Non-local operations play a crucial role in computer vision enabling the capture of long-range dependencies through weighted sums of features across the input, surpassing the constraints of traditional convolution operations that focus solely on local neighborhoods. Non-local operations typically require computing pairwise relationships between all elements in a set, leading to quadratic complexity in terms of time and memory. Due to the high computational and memory demands, scaling non-local neural networks to large-scale problems can be challenging. This article introduces a hybrid quantum-classical scalable non-local neural network, referred to as Quantum Non-Local Neural Network (QNL-Net), to enhance pattern recognition. The proposed QNL-Net relies on inherent quantum parallelism to allow the simultaneous processing of a large number of input features enabling more efficient computations in quantum-enhanced feature space and involving pairwise relationships through quantum entanglement. We benchmark our proposed QNL-Net with other quantum counterparts to binary classification with datasets MNIST and CIFAR-10. The simulation findings showcase our QNL-Net achieves cutting-edge accuracy levels in binary image classification among quantum classifiers while utilizing fewer qubits.
There is unprecedented development in machine learning, exemplified by recent large language models and world simulators, which are artificial neural networks running on digital computers. However, they still cannot parallel human brains in terms of energy efficiency and the streamlined adaptability to inputs of different difficulties, due to differences in signal representation, optimization, run-time reconfigurability, and hardware architecture. To address these fundamental challenges, we introduce pruning optimization for input-aware dynamic memristive spiking neural network (PRIME). Signal representation-wise, PRIME employs leaky integrate-and-fire neurons to emulate the brain's inherent spiking mechanism. Drawing inspiration from the brain's structural plasticity, PRIME optimizes the topology of a random memristive spiking neural network without expensive memristor conductance fine-tuning. For runtime reconfigurability, inspired by the brain's dynamic adjustment of computational depth, PRIME employs an input-aware dynamic early stop policy to minimize latency during inference, thereby boosting energy efficiency without compromising performance. Architecture-wise, PRIME leverages memristive in-memory computing, mirroring the brain and mitigating the von Neumann bottleneck. We validated our system using a 40 nm 256 Kb memristor-based in-memory computing macro on neuromorphic image classification and image inpainting. Our results demonstrate the classification accuracy and Inception Score are comparable to the software baseline, while achieving maximal 62.50-fold improvements in energy efficiency, and maximal 77.0% computational load savings. The system also exhibits robustness against stochastic synaptic noise of analogue memristors. Our software-hardware co-designed model paves the way to future brain-inspired neuromorphic computing with brain-like energy efficiency and adaptivity.
Multiple Instance Learning (MIL) represents the predominant framework in Whole Slide Image (WSI) classification, covering aspects such as sub-typing, diagnosis, and beyond. Current MIL models predominantly rely on instance-level features derived from pretrained models such as ResNet. These models segment each WSI into independent patches and extract features from these local patches, leading to a significant loss of global spatial context and restricting the model's focus to merely local features. To address this issue, we propose a novel MIL framework, named SAM-MIL, that emphasizes spatial contextual awareness and explicitly incorporates spatial context by extracting comprehensive, image-level information. The Segment Anything Model (SAM) represents a pioneering visual segmentation foundational model that can capture segmentation features without the need for additional fine-tuning, rendering it an outstanding tool for extracting spatial context directly from raw WSIs. Our approach includes the design of group feature extraction based on spatial context and a SAM-Guided Group Masking strategy to mitigate class imbalance issues. We implement a dynamic mask ratio for different segmentation categories and supplement these with representative group features of categories. Moreover, SAM-MIL divides instances to generate additional pseudo-bags, thereby augmenting the training set, and introduces consistency of spatial context across pseudo-bags to further enhance the model's performance. Experimental results on the CAMELYON-16 and TCGA Lung Cancer datasets demonstrate that our proposed SAM-MIL model outperforms existing mainstream methods in WSIs classification. Our open-source implementation code is is available at https://github.com/FangHeng/SAM-MIL.
