The anti-cancer immune response relies on the bindings between T-cell receptors (TCRs) and antigens, which elicits adaptive immunity to eliminate tumor cells. This ability of the immune system to respond to novel various neoantigens arises from the immense diversity of TCR repository. However, TCR diversity poses a significant challenge on accurately predicting antigen-TCR bindings. In this study, we introduce a lightweight masked language model, termed tcrLM, to address this challenge. Our approach involves randomly masking segments of TCR sequences and training tcrLM to infer the masked segments, thereby enabling the extraction of expressive features from TCR sequences. To further enhance robustness, we incorporate virtual adversarial training into tcrLM. We construct the largest TCR CDR3 sequence set with more than 100 million distinct sequences, and pretrain tcrLM on these sequences. The pre-trained encoder is subsequently applied to predict TCR-antigen binding specificity. We evaluate model performance on three test datasets: independent, external, and COVID-19 test set. The results demonstrate that tcrLM not only surpasses existing TCR-antigen binding prediction methods, but also outperforms other mainstream protein language models. More interestingly, tcrLM effectively captures the biochemical properties and positional preference of amino acids within TCR sequences. Additionally, the predicted TCR-neoantigen binding scores indicates the immunotherapy responses and clinical outcomes in a melanoma cohort. These findings demonstrate the potential of tcrLM in predicting TCR-antigen binding specificity, with significant implications for advancing immunotherapy and personalized medicine.
Activation steering methods were shown to be effective in conditioning language model generation by additively intervening over models' intermediate representations. However, the evaluation of these techniques has so far been limited to single conditioning properties and synthetic settings. In this work, we conduct a comprehensive evaluation of various activation steering strategies, highlighting the property-dependent nature of optimal parameters to ensure a robust effect throughout generation. To address this issue, we propose Dynamic Activation Composition, an information-theoretic approach to modulate the steering intensity of one or more properties throughout generation. Our experiments on multi-property steering show that our method successfully maintains high conditioning while minimizing the impact of conditioning on generation fluency.
Tool learning aims to enhance and expand large language models' (LLMs) capabilities with external tools, which has gained significant attention recently. Current methods have shown that LLMs can effectively handle a certain amount of tools through in-context learning or fine-tuning. However, in real-world scenarios, the number of tools is typically extensive and irregularly updated, emphasizing the necessity for a dedicated tool retrieval component. Tool retrieval is nontrivial due to the following challenges: 1) complex user instructions and tool descriptions; 2) misalignment between tool retrieval and tool usage models. To address the above issues, we propose to enhance tool retrieval with iterative feedback from the large language model. Specifically, we prompt the tool usage model, i.e., the LLM, to provide feedback for the tool retriever model in multi-round, which could progressively improve the tool retriever's understanding of instructions and tools and reduce the gap between the two standalone components. We build a unified and comprehensive benchmark to evaluate tool retrieval models. The extensive experiments indicate that our proposed approach achieves advanced performance in both in-domain evaluation and out-of-domain evaluation.
We present a simple meta quantization approach that quantizes different layers of a large language model (LLM) at different bit levels, and is independent of the underlying quantization technique. Specifically, we quantize the most important layers to higher bit precision and less important layers to lower bits. We propose two effective strategies to measure the importance of layers within LLMs: the first measures the importance of a layer based on how different its output embeddings are from the input embeddings (higher is better); the second estimates the importance of a layer using the number of layer weights that are much larger than average (smaller is better). We show that quantizing different layers at varying bits according to our importance scores results in minimal performance drop with a far more compressed model size. Finally, we present several practical key takeaways from our variable layer-wise quantization experiments: (a) LLM performance under variable quantization remains close to the original model until 25-50% of layers are moved in lower quantization using our proposed ordering but only until 5-10% if moved using no specific ordering; (b) Adding layer importance to inherently dynamic quantization techniques can further improve their performance, showing that our approach is complementary to other dynamic quantization methods; (c) Quantizing LLMs to lower bits performs substantially better than pruning unless extreme quantization (2-bit) is used; and (d) Layer-wise quantization to lower bits works better in the case of larger LLMs with more layers compared to smaller LLMs with fewer layers. Our code is publicly available at https://github.com/RazvanDu/LayerwiseQuant/.
