Pixel-level annotation is expensive and time-consuming. Semi-supervised segmentation methods address this challenge by learning models on few labeled images alongside a large corpus of unlabeled images. Although foundation models could further account for label scarcity, effective mechanisms for their exploitation remain underexplored. We address this by devising a novel semi-supervised panoptic approach fueled by two dedicated foundation models. We enhance recognition by complementing unsupervised mask-transformer consistency with zero-shot classification of CLIP features. We enhance localization by class-agnostic decoder warm-up with respect to SAM pseudo-labels. The resulting decoupled enhancement of recognition and localization (DEARLi) particularly excels in the most challenging semi-supervised scenarios with large taxonomies and limited labeled data. Moreover, DEARLi outperforms the state of the art in semi-supervised semantic segmentation by a large margin while requiring 8x less GPU memory, in spite of being trained only for the panoptic objective. We observe 29.9 PQ and 38.9 mIoU on ADE20K with only 158 labeled images. The source code is available at https://github.com/helen1c/DEARLi.
Human Activity Recognition (HAR), which uses data from Inertial Measurement Unit (IMU) sensors, has many practical applications in healthcare and assisted living environments. However, its use in real-world scenarios has been limited by the lack of comprehensive IMU-based HAR datasets that cover a wide range of activities and the lack of transparency in existing HAR models. Zero-shot HAR (ZS-HAR) overcomes the data limitations, but current models struggle to explain their decisions, making them less transparent. This paper introduces a novel IMU-based ZS-HAR model called the Self-Explainable Zero-shot Human Activity Recognition Network (SEZ-HARN). It can recognize activities not encountered during training and provide skeleton videos to explain its decision-making process. We evaluate the effectiveness of the proposed SEZ-HARN on four benchmark datasets PAMAP2, DaLiAc, HTD-MHAD and MHealth and compare its performance against three state-of-the-art black-box ZS-HAR models. The experiment results demonstrate that SEZ-HARN produces realistic and understandable explanations while achieving competitive Zero-shot recognition accuracy. SEZ-HARN achieves a Zero-shot prediction accuracy within 3\% of the best-performing black-box model on PAMAP2 while maintaining comparable performance on the other three datasets.
Adapting a single agent to a new multi-agent system brings challenges, necessitating adjustments across various tasks, environments, and interactions with unknown teammates and opponents. Addressing this challenge is highly complex, and researchers have proposed two simplified scenarios, Multi-agent reinforcement learning for zero-shot learning and Ad-Hoc Teamwork. Building on these foundations, we propose a more comprehensive setting, Agent Collaborative-Competitive Adaptation (ACCA), which evaluates an agent to generalize across diverse scenarios, tasks, and interactions with both unfamiliar opponents and teammates. In ACCA, agents adjust to task and environmental changes, collaborate with unseen teammates, and compete against unknown opponents. We introduce a new modeling approach, Multi-Retrieval and Dynamic Generation (MRDG), that effectively models both teammates and opponents using their behavioral trajectories. This method incorporates a positional encoder for varying team sizes and a hypernetwork module to boost agents' learning and adaptive capabilities. Additionally, a viewpoint alignment module harmonizes the observational perspectives of retrieved teammates and opponents with the learning agent. Extensive tests in benchmark scenarios like SMAC, Overcooked-AI, and Melting Pot show that MRDG significantly improves robust collaboration and competition with unseen teammates and opponents, surpassing established baselines. Our code is available at: https://github.com/vcis-wangchenxu/MRDG.git
