high segmentation performance, with mean DSCs as follows: liver 0.821 \pm 0.192, right kidney 0.862 \pm 0.212, left kidney 0.870 \pm 0.154, and spleen 0.891 \pm 0.131. Smaller organs showed lower performance: gallbladder 0.531 \pm 0.291, pancreas 0.361 \pm 0.197, and adrenal glands, right 0.203 \pm 0.222, left 0.308 \pm 0.234. The initial slice for segmentation and the use of negative prompts significantly influenced the results. By removing negative prompts from the input, the DSCs significantly decreased for six organs. Conclusion: SAM 2 demonstrated promising zero-shot performance in segmenting certain abdominal organs in CT scans, particularly larger organs. Performance was significantly influenced by input negative prompts and initial slice selection, highlighting the importance of optimizing these factors.
In multi-label classification, machine learning encounters the challenge of domain generalization when handling tasks with distributions differing from the training data. Existing approaches primarily focus on vision object recognition and neglect the integration of natural language. Recent advancements in vision-language pre-training leverage supervision from extensive visual-language pairs, enabling learning across diverse domains and enhancing recognition in multi-modal scenarios. However, these approaches face limitations in loss function utilization, generality across backbones, and class-aware visual fusion. This paper proposes solutions to these limitations by inferring the actual loss, broadening evaluations to larger vision-language backbones, and introducing Mixup-CLIPood, which incorporates a novel mix-up loss for enhanced class-aware visual fusion. Our method demonstrates superior performance in domain generalization across multiple datasets.
Due to domain shift, deep learning image classifiers perform poorly when applied to a domain different from the training one. For instance, a classifier trained on chest X-ray (CXR) images from one hospital may not generalize to images from another hospital due to variations in scanner settings or patient characteristics. In this paper, we introduce our CROCODILE framework, showing how tools from causality can foster a model's robustness to domain shift via feature disentanglement, contrastive learning losses, and the injection of prior knowledge. This way, the model relies less on spurious correlations, learns the mechanism bringing from images to prediction better, and outperforms baselines on out-of-distribution (OOD) data. We apply our method to multi-label lung disease classification from CXRs, utilizing over 750000 images from four datasets. Our bias-mitigation method improves domain generalization and fairness, broadening the applicability and reliability of deep learning models for a safer medical image analysis. Find our code at: https://github.com/gianlucarloni/crocodile.
This work addresses the challenge of factual consistency in text generation systems. We unify the tasks of Natural Language Inference, Summarization Evaluation, Factuality Verification and Factual Consistency Evaluation to train models capable of evaluating the factual consistency of source-target pairs across diverse domains. We rigorously evaluate these against eight baselines on a comprehensive benchmark suite comprising 22 datasets that span various tasks, domains, and document lengths. Results demonstrate that our method achieves state-of-the-art performance on this heterogeneous benchmark while addressing efficiency concerns and attaining cross-domain generalization.
We introduce a novel computational unit, termed PushPull-Conv, in the first layer of a ResNet architecture, inspired by the anti-phase inhibition phenomenon observed in the primary visual cortex. This unit redefines the traditional convolutional layer by implementing a pair of complementary filters: a trainable push kernel and its counterpart, the pull kernel. The push kernel (analogous to traditional convolution) learns to respond to specific stimuli, while the pull kernel reacts to the same stimuli but of opposite contrast. This configuration enhances stimulus selectivity and effectively inhibits response in regions lacking preferred stimuli. This effect is attributed to the push and pull kernels, which produce responses of comparable magnitude in such regions, thereby neutralizing each other. The incorporation of the PushPull-Conv into ResNets significantly increases their robustness to image corruption. Our experiments with benchmark corruption datasets show that the PushPull-Conv can be combined with other data augmentation techniques to further improve model robustness. We set a new robustness benchmark on ResNet50 achieving an $mCE$ of 49.95$\%$ on ImageNet-C when combining PRIME augmentation with PushPull inhibition.
Despite the considerable advancements achieved by deep neural networks, their performance tends to degenerate when the test environment diverges from the training ones. Domain generalization (DG) solves this issue by learning representations independent of domain-related information, thus facilitating extrapolation to unseen environments. Existing approaches typically focus on formulating tailored training objectives to extract shared features from the source data. However, the disjointed training and testing procedures may compromise robustness, particularly in the face of unforeseen variations during deployment. In this paper, we propose a novel and holistic framework based on causality, named InPer, designed to enhance model generalization by incorporating causal intervention during training and causal perturbation during testing. Specifically, during the training phase, we employ entropy-based causal intervention (EnIn) to refine the selection of causal variables. To identify samples with anti-interference causal variables from the target domain, we propose a novel metric, homeostatic score, through causal perturbation (HoPer) to construct a prototype classifier in test time. Experimental results across multiple cross-domain tasks confirm the efficacy of InPer.
