Despite continuous advancements in cancer treatment, brain metastatic disease remains a significant complication of primary cancer and is associated with an unfavorable prognosis. One approach for improving diagnosis, management, and outcomes is to implement algorithms based on artificial intelligence for the automated segmentation of both pre- and post-treatment MRI brain images. Such algorithms rely on volumetric criteria for lesion identification and treatment response assessment, which are still not available in clinical practice. Therefore, it is critical to establish tools for rapid volumetric segmentations methods that can be translated to clinical practice and that are trained on high quality annotated data. The BraTS-METS 2025 Lighthouse Challenge aims to address this critical need by establishing inter-rater and intra-rater variability in dataset annotation by generating high quality annotated datasets from four individual instances of segmentation by neuroradiologists while being recorded on video (two instances doing "from scratch" and two instances after AI pre-segmentation). This high-quality annotated dataset will be used for testing phase in 2025 Lighthouse challenge and will be publicly released at the completion of the challenge. The 2025 Lighthouse challenge will also release the 2023 and 2024 segmented datasets that were annotated using an established pipeline of pre-segmentation, student annotation, two neuroradiologists checking, and one neuroradiologist finalizing the process. It builds upon its previous edition by including post-treatment cases in the dataset. Using these high-quality annotated datasets, the 2025 Lighthouse challenge plans to test benchmark algorithms for automated segmentation of pre-and post-treatment brain metastases (BM), trained on diverse and multi-institutional datasets of MRI images obtained from patients with brain metastases.
Diffusion Probabilistic Models (DPMs) have demonstrated significant potential in 3D medical image segmentation tasks. However, their high computational cost and inability to fully capture global 3D contextual information limit their practical applications. To address these challenges, we propose a novel text-guided diffusion model framework, TextDiffSeg. This method leverages a conditional diffusion framework that integrates 3D volumetric data with natural language descriptions, enabling cross-modal embedding and establishing a shared semantic space between visual and textual modalities. By enhancing the model's ability to recognize complex anatomical structures, TextDiffSeg incorporates innovative label embedding techniques and cross-modal attention mechanisms, effectively reducing computational complexity while preserving global 3D contextual integrity. Experimental results demonstrate that TextDiffSeg consistently outperforms existing methods in segmentation tasks involving kidney and pancreas tumors, as well as multi-organ segmentation scenarios. Ablation studies further validate the effectiveness of key components, highlighting the synergistic interaction between text fusion, image feature extractor, and label encoder. TextDiffSeg provides an efficient and accurate solution for 3D medical image segmentation, showcasing its broad applicability in clinical diagnosis and treatment planning.
Deep learning models have achieved impressive performance in medical image segmentation, yet their black-box nature limits clinical adoption. In vascular applications, trustworthy segmentation should rely on both local image cues and global anatomical structures, such as vessel connectivity or branching. However, the extent to which models leverage such global context remains unclear. We present a novel explainability pipeline for 3D vessel segmentation, combining gradient-based attribution with graph-guided point selection and a blob-based analysis of Saliency maps. Using vascular graphs extracted from ground truth, we define anatomically meaningful points of interest (POIs) and assess the contribution of input voxels via Saliency maps. These are analyzed at both global and local scales using a custom blob detector. Applied to IRCAD and Bullitt datasets, our analysis shows that model decisions are dominated by highly localized attribution blobs centered near POIs. Attribution features show little correlation with vessel-level properties such as thickness, tubularity, or connectivity -- suggesting limited use of global anatomical reasoning. Our results underline the importance of structured explainability tools and highlight the current limitations of segmentation models in capturing global vascular context.