As large language models (LLMs) continue to revolutionize AI research, there is a growing interest in building large-scale brain foundation models to advance neuroscience. While most existing brain foundation models are pre-trained on time-series signals or region-of-interest (ROI) features, we propose a novel graph-based pre-training paradigm for constructing a brain graph foundation model. In this paper, we introduce the Brain Graph Foundation Model, termed BrainGFM, a unified framework that leverages graph contrastive learning and graph masked autoencoders for large-scale fMRI-based pre-training. BrainGFM is pre-trained on a diverse mixture of brain atlases with varying parcellations, significantly expanding the pre-training corpus and enhancing the model's ability to generalize across heterogeneous fMRI-derived brain representations. To support efficient and versatile downstream transfer, we integrate both graph prompts and language prompts into the model design, enabling BrainGFM to flexibly adapt to a wide range of atlases, neurological and psychiatric disorders, and task settings. Furthermore, we employ meta-learning to optimize the graph prompts, facilitating strong generalization to previously unseen disorders under both few-shot and zero-shot learning conditions via language-guided prompting. BrainGFM is pre-trained on 27 neuroimaging datasets spanning 25 common neurological and psychiatric disorders, encompassing 2 types of brain atlases (functional and anatomical) across 8 widely-used parcellations, and covering over 25,000 subjects, 60,000 fMRI scans, and a total of 400,000 graph samples aggregated across all atlases and parcellations. The code is available at: https://github.com/weixinxu666/BrainGFM
Medical vision-language alignment through cross-modal contrastive learning shows promising performance in image-text matching tasks, such as retrieval and zero-shot classification. However, conventional cross-modal contrastive learning (CLIP-based) methods suffer from suboptimal visual representation capabilities, which also limits their effectiveness in vision-language alignment. In contrast, although the models pretrained via multimodal masked modeling struggle with direct cross-modal matching, they excel in visual representation. To address this contradiction, we propose ALTA (ALign Through Adapting), an efficient medical vision-language alignment method that utilizes only about 8% of the trainable parameters and less than 1/5 of the computational consumption required for masked record modeling. ALTA achieves superior performance in vision-language matching tasks like retrieval and zero-shot classification by adapting the pretrained vision model from masked record modeling. Additionally, we integrate temporal-multiview radiograph inputs to enhance the information consistency between radiographs and their corresponding descriptions in reports, further improving the vision-language alignment. Experimental evaluations show that ALTA outperforms the best-performing counterpart by over 4% absolute points in text-to-image accuracy and approximately 6% absolute points in image-to-text retrieval accuracy. The adaptation of vision-language models during efficient alignment also promotes better vision and language understanding. Code is publicly available at https://github.com/DopamineLcy/ALTA.
Foundational to the Chinese language and culture, Chinese characters encompass extraordinarily extensive and ever-expanding categories, with the latest Chinese GB18030-2022 standard containing 87,887 categories. The accurate recognition of this vast number of characters, termed mega-category recognition, presents a formidable yet crucial challenge for cultural heritage preservation and digital applications. Despite significant advances in Optical Character Recognition (OCR), mega-category recognition remains unexplored due to the absence of comprehensive datasets, with the largest existing dataset containing merely 16,151 categories. To bridge this critical gap, we introduce MegaHan97K, a mega-category, large-scale dataset covering an unprecedented 97,455 categories of Chinese characters. Our work offers three major contributions: (1) MegaHan97K is the first dataset to fully support the latest GB18030-2022 standard, providing at least six times more categories than existing datasets; (2) It effectively addresses the long-tail distribution problem by providing balanced samples across all categories through its three distinct subsets: handwritten, historical and synthetic subsets; (3) Comprehensive benchmarking experiments reveal new challenges in mega-category scenarios, including increased storage demands, morphologically similar character recognition, and zero-shot learning difficulties, while also unlocking substantial opportunities for future research. To the best of our knowledge, the MetaHan97K is likely the dataset with the largest classes not only in the field of OCR but may also in the broader domain of pattern recognition. The dataset is available at https://github.com/SCUT-DLVCLab/MegaHan97K.
