Pneumonia is a leading cause of mortality in children under five, requiring accurate chest X-ray diagnosis. This study presents a machine learning-based Pediatric Chest Pneumonia Classification System to assist healthcare professionals in diagnosing pneumonia from chest X-ray images. The CNN-based model was trained on 5,863 labeled chest X-ray images from children aged 0-5 years from the Guangzhou Women and Children's Medical Center. To address limited data, we applied augmentation techniques (rotation, zooming, shear, horizontal flipping) and employed GANs to generate synthetic images, addressing class imbalance. The system achieved optimal performance using combined original, augmented, and GAN-generated data, evaluated through accuracy and F1 score metrics. The final model was deployed via a Flask web application, enabling real-time classification with probability estimates. Results demonstrate the potential of deep learning and GANs in improving diagnostic accuracy and efficiency for pediatric pneumonia classification, particularly valuable in resource-limited clinical settings https://github.com/AbdulManaf12/Pediatric-Chest-Pneumonia-Classification
Large multimodal models (LMMs) have shown impressive capabilities in a wide range of visual tasks. However, they often struggle with fine-grained visual reasoning, failing to identify domain-specific objectives and provide justifiable explanations for their predictions. To address this, we propose a novel visual rejection sampling framework to improve the cognition and explainability of LMMs using self-synthesized data. Specifically, visual fine-tuning requires images, queries, and target answers. Our approach begins by synthesizing interpretable answers that include human-verifiable visual features. These features are based on expert-defined concepts, carefully selected based on their alignment with the image content. After each round of fine-tuning, we apply a reward model-free filtering mechanism to select the highest-quality interpretable answers for the next round of tuning. This iterative process of data synthesis and fine-tuning progressively improves the model's ability to generate accurate and reasonable explanations. Experimental results demonstrate the effectiveness of our method in improving both the accuracy and explainability of specialized visual classification tasks.
Pneumonia, a prevalent respiratory infection, remains a leading cause of morbidity and mortality worldwide, particularly among vulnerable populations. Chest X-rays serve as a primary tool for pneumonia detection; however, variations in imaging conditions and subtle visual indicators complicate consistent interpretation. Automated tools can enhance traditional methods by improving diagnostic reliability and supporting clinical decision-making. In this study, we propose a novel multi-scale transformer approach for pneumonia detection that integrates lung segmentation and classification into a unified framework. Our method introduces a lightweight transformer-enhanced TransUNet for precise lung segmentation, achieving a Dice score of 95.68% on the "Chest X-ray Masks and Labels" dataset with fewer parameters than traditional transformers. For classification, we employ pre-trained ResNet models (ResNet-50 and ResNet-101) to extract multi-scale feature maps, which are then processed through a modified transformer module to enhance pneumonia detection. This integration of multi-scale feature extraction and lightweight transformer modules ensures robust performance, making our method suitable for resource-constrained clinical environments. Our approach achieves 93.75% accuracy on the "Kermany" dataset and 96.04% accuracy on the "Cohen" dataset, outperforming existing methods while maintaining computational efficiency. This work demonstrates the potential of multi-scale transformer architectures to improve pneumonia diagnosis, offering a scalable and accurate solution to global healthcare challenges."https://github.com/amirrezafateh/Multi-Scale-Transformer-Pneumonia"
Pneumonia is a respiratory infection caused by bacteria, fungi, or viruses. It affects many people, particularly those in developing or underdeveloped nations with high pollution levels, unhygienic living conditions, overcrowding, and insufficient medical infrastructure. Pneumonia can cause pleural effusion, where fluids fill the lungs, leading to respiratory difficulty. Early diagnosis is crucial to ensure effective treatment and increase survival rates. Chest X-ray imaging is the most commonly used method for diagnosing pneumonia. However, visual examination of chest X-rays can be difficult and subjective. In this study, we have developed a computer-aided diagnosis system for automatic pneumonia detection using chest X-ray images. We have used DenseNet-121 and ResNet50 as the backbone for the binary class (pneumonia and normal) and multi-class (bacterial pneumonia, viral pneumonia, and normal) classification tasks, respectively. We have also implemented a channel-specific spatial attention mechanism, called Fuzzy Channel Selective Spatial Attention Module (FCSSAM), to highlight the specific spatial regions of relevant channels while removing the irrelevant channels of the extracted features by the backbone. We evaluated the proposed approach on a publicly available chest X-ray dataset, using binary and multi-class classification setups. Our proposed method achieves accuracy rates of 97.15\% and 79.79\% for the binary and multi-class classification setups, respectively. The results of our proposed method are superior to state-of-the-art (SOTA) methods. The code of the proposed model will be available at: https://github.com/AyushRoy2001/FA-Net.
