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arXiv:2506.08158공식 코드 · Papers with Code

ETT-CKGE: Efficient Task-driven Tokens for Continual Knowledge Graph Embedding

Continual Knowledge Graph Embedding (CKGE) seeks to integrate new knowledge while preserving past information. However, existing methods struggle with efficiency and scalability due to two key limitations: (1) suboptimal knowledge preservation between snapshots caused by manually designed node/relation importance scores that ignore graph dependencies relevant to the downstream task, and (2) computationally expensive graph traversal for node/relation importance calculation, leading to slow training and high memory overhead. To address these limitations, we introduce ETT-CKGE (Efficient, Task-driven, Tokens for Continual Knowledge Graph Embedding), a novel task-guided CKGE method that leverages efficient task-driven tokens for efficient and effective knowledge transfer between snapshots. Our method introduces a set of learnable tokens that directly capture task-relevant signals, eliminating the need for explicit node scoring or traversal. These tokens serve as consistent and reusable guidance across snapshots, enabling efficient token-masked embedding alignment between snapshots. Importantly, knowledge transfer is achieved through simple matrix operations, significantly reducing training time and memory usage. Extensive experiments across six benchmark datasets demonstrate that ETT-CKGE consistently achieves superior or competitive predictive performance, while substantially improving training efficiency and scalability compared to state-of-the-art CKGE methods. The code is available at: https://github.com/lijingzhu1/ETT-CKGE/tree/main

arXiv:2506.07534공식 코드 · Papers with Code

Flowing Datasets with Wasserstein over Wasserstein Gradient Flows

Many applications in machine learning involve data represented as probability distributions. The emergence of such data requires radically novel techniques to design tractable gradient flows on probability distributions over this type of (infinite-dimensional) objects. For instance, being able to flow labeled datasets is a core task for applications ranging from domain adaptation to transfer learning or dataset distillation. In this setting, we propose to represent each class by the associated conditional distribution of features, and to model the dataset as a mixture distribution supported on these classes (which are themselves probability distributions), meaning that labeled datasets can be seen as probability distributions over probability distributions. We endow this space with a metric structure from optimal transport, namely the Wasserstein over Wasserstein (WoW) distance, derive a differential structure on this space, and define WoW gradient flows. The latter enables to design dynamics over this space that decrease a given objective functional. We apply our framework to transfer learning and dataset distillation tasks, leveraging our gradient flow construction as well as novel tractable functionals that take the form of Maximum Mean Discrepancies with Sliced-Wasserstein based kernels between probability distributions.

arXiv:2506.00381공식 코드 · Papers with Code

Neuro2Semantic: A Transfer Learning Framework for Semantic Reconstruction of Continuous Language from Human Intracranial EEG

Decoding continuous language from neural signals remains a significant challenge in the intersection of neuroscience and artificial intelligence. We introduce Neuro2Semantic, a novel framework that reconstructs the semantic content of perceived speech from intracranial EEG (iEEG) recordings. Our approach consists of two phases: first, an LSTM-based adapter aligns neural signals with pre-trained text embeddings; second, a corrector module generates continuous, natural text directly from these aligned embeddings. This flexible method overcomes the limitations of previous decoding approaches and enables unconstrained text generation. Neuro2Semantic achieves strong performance with as little as 30 minutes of neural data, outperforming a recent state-of-the-art method in low-data settings. These results highlight the potential for practical applications in brain-computer interfaces and neural decoding technologies.

arXiv:2503.04647공식 코드 · Papers with Code

Implicit Cross-Lingual Rewarding for Efficient Multilingual Preference Alignment

Direct Preference Optimization (DPO) has become a prominent method for aligning Large Language Models (LLMs) with human preferences. While DPO has enabled significant progress in aligning English LLMs, multilingual preference alignment is hampered by data scarcity. To address this, we propose a novel approach that $\textit{captures}$ learned preferences from well-aligned English models by implicit rewards and $\textit{transfers}$ them to other languages through iterative training. Specifically, we derive an implicit reward model from the logits of an English DPO-aligned model and its corresponding reference model. This reward model is then leveraged to annotate preference relations in cross-lingual instruction-following pairs, using English instructions to evaluate multilingual responses. The annotated data is subsequently used for multilingual DPO fine-tuning, facilitating preference knowledge transfer from English to other languages. Fine-tuning Llama3 for two iterations resulted in a 12.72% average improvement in Win Rate and a 5.97% increase in Length Control Win Rate across all training languages on the X-AlpacaEval leaderboard. Our findings demonstrate that leveraging existing English-aligned models can enable efficient and effective multilingual preference alignment, significantly reducing the need for extensive multilingual preference data. The code is available at https://github.com/ZNLP/Implicit-Cross-Lingual-Rewarding