Classifying geospatial imagery remains a major bottleneck for applications such as disaster response and land-use monitoring-particularly in regions where annotated data is scarce or unavailable. Existing tools (e.g., RS-CLIP) that claim zero-shot classification capabilities for satellite imagery nonetheless rely on task-specific pretraining and adaptation to reach competitive performance. We introduce GeoVision Labeler (GVL), a strictly zero-shot classification framework: a vision Large Language Model (vLLM) generates rich, human-readable image descriptions, which are then mapped to user-defined classes by a conventional Large Language Model (LLM). This modular, and interpretable pipeline enables flexible image classification for a large range of use cases. We evaluated GVL across three benchmarks-SpaceNet v7, UC Merced, and RESISC45. It achieves up to 93.2% zero-shot accuracy on the binary Buildings vs. No Buildings task on SpaceNet v7. For complex multi-class classification tasks (UC Merced, RESISC45), we implemented a recursive LLM-driven clustering to form meta-classes at successive depths, followed by hierarchical classification-first resolving coarse groups, then finer distinctions-to deliver competitive zero-shot performance. GVL is open-sourced at https://github.com/microsoft/geo-vision-labeler to catalyze adoption in real-world geospatial workflows.
Contrastive Language-Image Pretraining (CLIP) has demonstrated strong zero-shot performance across diverse downstream text-image tasks. Existing CLIP methods typically optimize a contrastive objective using negative samples drawn from each minibatch. To achieve robust representation learning, these methods require extremely large batch sizes and escalate computational demands to hundreds or even thousands of GPUs. Prior approaches to mitigate this issue often compromise downstream performance, prolong training duration, or face scalability challenges with very large datasets. To overcome these limitations, we propose AmorLIP, an efficient CLIP pretraining framework that amortizes expensive computations involved in contrastive learning through lightweight neural networks, which substantially improves training efficiency and performance. Leveraging insights from a spectral factorization of energy-based models, we introduce novel amortization objectives along with practical techniques to improve training stability. Extensive experiments across 38 downstream tasks demonstrate the superior zero-shot classification and retrieval capabilities of AmorLIP, consistently outperforming standard CLIP baselines with substantial relative improvements of up to 12.24%.
We present CrypticBio, the largest publicly available multimodal dataset of visually confusing species, specifically curated to support the development of AI models in the context of biodiversity applications. Visually confusing or cryptic species are groups of two or more taxa that are nearly indistinguishable based on visual characteristics alone. While much existing work addresses taxonomic identification in a broad sense, datasets that directly address the morphological confusion of cryptic species are small, manually curated, and target only a single taxon. Thus, the challenge of identifying such subtle differences in a wide range of taxa remains unaddressed. Curated from real-world trends in species misidentification among community annotators of iNaturalist, CrypticBio contains 52K unique cryptic groups spanning 67K species, represented in 166 million images. Rich research-grade image annotations--including scientific, multicultural, and multilingual species terminology, hierarchical taxonomy, spatiotemporal context, and associated cryptic groups--address multimodal AI in biodiversity research. For easy dataset curation, we provide an open-source pipeline CrypticBio-Curate. The multimodal nature of the dataset beyond vision-language arises from the integration of geographical and temporal data as complementary cues to identifying cryptic species. To highlight the importance of the dataset, we benchmark a suite of state-of-the-art foundation models across CrypticBio subsets of common, unseen, endangered, and invasive species, and demonstrate the substantial impact of geographical context on vision-language zero-shot learning for cryptic species. By introducing CrypticBio, we aim to catalyze progress toward real-world-ready biodiversity AI models capable of handling the nuanced challenges of species ambiguity.
Remarkable progress in zero-shot learning (ZSL) has been achieved using generative models. However, existing generative ZSL methods merely generate (imagine) the visual features from scratch guided by the strong class semantic vectors annotated by experts, resulting in suboptimal generative performance and limited scene generalization. To address these and advance ZSL, we propose an inductive variational autoencoder for generative zero-shot learning, dubbed GenZSL. Mimicking human-level concept learning, GenZSL operates by inducting new class samples from similar seen classes using weak class semantic vectors derived from target class names (i.e., CLIP text embedding). To ensure the generation of informative samples for training an effective ZSL classifier, our GenZSL incorporates two key strategies. Firstly, it employs class diversity promotion to enhance the diversity of class semantic vectors. Secondly, it utilizes target class-guided information boosting criteria to optimize the model. Extensive experiments conducted on three popular benchmark datasets showcase the superiority and potential of our GenZSL with significant efficacy and efficiency over f-VAEGAN, e.g., 24.7% performance gains and more than $60\times$ faster training speed on AWA2. Codes are available at https://github.com/shiming-chen/GenZSL.
