Semi-supervised learning (SSL) has attracted much attention since it reduces the expensive costs of collecting adequate well-labeled training data, especially for deep learning methods. However, traditional SSL is built upon an assumption that labeled and unlabeled data should be from the same distribution \textit{e.g.,} classes and domains. However, in practical scenarios, unlabeled data would be from unseen classes or unseen domains, and it is still challenging to exploit them by existing SSL methods. Therefore, in this paper, we proposed a unified framework to leverage these unseen unlabeled data for open-scenario semi-supervised medical image classification. We first design a novel scoring mechanism, called dual-path outliers estimation, to identify samples from unseen classes. Meanwhile, to extract unseen-domain samples, we then apply an effective variational autoencoder (VAE) pre-training. After that, we conduct domain adaptation to fully exploit the value of the detected unseen-domain samples to boost semi-supervised training. We evaluated our proposed framework on dermatology and ophthalmology tasks. Extensive experiments demonstrate our model can achieve superior classification performance in various medical SSL scenarios. The code implementations are accessible at: https://github.com/PyJulie/USSL4MIC.
Effective semi-supervised learning (SSL) in medical image analysis (MIA) must address two challenges: 1) work effectively on both multi-class (e.g., lesion classification) and multi-label (e.g., multiple-disease diagnosis) problems, and 2) handle imbalanced learning (because of the high variance in disease prevalence). One strategy to explore in SSL MIA is based on the pseudo labelling strategy, but it has a few shortcomings. Pseudo-labelling has in general lower accuracy than consistency learning, it is not specifically designed for both multi-class and multi-label problems, and it can be challenged by imbalanced learning. In this paper, unlike traditional methods that select confident pseudo label by threshold, we propose a new SSL algorithm, called anti-curriculum pseudo-labelling (ACPL), which introduces novel techniques to select informative unlabelled samples, improving training balance and allowing the model to work for both multi-label and multi-class problems, and to estimate pseudo labels by an accurate ensemble of classifiers (improving pseudo label accuracy). We run extensive experiments to evaluate ACPL on two public medical image classification benchmarks: Chest X-Ray14 for thorax disease multi-label classification and ISIC2018 for skin lesion multi-class classification. Our method outperforms previous SOTA SSL methods on both datasets
Federated learning (FL) has emerged with increasing popularity to collaborate distributed medical institutions for training deep networks. However, despite existing FL algorithms only allow the supervised training setting, most hospitals in realistic usually cannot afford the intricate data labeling due to absence of budget or expertise. This paper studies a practical yet challenging FL problem, named \textit{Federated Semi-supervised Learning} (FSSL), which aims to learn a federated model by jointly utilizing the data from both labeled and unlabeled clients (i.e., hospitals). We present a novel approach for this problem, which improves over traditional consistency regularization mechanism with a new inter-client relation matching scheme. The proposed learning scheme explicitly connects the learning across labeled and unlabeled clients by aligning their extracted disease relationships, thereby mitigating the deficiency of task knowledge at unlabeled clients and promoting discriminative information from unlabeled samples. We validate our method on two large-scale medical image classification datasets. The effectiveness of our method has been demonstrated with the clear improvements over state-of-the-arts as well as the thorough ablation analysis on both tasks\footnote{Code will be made available at \url{https://github.com/liuquande/FedIRM}}.
The training of deep learning models generally requires a large amount of annotated data for effective convergence and generalisation. However, obtaining high-quality annotations is a laboursome and expensive process due to the need of expert radiologists for the labelling task. The study of semi-supervised learning in medical image analysis is then of crucial importance given that it is much less expensive to obtain unlabelled images than to acquire images labelled by expert radiologists. Essentially, semi-supervised methods leverage large sets of unlabelled data to enable better training convergence and generalisation than using only the small set of labelled images. In this paper, we propose Self-supervised Mean Teacher for Semi-supervised (S$^2$MTS$^2$) learning that combines self-supervised mean-teacher pre-training with semi-supervised fine-tuning. The main innovation of S$^2$MTS$^2$ is the self-supervised mean-teacher pre-training based on the joint contrastive learning, which uses an infinite number of pairs of positive query and key features to improve the mean-teacher representation. The model is then fine-tuned using the exponential moving average teacher framework trained with semi-supervised learning. We validate S$^2$MTS$^2$ on the multi-label classification problems from Chest X-ray14 and CheXpert, and the multi-class classification from ISIC2018, where we show that it outperforms the previous SOTA semi-supervised learning methods by a large margin.
The recent research in semi-supervised learning (SSL) is mostly dominated by consistency regularization based methods which achieve strong performance. However, they heavily rely on domain-specific data augmentations, which are not easy to generate for all data modalities. Pseudo-labeling (PL) is a general SSL approach that does not have this constraint but performs relatively poorly in its original formulation. We argue that PL underperforms due to the erroneous high confidence predictions from poorly calibrated models; these predictions generate many incorrect pseudo-labels, leading to noisy training. We propose an uncertainty-aware pseudo-label selection (UPS) framework which improves pseudo labeling accuracy by drastically reducing the amount of noise encountered in the training process. Furthermore, UPS generalizes the pseudo-labeling process, allowing for the creation of negative pseudo-labels; these negative pseudo-labels can be used for multi-label classification as well as negative learning to improve the single-label classification. We achieve strong performance when compared to recent SSL methods on the CIFAR-10 and CIFAR-100 datasets. Also, we demonstrate the versatility of our method on the video dataset UCF-101 and the multi-label dataset Pascal VOC.
Computer-aided diagnosis via deep learning relies on large-scale annotated data sets, which can be costly when involving expert knowledge. Semi-supervised learning (SSL) mitigates this challenge by leveraging unlabeled data. One effective SSL approach is to regularize the local smoothness of neural functions via perturbations around single data points. In this work, we argue that regularizing the global smoothness of neural functions by filling the void in between data points can further improve SSL. We present a novel SSL approach that trains the neural network on linear mixing of labeled and unlabeled data, at both the input and latent space in order to regularize different portions of the network. We evaluated the presented model on two distinct medical image data sets for semi-supervised classification of thoracic disease and skin lesion, demonstrating its improved performance over SSL with local perturbations and SSL with global mixing but at the input space only. Our code is available at https://github.com/Prasanna1991/LatentMixing.