While deep learning-based computer-aided diagnosis for skin lesion image analysis is approaching dermatologists' performance levels, there are several works showing that incorporating additional features such as shape priors, texture, color constancy, and illumination further improves the lesion diagnosis performance. In this work, we look at another clinically useful feature, skin lesion elevation, and investigate the feasibility of predicting and leveraging skin lesion elevation labels. Specifically, we use a deep learning model to predict image-level lesion elevation labels from 2D skin lesion images. We test the elevation prediction accuracy on the derm7pt dataset, and use the elevation prediction model to estimate elevation labels for images from five other datasets: ISIC 2016, 2017, and 2018 Challenge datasets, MSK, and DermoFit. We evaluate cross-domain generalization by using these estimated elevation labels as auxiliary inputs to diagnosis models, and show that these improve the classification performance, with AUROC improvements of up to 6.29% and 2.69% for dermoscopic and clinical images, respectively. The code is publicly available at https://github.com/sfu-mial/LesionElevation.
The capability gap between open-source and closed-source large language models (LLMs) remains a challenge in text-to-SQL tasks. In this paper, we introduce a synthetic data approach that combines data produced by larger, more powerful models (strong models) with error information data generated by smaller, not well-aligned models (weak models). The method not only enhances the domain generalization of text-to-SQL models but also explores the potential of error data supervision through preference learning. Furthermore, we employ the synthetic data approach for instruction tuning on open-source LLMs, resulting SENSE, a specialized text-to-SQL model. The effectiveness of SENSE is demonstrated through state-of-the-art results on the SPIDER and BIRD benchmarks, bridging the performance gap between open-source models and methods prompted by closed-source models.
This study investigates the impact of self-supervised pretraining of 3D semantic segmentation models on a large-scale, domain-specific dataset. We introduce BRAINS-45K, a dataset of 44,756 brain MRI volumes from public sources, the largest public dataset available, and revisit a number of design choices for pretraining modern segmentation architectures by simplifying and optimizing state-of-the-art methods, and combining them with a novel augmentation strategy. The resulting AMAES framework is based on masked-image-modeling and intensity-based augmentation reversal and balances memory usage, runtime, and finetuning performance. Using the popular U-Net and the recent MedNeXt architecture as backbones, we evaluate the effect of pretraining on three challenging downstream tasks, covering single-sequence, low-resource settings, and out-of-domain generalization. The results highlight that pretraining on the proposed dataset with AMAES significantly improves segmentation performance in the majority of evaluated cases, and that it is beneficial to pretrain the model with augmentations, despite pretraing on a large-scale dataset. Code and model checkpoints for reproducing results, as well as the BRAINS-45K dataset are available at \url{https://github.com/asbjrnmunk/amaes}.
In this work, we propose a training-free method to inject visual prompts into Multimodal Large Language Models (MLLMs) through test-time optimization of a learnable latent variable. We observe that attention, as the core module of MLLMs, connects text prompt tokens and visual tokens, ultimately determining the final results. Our approach involves adjusting visual tokens from the MLP output at test time, controlling the attention response to ensure text prompt tokens attend to visual tokens in referring regions. We optimize a learnable latent variable based on an energy function, enhancing the strength of referring regions in the attention map. This enables detailed region description and reasoning without the need for substantial training costs or model retraining. Our method offers a promising direction for integrating referring abilities into MLLMs, and supports referring with box, mask, scribble and point. The results demonstrate that our method exhibits out-of-domain generalization and interpretability.
Model attribution for LLM-generated disinformation poses a significant challenge in understanding its origins and mitigating its spread. This task is especially challenging because modern large language models (LLMs) produce disinformation with human-like quality. Additionally, the diversity in prompting methods used to generate disinformation complicates accurate source attribution. These methods introduce domain-specific features that can mask the fundamental characteristics of the models. In this paper, we introduce the concept of model attribution as a domain generalization problem, where each prompting method represents a unique domain. We argue that an effective attribution model must be invariant to these domain-specific features. It should also be proficient in identifying the originating models across all scenarios, reflecting real-world detection challenges. To address this, we introduce a novel approach based on Supervised Contrastive Learning. This method is designed to enhance the model's robustness to variations in prompts and focuses on distinguishing between different source LLMs. We evaluate our model through rigorous experiments involving three common prompting methods: ``open-ended'', ``rewriting'', and ``paraphrasing'', and three advanced LLMs: ``llama 2'', ``chatgpt'', and ``vicuna''. Our results demonstrate the effectiveness of our approach in model attribution tasks, achieving state-of-the-art performance across diverse and unseen datasets.
Machine learning (ML) has demonstrated significant promise in accelerating drug design. Active ML-guided optimization of therapeutic molecules typically relies on a surrogate model predicting the target property of interest. The model predictions are used to determine which designs to evaluate in the lab, and the model is updated on the new measurements to inform the next cycle of decisions. A key challenge is that the experimental feedback from each cycle inspires changes in the candidate proposal or experimental protocol for the next cycle, which lead to distribution shifts. To promote robustness to these shifts, we must account for them explicitly in the model training. We apply domain generalization (DG) methods to classify the stability of interactions between an antibody and antigen across five domains defined by design cycles. Our results suggest that foundational models and ensembling improve predictive performance on out-of-distribution domains. We publicly release our codebase extending the DG benchmark ``DomainBed,'' and the associated dataset of antibody sequences and structures emulating distribution shifts across design cycles.