Accurate segmentation of abdominal adipose tissue, including subcutaneous (SAT) and visceral adipose tissue (VAT), along with liver segmentation, is essential for understanding body composition and associated health risks such as type 2 diabetes and cardiovascular disease. This study proposes Attention GhostUNet++, a novel deep learning model incorporating Channel, Spatial, and Depth Attention mechanisms into the Ghost UNet++ bottleneck for automated, precise segmentation. Evaluated on the AATTCT-IDS and LiTS datasets, the model achieved Dice coefficients of 0.9430 for VAT, 0.9639 for SAT, and 0.9652 for liver segmentation, surpassing baseline models. Despite minor limitations in boundary detail segmentation, the proposed model significantly enhances feature refinement, contextual understanding, and computational efficiency, offering a robust solution for body composition analysis. The implementation of the proposed Attention GhostUNet++ model is available at:https://github.com/MansoorHayat777/Attention-GhostUNetPlusPlus.
Tokenization is a crucial step in NLP, especially with the rise of large language models (LLMs), impacting downstream performance, computational cost, and efficiency. Existing LLMs rely on the classical Byte-pair Encoding (BPE) algorithm for subword tokenization that greedily merges frequent character bigrams. This often leads to segmentation that does not align with linguistically meaningful units. To address this, we propose morphology-aware segmentation as a pre-tokenization step prior to applying BPE. To facilitate morphology-aware segmentation, we create a novel dataset for Hindi and Marathi, incorporating sandhi splitting to enhance the subword tokenization. Experiments on downstream tasks show that morphologically grounded tokenization improves performance for machine translation and language modeling. Additionally, to handle the ambiguity in the Unicode characters for diacritics, particularly dependent vowels in syllable-based writing systems, we introduce Constrained BPE (CBPE), an extension to the traditional BPE algorithm that incorporates script-specific constraints. Specifically, CBPE handles dependent vowels. Our results show that CBPE achieves a 1.68\% reduction in fertility scores while maintaining comparable or improved downstream performance in machine translation, offering a computationally efficient alternative to standard BPE. Moreover, to evaluate segmentation across different tokenization algorithms, we introduce a new human evaluation metric, \textit{EvalTok}, enabling more human-grounded assessment.
Complex video object segmentation continues to face significant challenges in small object recognition, occlusion handling, and dynamic scene modeling. This report presents our solution, which ranked second in the MOSE track of CVPR 2025 PVUW Challenge. Based on an existing segmentation framework, we propose an improved model named MASSeg for complex video object segmentation, and construct an enhanced dataset, MOSE+, which includes typical scenarios with occlusions, cluttered backgrounds, and small target instances. During training, we incorporate a combination of inter-frame consistent and inconsistent data augmentation strategies to improve robustness and generalization. During inference, we design a mask output scaling strategy to better adapt to varying object sizes and occlusion levels. As a result, MASSeg achieves a J score of 0.8250, F score of 0.9007, and a J&F score of 0.8628 on the MOSE test set.
In robot-assisted laparoscopic radical prostatectomy (RALP), the location of the instrument tip is important to register the ultrasound frame with the laparoscopic camera frame. A long-standing limitation is that the instrument tip position obtained from the da Vinci API is inaccurate and requires hand-eye calibration. Thus, directly computing the position of the tool tip in the camera frame using the vision-based method becomes an attractive solution. Besides, surgical instrument tip detection is the key component of other tasks, like surgical skill assessment and surgery automation. However, this task is challenging due to the small size of the tool tip and the articulation of the surgical instrument. Surgical instrument segmentation becomes relatively easy due to the emergence of the Segmentation Foundation Model, i.e., Segment Anything. Based on this advancement, we explore the deep learning-based surgical instrument tip detection approach that takes the part-level instrument segmentation mask as input. Comparison experiments with a hand-crafted image-processing approach demonstrate the superiority of the proposed method on simulated and real datasets.
Video Object Segmentation (VOS) is one of the most fundamental and challenging tasks in computer vision and has a wide range of applications. Most existing methods rely on spatiotemporal memory networks to extract frame-level features and have achieved promising results on commonly used datasets. However, these methods often struggle in more complex real-world scenarios. This paper addresses this issue, aiming to achieve accurate segmentation of video objects in challenging scenes. We propose fine-tuning VOS (FVOS), optimizing existing methods for specific datasets through tailored training. Additionally, we introduce a morphological post-processing strategy to address the issue of excessively large gaps between adjacent objects in single-model predictions. Finally, we apply a voting-based fusion method on multi-scale segmentation results to generate the final output. Our approach achieves J&F scores of 76.81% and 83.92% during the validation and testing stages, respectively, securing third place overall in the MOSE Track of the 4th PVUW challenge 2025.