arXiv:2506.03954공식 코드 · Papers with Code

HtFLlib: A Comprehensive Heterogeneous Federated Learning Library and Benchmark

As AI evolves, collaboration among heterogeneous models helps overcome data scarcity by enabling knowledge transfer across institutions and devices. Traditional Federated Learning (FL) only supports homogeneous models, limiting collaboration among clients with heterogeneous model architectures. To address this, Heterogeneous Federated Learning (HtFL) methods are developed to enable collaboration across diverse heterogeneous models while tackling the data heterogeneity issue at the same time. However, a comprehensive benchmark for standardized evaluation and analysis of the rapidly growing HtFL methods is lacking. Firstly, the highly varied datasets, model heterogeneity scenarios, and different method implementations become hurdles to making easy and fair comparisons among HtFL methods. Secondly, the effectiveness and robustness of HtFL methods are under-explored in various scenarios, such as the medical domain and sensor signal modality. To fill this gap, we introduce the first Heterogeneous Federated Learning Library (HtFLlib), an easy-to-use and extensible framework that integrates multiple datasets and model heterogeneity scenarios, offering a robust benchmark for research and practical applications. Specifically, HtFLlib integrates (1) 12 datasets spanning various domains, modalities, and data heterogeneity scenarios; (2) 40 model architectures, ranging from small to large, across three modalities; (3) a modularized and easy-to-extend HtFL codebase with implementations of 10 representative HtFL methods; and (4) systematic evaluations in terms of accuracy, convergence, computation costs, and communication costs. We emphasize the advantages and potential of state-of-the-art HtFL methods and hope that HtFLlib will catalyze advancing HtFL research and enable its broader applications. The code is released at https://github.com/TsingZ0/HtFLlib.

arXiv:2506.03523공식 코드 · Papers with Code

TokAlign: Efficient Vocabulary Adaptation via Token Alignment

Tokenization serves as a foundational step for Large Language Models (LLMs) to process text. In new domains or languages, the inefficiency of the tokenizer will slow down the training and generation of LLM. The mismatch in vocabulary also hinders deep knowledge transfer between LLMs like token-level distillation. To mitigate this gap, we propose an efficient method named TokAlign to replace the vocabulary of LLM from the token co-occurrences view, and further transfer the token-level knowledge between models. It first aligns the source vocabulary to the target one by learning a one-to-one mapping matrix for token IDs. Model parameters, including embeddings, are rearranged and progressively fine-tuned for the new vocabulary. Our method significantly improves multilingual text compression rates and vocabulary initialization for LLMs, decreasing the perplexity from 3.4$\text{e}^2$ of strong baseline methods to 1.2$\text{e}^2$ after initialization. Experimental results on models across multiple parameter scales demonstrate the effectiveness and generalization of TokAlign, which costs as few as 5k steps to restore the performance of the vanilla model. After unifying vocabularies between LLMs, token-level distillation can remarkably boost (+4.4% than sentence-level distillation) the base model, costing only 235M tokens.

arXiv:2506.01923공식 코드 · Papers with Code

TaxaDiffusion: Progressively Trained Diffusion Model for Fine-Grained Species Generation

We propose TaxaDiffusion, a taxonomy-informed training framework for diffusion models to generate fine-grained animal images with high morphological and identity accuracy. Unlike standard approaches that treat each species as an independent category, TaxaDiffusion incorporates domain knowledge that many species exhibit strong visual similarities, with distinctions often residing in subtle variations of shape, pattern, and color. To exploit these relationships, TaxaDiffusion progressively trains conditioned diffusion models across different taxonomic levels -- starting from broad classifications such as Class and Order, refining through Family and Genus, and ultimately distinguishing at the Species level. This hierarchical learning strategy first captures coarse-grained morphological traits shared by species with common ancestors, facilitating knowledge transfer before refining fine-grained differences for species-level distinction. As a result, TaxaDiffusion enables accurate generation even with limited training samples per species. Extensive experiments on three fine-grained animal datasets demonstrate that outperforms existing approaches, achieving superior fidelity in fine-grained animal image generation. Project page: https://amink8.github.io/TaxaDiffusion/

arXiv:2503.02101공식 코드 · Papers with Code

Generalized Diffusion Detector: Mining Robust Features from Diffusion Models for Domain-Generalized Detection