Pneumonia remains a significant cause of child mortality, particularly in developing countries where resources and expertise are limited. The automated detection of Pneumonia can greatly assist in addressing this challenge. In this research, an XOR based Particle Swarm Optimization (PSO) is proposed to select deep features from the second last layer of a RegNet model, aiming to improve the accuracy of the CNN model on Pneumonia detection. The proposed XOR PSO algorithm offers simplicity by incorporating just one hyperparameter for initialization, and each iteration requires minimal computation time. Moreover, it achieves a balance between exploration and exploitation, leading to convergence on a suitable solution. By extracting 163 features, an impressive accuracy level of 98% was attained which demonstrates comparable accuracy to previous PSO-based methods. The source code of the proposed method is available in the GitHub repository.
Biomedical data is inherently multimodal, comprising physical measurements and natural language narratives. A generalist biomedical AI model needs to simultaneously process different modalities of data, including text and images. Therefore, training an effective generalist biomedical model requires high-quality multimodal data, such as parallel image-text pairs. Here, we present PMC-15M, a novel dataset that is two orders of magnitude larger than existing biomedical multimodal datasets such as MIMIC-CXR, and spans a diverse range of biomedical image types. PMC-15M contains 15 million biomedical image-text pairs collected from 4.4 million scientific articles. Based on PMC-15M, we have pretrained BiomedCLIP, a multimodal foundation model, with domain-specific adaptations tailored to biomedical vision-language processing. We conducted extensive experiments and ablation studies on standard biomedical imaging tasks from retrieval to classification to visual question-answering (VQA). BiomedCLIP achieved new state-of-the-art results in a wide range of standard datasets, substantially outperforming prior approaches. Intriguingly, by large-scale pretraining on diverse biomedical image types, BiomedCLIP even outperforms state-of-the-art radiology-specific models such as BioViL in radiology-specific tasks such as RSNA pneumonia detection. In summary, BiomedCLIP is a fully open-access foundation model that achieves state-of-the-art performance on various biomedical tasks, paving the way for transformative multimodal biomedical discovery and applications. We release our models at https://aka.ms/biomedclip to facilitate future research in multimodal biomedical AI.
Well-annotated medical datasets enable deep neural networks (DNNs) to gain strong power in extracting lesion-related features. Building such large and well-designed medical datasets is costly due to the need for high-level expertise. Model pre-training based on ImageNet is a common practice to gain better generalization when the data amount is limited. However, it suffers from the domain gap between natural and medical images. In this work, we pre-train DNNs on ultrasound (US) domains instead of ImageNet to reduce the domain gap in medical US applications. To learn US image representations based on unlabeled US videos, we propose a novel meta-learning-based contrastive learning method, namely Meta Ultrasound Contrastive Learning (Meta-USCL). To tackle the key challenge of obtaining semantically consistent sample pairs for contrastive learning, we present a positive pair generation module along with an automatic sample weighting module based on meta-learning. Experimental results on multiple computer-aided diagnosis (CAD) problems, including pneumonia detection, breast cancer classification, and breast tumor segmentation, show that the proposed self-supervised method reaches state-of-the-art (SOTA). The codes are available at https://github.com/Schuture/Meta-USCL.