Pretrained vision-language models (VLMs), e.g., CLIP, demonstrate impressive zero-shot capabilities on downstream tasks. Prior research highlights the crucial role of visual augmentation techniques, like random cropping, in alignment with fine-grained class descriptions generated by large language models (LLMs), significantly enhancing zero-shot performance by incorporating multi-view information. However, the inherent randomness of these augmentations can inevitably introduce background artifacts and cause models to overly focus on local details, compromising global semantic understanding. To address these issues, we propose an \textbf{A}ttention-\textbf{B}ased \textbf{S}election (\textbf{ABS}) method from local details to global context, which applies attention-guided cropping in both raw images and feature space, supplement global semantic information through strategic feature selection. Additionally, we introduce a soft matching technique to effectively filter LLM descriptions for better alignment. \textbf{ABS} achieves state-of-the-art performance on out-of-distribution generalization and zero-shot classification tasks. Notably, \textbf{ABS} is training-free and even rivals few-shot and test-time adaptation methods. Our code is available at \href{https://github.com/BIT-DA/ABS}{\textcolor{darkgreen}{https://github.com/BIT-DA/ABS}}.
Learning robust representations from data often requires scale, which has led to the success of recent zero-shot models such as CLIP. However, the obtained robustness can easily be deteriorated when these models are fine-tuned on other downstream tasks (e.g., of smaller scales). Previous works often interpret this phenomenon in the context of domain shift, developing fine-tuning methods that aim to preserve the original domain as much as possible. However, in a different context, fine-tuned models with limited data are also prone to learning features that are spurious to humans, such as background or texture. In this paper, we propose StarFT (Spurious Textual Alignment Regularization), a novel framework for fine-tuning zero-shot models to enhance robustness by preventing them from learning spuriosity. We introduce a regularization that aligns the output distribution for spuriosity-injected labels with the original zero-shot model, ensuring that the model is not induced to extract irrelevant features further from these descriptions. We leverage recent language models to get such spuriosity-injected labels by generating alternative textual descriptions that highlight potentially confounding features. Extensive experiments validate the robust generalization of StarFT and its emerging properties: zero-shot group robustness and improved zero-shot classification. Notably, StarFT boosts both worst-group and average accuracy by 14.30% and 3.02%, respectively, in the Waterbirds group shift scenario, where other robust fine-tuning baselines show even degraded performance.
Pre-trained vision-language models such as contrastive language-image pre-training (CLIP) have demonstrated a remarkable generalizability, which has enabled a wide range of applications represented by zero-shot classification. However, vision-language models still suffer when they face datasets with large gaps from training ones, i.e., distribution shifts. We found that CLIP is especially vulnerable to sensor degradation, a type of realistic distribution shift caused by sensor conditions such as weather, light, or noise. Collecting a new dataset from a test distribution for fine-tuning highly costs since sensor degradation occurs unexpectedly and has a range of variety. Thus, we investigate test-time adaptation (TTA) of zero-shot classification, which enables on-the-fly adaptation to the test distribution with unlabeled test data. Existing TTA methods for CLIP mainly focus on modifying image and text embeddings or predictions to address distribution shifts. Although these methods can adapt to domain shifts, such as fine-grained labels spaces or different renditions in input images, they fail to adapt to distribution shifts caused by sensor degradation. We found that this is because image embeddings are "corrupted" in terms of uniformity, a measure related to the amount of information. To make models robust to sensor degradation, we propose a novel method called uniformity-aware information-balanced TTA (UnInfo). To address the corruption of image embeddings, we introduce uniformity-aware confidence maximization, information-aware loss balancing, and knowledge distillation from the exponential moving average (EMA) teacher. Through experiments, we demonstrate that our UnInfo improves accuracy under sensor degradation by retaining information in terms of uniformity.
