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arXiv:2504.17699공식 코드 · Papers with Code

Quadratic Interest Network for Multimodal Click-Through Rate Prediction

Multimodal click-through rate (CTR) prediction is a key technique in industrial recommender systems. It leverages heterogeneous modalities such as text, images, and behavioral logs to capture high-order feature interactions between users and items, thereby enhancing the system's understanding of user interests and its ability to predict click behavior. The primary challenge in this field lies in effectively utilizing the rich semantic information from multiple modalities while satisfying the low-latency requirements of online inference in real-world applications. To foster progress in this area, the Multimodal CTR Prediction Challenge Track of the WWW 2025 EReL@MIR Workshop formulates the problem into two tasks: (1) Task 1 of Multimodal Item Embedding: this task aims to explore multimodal information extraction and item representation learning methods that enhance recommendation tasks; and (2) Task 2 of Multimodal CTR Prediction: this task aims to explore what multimodal recommendation model can effectively leverage multimodal embedding features and achieve better performance. In this paper, we propose a novel model for Task 2, named Quadratic Interest Network (QIN) for Multimodal CTR Prediction. Specifically, QIN employs adaptive sparse target attention to extract multimodal user behavior features, and leverages Quadratic Neural Networks to capture high-order feature interactions. As a result, QIN achieved an AUC of 0.9798 on the leaderboard and ranked second in the competition. The model code, training logs, hyperparameter configurations, and checkpoints are available at https://github.com/salmon1802/QIN.

arXiv:2505.00389공식 코드 · Papers with Code

CSE-SFP: Enabling Unsupervised Sentence Representation Learning via a Single Forward Pass

As a fundamental task in Information Retrieval and Computational Linguistics, sentence representation has profound implications for a wide range of practical applications such as text clustering, content analysis, question-answering systems, and web search. Recent advances in pre-trained language models (PLMs) have driven remarkable progress in this field, particularly through unsupervised embedding derivation methods centered on discriminative PLMs like BERT. However, due to time and computational constraints, few efforts have attempted to integrate unsupervised sentence representation with generative PLMs, which typically possess much larger parameter sizes. Given that state-of-the-art models in both academia and industry are predominantly based on generative architectures, there is a pressing need for an efficient unsupervised text representation framework tailored to decoder-only PLMs. To address this concern, we propose CSE-SFP, an innovative method that exploits the structural characteristics of generative models. Compared to existing strategies, CSE-SFP requires only a single forward pass to perform effective unsupervised contrastive learning. Rigorous experimentation demonstrates that CSE-SFP not only produces higher-quality embeddings but also significantly reduces both training time and memory consumption. Furthermore, we introduce two ratio metrics that jointly assess alignment and uniformity, thereby providing a more robust means for evaluating the semantic spatial properties of encoding models.

arXiv:2505.02692공식 코드 · Papers with Code

fastabx: A library for efficient computation of ABX discriminability

We introduce fastabx, a high-performance Python library for building ABX discrimination tasks. ABX is a measure of the separation between generic categories of interest. It has been used extensively to evaluate phonetic discriminability in self-supervised speech representations. However, its broader adoption has been limited by the absence of adequate tools. fastabx addresses this gap by providing a framework capable of constructing any type of ABX task while delivering the efficiency necessary for rapid development cycles, both in task creation and in calculating distances between representations. We believe that fastabx will serve as a valuable resource for the broader representation learning community, enabling researchers to systematically investigate what information can be directly extracted from learned representations across several domains beyond speech processing. The source code is available at https://github.com/bootphon/fastabx.

arXiv:2505.02022공식 코드 · Papers with Code

NbBench: Benchmarking Language Models for Comprehensive Nanobody Tasks

Nanobodies, single-domain antibody fragments derived from camelid heavy-chain-only antibodies, exhibit unique advantages such as compact size, high stability, and strong binding affinity, making them valuable tools in therapeutics and diagnostics. While recent advances in pretrained protein and antibody language models (PPLMs and PALMs) have greatly enhanced biomolecular understanding, nanobody-specific modeling remains underexplored and lacks a unified benchmark. To address this gap, we introduce NbBench, the first comprehensive benchmark suite for nanobody representation learning. Spanning eight biologically meaningful tasks across nine curated datasets, NbBench encompasses structure annotation, binding prediction, and developability assessment. We systematically evaluate eleven representative models--including general-purpose protein LMs, antibody-specific LMs, and nanobody-specific LMs--in a frozen setting. Our analysis reveals that antibody language models excel in antigen-related tasks, while performance on regression tasks such as thermostability and affinity remains challenging across all models. Notably, no single model consistently outperforms others across all tasks. By standardizing datasets, task definitions, and evaluation protocols, NbBench offers a reproducible foundation for assessing and advancing nanobody modeling.