Pneumonia is one of the major reasons for child mortality especially in income-deprived regions of the world. Although it can be detected and treated with very less sophisticated instruments and medication, Pneumonia detection still remains a major concern in developing countries. Computer-aided based diagnosis (CAD) systems can be used in such countries due to their lower operating costs than professional medical experts. In this paper, we propose a CAD system for Pneumonia detection from Chest X-rays, using the concepts of deep learning and a meta-heuristic algorithm. We first extract deep features from the pre-trained ResNet50, fine-tuned on a target Pneumonia dataset. Then, we propose a feature selection technique based on particle swarm optimization (PSO), which is modified using a memory-based adaptation parameter, and enriched by incorporating an altruistic behavior into the agents. We name our feature selection method as adaptive and altruistic PSO (AAPSO). The proposed method successfully eliminates non-informative features obtained from the ResNet50 model, thereby improving the Pneumonia detection ability of the overall framework. Extensive experimentation and thorough analysis on a publicly available Pneumonia dataset establish the superiority of the proposed method over several other frameworks used for Pneumonia detection. Apart from Pneumonia detection, AAPSO is further evaluated on some standard UCI datasets, gene expression datasets for cancer prediction and a COVID-19 prediction dataset. The overall results are satisfactory, thereby confirming the usefulness of AAPSO in dealing with varied real-life problems. The supporting source codes of this work can be found at https://github.com/rishavpramanik/AAPSO
Supervised dictionary learning (SDL) is a classical machine learning method that simultaneously seeks feature extraction and classification tasks, which are not necessarily a priori aligned objectives. The goal of SDL is to learn a class-discriminative dictionary, which is a set of latent feature vectors that can well-explain both the features as well as labels of observed data. In this paper, we provide a systematic study of SDL, including the theory, algorithm, and applications of SDL. First, we provide a novel framework that `lifts' SDL as a convex problem in a combined factor space and propose a low-rank projected gradient descent algorithm that converges exponentially to the global minimizer of the objective. We also formulate generative models of SDL and provide global estimation guarantees of the true parameters depending on the hyperparameter regime. Second, viewed as a nonconvex constrained optimization problem, we provided an efficient block coordinate descent algorithm for SDL that is guaranteed to find an $\varepsilon$-stationary point of the objective in $O(\varepsilon^{-1}(\log \varepsilon^{-1})^{2})$ iterations. For the corresponding generative model, we establish a novel non-asymptotic local consistency result for constrained and regularized maximum likelihood estimation problems, which may be of independent interest. Third, we apply SDL for imbalanced document classification by supervised topic modeling and also for pneumonia detection from chest X-ray images. We also provide simulation studies to demonstrate that SDL becomes more effective when there is a discrepancy between the best reconstructive and the best discriminative dictionaries.
Multi-modal data abounds in biomedicine, such as radiology images and reports. Interpreting this data at scale is essential for improving clinical care and accelerating clinical research. Biomedical text with its complex semantics poses additional challenges in vision--language modelling compared to the general domain, and previous work has used insufficiently adapted models that lack domain-specific language understanding. In this paper, we show that principled textual semantic modelling can substantially improve contrastive learning in self-supervised vision--language processing. We release a language model that achieves state-of-the-art results in radiology natural language inference through its improved vocabulary and novel language pretraining objective leveraging semantics and discourse characteristics in radiology reports. Further, we propose a self-supervised joint vision--language approach with a focus on better text modelling. It establishes new state of the art results on a wide range of publicly available benchmarks, in part by leveraging our new domain-specific language model. We release a new dataset with locally-aligned phrase grounding annotations by radiologists to facilitate the study of complex semantic modelling in biomedical vision--language processing. A broad evaluation, including on this new dataset, shows that our contrastive learning approach, aided by textual-semantic modelling, outperforms prior methods in segmentation tasks, despite only using a global-alignment objective.
In this paper, we consider image quality assessment (IQA) as a measure of how images are amenable with respect to a given downstream task, or task amenability. When the task is performed using machine learning algorithms, such as a neural-network-based task predictor for image classification or segmentation, the performance of the task predictor provides an objective estimate of task amenability. In this work, we use an IQA controller to predict the task amenability which, itself being parameterised by neural networks, can be trained simultaneously with the task predictor. We further develop a meta-reinforcement learning framework to improve the adaptability for both IQA controllers and task predictors, such that they can be fine-tuned efficiently on new datasets or meta-tasks. We demonstrate the efficacy of the proposed task-specific, adaptable IQA approach, using two clinical applications for ultrasound-guided prostate intervention and pneumonia detection on X-ray images.