Image segmentation beyond predefined categories is a key challenge in remote sensing, where novel and unseen classes often emerge during inference. Open-vocabulary image Segmentation addresses these generalization issues in traditional supervised segmentation models while reducing reliance on extensive per-pixel annotations, which are both expensive and labor-intensive to obtain. Most Open-Vocabulary Segmentation (OVS) methods are designed for natural images but struggle with remote sensing data due to scale variations, orientation changes, and complex scene compositions. This necessitates the development of OVS approaches specifically tailored for remote sensing. In this context, we propose AerOSeg, a novel OVS approach for remote sensing data. First, we compute robust image-text correlation features using multiple rotated versions of the input image and domain-specific prompts. These features are then refined through spatial and class refinement blocks. Inspired by the success of the Segment Anything Model (SAM) in diverse domains, we leverage SAM features to guide the spatial refinement of correlation features. Additionally, we introduce a semantic back-projection module and loss to ensure the seamless propagation of SAM's semantic information throughout the segmentation pipeline. Finally, we enhance the refined correlation features using a multi-scale attention-aware decoder to produce the final segmentation map. We validate our SAM-guided Open-Vocabulary Remote Sensing Segmentation model on three benchmark remote sensing datasets: iSAID, DLRSD, and OpenEarthMap. Our model outperforms state-of-the-art open-vocabulary segmentation methods, achieving an average improvement of 2.54 h-mIoU.
This report provides a comprehensive overview of the 4th Pixel-level Video Understanding in the Wild (PVUW) Challenge, held in conjunction with CVPR 2025. It summarizes the challenge outcomes, participating methodologies, and future research directions. The challenge features two tracks: MOSE, which focuses on complex scene video object segmentation, and MeViS, which targets motion-guided, language-based video segmentation. Both tracks introduce new, more challenging datasets designed to better reflect real-world scenarios. Through detailed evaluation and analysis, the challenge offers valuable insights into the current state-of-the-art and emerging trends in complex video segmentation. More information can be found on the workshop website: https://pvuw.github.io/.
Recently supervised learning rapidly develops in scene text segmentation. However, the lack of high-quality datasets and the high cost of pixel annotation greatly limit the development of them. Considering the well-performed few-shot learning methods for downstream tasks, we investigate the application of the few-shot learning method to scene text segmentation. We propose TSAL, which leverages CLIP's prior knowledge to learn text attributes for segmentation. To fully utilize the semantic and texture information in the image, a visual-guided branch is proposed to separately extract text and background features. To reduce data dependency and improve text detection accuracy, the adaptive prompt-guided branch employs effective adaptive prompt templates to capture various text attributes. To enable adaptive prompts capture distinctive text features and complex background distribution, we propose Adaptive Feature Alignment module(AFA). By aligning learnable tokens of different attributes with visual features and prompt prototypes, AFA enables adaptive prompts to capture both general and distinctive attribute information. TSAL can capture the unique attributes of text and achieve precise segmentation using only few images. Experiments demonstrate that our method achieves SOTA performance on multiple text segmentation datasets under few-shot settings and show great potential in text-related domains.
Despite remarkable advancements in pixel-level medical image perception, existing methods are either limited to specific tasks or heavily rely on accurate bounding boxes or text labels as input prompts. However, the medical knowledge required for input is a huge obstacle for general public, which greatly reduces the universality of these methods. Compared with these domain-specialized auxiliary information, general users tend to rely on oral queries that require logical reasoning. In this paper, we introduce a novel medical vision task: Medical Reasoning Segmentation and Detection (MedSD), which aims to comprehend implicit queries about medical images and generate the corresponding segmentation mask and bounding box for the target object. To accomplish this task, we first introduce a Multi-perspective, Logic-driven Medical Reasoning Segmentation and Detection (MLMR-SD) dataset, which encompasses a substantial collection of medical entity targets along with their corresponding reasoning. Furthermore, we propose MediSee, an effective baseline model designed for medical reasoning segmentation and detection. The experimental results indicate that the proposed method can effectively address MedSD with implicit colloquial queries and outperform traditional medical referring segmentation methods.