arXiv:2504.18539공식 코드 · Papers with Code

Multi-Task Corrupted Prediction for Learning Robust Audio-Visual Speech Representation

Audio-visual speech recognition (AVSR) incorporates auditory and visual modalities to improve recognition accuracy, particularly in noisy environments where audio-only speech systems are insufficient. While previous research has largely addressed audio disruptions, few studies have dealt with visual corruptions, e.g., lip occlusions or blurred videos, which are also detrimental. To address this real-world challenge, we propose CAV2vec, a novel self-supervised speech representation learning framework particularly designed to handle audio-visual joint corruption. CAV2vec employs a self-distillation approach with a corrupted prediction task, where the student model learns to predict clean targets, generated by the teacher model, with corrupted input frames. Specifically, we suggest a unimodal multi-task learning, which distills cross-modal knowledge and aligns the corrupted modalities, by predicting clean audio targets with corrupted videos, and clean video targets with corrupted audios. This strategy mitigates the dispersion in the representation space caused by corrupted modalities, leading to more reliable and robust audio-visual fusion. Our experiments on robust AVSR benchmarks demonstrate that the corrupted representation learning method significantly enhances recognition accuracy across generalized environments involving various types of corruption. Our code is available at https://github.com/sungnyun/cav2vec.

arXiv:2505.02972공식 코드 · Papers with Code

GeoERM: Geometry-Aware Multi-Task Representation Learning on Riemannian Manifolds

Multi-Task Learning (MTL) seeks to boost statistical power and learning efficiency by discovering structure shared across related tasks. State-of-the-art MTL representation methods, however, usually treat the latent representation matrix as a point in ordinary Euclidean space, ignoring its often non-Euclidean geometry, thus sacrificing robustness when tasks are heterogeneous or even adversarial. We propose GeoERM, a geometry-aware MTL framework that embeds the shared representation on its natural Riemannian manifold and optimizes it via explicit manifold operations. Each training cycle performs (i) a Riemannian gradient step that respects the intrinsic curvature of the search space, followed by (ii) an efficient polar retraction to remain on the manifold, guaranteeing geometric fidelity at every iteration. The procedure applies to a broad class of matrix-factorized MTL models and retains the same per-iteration cost as Euclidean baselines. Across a set of synthetic experiments with task heterogeneity and on a wearable-sensor activity-recognition benchmark, GeoERM consistently improves estimation accuracy, reduces negative transfer, and remains stable under adversarial label noise, outperforming leading MTL and single-task alternatives.

arXiv:2504.21254공식 코드 · Papers with Code

ABG-NAS: Adaptive Bayesian Genetic Neural Architecture Search for Graph Representation Learning

Effective and efficient graph representation learning is essential for enabling critical downstream tasks, such as node classification, link prediction, and subgraph search. However, existing graph neural network (GNN) architectures often struggle to adapt to diverse and complex graph structures, limiting their ability to produce structure-aware and task-discriminative representations. To address this challenge, we propose ABG-NAS, a novel framework for automated graph neural network architecture search tailored for efficient graph representation learning. ABG-NAS encompasses three key components: a Comprehensive Architecture Search Space (CASS), an Adaptive Genetic Optimization Strategy (AGOS), and a Bayesian-Guided Tuning Module (BGTM). CASS systematically explores diverse propagation (P) and transformation (T) operations, enabling the discovery of GNN architectures capable of capturing intricate graph characteristics. AGOS dynamically balances exploration and exploitation, ensuring search efficiency and preserving solution diversity. BGTM further optimizes hyperparameters periodically, enhancing the scalability and robustness of the resulting architectures. Empirical evaluations on benchmark datasets (Cora, PubMed, Citeseer, and CoraFull) demonstrate that ABG-NAS consistently outperforms both manually designed GNNs and state-of-the-art neural architecture search (NAS) methods. These results highlight the potential of ABG-NAS to advance graph representation learning by providing scalable and adaptive solutions for diverse graph structures. Our code is publicly available at https://github.com/sserranw/ABG-NAS.