Distillation-based self-supervised learning typically leads to more compressed representations due to its radical clustering process and the implementation of a sharper target distribution. To overcome this limitation and preserve more information from input, we introduce UDI, conceptualized as Unsqueezed Distillation-based self-supervised learning (SSL). UDI enriches the learned representation by encouraging multimodal prediction distilled from a consolidated profile of local predictions that are derived via stratified sampling. Our evaluations show that UDI not only promotes semantically meaningful representations at instance level, delivering superior or competitive results to state-of-the-art SSL methods in image classification, but also effectively preserves the nuisance of input, which yields significant improvement in dense prediction tasks, including object detection and segmentation. Additionally, UDI performs competitively in low-shot image classification, improving the scalability of joint-embedding pipelines. Various visualizations and ablation studies are presented to further elucidate the mechanisms behind UDI. Our source code is available at https://github.com/ISL-CV/udi.
Low-rank adaptation, also known as LoRA, has emerged as a prominent method for parameter-efficient fine-tuning of foundation models. Despite its computational efficiency, LoRA still yields inferior performance compared to full fine-tuning. In this paper, we first uncover a fundamental connection between the optimization processes of LoRA and full fine-tuning: using LoRA for optimization is mathematically equivalent to full fine-tuning using a low-rank gradient for parameter updates. And this low-rank gradient can be expressed in terms of the gradients of the two low-rank matrices in LoRA. Leveraging this insight, we introduce LoRA-Pro, a method that enhances LoRA's performance by strategically adjusting the gradients of these low-rank matrices. This adjustment allows the low-rank gradient to more accurately approximate the full fine-tuning gradient, thereby narrowing the performance gap between LoRA and full fine-tuning. Furthermore, we theoretically derive the optimal solutions for adjusting the gradients of the low-rank matrices, applying them during fine-tuning in LoRA-Pro. We conduct extensive experiments across natural language understanding, dialogue generation, mathematical reasoning, code generation, and image classification tasks, demonstrating that LoRA-Pro substantially improves LoRA's performance, effectively narrowing the gap with full fine-tuning. Code is publicly available at https://github.com/mrflogs/LoRA-Pro.
Recent advancements in graph-based approaches for multiplexed immunofluorescence (mIF) images have significantly propelled the field forward, offering deeper insights into patient-level phenotyping. However, current graph-based methodologies encounter two primary challenges: (1) Cellular Heterogeneity, where existing approaches fail to adequately address the inductive biases inherent in graphs, particularly the homophily characteristic observed in cellular connectivity and; (2) Scalability, where handling cellular graphs from high-dimensional images faces difficulties in managing a high number of cells. To overcome these limitations, we introduce Mew, a novel framework designed to efficiently process mIF images through the lens of multiplex network. Mew innovatively constructs a multiplex network comprising two distinct layers: a Voronoi network for geometric information and a Cell-type network for capturing cell-wise homogeneity. This framework equips a scalable and efficient Graph Neural Network (GNN), capable of processing the entire graph during training. Furthermore, Mew integrates an interpretable attention module that autonomously identifies relevant layers for image classification. Extensive experiments on a real-world patient dataset from various institutions highlight Mew's remarkable efficacy and efficiency, marking a significant advancement in mIF image analysis. The source code of Mew can be found here: \url{https://github.com/UNITES-Lab/Mew}
Recent studies have underscored the capabilities of natural imaging foundation models to serve as powerful feature extractors, even in a zero-shot setting for medical imaging data. Most commonly, a shallow multi-layer perceptron (MLP) is appended to the feature extractor to facilitate end-to-end learning and downstream prediction tasks such as classification, thus representing the de facto standard. However, as graph neural networks (GNNs) have become a practicable choice for various tasks in medical research in the recent past, we direct attention to the question of how effective GNNs are compared to MLP prediction heads for the task of 3D medical image classification, proposing them as a potential alternative. In our experiments, we devise a subject-level graph for each volumetric dataset instance. Therein latent representations of all slices in the volume, encoded through a DINOv2 pretrained vision transformer (ViT), constitute the nodes and their respective node features. We use public datasets to compare the classification heads numerically and evaluate various graph construction and graph convolution methods in our experiments. Our findings show enhancements of the GNN in classification performance and substantial improvements in runtime compared to an MLP prediction head. Additional robustness evaluations further validate the promising performance of the GNN, promoting them as a suitable alternative to traditional MLP classification heads. Our code is publicly available at: https://github.com/compai-lab/2024-miccai-grail-kiechle
Colorectal polyps are generally benign alterations that, if not identified promptly and managed successfully, can progress to cancer and cause affectations on the colon mucosa, known as adenocarcinoma. Today advances in Deep Learning have demonstrated the ability to achieve significant performance in image classification and detection in medical diagnosis applications. Nevertheless, these models are prone to overfitting, and making decisions based only on point estimations may provide incorrect predictions. Thus, to obtain a more informed decision, we must consider point estimations along with their reliable uncertainty quantification. In this paper, we built different Bayesian neural network approaches based on the flexibility of posterior distribution to develop semantic segmentation of colorectal polyp images. We found that these models not only provide state-of-the-art performance on the segmentation of this medical dataset but also, yield accurate uncertainty estimates. We applied multiplicative normalized flows(MNF) and reparameterization trick on the UNET, FPN, and LINKNET architectures tested with multiple backbones in deterministic and Bayesian versions. We report that the FPN + EfficientnetB7 architecture with MNF is the most promising option given its IOU of 0.94 and Expected Calibration Error (ECE) of 0.004, combined with its superiority in identifying difficult-to-detect colorectal polyps, which is effective in clinical areas where early detection prevents the development of colon cancer.
