Pose diversity is an inherent representative characteristic of 2D images. Due to the 3D to 2D projection mechanism, there is evident content discrepancy among distinct pose images. This is the main obstacle bothering pose transformation related researches. To deal with this challenge, we propose a fine-grained incremental evolution centered pose generation framework, rather than traditional direct one-to-one in a rush. Since proposed approach actually bypasses the theoretical difficulty of directly modeling dramatic non-linear variation, the incurred content distortion and blurring could be effectively constrained, at the same time the various individual pose details, especially clothes texture, could be precisely maintained. In order to systematically guide the evolution course, both global and incremental evolution constraints are elaborately designed and merged into the overall framework. And a novel triple-path knowledge fusion structure is worked out to take full advantage of all available valuable knowledge to conduct high-quality pose synthesis. In addition, our framework could generate a series of valuable byproducts, namely the various intermediate poses. Extensive experiments have been conducted to verify the effectiveness of the proposed approach. Code is available at https://github.com/Xiaofei-CN/Incremental-Evolution-Pose-Generation.
Text-to-image (T2I) models achieve high-fidelity generation through extensive training on large datasets. However, these models may unintentionally pick up undesirable biases of their training data, such as over-representation of particular identities in gender or ethnicity neutral prompts. Existing alignment methods such as Reinforcement Learning from Human Feedback (RLHF) and Direct Preference Optimization (DPO) fail to address this problem effectively because they operate on pairwise preferences consisting of individual samples, while the aforementioned biases can only be measured at a population level. For example, a single sample for the prompt "doctor" could be male or female, but a model generating predominantly male doctors even with repeated sampling reflects a gender bias. To address this limitation, we introduce PopAlign, a novel approach for population-level preference optimization, while standard optimization would prefer entire sets of samples over others. We further derive a stochastic lower bound that directly optimizes for individual samples from preferred populations over others for scalable training. Using human evaluation and standard image quality and bias metrics, we show that PopAlign significantly mitigates the bias of pretrained T2I models while largely preserving the generation quality. Code is available at https://github.com/jacklishufan/PopAlignSDXL.
Recent breakthroughs in text-to-image diffusion models have significantly advanced the generation of high-fidelity, photo-realistic images from textual descriptions. Yet, these models often struggle with interpreting spatial arrangements from text, hindering their ability to produce images with precise spatial configurations. To bridge this gap, layout-to-image generation has emerged as a promising direction. However, training-based approaches are limited by the need for extensively annotated datasets, leading to high data acquisition costs and a constrained conceptual scope. Conversely, training-free methods face challenges in accurately locating and generating semantically similar objects within complex compositions. This paper introduces a novel training-free approach designed to overcome adversarial semantic intersections during the diffusion conditioning phase. By refining intra-token loss with selective sampling and enhancing the diffusion process with attention redistribution, we propose two innovative constraints: 1) an inter-token constraint that resolves token conflicts to ensure accurate concept synthesis; and 2) a self-attention constraint that improves pixel-to-pixel relationships. Our evaluations confirm the effectiveness of leveraging layout information for guiding the diffusion process, generating content-rich images with enhanced fidelity and complexity. Code is available at https://github.com/Papple-F/csg.git.
Mass spectrometry plays a fundamental role in elucidating the structures of unknown molecules and subsequent scientific discoveries. One formulation of the structure elucidation task is the conditional de novo generation of molecular structure given a mass spectrum. Toward a more accurate and efficient scientific discovery pipeline for small molecules, we present DiffMS, a formula-restricted encoder-decoder generative network that achieves state-of-the-art performance on this task. The encoder utilizes a transformer architecture and models mass spectra domain knowledge such as peak formulae and neutral losses, and the decoder is a discrete graph diffusion model restricted by the heavy-atom composition of a known chemical formula. To develop a robust decoder that bridges latent embeddings and molecular structures, we pretrain the diffusion decoder with fingerprint-structure pairs, which are available in virtually infinite quantities, compared to structure-spectrum pairs that number in the tens of thousands. Extensive experiments on established benchmarks show that DiffMS outperforms existing models on de novo molecule generation. We provide several ablations to demonstrate the effectiveness of our diffusion and pretraining approaches and show consistent performance scaling with increasing pretraining dataset size. DiffMS code is publicly available at https://github.com/coleygroup/DiffMS.