arXiv:2505.03186공식 코드 · Papers with Code

CoGenAV: Versatile Audio-Visual Representation Learning via Contrastive-Generative Synchronization

The inherent synchronization between a speaker's lip movements, voice, and the underlying linguistic content offers a rich source of information for improving speech processing tasks, especially in challenging conditions where traditional audio-only systems falter. We introduce CoGenAV, a powerful and data-efficient model designed to learn versatile audio-visual representations applicable across a wide range of speech and audio-visual tasks. CoGenAV is trained by optimizing a dual objective derived from natural audio-visual synchrony, contrastive feature alignment and generative text prediction, using only 223 hours of labeled data from the LRS2 dataset. This contrastive-generative synchronization strategy effectively captures fundamental cross-modal correlations. We showcase the effectiveness and versatility of the learned CoGenAV representations on multiple benchmarks. When utilized for Audio-Visual Speech Recognition (AVSR) on LRS2, these representations contribute to achieving a state-of-the-art Word Error Rate (WER) of 1.27. They also enable strong performance in Visual Speech Recognition (VSR) with a WER of 20.5 on LRS2, and significantly improve performance in noisy environments by over 70%. Furthermore, CoGenAV representations benefit speech reconstruction tasks, boosting performance in Speech Enhancement and Separation, and achieve competitive results in audio-visual synchronization tasks like Active Speaker Detection (ASD). Our model will be open-sourced to facilitate further development and collaboration within both academia and industry.

arXiv:2505.02831공식 코드 · Papers with Code

No Other Representation Component Is Needed: Diffusion Transformers Can Provide Representation Guidance by Themselves

Recent studies have demonstrated that learning a meaningful internal representation can both accelerate generative training and enhance the generation quality of diffusion transformers. However, existing approaches necessitate to either introduce an external and complex representation training framework or rely on a large-scale, pre-trained representation foundation model to provide representation guidance during the original generative training process. In this study, we posit that the unique discriminative process inherent to diffusion transformers enables them to offer such guidance without requiring external representation components. We therefore propose Self-Representation Alignment (SRA), a simple yet straightforward method that obtains representation guidance through a self-distillation manner. Specifically, SRA aligns the output latent representation of the diffusion transformer in the earlier layer with higher noise to that in the later layer with lower noise to progressively enhance the overall representation learning during only the generative training process. Experimental results indicate that applying SRA to DiTs and SiTs yields consistent performance improvements. Moreover, SRA not only significantly outperforms approaches relying on auxiliary, complex representation training frameworks but also achieves performance comparable to methods that are heavily dependent on powerful external representation priors.

arXiv:2505.02331공식 코드 · Papers with Code

VAEmo: Efficient Representation Learning for Visual-Audio Emotion with Knowledge Injection

Audiovisual emotion recognition (AVER) aims to infer human emotions from nonverbal visual-audio (VA) cues, offering modality-complementary and language-agnostic advantages. However, AVER remains challenging due to the inherent ambiguity of emotional expressions, cross-modal expressive disparities, and the scarcity of reliably annotated data. Recent self-supervised AVER approaches have introduced strong multimodal representations, yet they predominantly rely on modality-specific encoders and coarse content-level alignment, limiting fine-grained emotional semantic modeling. To address these issues, we propose VAEmo, an efficient two-stage framework for emotion-centric joint VA representation learning with external knowledge injection. In Stage 1, a unified and lightweight representation network is pre-trained on large-scale speaker-centric VA corpora via masked reconstruction and contrastive objectives, mitigating the modality gap and learning expressive, complementary representations without emotion labels. In Stage 2, multimodal large language models automatically generate detailed affective descriptions according to our well-designed chain-of-thought prompting for only a small subset of VA samples; these rich textual semantics are then injected by aligning their corresponding embeddings with VA representations through dual-path contrastive learning, further bridging the emotion gap. Extensive experiments on multiple downstream AVER benchmarks show that VAEmo achieves state-of-the-art performance with a compact design, highlighting the benefit of unified cross-modal encoding and emotion-aware semantic guidance for efficient, generalizable VA emotion representations.

arXiv:2504.21707공식 코드 · Papers with Code

Recursive KL Divergence Optimization: A Dynamic Framework for Representation Learning