Clustering tabular data remains a significant open challenge in data analysis and machine learning. Unlike for image data, similarity between tabular records often varies across datasets, making the definition of clusters highly dataset-dependent. Furthermore, the absence of supervised signals complicates hyperparameter tuning in deep learning clustering methods, frequently resulting in unstable performance. To address these issues and reduce the need for per-dataset tuning, we adopt an emerging approach in deep learning: zero-shot learning. We propose ZEUS, a self-contained model capable of clustering new datasets without any additional training or fine-tuning. It operates by decomposing complex datasets into meaningful components that can then be clustered effectively. Thanks to pre-training on synthetic datasets generated from a latent-variable prior, it generalizes across various datasets without requiring user intervention. To the best of our knowledge, ZEUS is the first zero-shot method capable of generating embeddings for tabular data in a fully unsupervised manner. Experimental results demonstrate that it performs on par with or better than traditional clustering algorithms and recent deep learning-based methods, while being significantly faster and more user-friendly.
Recent advances in vision language models (VLMs) have enabled broad progress in the general medical field. However, pathology still remains a more challenging subdomain, with current pathology specific VLMs exhibiting limitations in both diagnostic accuracy and reasoning plausibility. Such shortcomings are largely attributable to the nature of current pathology datasets, which are primarily composed of image description pairs that lack the depth and structured diagnostic paradigms employed by real world pathologists. In this study, we leverage pathology textbooks and real world pathology experts to construct high-quality, reasoning-oriented datasets. Building on this, we introduce Patho-R1, a multimodal RL-based pathology Reasoner, trained through a three-stage pipeline: (1) continued pretraining on 3.5 million image-text pairs for knowledge infusion; (2) supervised fine-tuning on 500k high-quality Chain-of-Thought samples for reasoning incentivizing; (3) reinforcement learning using Group Relative Policy Optimization and Decoupled Clip and Dynamic sAmpling Policy Optimization strategies for multimodal reasoning quality refinement. To further assess the alignment quality of our dataset, we propose PathoCLIP, trained on the same figure-caption corpus used for continued pretraining. Comprehensive experimental results demonstrate that both PathoCLIP and Patho-R1 achieve robust performance across a wide range of pathology-related tasks, including zero-shot classification, cross-modal retrieval, Visual Question Answering, and Multiple Choice Question. Our project is available at the Patho-R1 repository: https://github.com/Wenchuan-Zhang/Patho-R1.
Compositional Zero-Shot Learning (CZSL) aims to recognize unseen state-object combinations by leveraging known combinations. Existing studies basically rely on the cross-modal alignment capabilities of CLIP but tend to overlook its limitations in capturing fine-grained local features, which arise from its architectural and training paradigm. To address this issue, we propose a Multi-Stage Cross-modal Interaction (MSCI) model that effectively explores and utilizes intermediate-layer information from CLIP's visual encoder. Specifically, we design two self-adaptive aggregators to extract local information from low-level visual features and integrate global information from high-level visual features, respectively. These key information are progressively incorporated into textual representations through a stage-by-stage interaction mechanism, significantly enhancing the model's perception capability for fine-grained local visual information. Additionally, MSCI dynamically adjusts the attention weights between global and local visual information based on different combinations, as well as different elements within the same combination, allowing it to flexibly adapt to diverse scenarios. Experiments on three widely used datasets fully validate the effectiveness and superiority of the proposed model. Data and code are available at https://github.com/ltpwy/MSCI.
