Medical Relation Extraction (MRE) task aims to extract relations between entities in medical texts. Traditional relation extraction methods achieve impressive success by exploring the syntactic information, e.g., dependency tree. However, the quality of the 1-best dependency tree for medical texts produced by an out-of-domain parser is relatively limited so that the performance of medical relation extraction method may degenerate. To this end, we propose a method to jointly model semantic and syntactic information from medical texts based on causal explanation theory. We generate dependency forests consisting of the semantic-embedded 1-best dependency tree. Then, a task-specific causal explainer is adopted to prune the dependency forests, which are further fed into a designed graph convolutional network to learn the corresponding representation for downstream task. Empirically, the various comparisons on benchmark medical datasets demonstrate the effectiveness of our model.
Language model (LM) pretraining can learn various knowledge from text corpora, helping downstream tasks. However, existing methods such as BERT model a single document, and do not capture dependencies or knowledge that span across documents. In this work, we propose LinkBERT, an LM pretraining method that leverages links between documents, e.g., hyperlinks. Given a text corpus, we view it as a graph of documents and create LM inputs by placing linked documents in the same context. We then pretrain the LM with two joint self-supervised objectives: masked language modeling and our new proposal, document relation prediction. We show that LinkBERT outperforms BERT on various downstream tasks across two domains: the general domain (pretrained on Wikipedia with hyperlinks) and biomedical domain (pretrained on PubMed with citation links). LinkBERT is especially effective for multi-hop reasoning and few-shot QA (+5% absolute improvement on HotpotQA and TriviaQA), and our biomedical LinkBERT sets new states of the art on various BioNLP tasks (+7% on BioASQ and USMLE). We release our pretrained models, LinkBERT and BioLinkBERT, as well as code and data at https://github.com/michiyasunaga/LinkBERT.
Artificial Intelligence (AI), along with the recent progress in biomedical language understanding, is gradually changing medical practice. With the development of biomedical language understanding benchmarks, AI applications are widely used in the medical field. However, most benchmarks are limited to English, which makes it challenging to replicate many of the successes in English for other languages. To facilitate research in this direction, we collect real-world biomedical data and present the first Chinese Biomedical Language Understanding Evaluation (CBLUE) benchmark: a collection of natural language understanding tasks including named entity recognition, information extraction, clinical diagnosis normalization, single-sentence/sentence-pair classification, and an associated online platform for model evaluation, comparison, and analysis. To establish evaluation on these tasks, we report empirical results with the current 11 pre-trained Chinese models, and experimental results show that state-of-the-art neural models perform by far worse than the human ceiling. Our benchmark is released at \url{https://tianchi.aliyun.com/dataset/dataDetail?dataId=95414&lang=en-us}.
Medical relation extraction discovers relations between entity mentions in text, such as research articles. For this task, dependency syntax has been recognized as a crucial source of features. Yet in the medical domain, 1-best parse trees suffer from relatively low accuracies, diminishing their usefulness. We investigate a method to alleviate this problem by utilizing dependency forests. Forests contain many possible decisions and therefore have higher recall but more noise compared with 1-best outputs. A graph neural network is used to represent the forests, automatically distinguishing the useful syntactic information from parsing noise. Results on two biomedical benchmarks show that our method outperforms the standard tree-based methods, giving the state-of-the-art results in the literature.
Biomedical text mining is becoming increasingly important as the number of biomedical documents rapidly grows. With the progress in natural language processing (NLP), extracting valuable information from biomedical literature has gained popularity among researchers, and deep learning has boosted the development of effective biomedical text mining models. However, directly applying the advancements in NLP to biomedical text mining often yields unsatisfactory results due to a word distribution shift from general domain corpora to biomedical corpora. In this article, we investigate how the recently introduced pre-trained language model BERT can be adapted for biomedical corpora. We introduce BioBERT (Bidirectional Encoder Representations from Transformers for Biomedical Text Mining), which is a domain-specific language representation model pre-trained on large-scale biomedical corpora. With almost the same architecture across tasks, BioBERT largely outperforms BERT and previous state-of-the-art models in a variety of biomedical text mining tasks when pre-trained on biomedical corpora. While BERT obtains performance comparable to that of previous state-of-the-art models, BioBERT significantly outperforms them on the following three representative biomedical text mining tasks: biomedical named entity recognition (0.62% F1 score improvement), biomedical relation extraction (2.80% F1 score improvement) and biomedical question answering (12.24% MRR improvement). Our analysis results show that pre-training BERT on biomedical corpora helps it to understand complex biomedical texts. We make the pre-trained weights of BioBERT freely available at https://github.com/naver/biobert-pretrained, and the source code for fine-tuning BioBERT available at https://github.com/dmis-lab/biobert.
Mining relationships between treatment(s) and medical problem(s) is vital in the biomedical domain. This helps in various applications, such as decision support system, safety surveillance, and new treatment discovery. We propose a deep learning approach that utilizes both word level and sentence-level representations to extract the relationships between treatment and problem. While deep learning techniques demand a large amount of data for training, we make use of a rule-based system particularly for relationship classes with fewer samples. Our final relations are derived by jointly combining the results from deep learning and rule-based models. Our system achieved a promising performance on the relationship classes of I2b2 2010 relation extraction task.
Simultaneous administration of multiple drugs can have synergistic or antagonistic effects as one drug can affect activities of other drugs. Synergistic effects lead to improved therapeutic outcomes, whereas, antagonistic effects can be life-threatening, may lead to increased healthcare cost, or may even cause death. Thus identification of unknown drug-drug interaction (DDI) is an important concern for efficient and effective healthcare. Although multiple resources for DDI exist, they are often unable to keep pace with rich amount of information available in fast growing biomedical texts. Most existing methods model DDI extraction from text as a classification problem and mainly rely on handcrafted features. Some of these features further depend on domain specific tools. Recently neural network models using latent features have been shown to give similar or better performance than the other existing models dependent on handcrafted features. In this paper, we present three models namely, {\it B-LSTM}, {\it AB-LSTM} and {\it Joint AB-LSTM} based on long short-term memory (LSTM) network. All three models utilize word and position embedding as latent features and thus do not rely on explicit feature engineering. Further use of bidirectional long short-term memory (Bi-LSTM) networks allow implicit feature extraction from the whole sentence. The two models, {\it AB-LSTM} and {\it Joint AB-LSTM} also use attentive pooling in the output of Bi-LSTM layer to assign weights to features. Our experimental results on the SemEval-2013 DDI extraction dataset show that the {\it Joint AB-LSTM} model outperforms all the existing methods, including those relying on handcrafted features. The other two proposed LSTM models also perform competitively with state-of-the-art methods.
Cognitive computing systems require human labeled data for evaluation, and often for training. The standard practice used in gathering this data minimizes disagreement between annotators, and we have found this results in data that fails to account for the ambiguity inherent in language. We have proposed the CrowdTruth method for collecting ground truth through crowdsourcing, that reconsiders the role of people in machine learning based on the observation that disagreement between annotators provides a useful signal for phenomena such as ambiguity in the text. We report on using this method to build an annotated data set for medical relation extraction for the $cause$ and $treat$ relations, and how this data performed in a supervised training experiment. We demonstrate that by modeling ambiguity, labeled data gathered from crowd workers can (1) reach the level of quality of domain experts for this task while reducing the cost, and (2) provide better training data at scale than distant supervision. We further propose and validate new weighted measures for precision, recall, and F-measure, that account for ambiguity in both human and machine performance on this task.