We propose a generalization of modern representation learning objectives by reframing them as recursive divergence alignment processes over localized conditional distributions While recent frameworks like Information Contrastive Learning I-Con unify multiple learning paradigms through KL divergence between fixed neighborhood conditionals we argue this view underplays a crucial recursive structure inherent in the learning process. We introduce Recursive KL Divergence Optimization RKDO a dynamic formalism where representation learning is framed as the evolution of KL divergences across data neighborhoods. This formulation captures contrastive clustering and dimensionality reduction methods as static slices while offering a new path to model stability and local adaptation. Our experiments demonstrate that RKDO offers dual efficiency advantages approximately 30 percent lower loss values compared to static approaches across three different datasets and 60 to 80 percent reduction in computational resources needed to achieve comparable results. This suggests that RKDOs recursive updating mechanism provides a fundamentally more efficient optimization landscape for representation learning with significant implications for resource constrained applications.

arXiv:2504.15041공식 코드 · Papers with Code

Distribution-aware Forgetting Compensation for Exemplar-Free Lifelong Person Re-identification

Lifelong Person Re-identification (LReID) suffers from a key challenge in preserving old knowledge while adapting to new information. The existing solutions include rehearsal-based and rehearsal-free methods to address this challenge. Rehearsal-based approaches rely on knowledge distillation, continuously accumulating forgetting during the distillation process. Rehearsal-free methods insufficiently learn the distribution of each domain, leading to forgetfulness over time. To solve these issues, we propose a novel Distribution-aware Forgetting Compensation (DAFC) model that explores cross-domain shared representation learning and domain-specific distribution integration without using old exemplars or knowledge distillation. We propose a Text-driven Prompt Aggregation (TPA) that utilizes text features to enrich prompt elements and guide the prompt model to learn fine-grained representations for each instance. This can enhance the differentiation of identity information and establish the foundation for domain distribution awareness. Then, Distribution-based Awareness and Integration (DAI) is designed to capture each domain-specific distribution by a dedicated expert network and adaptively consolidate them into a shared region in high-dimensional space. In this manner, DAI can consolidate and enhance cross-domain shared representation learning while alleviating catastrophic forgetting. Furthermore, we develop a Knowledge Consolidation Mechanism (KCM) that comprises instance-level discrimination and cross-domain consistency alignment strategies to facilitate model adaptive learning of new knowledge from the current domain and promote knowledge consolidation learning between acquired domain-specific distributions, respectively. Experimental results show that our DAFC outperform state-of-the-art methods by at least 9.8\%/6.6\% and 6.4\%/6.2\% of average mAP/R@1 on two training orders.

arXiv:2504.11840공식 코드 · Papers with Code

GT-SVQ: A Linear-Time Graph Transformer for Node Classification Using Spiking Vector Quantization

Graph Transformers (GTs), which simultaneously integrate message-passing and self-attention mechanisms, have achieved promising empirical results in some graph prediction tasks. Although these approaches show the potential of Transformers in capturing long-range graph topology information, issues concerning the quadratic complexity and high computing energy consumption severely limit the scalability of GTs on large-scale graphs. Recently, as brain-inspired neural networks, Spiking Neural Networks (SNNs), facilitate the development of graph representation learning methods with lower computational and storage overhead through the unique event-driven spiking neurons. Inspired by these characteristics, we propose a linear-time Graph Transformer using Spiking Vector Quantization (GT-SVQ) for node classification. GT-SVQ reconstructs codebooks based on rate coding outputs from spiking neurons, and injects the codebooks into self-attention blocks to aggregate global information in linear complexity. Besides, spiking vector quantization effectively alleviates codebook collapse and the reliance on complex machinery (distance measure, auxiliary loss, etc.) present in previous vector quantization-based graph learning methods. In experiments, we compare GT-SVQ with other state-of-the-art baselines on node classification datasets ranging from small to large. Experimental results show that GT-SVQ has achieved competitive performances on most datasets while maintaining up to 130x faster inference speed compared to other GTs.