Multispectral (MS) snapshot cameras equipped with a MS filter array (MSFA), capture multiple spectral bands in a single shot, resulting in a raw mosaic image where each pixel holds only one channel value. The fully-defined MS image is estimated from the raw one through \textit{demosaicing}, which inevitably introduces spatio-spectral artifacts. Moreover, training on fully-defined MS images can be computationally intensive, particularly with deep neural networks (DNNs), and may result in features lacking discrimination power due to suboptimal learning of spatio-spectral interactions. Furthermore, outdoor MS image acquisition occurs under varying lighting conditions, leading to illumination-dependent features. This paper presents an original approach to learn discriminant and illumination-robust features directly from raw images. It involves: \textit{raw spectral constancy} to mitigate the impact of illumination, \textit{MSFA-preserving} transformations suited for raw image augmentation to train DNNs on diverse raw textures, and \textit{raw-mixing} to capture discriminant spatio-spectral interactions in raw images. Experiments on MS image classification show that our approach outperforms both handcrafted and recent deep learning-based methods, while also requiring significantly less computational effort. The source code is available at https://github.com/AnisAmziane/RawTexture.
This paper aims to adapt the source model to the target environment, leveraging small user feedback (i.e., labeled target data) readily available in real-world applications. We find that existing semi-supervised domain adaptation (SemiSDA) methods often suffer from poorly improved adaptation performance when directly utilizing such feedback data, as shown in Figure 1. We analyze this phenomenon via a novel concept called Negatively Biased Feedback (NBF), which stems from the observation that user feedback is more likely for data points where the model produces incorrect predictions. To leverage this feedback while avoiding the issue, we propose a scalable adapting approach, Retrieval Latent Defending. This approach helps existing SemiSDA methods to adapt the model with a balanced supervised signal by utilizing latent defending samples throughout the adaptation process. We demonstrate the problem caused by NBF and the efficacy of our approach across various benchmarks, including image classification, semantic segmentation, and a real-world medical imaging application. Our extensive experiments reveal that integrating our approach with multiple state-of-the-art SemiSDA methods leads to significant performance improvements.
Advances in generative models increase the need for sample quality assessment. To do so, previous methods rely on a pre-trained feature extractor to embed the generated samples and real samples into a common space for comparison. However, different feature extractors might lead to inconsistent assessment outcomes. Moreover, these methods are not applicable for domains where a robust, universal feature extractor does not yet exist, such as medical images or 3D assets. In this paper, we propose to directly examine the latent space of the trained generative model to infer generated sample quality. This is feasible because the quality a generated sample directly relates to the amount of training data resembling it, and we can infer this information by examining the density of the latent space. Accordingly, we use a latent density score function to quantify sample quality. We show that the proposed score correlates highly with the sample quality for various generative models including VAEs, GANs and Latent Diffusion Models. Compared with previous quality assessment methods, our method has the following advantages: 1) pre-generation quality estimation with reduced computational cost, 2) generalizability to various domains and modalities, and 3) applicability to latent-based image editing and generation methods. Extensive experiments demonstrate that our proposed methods can benefit downstream tasks such as few-shot image classification and latent face image editing. Code is available at https://github.com/cvlab-stonybrook/LS-sample-quality.