As large language models (LLMs) constantly evolve, ensuring their safety remains a critical research problem. Previous red-teaming approaches for LLM safety have primarily focused on single prompt attacks or goal hijacking. To the best of our knowledge, we are the first to study LLM safety in multi-turn dialogue coreference. We created a dataset of 1,400 questions across 14 categories, each featuring multi-turn coreference safety attacks. We then conducted detailed evaluations on five widely used open-source LLMs. The results indicated that under multi-turn coreference safety attacks, the highest attack success rate was 56% with the LLaMA2-Chat-7b model, while the lowest was 13.9% with the Mistral-7B-Instruct model. These findings highlight the safety vulnerabilities in LLMs during dialogue coreference interactions.
As large language models (LLMs) have advanced rapidly, concerns regarding their safety have become prominent. In this paper, we discover that code-switching in red-teaming queries can effectively elicit undesirable behaviors of LLMs, which are common practices in natural language. We introduce a simple yet effective framework, CSRT, to synthesize code-switching red-teaming queries and investigate the safety and multilingual understanding of LLMs comprehensively. Through extensive experiments with ten state-of-the-art LLMs and code-switching queries combining up to 10 languages, we demonstrate that the CSRT significantly outperforms existing multilingual red-teaming techniques, achieving 46.7% more attacks than standard attacks in English and being effective in conventional safety domains. We also examine the multilingual ability of those LLMs to generate and understand code-switching texts. Additionally, we validate the extensibility of the CSRT by generating code-switching attack prompts with monolingual data. We finally conduct detailed ablation studies exploring code-switching and propound unintended correlation between resource availability of languages and safety alignment in existing multilingual LLMs.
Multi-step reasoning instruction, such as chain-of-thought prompting, is widely adopted to explore better language models (LMs) performance. We report on the systematic strategy that LMs employ in such a multi-step reasoning process. Our controlled experiments reveal that LMs rely more heavily on heuristics, such as lexical overlap, in the earlier stages of reasoning, where more reasoning steps remain to reach a goal. Conversely, their reliance on heuristics decreases as LMs progress closer to the final answer through multiple reasoning steps. This suggests that LMs can backtrack only a limited number of future steps and dynamically combine heuristic strategies with rationale ones in tasks involving multi-step reasoning.
Multilingual LLMs often have knowledge disparities across languages, with larger gaps in under-resourced languages. Teaching LLMs to abstain in the face of knowledge gaps is thus a promising strategy to mitigate hallucinations in multilingual settings. However, previous studies on LLM abstention primarily focus on English; we find that directly applying existing solutions beyond English results in up to 20.5% performance gaps between high and low-resource languages, potentially due to LLMs' drop in calibration and reasoning beyond a few resource-rich languages. To this end, we propose strategies to enhance LLM abstention by learning from multilingual feedback, where LLMs self-reflect on proposed answers in one language by generating multiple feedback items in related languages: we show that this helps identifying the knowledge gaps across diverse languages, cultures, and communities. Extensive experiments demonstrate that our multilingual feedback approach outperforms various strong baselines, achieving up to 9.2% improvement for low-resource languages across three black-box and open models on three datasets, featuring open-book, closed-book, and commonsense QA. Further analysis reveals that multilingual feedback is both an effective and a more equitable abstain strategy to serve diverse language speakers, and cultural factors have great impact on language selection and LLM abstention behavior, highlighting future directions for multilingual and multi-cultural reliable language modeling.