Underwater dense prediction, especially depth estimation and semantic segmentation, is crucial for gaining a comprehensive understanding of underwater scenes. Nevertheless, high-quality and large-scale underwater datasets with dense annotations remain scarce because of the complex environment and the exorbitant data collection costs. This paper proposes a unified Text-to-Image and DEnse annotation generation method (TIDE) for underwater scenes. It relies solely on text as input to simultaneously generate realistic underwater images and multiple highly consistent dense annotations. Specifically, we unify the generation of text-to-image and text-to-dense annotations within a single model. The Implicit Layout Sharing mechanism (ILS) and cross-modal interaction method called Time Adaptive Normalization (TAN) are introduced to jointly optimize the consistency between image and dense annotations. We synthesize a large-scale underwater dataset using TIDE to validate the effectiveness of our method in underwater dense prediction tasks. The results demonstrate that our method effectively improves the performance of existing underwater dense prediction models and mitigates the scarcity of underwater data with dense annotations. We hope our method can offer new perspectives on alleviating data scarcity issues in other fields. The code is available at https: //github.com/HongkLin/TIDE.
Can we leverage LLMs to model the process of discovering novel language model (LM) architectures? Inspired by real research, we propose a multi-agent LLM approach that simulates the conventional stages of research, from ideation and literature search (proposal stage) to design implementation (code generation), generative pre-training, and downstream evaluation (verification). Using ideas from scaling laws, our system, Genesys, employs a Ladder of Scales approach; new designs are proposed, adversarially reviewed, implemented, and selectively verified at increasingly larger model scales (14M$\sim$350M parameters) with a narrowing budget (the number of models we can train at each scale). To help make discovery efficient and factorizable, Genesys uses a novel genetic programming backbone, which we show has empirical advantages over commonly used direct prompt generation workflows (e.g., $\sim$86\% percentage point improvement in successful design generation, a key bottleneck). We report experiments involving 1,162 newly discovered designs (1,062 fully verified through pre-training) and find the best designs to be highly competitive with known architectures (e.g., outperform GPT2, Mamba2, etc., on 6/9 common benchmarks). We couple these results with comprehensive system-level ablations and formal results, which give broader insights into the design of effective autonomous discovery systems.
Generating diverse and natural human motion sequences based on textual descriptions constitutes a fundamental and challenging research area within the domains of computer vision, graphics, and robotics. Despite significant advancements in this field, current methodologies often face challenges regarding zero-shot generalization capabilities, largely attributable to the limited size of training datasets. Moreover, the lack of a comprehensive evaluation framework impedes the advancement of this task by failing to identify directions for improvement. In this work, we aim to push text-to-motion into a new era, that is, to achieve the generalization ability of zero-shot. To this end, firstly, we develop an efficient annotation pipeline and introduce MotionMillion-the largest human motion dataset to date, featuring over 2,000 hours and 2 million high-quality motion sequences. Additionally, we propose MotionMillion-Eval, the most comprehensive benchmark for evaluating zero-shot motion generation. Leveraging a scalable architecture, we scale our model to 7B parameters and validate its performance on MotionMillion-Eval. Our results demonstrate strong generalization to out-of-domain and complex compositional motions, marking a significant step toward zero-shot human motion generation. The code is available at https://github.com/VankouF/MotionMillion-Codes.
Recent advancements in text-to-image generation models have excelled in creating diverse and realistic images. This success extends to food imagery, where various conditional inputs like cooking styles, ingredients, and recipes are utilized. However, a yet-unexplored challenge is generating a sequence of procedural images based on cooking steps from a recipe. This could enhance the cooking experience with visual guidance and possibly lead to an intelligent cooking simulation system. To fill this gap, we introduce a novel task called \textbf{cooking procedural image generation}. This task is inherently demanding, as it strives to create photo-realistic images that align with cooking steps while preserving sequential consistency. To collectively tackle these challenges, we present \textbf{CookingDiffusion}, a novel approach that leverages Stable Diffusion and three innovative Memory Nets to model procedural prompts. These prompts encompass text prompts (representing cooking steps), image prompts (corresponding to cooking images), and multi-modal prompts (mixing cooking steps and images), ensuring the consistent generation of cooking procedural images. To validate the effectiveness of our approach, we preprocess the YouCookII dataset, establishing a new benchmark. Our experimental results demonstrate that our model excels at generating high-quality cooking procedural images with remarkable consistency across sequential cooking steps, as measured by both the FID and the proposed Average Procedure Consistency metrics. Furthermore, CookingDiffusion demonstrates the ability to manipulate ingredients and cooking methods in a recipe. We will make our code, models, and dataset publicly accessible.