Domain generalization (DG) for object detection aims to enhance detectors' performance in unseen scenarios. This task remains challenging due to complex variations in real-world applications. Recently, diffusion models have demonstrated remarkable capabilities in diverse scene generation, which inspires us to explore their potential for improving DG tasks. Instead of generating images, our method extracts multi-step intermediate features during the diffusion process to obtain domain-invariant features for generalized detection. Furthermore, we propose an efficient knowledge transfer framework that enables detectors to inherit the generalization capabilities of diffusion models through feature and object-level alignment, without increasing inference time. We conduct extensive experiments on six challenging DG benchmarks. The results demonstrate that our method achieves substantial improvements of 14.0% mAP over existing DG approaches across different domains and corruption types. Notably, our method even outperforms most domain adaptation methods without accessing any target domain data. Moreover, the diffusion-guided detectors show consistent improvements of 15.9% mAP on average compared to the baseline. Our work aims to present an effective approach for domain-generalized detection and provide potential insights for robust visual recognition in real-world scenarios. The code is available at \href{https://github.com/heboyong/Generalized-Diffusion-Detector}{Generalized Diffusion Detector}

arXiv:2505.24693공식 코드 · Papers with Code

Conformal Prediction for Zero-Shot Models

Vision-language models pre-trained at large scale have shown unprecedented adaptability and generalization to downstream tasks. Although its discriminative potential has been widely explored, its reliability and uncertainty are still overlooked. In this work, we investigate the capabilities of CLIP models under the split conformal prediction paradigm, which provides theoretical guarantees to black-box models based on a small, labeled calibration set. In contrast to the main body of literature on conformal predictors in vision classifiers, foundation models exhibit a particular characteristic: they are pre-trained on a one-time basis on an inaccessible source domain, different from the transferred task. This domain drift negatively affects the efficiency of the conformal sets and poses additional challenges. To alleviate this issue, we propose Conf-OT, a transfer learning setting that operates transductive over the combined calibration and query sets. Solving an optimal transport problem, the proposed method bridges the domain gap between pre-training and adaptation without requiring additional data splits but still maintaining coverage guarantees. We comprehensively explore this conformal prediction strategy on a broad span of 15 datasets and three non-conformity scores. Conf-OT provides consistent relative improvements of up to 20% on set efficiency while being 15 times faster than popular transductive approaches.

arXiv:2505.24567공식 코드 · Papers with Code

Unleashing the Power of Intermediate Domains for Mixed Domain Semi-Supervised Medical Image Segmentation

Both limited annotation and domain shift are prevalent challenges in medical image segmentation. Traditional semi-supervised segmentation and unsupervised domain adaptation methods address one of these issues separately. However, the coexistence of limited annotation and domain shift is quite common, which motivates us to introduce a novel and challenging scenario: Mixed Domain Semi-supervised medical image Segmentation (MiDSS), where limited labeled data from a single domain and a large amount of unlabeled data from multiple domains. To tackle this issue, we propose the UST-RUN framework, which fully leverages intermediate domain information to facilitate knowledge transfer. We employ Unified Copy-paste (UCP) to construct intermediate domains, and propose a Symmetric GuiDance training strategy (SymGD) to supervise unlabeled data by merging pseudo-labels from intermediate samples. Subsequently, we introduce a Training Process aware Random Amplitude MixUp (TP-RAM) to progressively incorporate style-transition components into intermediate samples. To generate more diverse intermediate samples, we further select reliable samples with high-quality pseudo-labels, which are then mixed with other unlabeled data. Additionally, we generate sophisticated intermediate samples with high-quality pseudo-labels for unreliable samples, ensuring effective knowledge transfer for them. Extensive experiments on four public datasets demonstrate the superiority of UST-RUN. Notably, UST-RUN achieves a 12.94% improvement in Dice score on the Prostate dataset. Our code is available at https://github.com/MQinghe/UST-RUN

arXiv:2505.23181공식 코드 · Papers with Code

FreRA: A Frequency-Refined Augmentation for Contrastive Learning on Time Series Classification