High-efficiency deep learning (DL) models are necessary not only to facilitate their use in devices with limited resources but also to improve resources required for training. Convolutional neural networks (ConvNets) typically exert severe demands on local device resources and this conventionally limits their adoption within mobile and embedded platforms. This brief presents work toward utilizing static convolutional filters generated from the space of local binary patterns (LBPs) and Haar features to design efficient ConvNet architectures. These are referred to as Structured Ternary Patterns (STePs) and can be generated during network initialization in a systematic way instead of having learnable weight parameters thus reducing the total weight updates. The ternary values require significantly less storage and with the appropriate low-level implementation, can also lead to inference improvements. The proposed approach is validated using four image classification datasets, demonstrating that common network backbones can be made more efficient and provide competitive results. It is also demonstrated that it is possible to generate completely custom STeP-based networks that provide good trade-offs for on-device applications such as unmanned aerial vehicle (UAV)-based aerial vehicle detection. The experimental results show that the proposed method maintains high detection accuracy while reducing the trainable parameters by 40-80%. This work motivates further research toward good priors for non-learnable weights that can make DL architectures more efficient without having to alter the network during or after training.
This study proposes two novel learning rate schedulers -- Hyperbolic Learning Rate Scheduler (HyperbolicLR) and Exponential Hyperbolic Learning Rate Scheduler (ExpHyperbolicLR) -- to address the epoch sensitivity problem that often causes inconsistent learning curves in conventional methods. By leveraging the asymptotic behavior of hyperbolic curves, the proposed schedulers maintain more stable learning curves across varying epoch settings. Specifically, HyperbolicLR applies this property directly in the epoch-learning rate space, while ExpHyperbolicLR extends it to an exponential space. We first determine optimal hyperparameters for each scheduler on a small number of epochs, fix these hyperparameters, and then evaluate performance as the number of epochs increases. Experimental results on various deep learning tasks (e.g., image classification, time series forecasting, and operator learning) demonstrate that both HyperbolicLR and ExpHyperbolicLR achieve more consistent performance improvements than conventional schedulers as training duration grows. These findings suggest that our hyperbolic-based schedulers offer a more robust and efficient approach to deep network optimization, particularly in scenarios constrained by computational resources or time.
State-space models (SSMs) have recently shown promise in capturing long-range dependencies with subquadratic computational complexity, making them attractive for various applications. However, purely SSM-based models face critical challenges related to stability and achieving state-of-the-art performance in computer vision tasks. Our paper addresses the challenges of scaling SSM-based models for computer vision, particularly the instability and inefficiency of large model sizes. We introduce a parameter-efficient modulated group mamba layer that divides the input channels into four groups and applies our proposed SSM-based efficient Visual Single Selective Scanning (VSSS) block independently to each group, with each VSSS block scanning in one of the four spatial directions. The Modulated Group Mamba layer also wraps the four VSSS blocks into a channel modulation operator to improve cross-channel communication. Furthermore, we introduce a distillation-based training objective to stabilize the training of large models, leading to consistent performance gains. Our comprehensive experiments demonstrate the merits of the proposed contributions, leading to superior performance over existing methods for image classification on ImageNet-1K, object detection, instance segmentation on MS-COCO, and semantic segmentation on ADE20K. Our tiny variant with 23M parameters achieves state-of-the-art performance with a classification top-1 accuracy of 83.3% on ImageNet-1K, while being 26% efficient in terms of parameters, compared to the best existing Mamba design of same model size. Code and models are available at: https://github.com/Amshaker/GroupMamba.
As deep learning-based systems have become an integral part of everyday life, limitations in their generalization ability have begun to emerge. Machine learning algorithms typically rely on the i.i.d. assumption, meaning that their training and validation data are expected to follow the same distribution, which does not necessarily hold in practice. In the case of image classification, one frequent reason that algorithms fail to generalize is that they rely on spurious correlations present in training data, such as associating image styles with target classes. These associations may not be present in the unseen test data, leading to significant degradation of their effectiveness. In this work, we attempt to mitigate this Domain Generalization (DG) problem by training a robust feature extractor which disregards features attributed to image-style but infers based on style-invariant image representations. To achieve this, we train CycleGAN models to learn the different styles present in the training data and randomly mix them together to create samples with novel style attributes to improve generalization. Experimental results on the PACS DG benchmark validate the proposed method.