In the research, we developed a computer vision solution to support diagnostic radiology in differentiating between COVID-19 pneumonia, influenza virus pneumonia, and normal biomarkers. The chest radiograph appearance of COVID-19 pneumonia is thought to be nonspecific, having presented a challenge to identify an optimal architecture of a convolutional neural network (CNN) that would classify with a high sensitivity among the pulmonary inflammation features of COVID-19 and non-COVID-19 types of pneumonia. Rahman (2021) states that COVID-19 radiography images observe unavailability and quality issues impacting the diagnostic process and affecting the accuracy of the deep learning detection models. A significant scarcity of COVID-19 radiography images introduced an imbalance in data motivating us to use over-sampling techniques. In the study, we include an extensive set of X-ray imaging of human lungs (CXR) with COVID-19 pneumonia, influenza virus pneumonia, and normal biomarkers to achieve an extensible and accurate CNN model. In the experimentation phase of the research, we evaluated a variety of convolutional network architectures, selecting a sequential convolutional network with two traditional convolutional layers and two pooling layers with maximum function. In its classification performance, the best performing model demonstrated a validation accuracy of 93% and an F1 score of 0.95. We chose the Azure Machine Learning service to perform network experimentation and solution deployment. The auto-scaling compute clusters offered a significant time reduction in network training. We would like to see scientists across fields of artificial intelligence and human biology collaborating and expanding on the proposed solution to provide rapid and comprehensive diagnostics, effectively mitigating the spread of the virus
Since the emergence of COVID-19, deep learning models have been developed to identify COVID-19 from chest X-rays. With little to no direct access to hospital data, the AI community relies heavily on public data comprising numerous data sources. Model performance results have been exceptional when training and testing on open-source data, surpassing the reported capabilities of AI in pneumonia-detection prior to the COVID-19 outbreak. In this study impactful models are trained on a widely used open-source data and tested on an external test set and a hospital dataset, for the task of classifying chest X-rays into one of three classes: COVID-19, non-COVID pneumonia and no-pneumonia. Classification performance of the models investigated is evaluated through ROC curves, confusion matrices and standard classification metrics. Explainability modules are implemented to explore the image features most important to classification. Data analysis and model evaluations show that the popular open-source dataset COVIDx is not representative of the real clinical problem and that results from testing on this are inflated. Dependence on open-source data can leave models vulnerable to bias and confounding variables, requiring careful analysis to develop clinically useful/viable AI tools for COVID-19 detection in chest X-rays.
One of the primary clinical observations for screening the infectious by the novel coronavirus is capturing a chest x-ray image. In most of the patients, a chest x-ray contains abnormalities, such as consolidation, which are the results of COVID-19 viral pneumonia. In this study, research is conducted on efficiently detecting imaging features of this type of pneumonia using deep convolutional neural networks in a large dataset. It is demonstrated that simple models, alongside the majority of pretrained networks in the literature, focus on irrelevant features for decision-making. In this paper, numerous chest x-ray images from various sources are collected, and the largest publicly accessible dataset is prepared. Finally, using the transfer learning paradigm, the well-known CheXNet model is utilized for developing COVID-CXNet. This powerful model is capable of detecting the novel coronavirus pneumonia based on relevant and meaningful features with precise localization. COVID-CXNet is a step towards a fully automated and robust COVID-19 detection system.