Accurate medical image segmentation is essential for effective diagnosis and treatment. Previously, PraNet-V1 was proposed to enhance polyp segmentation by introducing a reverse attention (RA) module that utilizes background information. However, PraNet-V1 struggles with multi-class segmentation tasks. To address this limitation, we propose PraNet-V2, which, compared to PraNet-V1, effectively performs a broader range of tasks including multi-class segmentation. At the core of PraNet-V2 is the Dual-Supervised Reverse Attention (DSRA) module, which incorporates explicit background supervision, independent background modeling, and semantically enriched attention fusion. Our PraNet-V2 framework demonstrates strong performance on four polyp segmentation datasets. Additionally, by integrating DSRA to iteratively enhance foreground segmentation results in three state-of-the-art semantic segmentation models, we achieve up to a 1.36% improvement in mean Dice score. Code is available at: https://github.com/ai4colonoscopy/PraNet-V2/tree/main/binary_seg/jittor.
Current methods for pathology image segmentation typically treat 2D slices independently, ignoring valuable cross-slice information. We present PathSeqSAM, a novel approach that treats 2D pathology slices as sequential video frames using SAM2's memory mechanisms. Our method introduces a distance-aware attention mechanism that accounts for variable physical distances between slices and employs LoRA for domain adaptation. Evaluated on the KPI Challenge 2024 dataset for glomeruli segmentation, PathSeqSAM demonstrates improved segmentation quality, particularly in challenging cases that benefit from cross-slice context. We have publicly released our code at https://github.com/JackyyyWang/PathSeqSAM.
Due to the success of CNN-based and Transformer-based models in various computer vision tasks, recent works study the applicability of CNN-Transformer hybrid architecture models in 3D multi-modality medical segmentation tasks. Introducing Transformer brings long-range dependent information modeling ability in 3D medical images to hybrid models via the self-attention mechanism. However, these models usually employ fixed receptive fields of 3D volumetric features within each self-attention layer, ignoring the multi-scale volumetric lesion features. To address this issue, we propose a CNN-Transformer hybrid 3D medical image segmentation model, named TMA-TransBTS, based on an encoder-decoder structure. TMA-TransBTS realizes simultaneous extraction of multi-scale 3D features and modeling of long-distance dependencies by multi-scale division and aggregation of 3D tokens in a self-attention layer. Furthermore, TMA-TransBTS proposes a 3D multi-scale cross-attention module to establish a link between the encoder and the decoder for extracting rich volume representations by exploiting the mutual attention mechanism of cross-attention and multi-scale aggregation of 3D tokens. Extensive experimental results on three public 3D medical segmentation datasets show that TMA-TransBTS achieves higher averaged segmentation results than previous state-of-the-art CNN-based 3D methods and CNN-Transform hybrid 3D methods for the segmentation of 3D multi-modality brain tumors.
Accurate segmentation of longitudinal CT scans is important for monitoring tumor progression and evaluating treatment responses. However, existing 3D segmentation models solely focus on spatial information. To address this gap, we propose OmniMamba4D, a novel segmentation model designed for 4D medical images (3D images over time). OmniMamba4D utilizes a spatio-temporal tetra-orientated Mamba block to effectively capture both spatial and temporal features. Unlike traditional 3D models, which analyze single-time points, OmniMamba4D processes 4D CT data, providing comprehensive spatio-temporal information on lesion progression. Evaluated on an internal dataset comprising of 3,252 CT scans, OmniMamba4D achieves a competitive Dice score of 0.682, comparable to state-of-the-arts (SOTA) models, while maintaining computational efficiency and better detecting disappeared lesions. This work demonstrates a new framework to leverage spatio-temporal information for longitudinal CT lesion segmentation.