arXiv:2504.13820공식 코드 · Papers with Code

CheXWorld: Exploring Image World Modeling for Radiograph Representation Learning

Humans can develop internal world models that encode common sense knowledge, telling them how the world works and predicting the consequences of their actions. This concept has emerged as a promising direction for establishing general-purpose machine-learning models in recent preliminary works, e.g., for visual representation learning. In this paper, we present CheXWorld, the first effort towards a self-supervised world model for radiographic images. Specifically, our work develops a unified framework that simultaneously models three aspects of medical knowledge essential for qualified radiologists, including 1) local anatomical structures describing the fine-grained characteristics of local tissues (e.g., architectures, shapes, and textures); 2) global anatomical layouts describing the global organization of the human body (e.g., layouts of organs and skeletons); and 3) domain variations that encourage CheXWorld to model the transitions across different appearance domains of radiographs (e.g., varying clarity, contrast, and exposure caused by collecting radiographs from different hospitals, devices, or patients). Empirically, we design tailored qualitative and quantitative analyses, revealing that CheXWorld successfully captures these three dimensions of medical knowledge. Furthermore, transfer learning experiments across eight medical image classification and segmentation benchmarks showcase that CheXWorld significantly outperforms existing SSL methods and large-scale medical foundation models. Code & pre-trained models are available at https://github.com/LeapLabTHU/CheXWorld.

arXiv:2504.04452공식 코드 · Papers with Code

COHESION: Composite Graph Convolutional Network with Dual-Stage Fusion for Multimodal Recommendation

Recent works in multimodal recommendations, which leverage diverse modal information to address data sparsity and enhance recommendation accuracy, have garnered considerable interest. Two key processes in multimodal recommendations are modality fusion and representation learning. Previous approaches in modality fusion often employ simplistic attentive or pre-defined strategies at early or late stages, failing to effectively handle irrelevant information among modalities. In representation learning, prior research has constructed heterogeneous and homogeneous graph structures encapsulating user-item, user-user, and item-item relationships to better capture user interests and item profiles. Modality fusion and representation learning were considered as two independent processes in previous work. In this paper, we reveal that these two processes are complementary and can support each other. Specifically, powerful representation learning enhances modality fusion, while effective fusion improves representation quality. Stemming from these two processes, we introduce a COmposite grapH convolutional nEtwork with dual-stage fuSION for the multimodal recommendation, named COHESION. Specifically, it introduces a dual-stage fusion strategy to reduce the impact of irrelevant information, refining all modalities using ID embedding in the early stage and fusing their representations at the late stage. It also proposes a composite graph convolutional network that utilizes user-item, user-user, and item-item graphs to extract heterogeneous and homogeneous latent relationships within users and items. Besides, it introduces a novel adaptive optimization to ensure balanced and reasonable representations across modalities. Extensive experiments on three widely used datasets demonstrate the significant superiority of COHESION over various competitive baselines.

arXiv:2502.12513공식 코드 · Papers with Code

RealSyn: An Effective and Scalable Multimodal Interleaved Document Transformation Paradigm

After pre-training on extensive image-text pairs, Contrastive Language-Image Pre-training (CLIP) demonstrates promising performance on a wide variety of benchmarks. However, a substantial volume of multimodal interleaved documents remains underutilized for contrastive vision-language representation learning. To fully leverage these unpaired documents, we initially establish a Real-World Data Extraction pipeline to extract high-quality images and texts. Then we design a hierarchical retrieval method to efficiently associate each image with multiple semantically relevant realistic texts. To further enhance fine-grained visual information, we propose an image semantic augmented generation module for synthetic text production. Furthermore, we employ a semantic balance sampling strategy to improve dataset diversity, enabling better learning of long-tail concepts. Based on these innovations, we construct RealSyn, a dataset combining realistic and synthetic texts, available in three scales: 15M, 30M, and 100M. We compare our dataset with other widely used datasets of equivalent scale for CLIP training. Models pre-trained on RealSyn consistently achieve state-of-the-art performance across various downstream tasks, including linear probe, zero-shot transfer, zero-shot robustness, and zero-shot retrieval. Furthermore, extensive experiments confirm that RealSyn significantly enhances contrastive vision-language representation learning and demonstrates robust scalability. To facilitate future research, the RealSyn dataset and pretrained model weights are released at https://github.com/deepglint/RealSyn.

arXiv:2504.12474공식 코드 · Papers with Code

Integrating Structural and Semantic Signals in Text-Attributed Graphs with BiGTex