Large Language Models (LLMs) have significantly advanced the field of information retrieval, particularly for reranking. Listwise LLM rerankers have showcased superior performance and generalizability compared to existing supervised approaches. However, conventional listwise LLM reranking methods lack efficiency as they provide ranking output in the form of a generated ordered sequence of candidate passage identifiers. Further, they are trained with the typical language modeling objective, which treats all ranking errors uniformly--potentially at the cost of misranking highly relevant passages. Addressing these limitations, we introduce FIRST, a novel listwise LLM reranking approach leveraging the output logits of the first generated identifier to directly obtain a ranked ordering of the candidates. Further, we incorporate a learning-to-rank loss during training, prioritizing ranking accuracy for the more relevant passages. Empirical results demonstrate that FIRST accelerates inference by 50% while maintaining a robust ranking performance with gains across the BEIR benchmark. Finally, to illustrate the practical effectiveness of listwise LLM rerankers, we investigate their application in providing relevance feedback for retrievers during inference. Our results show that LLM rerankers can provide a stronger distillation signal compared to cross-encoders, yielding substantial improvements in retriever recall after relevance feedback.
The goal of text style transfer is to transform the style of texts while preserving their original meaning, often with only a few examples of the target style. Existing style transfer methods generally rely on the few-shot capabilities of large language models or on complex controllable text generation approaches that are inefficient and underperform on fluency metrics. We introduce TinyStyler, a lightweight but effective approach, which leverages a small language model (800M params) and pre-trained authorship embeddings to perform efficient, few-shot text style transfer. We evaluate on the challenging task of authorship style transfer and find TinyStyler outperforms strong approaches such as GPT-4. We also evaluate TinyStyler's ability to perform text attribute style transfer (formal $\leftrightarrow$ informal) with automatic and human evaluations and find that the approach outperforms recent controllable text generation methods. Our model has been made publicly available at https://huggingface.co/tinystyler/tinystyler .
In the field of crisis/disaster informatics, social media is increasingly being used for improving situational awareness to inform response and relief efforts. Efficient and accurate text classification tools have been a focal area of investigation in crisis informatics. However, current methods mostly rely on single-label text classification models, which fails to capture different insights embedded in dynamic and multifaceted disaster-related social media data. This study introduces a novel approach to disaster text classification by enhancing a pre-trained Large Language Model (LLM) through instruction fine-tuning targeted for multi-label classification of disaster-related tweets. Our methodology involves creating a comprehensive instruction dataset from disaster-related tweets, which is then used to fine-tune an open-source LLM, thereby embedding it with disaster-specific knowledge. This fine-tuned model can classify multiple aspects of disaster-related information simultaneously, such as the type of event, informativeness, and involvement of human aid, significantly improving the utility of social media data for situational awareness in disasters. The results demonstrate that this approach enhances the categorization of critical information from social media posts, thereby facilitating a more effective deployment for situational awareness during emergencies. This research paves the way for more advanced, adaptable, and robust disaster management tools, leveraging the capabilities of LLMs to improve real-time situational awareness and response strategies in disaster scenarios.
This paper introduces a novel, entity-aware metric, termed as Radiological Report (Text) Evaluation (RaTEScore), to assess the quality of medical reports generated by AI models. RaTEScore emphasizes crucial medical entities such as diagnostic outcomes and anatomical details, and is robust against complex medical synonyms and sensitive to negation expressions. Technically, we developed a comprehensive medical NER dataset, RaTE-NER, and trained an NER model specifically for this purpose. This model enables the decomposition of complex radiological reports into constituent medical entities. The metric itself is derived by comparing the similarity of entity embeddings, obtained from a language model, based on their types and relevance to clinical significance. Our evaluations demonstrate that RaTEScore aligns more closely with human preference than existing metrics, validated both on established public benchmarks and our newly proposed RaTE-Eval benchmark.
The instruction-following ability of Large Language Models (LLMs) has cultivated a class of LLM-based systems capable of approaching complex tasks such as making edits to large code repositories. Due to the high sensitivity and unpredictability of LLM behavior in response to changes in prompting, robust evaluation tools are needed to drive future iteration of these systems. We propose RES-Q, a natural language instruction-based benchmark for evaluating $\textbf{R}$epository $\textbf{E}$diting $\textbf{S}$ystems, which consists of 100 handcrafted repository editing tasks derived from real GitHub commits. Given an edit instruction and a code repository, RES-Q evaluates an LLM system's ability to interpret the instruction, navigate the repository to gather relevant information, and construct an appropriate edit that satisfies the specified criteria. We argue that evaluating LLMs in this way addresses issues with traditional benchmarks and provides a more holistic assessment of a model's abilities. We evaluate various state-of-the-art LLMs as language agents in a repository-editing system built on Qurrent OS, our language agent development software. Despite their 1% pass@1 performance difference on HumanEval, we find Claude Sonnet 3.5 outperforms GPT-4o by 12% pass@1 on RES-Q, indicating RES-Q's capacity to differentiate model capability as traditional benchmarks approach saturation. We further investigate token efficiency, performance relationships with existing benchmarks, and interesting disparities between closed and open-source LLMs. Code and dataset are available at https://github.com/Qurrent-AI/RES-Q.