Machine learning supports materials design, atomistic simulation and experimental characterization, yet models and workflows remain fragmented. We present PaddleMaterials, an open-source framework integrating heterogeneous materials-learning tasks while preserving task-specific representations and scientific semantics. It unifies data processing, training, evaluation, pretrained-model management and workflows across six task classes: property prediction, structure generation, machine-learning interatomic potentials, electronic-structure fields, spectrum elucidation and microscopy image processing. Task interfaces record physical quantities, units, aggregation conventions and references, making cross-task composition verifiable. A shared compiler backend enables switching from dynamic-graph to compiled execution through one setting, using graph optimization, operator fusion and hardware-targeted code generation without changing model definitions. Across 65 model instances in 11 groups, compiled execution accelerated every instance in eight groups, with group median speedups of 11%-224% and group maximum speedups of 11%-336%. Case studies on LiMnO2 and toluene link structure generation or spectrum elucidation, interatomic-potential relaxation, property prediction and electron-density prediction, using same-geometry density functional theory (DFT) calculations as references. For LiMnO2, predicted formation energies for generated and relaxed structures differed from same-geometry PBE+U references by at most 7 meV per atom, while the computational cost of model steps was less than one-twentieth of a DFT single-point calculation. PaddleMaterials extends unified materials workflows beyond conventional property, potential and structure-generation tasks while supporting verifiable cross-task operations and compiled execution.
Test-driven development (TDD) is the practice of writing tests first and coding later, and the proponents of TDD expound its numerous benefits. For instance, given an issue on a source code repository, tests can clarify the desired behavior among stake-holders before anyone writes code for the agreed-upon fix. Although there has been a lot of work on automated test generation for the practice "write code first, test later", there has been little such automation for TDD. Ideally, tests for TDD should be fail-to-pass (i.e., fail before the issue is resolved and pass after) and have good adequacy with respect to covering the code changed during issue resolution. This paper introduces TDD-Bench Verified, a high-quality benchmark suite of 449 issues mined from real-world GitHub code repositories. The benchmark's evaluation harness runs only relevant tests in isolation for simple yet accurate coverage measurements, and the benchmark's dataset is filtered both by human judges and by execution in the harness. This paper also presents Auto-TDD, an LLM-based solution that takes as input an issue description and a codebase (prior to issue resolution) and returns as output a test that can be used to validate the changes made for resolving the issue. Our evaluation shows that Auto-TDD yields a better fail-to-pass rate than the strongest prior work while also yielding high coverage adequacy. Overall, we hope that this work helps make developers more productive at resolving issues while simultaneously leading to more robust fixes.
Dialogue systems for non-English languages have long been under-explored. In this paper, we take the first step to investigate few-shot cross-lingual transfer learning (FS-XLT) and multitask learning (MTL) in the context of open-domain dialogue generation for non-English languages with limited data. We observed catastrophic forgetting in both FS-XLT and MTL for all 6 languages in our preliminary experiments. To mitigate the issue, we propose a simple yet effective prompt learning approach that can preserve the multilinguality of multilingual pre-trained language model (mPLM) in FS-XLT and MTL by bridging the gap between pre-training and fine-tuning with Fixed-prompt LM Tuning and our hand-crafted prompts. Experimental results on all 6 languages in terms of both automatic and human evaluations demonstrate the effectiveness of our approach. Our code is available at https://github.com/JeremyLeiLiu/XLinguDial.