Text-attributed graphs (TAGs) present unique challenges in representation learning by requiring models to capture both the semantic richness of node-associated texts and the structural dependencies of the graph. While graph neural networks (GNNs) excel at modeling topological information, they lack the capacity to process unstructured text. Conversely, large language models (LLMs) are proficient in text understanding but are typically unaware of graph structure. In this work, we propose BiGTex (Bidirectional Graph Text), a novel architecture that tightly integrates GNNs and LLMs through stacked Graph-Text Fusion Units. Each unit allows for mutual attention between textual and structural representations, enabling information to flow in both directions, text influencing structure and structure guiding textual interpretation. The proposed architecture is trained using parameter-efficient fine-tuning (LoRA), keeping the LLM frozen while adapting to task-specific signals. Extensive experiments on five benchmark datasets demonstrate that BiGTex achieves state-of-the-art performance in node classification and generalizes effectively to link prediction. An ablation study further highlights the importance of soft prompting and bi-directional attention in the model's success.

arXiv:2504.10231공식 코드 · Papers with Code

A Model Zoo of Vision Transformers

The availability of large, structured populations of neural networks - called 'model zoos' - has led to the development of a multitude of downstream tasks ranging from model analysis, to representation learning on model weights or generative modeling of neural network parameters. However, existing model zoos are limited in size and architecture and neglect the transformer, which is among the currently most successful neural network architectures. We address this gap by introducing the first model zoo of vision transformers (ViT). To better represent recent training approaches, we develop a new blueprint for model zoo generation that encompasses both pre-training and fine-tuning steps, and publish 250 unique models. They are carefully generated with a large span of generating factors, and their diversity is validated using a thorough choice of weight-space and behavioral metrics. To further motivate the utility of our proposed dataset, we suggest multiple possible applications grounded in both extensive exploratory experiments and a number of examples from the existing literature. By extending previous lines of similar work, our model zoo allows researchers to push their model population-based methods from the small model regime to state-of-the-art architectures. We make our model zoo available at github.com/ModelZoos/ViTModelZoo.

arXiv:2504.10143공식 코드 · Papers with Code

On the Value of Cross-Modal Misalignment in Multimodal Representation Learning

Multimodal representation learning, exemplified by multimodal contrastive learning (MMCL) using image-text pairs, aims to learn powerful representations by aligning cues across modalities. This approach relies on the core assumption that the exemplar image-text pairs constitute two representations of an identical concept. However, recent research has revealed that real-world datasets often exhibit cross-modal misalignment. There are two distinct viewpoints on how to address this issue: one suggests mitigating the misalignment, and the other leveraging it. We seek here to reconcile these seemingly opposing perspectives, and to provide a practical guide for practitioners. Using latent variable models we thus formalize cross-modal misalignment by introducing two specific mechanisms: Selection bias, where some semantic variables are absent in the text, and perturbation bias, where semantic variables are altered -- both leading to misalignment in data pairs. Our theoretical analysis demonstrates that, under mild assumptions, the representations learned by MMCL capture exactly the information related to the subset of the semantic variables invariant to selection and perturbation biases. This provides a unified perspective for understanding misalignment. Based on this, we further offer actionable insights into how misalignment should inform the design of real-world ML systems. We validate our theoretical findings via extensive empirical studies on both synthetic data and real image-text datasets, shedding light on the nuanced impact of cross-modal misalignment on multimodal representation learning.

arXiv:2504.09544공식 코드 · Papers with Code

Causal integration of chemical structures improves representations of microscopy images for morphological profiling

Recent advances in self-supervised deep learning have improved our ability to quantify cellular morphological changes in high-throughput microscopy screens, a process known as morphological profiling. However, most current methods only learn from images, despite many screens being inherently multimodal, as they involve both a chemical or genetic perturbation as well as an image-based readout. We hypothesized that incorporating chemical compound structure during self-supervised pre-training could improve learned representations of images in high-throughput microscopy screens. We introduce a representation learning framework, MICON (Molecular-Image Contrastive Learning), that models chemical compounds as treatments that induce counterfactual transformations of cell phenotypes. MICON significantly outperforms classical hand-crafted features such as CellProfiler and existing deep-learning-based representation learning methods in challenging evaluation settings where models must identify reproducible effects of drugs across independent replicates and data-generating centers. We demonstrate that incorporating chemical compound information into the learning process provides consistent improvements in our evaluation setting and that modeling compounds specifically as treatments in a causal framework outperforms approaches that directly align images and compounds in a single representation space. Our findings point to a new direction for representation learning in morphological profiling, suggesting that methods should explicitly account for the multimodal nature of microscopy screening data.