The path to interpreting a language model often proceeds via analysis of circuits -- sparse computational subgraphs of the model that capture specific aspects of its behavior. Recent work has automated the task of discovering circuits. Yet, these methods have practical limitations, as they rely either on inefficient search algorithms or inaccurate approximations. In this paper, we frame automated circuit discovery as an optimization problem and propose *Edge Pruning* as an effective and scalable solution. Edge Pruning leverages gradient-based pruning techniques, but instead of removing neurons or components, it prunes the \emph{edges} between components. Our method finds circuits in GPT-2 that use less than half the number of edges compared to circuits found by previous methods while being equally faithful to the full model predictions on standard circuit-finding tasks. Edge Pruning is efficient even with as many as 100K examples, outperforming previous methods in speed and producing substantially better circuits. It also perfectly recovers the ground-truth circuits in two models compiled with Tracr. Thanks to its efficiency, we scale Edge Pruning to CodeLlama-13B, a model over 100x the scale that prior methods operate on. We use this setting for a case study comparing the mechanisms behind instruction prompting and in-context learning. We find two circuits with more than 99.96% sparsity that match the performance of the full model and reveal that the mechanisms in the two settings overlap substantially. Our case study shows that Edge Pruning is a practical and scalable tool for interpretability and sheds light on behaviors that only emerge in large models.
Chinese Spell Checking (CSC) aims to detect and correct spelling errors in sentences. Despite Large Language Models (LLMs) exhibit robust capabilities and are widely applied in various tasks, their performance on CSC is often unsatisfactory. We find that LLMs fail to meet the Chinese character-level constraints of the CSC task, namely equal length and phonetic similarity, leading to a performance bottleneck. Further analysis reveal that this issue stems from the granularity of tokenization, as current mixed character-word tokenization struggles to satisfy these character-level constraints. To address this issue, we propose C-LLM, a Large Language Model-based Chinese Spell Checking method that learns to check errors Character by Character. Character-level tokenization enables the model to learn character-level alignment, effectively mitigating issues related to character-level constraints. Furthermore, CSC is simplified to replication-dominated and substitution-supplemented tasks. Experiments on two CSC benchmarks demonstrate that C-LLM achieves an average improvement of 10% over existing methods. Specifically, it shows a 2.1% improvement in general scenarios and a significant 12% improvement in vertical domain scenarios, establishing state-of-the-art performance. The source code can be accessed at https://github.com/ktlKTL/C-LLM.