Medical vision-language models (VLMs) have shown promise as clinical assistants across various medical fields. However, specialized dermatology VLM capable of delivering professional and detailed diagnostic analysis remains underdeveloped, primarily due to less specialized text descriptions in current dermatology multimodal datasets. To address this issue, we propose MM-Skin, the first large-scale multimodal dermatology dataset that encompasses 3 imaging modalities, including clinical, dermoscopic, and pathological and nearly 10k high-quality image-text pairs collected from professional textbooks. In addition, we generate over 27k diverse, instruction-following vision question answering (VQA) samples (9 times the size of current largest dermatology VQA dataset). Leveraging public datasets and MM-Skin, we developed SkinVL, a dermatology-specific VLM designed for precise and nuanced skin disease interpretation. Comprehensive benchmark evaluations of SkinVL on VQA, supervised fine-tuning (SFT) and zero-shot classification tasks across 8 datasets, reveal its exceptional performance for skin diseases in comparison to both general and medical VLM models. The introduction of MM-Skin and SkinVL offers a meaningful contribution to advancing the development of clinical dermatology VLM assistants. MM-Skin is available at https://github.com/ZwQ803/MM-Skin
Drug resistance presents a major challenge in cancer therapy. Single cell profiling offers insights into cellular heterogeneity, yet the application of large-scale foundation models for predicting drug response in single cell data remains underexplored. To address this, we developed scDrugMap, an integrated framework featuring both a Python command-line interface and a web server for drug response prediction. scDrugMap evaluates a wide range of foundation models, including eight single-cell models and two large language models, using a curated dataset of over 326,000 cells in the primary collection and 18,800 cells in the validation set, spanning 36 datasets and diverse tissue and cancer types. We benchmarked model performance under pooled-data and cross-data evaluation settings, employing both layer freezing and Low-Rank Adaptation (LoRA) fine-tuning strategies. In the pooled-data scenario, scFoundation achieved the best performance, with mean F1 scores of 0.971 (layer freezing) and 0.947 (fine-tuning), outperforming the lowest-performing model by over 50%. In the cross-data setting, UCE excelled post fine-tuning (mean F1: 0.774), while scGPT led in zero-shot learning (mean F1: 0.858). Overall, scDrugMap provides the first large-scale benchmark of foundation models for drug response prediction in single-cell data and serves as a user-friendly, flexible platform for advancing drug discovery and translational research.
Contrastive Language-Image Pre-training (CLIP) excels in multimodal tasks such as image-text retrieval and zero-shot classification but struggles with fine-grained understanding due to its focus on coarse-grained short captions. To address this, we propose Fine-Grained CLIP (FG-CLIP), which enhances fine-grained understanding through three key innovations. First, we leverage large multimodal models to generate 1.6 billion long caption-image pairs for capturing global-level semantic details. Second, a high-quality dataset is constructed with 12 million images and 40 million region-specific bounding boxes aligned with detailed captions to ensure precise, context-rich representations. Third, 10 million hard fine-grained negative samples are incorporated to improve the model's ability to distinguish subtle semantic differences. We construct a comprehensive dataset, termed FineHARD, by integrating high-quality region-specific annotations with hard fine-grained negative samples. Corresponding training methods are meticulously designed for these data. Extensive experiments demonstrate that FG-CLIP outperforms the original CLIP and other state-of-the-art methods across various downstream tasks, including fine-grained understanding, open-vocabulary object detection, image-text retrieval, and general multimodal benchmarks. These results highlight FG-CLIP's effectiveness in capturing fine-grained image details and improving overall model performance. The data, code, and models are available at https://github.com/360CVGroup/FG-CLIP.
Large Language Models (LLMs) have shown impressive zero-shot performance across a variety of Natural Language Processing tasks, including document re-ranking. However, their effectiveness degrades on unseen tasks and domains, largely due to shifts in vocabulary and word distributions. In this paper, we investigate Task Arithmetic, a technique that combines the weights of LLMs pre-trained on different tasks or domains via simple mathematical operations, such as addition or subtraction, to adapt retrieval models without requiring additional fine-tuning. Our method is able to synthesize diverse tasks and domain knowledge into a single model, enabling effective zero-shot adaptation in different retrieval contexts. Extensive experiments on publicly available scientific, biomedical, and multilingual datasets show that our method improves state-of-the-art re-ranking performance by up to 18% in NDCG@10 and 15% in P@10. In addition to these empirical gains, our analysis provides insights into the strengths and limitations of Task Arithmetic as a practical strategy for zero-shot learning and model adaptation. We make our code publicly available at https://github.com/DetectiveMB/Task-Arithmetic-for-ZS-IR.