The outbreak of COVID-19 has shocked the entire world with its fairly rapid spread and has challenged different sectors. One of the most effective ways to limit its spread is the early and accurate diagnosing infected patients. Medical imaging, such as X-ray and Computed Tomography (CT), combined with the potential of Artificial Intelligence (AI), plays an essential role in supporting medical personnel in the diagnosis process. Thus, in this article five different deep learning models (ResNet18, ResNet34, InceptionV3, InceptionResNetV2 and DenseNet161) and their ensemble, using majority voting have been used to classify COVID-19, pneumoni{\ae} and healthy subjects using chest X-ray images. Multilabel classification was performed to predict multiple pathologies for each patient, if present. Firstly, the interpretability of each of the networks was thoroughly studied using local interpretability methods - occlusion, saliency, input X gradient, guided backpropagation, integrated gradients, and DeepLIFT, and using a global technique - neuron activation profiles. The mean Micro-F1 score of the models for COVID-19 classifications ranges from 0.66 to 0.875, and is 0.89 for the ensemble of the network models. The qualitative results showed that the ResNets were the most interpretable models. This research demonstrates the importance of using interpretability methods to compare different models before making a decision regarding the best performing model.
Pneumonia is the leading cause of death among young children and one of the top mortality causes worldwide. The pneumonia detection is usually performed through examine of chest X-ray radiograph by highly-trained specialists. This process is tedious and often leads to a disagreement between radiologists. Computer-aided diagnosis systems showed the potential for improving diagnostic accuracy. In this work, we develop the computational approach for pneumonia regions detection based on single-shot detectors, squeeze-and-excitation deep convolution neural networks, augmentations and multi-task learning. The proposed approach was evaluated in the context of the Radiological Society of North America Pneumonia Detection Challenge, achieving one of the best results in the challenge.
Convolutional neural networks have witnessed remarkable improvements in computational efficiency in recent years. A key driving force has been the idea of trading-off model expressivity and efficiency through a combination of $1\times 1$ and depth-wise separable convolutions in lieu of a standard convolutional layer. The price of the efficiency, however, is the sub-optimal flow of information across space and channels in the network. To overcome this limitation, we present MUXConv, a layer that is designed to increase the flow of information by progressively multiplexing channel and spatial information in the network, while mitigating computational complexity. Furthermore, to demonstrate the effectiveness of MUXConv, we integrate it within an efficient multi-objective evolutionary algorithm to search for the optimal model hyper-parameters while simultaneously optimizing accuracy, compactness, and computational efficiency. On ImageNet, the resulting models, dubbed MUXNets, match the performance (75.3% top-1 accuracy) and multiply-add operations (218M) of MobileNetV3 while being 1.6$\times$ more compact, and outperform other mobile models in all the three criteria. MUXNet also performs well under transfer learning and when adapted to object detection. On the ChestX-Ray 14 benchmark, its accuracy is comparable to the state-of-the-art while being $3.3\times$ more compact and $14\times$ more efficient. Similarly, detection on PASCAL VOC 2007 is 1.2% more accurate, 28% faster and 6% more compact compared to MobileNetV2. Code is available from https://github.com/human-analysis/MUXConv
Early advancements in convolutional neural networks (CNNs) architectures are primarily driven by human expertise and by elaborate design processes. Recently, neural architecture search was proposed with the aim of automating the network design process and generating task-dependent architectures. While existing approaches have achieved competitive performance in image classification, they are not well suited to problems where the computational budget is limited for two reasons: (1) the obtained architectures are either solely optimized for classification performance, or only for one deployment scenario; (2) the search process requires vast computational resources in most approaches. To overcome these limitations, we propose an evolutionary algorithm for searching neural architectures under multiple objectives, such as classification performance and floating-point operations (FLOPs). The proposed method addresses the first shortcoming by populating a set of architectures to approximate the entire Pareto frontier through genetic operations that recombine and modify architectural components progressively. Our approach improves computational efficiency by carefully down-scaling the architectures during the search as well as reinforcing the patterns commonly shared among past successful architectures through Bayesian model learning. The integration of these two main contributions allows an efficient design of architectures that are competitive and in most cases outperform both manually and automatically designed architectures on benchmark image classification datasets: CIFAR, ImageNet, and human chest X-ray. The flexibility provided from simultaneously obtaining multiple architecture choices for different compute requirements further differentiates our approach from other methods in the literature. Code is available at https://github.com/mikelzc1990/nsganetv1