Retrieving proper domain knowledge from an external database lies at the heart of end-to-end task-oriented dialog systems to generate informative responses. Most existing systems blend knowledge retrieval with response generation and optimize them with direct supervision from reference responses, leading to suboptimal retrieval performance when the knowledge base becomes large-scale. To address this, we propose to decouple knowledge retrieval from response generation and introduce a multi-grained knowledge retriever (MAKER) that includes an entity selector to search for relevant entities and an attribute selector to filter out irrelevant attributes. To train the retriever, we propose a novel distillation objective that derives supervision signals from the response generator. Experiments conducted on three standard benchmarks with both small and large-scale knowledge bases demonstrate that our retriever performs knowledge retrieval more effectively than existing methods. Our code has been made publicly available.\footnote{https://github.com/18907305772/MAKER}
To fully leverage the capabilities of diffusion models, we are often interested in optimizing downstream reward functions during inference. While numerous algorithms for reward-guided generation have been recently proposed due to their significance, current approaches predominantly focus on single-shot generation, transitioning from fully noised to denoised states. We propose a novel framework for inference-time reward optimization with diffusion models inspired by evolutionary algorithms. Our approach employs an iterative refinement process consisting of two steps in each iteration: noising and reward-guided denoising. This sequential refinement allows for the gradual correction of errors introduced during reward optimization. Besides, we provide a theoretical guarantee for our framework. Finally, we demonstrate its superior empirical performance in protein and cell-type-specific regulatory DNA design. The code is available at \href{https://github.com/masa-ue/ProDifEvo-Refinement}{https://github.com/masa-ue/ProDifEvo-Refinement}.
Large language models have been used to translate natural language questions to SQL queries. Without hard constraints on syntax and database schema, they occasionally produce invalid queries that are not executable. These failures limit the usage of these systems in real-life scenarios. We propose a neurosymbolic framework that imposes SQL syntax and schema constraints with unification-based definite clause grammars and thus guarantees the generation of valid queries. Our framework also builds a bi-directional interface to language models to leverage their natural language understanding abilities. The evaluation results on a subset of SQL grammars show that all our output queries are valid. This work is the first step towards extending language models with unification-based grammars. We demonstrate this extension enhances the validity, execution accuracy, and ground truth alignment of the underlying language model by a large margin. Our code is available at https://github.com/ML-KULeuven/deepstochlog-lm.
Uniform-state discrete diffusion models hold the promise of fast text generation due to their inherent ability to self-correct. However, they are typically outperformed by autoregressive models and masked diffusion models. In this work, we narrow this performance gap by leveraging a key insight: Uniform-state diffusion processes naturally emerge from an underlying Gaussian diffusion. Our method, Duo, transfers powerful techniques from Gaussian diffusion to improve both training and sampling. First, we introduce a curriculum learning strategy guided by the Gaussian process, doubling training speed by reducing variance. Models trained with curriculum learning surpass autoregressive models in zero-shot perplexity on 3 of 7 benchmarks. Second, we present Discrete Consistency Distillation, which adapts consistency distillation from the continuous to the discrete setting. This algorithm unlocks few-step generation in diffusion language models by accelerating sampling by two orders of magnitude. We provide the code and model checkpoints on the project page: http://s-sahoo.github.io/duo
In this work, we extend the SEEDS superpixel algorithm from 2D images to 3D volumes, resulting in 3D SEEDS, a faster, better, and open-source supervoxel algorithm for medical image analysis. We compare 3D SEEDS with the widely used supervoxel algorithm SLIC on 13 segmentation tasks across 10 organs. 3D SEEDS accelerates supervoxel generation by a factor of 10, improves the achievable Dice score by +6.5%, and reduces the under-segmentation error by -0.16%. The code is available at https://github.com/Zch0414/3d_seeds
In today’s fast-paced software development environment, Agile methodologies demand rapid delivery and continuous improvement, making automated testing essential for maintaining quality and accelerating feedback loops. Our study addresses the challenges of developing and maintaining automation code for web-based application testing. In this paper, we propose a novel approach that leverages large language models (LLMs) and a novel prompt technique, few-shot chain, to automate code generation for web application testing. We chose the Behavior-Driven Development (BDD) methodology owing to its advantages and selected the Cypress tool for automating web application testing, as it is one of the most popular and rapidly growing frameworks in this domain. We comprehensively evaluated various OpenAI models, including GPT-4-Turbo, GPT-4o, and GitHub Copilot, using zero-shot and few-shot chain prompt techniques. Furthermore, we extensively validated with a vast set of test cases to identify the optimal approach. Our results indicate that the Cypress automation code generated by GPT-4o using a few-shot chained prompt approach excels in generating complete code for each test case, with fewer empty methods and improved syntactical accuracy and maintainability. Based on these findings, we developed a novel open-source Visual Studio Code (IDE) extension, “Cypress Copilot” utilizing GPT-4o and a few-shot chain prompt technique, which has shown promising results. Finally, we validate the Cypress Copilot tool by generating automation code for end-to-end web tests, demonstrating its effectiveness in testing various web applications and its ability to streamline development processes. More importantly, we are releasing this tool to the open-source community, as it has the potential to be a promising partner in enhancing productivity in web application automation testing.