Contrastive learning has emerged as a competent approach for unsupervised representation learning. However, the design of an optimal augmentation strategy, although crucial for contrastive learning, is less explored for time series classification tasks. Existing predefined time-domain augmentation methods are primarily adopted from vision and are not specific to time series data. Consequently, this cross-modality incompatibility may distort the semantically relevant information of time series by introducing mismatched patterns into the data. To address this limitation, we present a novel perspective from the frequency domain and identify three advantages for downstream classification: global, independent, and compact. To fully utilize the three properties, we propose the lightweight yet effective Frequency Refined Augmentation (FreRA) tailored for time series contrastive learning on classification tasks, which can be seamlessly integrated with contrastive learning frameworks in a plug-and-play manner. Specifically, FreRA automatically separates critical and unimportant frequency components. Accordingly, we propose semantic-aware Identity Modification and semantic-agnostic Self-adaptive Modification to protect semantically relevant information in the critical frequency components and infuse variance into the unimportant ones respectively. Theoretically, we prove that FreRA generates semantic-preserving views. Empirically, we conduct extensive experiments on two benchmark datasets, including UCR and UEA archives, as well as five large-scale datasets on diverse applications. FreRA consistently outperforms ten leading baselines on time series classification, anomaly detection, and transfer learning tasks, demonstrating superior capabilities in contrastive representation learning and generalization in transfer learning scenarios across diverse datasets.

arXiv:2505.23745공식 코드 · Papers with Code

To Trust Or Not To Trust Your Vision-Language Model's Prediction

Vision-Language Models (VLMs) have demonstrated strong capabilities in aligning visual and textual modalities, enabling a wide range of applications in multimodal understanding and generation. While they excel in zero-shot and transfer learning scenarios, VLMs remain susceptible to misclassification, often yielding confident yet incorrect predictions. This limitation poses a significant risk in safety-critical domains, where erroneous predictions can lead to severe consequences. In this work, we introduce TrustVLM, a training-free framework designed to address the critical challenge of estimating when VLM's predictions can be trusted. Motivated by the observed modality gap in VLMs and the insight that certain concepts are more distinctly represented in the image embedding space, we propose a novel confidence-scoring function that leverages this space to improve misclassification detection. We rigorously evaluate our approach across 17 diverse datasets, employing 4 architectures and 2 VLMs, and demonstrate state-of-the-art performance, with improvements of up to 51.87% in AURC, 9.14% in AUROC, and 32.42% in FPR95 compared to existing baselines. By improving the reliability of the model without requiring retraining, TrustVLM paves the way for safer deployment of VLMs in real-world applications. The code will be available at https://github.com/EPFL-IMOS/TrustVLM.

arXiv:2505.22696공식 코드 · Papers with Code

When Does Neuroevolution Outcompete Reinforcement Learning in Transfer Learning Tasks?

The ability to continuously and efficiently transfer skills across tasks is a hallmark of biological intelligence and a long-standing goal in artificial systems. Reinforcement learning (RL), a dominant paradigm for learning in high-dimensional control tasks, is known to suffer from brittleness to task variations and catastrophic forgetting. Neuroevolution (NE) has recently gained attention for its robustness, scalability, and capacity to escape local optima. In this paper, we investigate an understudied dimension of NE: its transfer learning capabilities. To this end, we introduce two benchmarks: a) in stepping gates, neural networks are tasked with emulating logic circuits, with designs that emphasize modular repetition and variation b) ecorobot extends the Brax physics engine with objects such as walls and obstacles and the ability to easily switch between different robotic morphologies. Crucial in both benchmarks is the presence of a curriculum that enables evaluating skill transfer across tasks of increasing complexity. Our empirical analysis shows that NE methods vary in their transfer abilities and frequently outperform RL baselines. Our findings support the potential of NE as a foundation for building more adaptable agents and highlight future challenges for scaling NE to complex, real-world problems.

arXiv:2505.21046공식 코드 · Papers with Code

A domain adaptation neural network for digital twin-supported fault diagnosis

Digital twins offer a promising solution to the lack of sufficient labeled data in deep learning-based fault diagnosis by generating simulated data for model training. However, discrepancies between simulation and real-world systems can lead to a significant drop in performance when models are applied in real scenarios. To address this issue, we propose a fault diagnosis framework based on Domain-Adversarial Neural Networks (DANN), which enables knowledge transfer from simulated (source domain) to real-world (target domain) data. We evaluate the proposed framework using a publicly available robotics fault diagnosis dataset, which includes 3,600 sequences generated by a digital twin model and 90 real sequences collected from physical systems. The DANN method is compared with commonly used lightweight deep learning models such as CNN, TCN, Transformer, and LSTM. Experimental results show that incorporating domain adaptation significantly improves the diagnostic performance. For example, applying DANN to a baseline CNN model improves its accuracy from 70.00% to 80.22% on real-world test data, demonstrating the effectiveness of domain adaptation in bridging the sim-to-real gap.