Efficient adaption of large language models (LLMs) on edge devices is essential for applications requiring continuous and privacy-preserving adaptation and inference. However, existing tuning techniques fall short because of the high computation and memory overheads. To this end, we introduce a computation- and memory-efficient LLM tuning framework, called Edge-LLM, to facilitate affordable and effective LLM adaptation on edge devices. Specifically, Edge-LLM features three core components: (1) a layer-wise unified compression (LUC) technique to reduce the computation overhead by generating layer-wise pruning sparsity and quantization bit-width policies, (2) an adaptive layer tuning and voting scheme to reduce the memory overhead by reducing the backpropagation depth, and (3) a complementary hardware scheduling strategy to handle the irregular computation patterns introduced by LUC and adaptive layer tuning, thereby achieving efficient computation and data movements. Extensive experiments demonstrate that Edge-LLM achieves a 2.92x speed up and a 4x memory overhead reduction as compared to vanilla tuning methods with comparable task accuracy. Our code is available at https://github.com/GATECH-EIC/Edge-LLM
Image super-resolution pursuits reconstructing high-fidelity high-resolution counterpart for low-resolution image. In recent years, diffusion-based models have garnered significant attention due to their capabilities with rich prior knowledge. The success of diffusion models based on general text prompts has validated the effectiveness of textual control in the field of text2image. However, given the severe degradation commonly presented in low-resolution images, coupled with the randomness characteristics of diffusion models, current models struggle to adequately discern semantic and degradation information within severely degraded images. This often leads to obstacles such as semantic loss, visual artifacts, and visual hallucinations, which pose substantial challenges for practical use. To address these challenges, this paper proposes to leverage degradation-aligned language prompt for accurate, fine-grained, and high-fidelity image restoration. Complementary priors including semantic content descriptions and degradation prompts are explored. Specifically, on one hand, image-restoration prompt alignment decoder is proposed to automatically discern the degradation degree of LR images, thereby generating beneficial degradation priors for image restoration. On the other hand, much richly tailored descriptions from pretrained multimodal large language model elicit high-level semantic priors closely aligned with human perception, ensuring fidelity control for image restoration. Comprehensive comparisons with state-of-the-art methods have been done on several popular synthetic and real-world benchmark datasets. The quantitative and qualitative analysis have demonstrated that the proposed method achieves a new state-of-the-art perceptual quality level. Related source codes and pre-trained parameters were public in https://github.com/puppy210/DaLPSR.
Video sequences offer valuable temporal information, but existing large multimodal models (LMMs) fall short in understanding extremely long videos. Many works address this by reducing the number of visual tokens using visual resamplers. Alternatively, in this paper, we approach this problem from the perspective of the language model. By simply extrapolating the context length of the language backbone, we enable LMMs to comprehend orders of magnitude more visual tokens without any video training. We call this phenomenon long context transfer and carefully ablate its properties. To effectively measure LMMs' ability to generalize to long contexts in the vision modality, we develop V-NIAH (Visual Needle-In-A-Haystack), a purely synthetic long vision benchmark inspired by the language model's NIAH test. Our proposed Long Video Assistant (LongVA) can process 2000 frames or over 200K visual tokens without additional complexities. With its extended context length, LongVA achieves state-of-the-art performance on Video-MME among 7B-scale models by densely sampling more input frames. Our work is open-sourced at https://github.com/EvolvingLMMs-Lab/LongVA.
Neural codec language model (LM) has demonstrated strong capability in zero-shot text-to-speech (TTS) synthesis. However, the codec LM often suffers from limitations in inference speed and stability, due to its auto-regressive nature and implicit alignment between text and audio. In this work, to handle these challenges, we introduce a new variant of neural codec LM, namely TacoLM. Specifically, TacoLM introduces a gated attention mechanism to improve the training and inference efficiency and reduce the model size. Meanwhile, an additional gated cross-attention layer is included for each decoder layer, which improves the efficiency and content accuracy of the synthesized speech. In the evaluation of the Librispeech corpus, the proposed TacoLM achieves a better word error rate, speaker similarity, and mean opinion score, with 90% fewer parameters and 5.2 times speed up, compared with VALL-E. Demo and code is available at https://ereboas.github.io/TacoLM/.
Since the Transformer architecture emerged, language model development has grown, driven by their promising potential. Releasing these models into production requires properly understanding their behavior, particularly in sensitive domains like medicine. Despite this need, the medical literature still lacks practical assessment of pre-trained language models, which are especially valuable in settings where only consumer-grade computational resources are available. To address this gap, we have conducted a comprehensive survey of language models in the medical field and evaluated a subset of these for medical text classification and conditional text generation. The subset includes 53 models with 110 million to 13 billion parameters, spanning the Transformer-based model families and knowledge domains. Different approaches are employed for text classification, including zero-shot learning, enabling tuning without the need to train the model. These approaches are helpful in our target settings, where many users of language models find themselves. The results reveal remarkable performance across the tasks and datasets evaluated, underscoring the potential of certain models to contain medical knowledge, even without domain specialization. This study thus advocates for further exploration of model applications in medical contexts, particularly in computational resource-constrained settings, to benefit a wide range of users. The code is available on https://github.com/anpoc/Language-models-in-medicine.