Motivation: High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and B-cell receptors of any specific nucleotide sequence. These generation probabilities are very non-homogeneous, ranging over 20 orders of magnitude in real repertoires. Since the function of a receptor really depends on its protein sequence, it is important to be able to predict this probability of generation at the amino acid level. However, brute-force summation over all the nucleotide sequences with the correct amino acid translation is computationally intractable. The purpose of this paper is to present a solution to this problem. Results: We use dynamic programming to construct an efficient and flexible algorithm, called OLGA (Optimized Likelihood estimate of immunoGlobulin Amino-acid sequences), for calculating the probability of generating a given CDR3 amino acid sequence or motif, with or without V/J restriction, as a result of V(D)J recombination in B or T cells. We apply it to databases of epitope-specific T-cell receptors to evaluate the probability that a typical human subject will possess T cells responsive to specific disease-associated epitopes. The model prediction shows an excellent agreement with published data. We suggest that OLGA may be a useful tool to guide vaccine design. Availability: Source code is available at https://github.com/zsethna/OLGA
Advances in 3D imaging technology in recent years have allowed for increasingly high resolution volumetric images of large specimen. The resulting datasets of hundreds of Gigabytes in size call for new scalable and memory efficient approaches in the field of image processing, where some progress has been made already. At the same time, quantitative evaluation of these new methods is difficult both in terms of the availability of specific data sizes and in the generation of associated ground truth data. In this paper we present an algorithmic framework that can be used to efficiently generate test (and ground truth) volume data, optionally even in a streaming fashion. As the proposed nested sweeps algorithm is fast, it can be used to generate test data on demand. We analyze the asymptotic run time of the presented algorithm and compare it experimentally to alternative approaches as well as a hypothetical best-case baseline method. In a case study, the framework is applied to the popular VascuSynth software for vascular image generation, making it capable of efficiently producing larger-than-main memory volumes which is demonstrated by generating a trillion voxel (1TB) image. Implementations of the presented framework are available online in the form of the modified version of Vascusynth and the code used for the experimental evaluation. In addition, the test data generation procedure has been integrated into the popular volume rendering and processing framework Voreen.
Whistle contour extraction aims to derive animal whistles from time-frequency spectrograms as polylines. For toothed whales, whistle extraction results can serve as the basis for analyzing animal abundance, species identity, and social activities. During the last few decades, as long-term recording systems have become affordable, automated whistle extraction algorithms were proposed to process large volumes of recording data. Recently, a deep learning-based method demonstrated superior performance in extracting whistles under varying noise conditions. However, training such networks requires a large amount of labor-intensive annotation, which is not available for many species. To overcome this limitation, we present a framework of stage-wise generative adversarial networks (GANs), which compile new whistle data suitable for deep model training via three stages: generation of background noise in the spectrogram, generation of whistle contours, and generation of whistle signals. By separating the generation of different components in the samples, our framework composes visually promising whistle data and labels even when few expert annotated data are available. Regardless of the amount of human-annotated data, the proposed data augmentation framework leads to a consistent improvement in performance of the whistle extraction model, with a maximum increase of 1.69 in the whistle extraction mean F1-score. Our stage-wise GAN also surpasses one single GAN in improving whistle extraction models with augmented data. The data and code will be available at https://github.com/Paul-LiPu/CompositeGAN\_WhistleAugment.