arXiv:2505.19085공식 코드 · Papers with Code

Semantic-enhanced Co-attention Prompt Learning for Non-overlapping Cross-Domain Recommendation

Non-overlapping Cross-domain Sequential Recommendation (NCSR) is the task that focuses on domain knowledge transfer without overlapping entities. Compared with traditional Cross-domain Sequential Recommendation (CSR), NCSR poses several challenges: 1) NCSR methods often rely on explicit item IDs, overlooking semantic information among entities. 2) Existing CSR mainly relies on domain alignment for knowledge transfer, risking semantic loss during alignment. 3) Most previous studies do not consider the many-to-one characteristic, which is challenging because of the utilization of multiple source domains. Given the above challenges, we introduce the prompt learning technique for Many-to-one Non-overlapping Cross-domain Sequential Recommendation (MNCSR) and propose a Text-enhanced Co-attention Prompt Learning Paradigm (TCPLP). Specifically, we capture semantic meanings by representing items through text rather than IDs, leveraging natural language universality to facilitate cross-domain knowledge transfer. Unlike prior works that need to conduct domain alignment, we directly learn transferable domain information, where two types of prompts, i.e., domain-shared and domain-specific prompts, are devised, with a co-attention-based network for prompt encoding. Then, we develop a two-stage learning strategy, i.e., pre-train & prompt-tuning paradigm, for domain knowledge pre-learning and transferring, respectively. We conduct extensive experiments on three datasets and the experimental results demonstrate the superiority of our TCPLP. Our source codes have been publicly released.

arXiv:2505.18502공식 코드 · Papers with Code

Knowledge Grafting of Large Language Models

Cross-capability transfer is a key challenge in large language model (LLM) research, with applications in multi-task integration, model compression, and continual learning. Recent works like FuseLLM and FuseChat have demonstrated the potential of transferring multiple model capabilities to lightweight models, enhancing adaptability and efficiency, which motivates our investigation into more efficient cross-capability transfer methods. However, existing approaches primarily focus on small, homogeneous models, limiting their applicability. For large, heterogeneous models, knowledge distillation with full-parameter fine-tuning often overlooks the student model's intrinsic capacity and risks catastrophic forgetting, while PEFT methods struggle to effectively absorb knowledge from source LLMs. To address these issues, we introduce GraftLLM, a novel method that stores source model capabilities in a target model with SkillPack format. This approach preserves general capabilities, reduces parameter conflicts, and supports forget-free continual learning and model fusion. We employ a module-aware adaptive compression strategy to compress parameter updates, ensuring efficient storage while maintaining task-specific knowledge. The resulting SkillPack serves as a compact and transferable knowledge carrier, ideal for heterogeneous model fusion and continual learning. Experiments across various scenarios demonstrate that GraftLLM outperforms existing techniques in knowledge transfer, knowledge fusion, and forget-free learning, providing a scalable and efficient solution for cross-capability transfer. The code is publicly available at: https://github.com/duguodong7/GraftLLM.

arXiv:2505.20014공식 코드 · Papers with Code

Does Rationale Quality Matter? Enhancing Mental Disorder Detection via Selective Reasoning Distillation

The detection of mental health problems from social media and the interpretation of these results have been extensively explored. Research has shown that incorporating clinical symptom information into a model enhances domain expertise, improving its detection and interpretation performance. While large language models (LLMs) are shown to be effective for generating explanatory rationales in mental health detection, their substantially large parameter size and high computational cost limit their practicality. Reasoning distillation transfers this ability to smaller language models (SLMs), but inconsistencies in the relevance and domain alignment of LLM-generated rationales pose a challenge. This paper investigates how rationale quality impacts SLM performance in mental health detection and explanation generation. We hypothesize that ensuring high-quality and domain-relevant rationales enhances the distillation. To this end, we propose a framework that selects rationales based on their alignment with expert clinical reasoning. Experiments show that our quality-focused approach significantly enhances SLM performance in both mental disorder detection and rationale generation. This work highlights the importance of rationale quality and offers an insightful framework for knowledge transfer in mental health applications.