Masked AutoEncoders (MAE) have emerged as a robust self-supervised framework, offering remarkable performance across a wide range of downstream tasks. To increase the difficulty of the pretext task and learn richer visual representations, existing works have focused on replacing standard random masking with more sophisticated strategies, such as adversarial-guided and teacher-guided masking. However, these strategies depend on the input data thus commonly increasing the model complexity and requiring additional calculations to generate the mask patterns. This raises the question: Can we enhance MAE performance beyond random masking without relying on input data or incurring additional computational costs? In this work, we introduce a simple yet effective data-independent method, termed ColorMAE, which generates different binary mask patterns by filtering random noise. Drawing inspiration from color noise in image processing, we explore four types of filters to yield mask patterns with different spatial and semantic priors. ColorMAE requires no additional learnable parameters or computational overhead in the network, yet it significantly enhances the learned representations. We provide a comprehensive empirical evaluation, demonstrating our strategy's superiority in downstream tasks compared to random masking. Notably, we report an improvement of 2.72 in mIoU in semantic segmentation tasks relative to baseline MAE implementations.
We study the problem of continual test-time adaption where the goal is to adapt a source pre-trained model to a sequence of unlabelled target domains at test time. Existing methods on test-time training suffer from several limitations: (1) Mismatch between the feature extractor and classifier; (2) Interference between the main and self-supervised tasks; (3) Lack of the ability to quickly adapt to the current distribution. In light of these challenges, we propose a cascading paradigm that simultaneously updates the feature extractor and classifier at test time, mitigating the mismatch between them and enabling long-term model adaptation. The pre-training of our model is structured within a meta-learning framework, thereby minimizing the interference between the main and self-supervised tasks and encouraging fast adaptation in the presence of limited unlabelled data. Additionally, we introduce innovative evaluation metrics, average accuracy and forward transfer, to effectively measure the model's adaptation capabilities in dynamic, real-world scenarios. Extensive experiments and ablation studies demonstrate the superiority of our approach in a range of tasks including image classification, text classification, and speech recognition.
Vision-language models have been extensively explored across a wide range of tasks, achieving satisfactory performance; however, their application in medical imaging remains underexplored. In this work, we propose a unified framework - LiteGPT - for the medical imaging. We leverage multiple pre-trained visual encoders to enrich information and enhance the performance of vision-language models. To the best of our knowledge, this is the first study to utilize vision-language models for the novel task of joint localization and classification in medical images. Besides, we are pioneers in providing baselines for disease localization in chest X-rays. Finally, we set new state-of-the-art performance in the image classification task on the well-benchmarked VinDr-CXR dataset. All code and models are publicly available online: https://github.com/leduckhai/LiteGPT
Limited training data and severe class imbalance pose significant challenges to developing clinically robust deep learning models. Federated learning (FL) addresses the former by enabling different medical clients to collaboratively train a deep model without sharing privacy-sensitive data. However, class imbalance worsens due to variation in inter-client class distribution. We propose federated learning with non-parametric regularization (FedNPR and FedNPR-Per, a personalized version of FedNPR) to regularize the feature extractor and enhance useful and discriminative signal in the feature space. Our extensive experiments show that FedNPR outperform the existing state-of-the art FL approaches in class imbalance skin lesion classification and intracranial hemorrhage identification. Additionally, the non-parametric regularization module consistently improves the performance of existing state-of-the-art FL approaches. We believe that NPR is a valuable tool in FL under clinical settings.
Large-scale vision models have become integral in many applications due to their unprecedented performance and versatility across downstream tasks. However, the robustness of these foundation models has primarily been explored for a single task, namely image classification. The vulnerability of other common vision tasks, such as semantic segmentation and depth estimation, remains largely unknown. We present a comprehensive empirical evaluation of the adversarial robustness of self-supervised vision encoders across multiple downstream tasks. Our attacks operate in the encoder embedding space and at the downstream task output level. In both cases, current state-of-the-art adversarial fine-tuning techniques tested only for classification significantly degrade clean and robust performance on other tasks. Since the purpose of a foundation model is to cater to multiple applications at once, our findings reveal the need to enhance encoder robustness more broadly. Our code is available at ${github.com/layer6ai-labs/ssl-robustness}$.