Since human and environmental factors interfere, captured polyp images usually suffer from issues such as dim lighting, blur, and overexposure, which pose challenges for downstream polyp segmentation tasks. To address the challenges of noise-induced degradation in polyp images, we present AgentPolyp, a novel framework integrating CLIP-based semantic guidance and dynamic image enhancement with a lightweight neural network for segmentation. The agent first evaluates image quality using CLIP-driven semantic analysis (e.g., identifying ``low-contrast polyps with vascular textures") and adapts reinforcement learning strategies to dynamically apply multi-modal enhancement operations (e.g., denoising, contrast adjustment). A quality assessment feedback loop optimizes pixel-level enhancement and segmentation focus in a collaborative manner, ensuring robust preprocessing before neural network segmentation. This modular architecture supports plug-and-play extensions for various enhancement algorithms and segmentation networks, meeting deployment requirements for endoscopic devices.
Posidonia oceanica meadows are a species of seagrass highly dependent on rocks for their survival and conservation. In recent years, there has been a concerning global decline in this species, emphasizing the critical need for efficient monitoring and assessment tools. While deep learning-based semantic segmentation and visual automated monitoring systems have shown promise in a variety of applications, their performance in underwater environments remains challenging due to complex water conditions and limited datasets. This paper introduces a framework that combines machine learning and computer vision techniques to enable an autonomous underwater vehicle (AUV) to inspect the boundaries of Posidonia oceanica meadows autonomously. The framework incorporates an image segmentation module using an existing Mask R-CNN model and a strategy for Posidonia oceanica meadow boundary tracking. Furthermore, a new class dedicated to rocks is introduced to enhance the existing model, aiming to contribute to a comprehensive monitoring approach and provide a deeper understanding of the intricate interactions between the meadow and its surrounding environment. The image segmentation model is validated using real underwater images, while the overall inspection framework is evaluated in a realistic simulation environment, replicating actual monitoring scenarios with real underwater images. The results demonstrate that the proposed framework enables the AUV to autonomously accomplish the main tasks of underwater inspection and segmentation of rocks. Consequently, this work holds significant potential for the conservation and protection of marine environments, providing valuable insights into the status of Posidonia oceanica meadows and supporting targeted preservation efforts
This work tackles the challenge of continuous sign language segmentation, a key task with huge implications for sign language translation and data annotation. We propose a transformer-based architecture that models the temporal dynamics of signing and frames segmentation as a sequence labeling problem using the Begin-In-Out (BIO) tagging scheme. Our method leverages the HaMeR hand features, and is complemented with 3D Angles. Extensive experiments show that our model achieves state-of-the-art results on the DGS Corpus, while our features surpass prior benchmarks on BSLCorpus.
While MLLMs have demonstrated adequate image understanding capabilities, they still struggle with pixel-level comprehension, limiting their practical applications. Current evaluation tasks like VQA and visual grounding remain too coarse to assess fine-grained pixel comprehension accurately. Though segmentation is foundational for pixel-level understanding, existing methods often require MLLMs to generate implicit tokens, decoded through external pixel decoders. This approach disrupts the MLLM's text output space, potentially compromising language capabilities and reducing flexibility and extensibility, while failing to reflect the model's intrinsic pixel-level understanding. Thus, we introduce the Human-Like Mask Annotation Task (HLMAT), a new paradigm where MLLMs mimic human annotators using interactive segmentation tools. Modeling segmentation as a multi-step Markov Decision Process, HLMAT enables MLLMs to iteratively generate text-based click points, achieving high-quality masks without architectural changes or implicit tokens. Through this setup, we develop SegAgent, a model fine-tuned on human-like annotation trajectories, which achieves performance comparable to state-of-the-art (SOTA) methods and supports additional tasks like mask refinement and annotation filtering. HLMAT provides a protocol for assessing fine-grained pixel understanding in MLLMs and introduces a vision-centric, multi-step decision-making task that facilitates exploration of MLLMs' visual reasoning abilities. Our adaptations of policy improvement method StaR and PRM-guided tree search further enhance model robustness in complex segmentation tasks, laying a foundation for future advancements in fine-grained visual perception and multi-step decision-making for MLLMs.