arXiv:2505.19779공식 코드 · Papers with Code

Advancements in Medical Image Classification through Fine-Tuning Natural Domain Foundation Models

Using massive datasets, foundation models are large-scale, pre-trained models that perform a wide range of tasks. These models have shown consistently improved results with the introduction of new methods. It is crucial to analyze how these trends impact the medical field and determine whether these advancements can drive meaningful change. This study investigates the application of recent state-of-the-art foundation models, DINOv2, MAE, VMamba, CoCa, SAM2, and AIMv2, for medical image classification. We explore their effectiveness on datasets including CBIS-DDSM for mammography, ISIC2019 for skin lesions, APTOS2019 for diabetic retinopathy, and CHEXPERT for chest radiographs. By fine-tuning these models and evaluating their configurations, we aim to understand the potential of these advancements in medical image classification. The results indicate that these advanced models significantly enhance classification outcomes, demonstrating robust performance despite limited labeled data. Based on our results, AIMv2, DINOv2, and SAM2 models outperformed others, demonstrating that progress in natural domain training has positively impacted the medical domain and improved classification outcomes. Our code is publicly available at: https://github.com/sajjad-sh33/Medical-Transfer-Learning.

arXiv:2505.16130공식 코드 · Papers with Code

Scalable Graph Generative Modeling via Substructure Sequences

Graph neural networks (GNNs) has been predominantly driven by message-passing, where node representations are iteratively updated via local neighborhood aggregation. Despite their success, message-passing suffers from fundamental limitations -- including constrained expressiveness, over-smoothing, over-squashing, and limited capacity to model long-range dependencies. These issues hinder scalability: increasing data size or model size often fails to yield improved performance, limiting the viability of GNNs as backbones for graph foundation models. In this work, we explore pathways beyond message-passing and introduce Generative Graph Pattern Machine (G$^2$PM), a generative Transformer pre-training framework for graphs. G$^2$PM represents graph instances (nodes, edges, or entire graphs) as sequences of substructures, and employs generative pre-training over the sequences to learn generalizable, transferable representations. Empirically, G$^2$PM demonstrates strong scalability: on the ogbn-arxiv benchmark, it continues to improve with model sizes up to 60M parameters, outperforming prior generative approaches that plateau at significantly smaller scales (e.g., 3M). In addition, we systematically analyze the model design space, highlighting key architectural choices that contribute to its scalability and generalization. Across diverse tasks -- including node classification, graph classification, and transfer learning -- G$^2$PM consistently outperforms strong baselines, establishing a compelling foundation for scalable graph learning. The code and dataset are available at https://github.com/Zehong-Wang/G2PM.

arXiv:2505.14725공식 코드 · Papers with Code

HR-VILAGE-3K3M: A Human Respiratory Viral Immunization Longitudinal Gene Expression Dataset for Systems Immunity

Respiratory viral infections pose a global health burden, yet the cellular immune responses driving protection or pathology remain unclear. Natural infection cohorts often lack pre-exposure baseline data and structured temporal sampling. In contrast, inoculation and vaccination trials generate insightful longitudinal transcriptomic data. However, the scattering of these datasets across platforms, along with inconsistent metadata and preprocessing procedure, hinders AI-driven discovery. To address these challenges, we developed the Human Respiratory Viral Immunization LongitudinAl Gene Expression (HR-VILAGE-3K3M) repository: an AI-ready, rigorously curated dataset that integrates 14,136 RNA-seq profiles from 3,178 subjects across 66 studies encompassing over 2.56 million cells. Spanning vaccination, inoculation, and mixed exposures, the dataset includes microarray, bulk RNA-seq, and single-cell RNA-seq from whole blood, PBMCs, and nasal swabs, sourced from GEO, ImmPort, and ArrayExpress. We harmonized subject-level metadata, standardized outcome measures, applied unified preprocessing pipelines with rigorous quality control, and aligned all data to official gene symbols. To demonstrate the utility of HR-VILAGE-3K3M, we performed predictive modeling of vaccine responders and evaluated batch-effect correction methods. Beyond these initial demonstrations, it supports diverse systems immunology applications and benchmarking of feature selection and transfer learning algorithms. Its scale and heterogeneity also make it ideal for pretraining foundation models of the human immune response and for advancing multimodal learning frameworks. As the largest longitudinal transcriptomic resource for human respiratory viral immunization, it provides an accessible platform for reproducible AI-driven research, accelerating systems immunology and vaccine development against emerging viral threats.